Arc-PET: Cost-Effective Whole-Body Scanner with High Sensitivity and High Spatial Resolution

2020 ◽  
Author(s):  
Eric W. Petersen ◽  
Wei Zhao ◽  
Amir Goldan
Keyword(s):  
Spatial Resolution ◽  
High Spatial Resolution ◽  
High Sensitivity ◽  
Cost Effective ◽  
Whole Body ◽  
Body Scanner

Applications of a Laboratory X-ray Micropsobe to Materials Analysis

1988 ◽  
Vol 32 ◽  
pp. 115-120 ◽  
Author(s):  
D. A. Carpenter ◽  
M. A. Taylor ◽  
C. E. Holcombe
Keyword(s):  
Spatial Resolution ◽  
High Spatial Resolution ◽  
High Sensitivity ◽  
Specimen Preparation ◽  
X Rays ◽  
Glass Capillary ◽  
Materials Analysis ◽  
X Ray ◽  
Small Glass

A laboratory-based X-ray microprobe, composed of a high-brilliance microfocus X-ray tube, coupled with a small glass capillary, has been developed for materials applications. Because of total external reflectance of X rays from the smooth inside bore of the glass capillary, the microprobe has a high sensitivity as well as a high spatial resolution. The use of X rays to excite elemental fluorescence offers the advantages of good peak-to-background, the ability to operate in air, and minimal specimen preparation. In addition, the development of laboratory-based instrumentation has been of Interest recently because of greater accessibility when compared with synchrotron X-ray microprobes.

High spatial resolution at very high sensitivity using synchrotron radiation excited XPS

1989 ◽  
Vol 60 (7) ◽  
pp. 2172-2175 ◽  
Author(s):  
M. Schaible ◽  
H. Petersen ◽  
W. Braun ◽  
E.‐E. Koch
Keyword(s):  
Synchrotron Radiation ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
High Sensitivity ◽  
Very High

High-sensitivity colorimetric detection of DNA hybridization on a gold surface with high spatial resolution

2002 ◽  
Vol 14 (1) ◽  
pp. 7-10 ◽  
Author(s):  
R Wirtz ◽  
C W lti ◽  
W A Germishuizen ◽  
M Pepper ◽  
A P J Middelberg ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Dna Hybridization ◽  
High Spatial Resolution ◽  
Colorimetric Detection ◽  
High Sensitivity ◽  
Gold Surface

99mTc-labeled and gadolinium-chelated transferrin enhances the sensitivity and specificity of dual-modality SPECT/MR imaging of breast cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (25) ◽  
pp. 20532-20541 ◽  
Author(s):  
Bingxin Gu ◽  
Jiali Cai ◽  
Jianping Zhang ◽  
Xiaoping Xu ◽  
Jianming Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Sensitivity And Specificity ◽  
Spatial Resolution ◽  
Breast Tumor ◽  
High Spatial Resolution ◽  
High Sensitivity ◽  
Dual Modality

A dual-modal probe 99mTc–Tf–DTPA–Gd could provide high spatial resolution and high sensitivity images of breast tumor.

scholarly journals NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues

2016 ◽  
Vol 65 (3) ◽  
pp. 669-672 ◽  
Author(s):  
Cuiwen He ◽  
Loren G Fong ◽  
Stephen G Young ◽  
Haibo Jiang
Keyword(s):  
Mass Spectrometry ◽  
Spatial Resolution ◽  
Mass Spectrometry Imaging ◽  
Secondary Ion Mass Spectrometry ◽  
High Spatial Resolution ◽  
High Sensitivity ◽  
New Approach ◽  
The Past ◽  
Secondary Ion ◽  
In Cells

Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity.

