Self-assembling Combretastatin A4 Incorporated Protamine/Nanodiamond Hybrids for Combined Anti-angiogenesis and Mild Photothermal Therapy in Liver Cancer

2021 ◽  
Author(s):  
Yun hao Li ◽  
Jian qing Lu ◽  
Xiong wei Deng ◽  
Xuan Wang ◽  
Fan Jia ◽  
...  
Nanoscale ◽  
2022 ◽  
Author(s):  
Xiaojie Zhang ◽  
Changsheng Zhou ◽  
Fanghua Wu ◽  
Chang Gao ◽  
Qianqian Liu ◽  
...  

Abstract Long-term unsolved health problems from pre-/Intra-/postoperative complications and thermal ablation complications pose threats to liver cancer patients. To reduce the threats, we propose a multimodal-imaging guided surgical navigation system...


2017 ◽  
Vol 9 (36) ◽  
pp. 30306-30317 ◽  
Author(s):  
Zheng Wang ◽  
Zhimin Chang ◽  
Mengmeng Lu ◽