Kelvin Probe Force Microscope Measurement Uncertainty

2011 ◽  
Vol 222 ◽  
pp. 114-117
Author(s):  
Maciej Ligowski ◽  
Michiharu Tabe ◽  
Ryszard Jabłoński
Keyword(s):  
Measurement Uncertainty ◽  
Spatial Resolution ◽  
Surface Potential ◽  
High Spatial Resolution ◽  
High Sensitivity ◽  
Kelvin Probe ◽  
Force Microscopy ◽  
Calibration Methods ◽  
Standard Calibration ◽  
Nanoscale Measurements

Kelvin Probe Force Microscopy is an attractive technique for characterizing the surface potential of various samples. The main advantage of this technique is its high spatial resolution together with high sensitivity. However as in any nanoscale measurements also in case of KFM it is extremly difficult to describe the uncertainty of the measurement. Moreover, a wide variety of measuring conditions, together with the complicated operation principle cause situation, where no standard calibration methods are available. In the paper we propose the model of the KFM microscope and analyze the uncertainty of the KFM measurement.

scholarly journals High Performance Molecular Imaging with MALDI Trapped Ion Mobility Time-of-Flight (timsTOF) Mass Spectrometry

2019 ◽  
Author(s):  
Jeffrey Spraggins ◽  
Katerina Djambazova ◽  
Emilio Rivera ◽  
Lukasz Migas ◽  
Elizabeth Neumann ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Imaging ◽  
Spatial Resolution ◽  
Ion Mobility ◽  
Measurement Errors ◽  
High Performance ◽  
High Spatial Resolution ◽  
Biological Tissues ◽  
Whole Body ◽  
Trapped Ion

Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of biological tissues at cellular resolutions. New developments and technologies are essential for uncovering the molecular drivers of native physiological function and disease. Instrumentation must maximize spatial resolution, throughput, sensitivity, and specificity, because tissue imaging experiments consist of thousands to millions of pixels. Here, we report the development and application of a matrix-assisted laser desorption/ionization (MALDI) trapped ion mobility spectrometry imaging platform. This prototype MALDI timsTOF instrument is capable of 10 µm spatial resolutions and 20 pixels/s throughput molecular imaging. The MALDI source utilizes a Bruker SmartBeam 3-D laser system that can generate a square burn pattern of <10 x 10 µm at the sample surface. General image performance was assessed using murine kidney and brain tissues and demonstrate that high spatial resolution imaging data can be generated rapidly with mass measurement errors < 5 ppm and ~40,000 resolving power. Initial TIMS-based imaging experiments were performed on whole body mouse pup tissue demonstrating the separation of closely isobaric [PC(32:0)+Na]<sup>+</sup>and [PC(34:3)+H]<sup>+</sup>(3 mDa mass difference) in the gas-phase. We have shown that the MALDI timsTOF platform can maintain reasonable data acquisition rates (>2 pixels/s) while providing the specificity necessary to differentiate components in complex mixtures of lipid adducts. The combination of high spatial resolution and throughput imaging capabilities with high-performance TIMS separations provides a uniquely tunable platform to address many challenges associated with advanced molecular imaging applications.

scholarly journals Wide Swath and High Resolution Airborne HyperSpectral Imaging System and Flight Validation

Sensors ◽  
2019 ◽  
Vol 19 (7) ◽  
pp. 1667 ◽  
Author(s):  
Dong Zhang ◽  
Liyin Yuan ◽  
Shengwei Wang ◽  
Hongxuan Yu ◽  
Changxing Zhang ◽  
...  
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
Spectral Resolution ◽  
High Efficiency ◽  
High Spatial Resolution ◽  
Imaging System ◽  
High Sensitivity ◽  
Field Of View ◽  
High Spectral Resolution ◽  
Wide Swath

Wide Swath and High Resolution Airborne Pushbroom Hyperspectral Imager (WiSHiRaPHI) is the new-generation airborne hyperspectral imager instrument of China, aimed at acquiring accurate spectral curve of target on the ground with both high spatial resolution and high spectral resolution. The spectral sampling interval of WiSHiRaPHI is 2.4 nm and the spectral resolution is 3.5 nm (FWHM), integrating 256 channels coving from 400 nm to 1000 nm. The instrument has a 40-degree field of view (FOV), 0.125 mrad instantaneous field of view (IFOV) and can work in high spectral resolution mode, high spatial resolution mode and high sensitivity mode for different applications, which can adapt to the Velocity to Height Ratio (VHR) lower than 0.04. The integration has been finished, and several airborne flight validation experiments have been conducted. The results showed the system’s excellent performance and high efficiency.

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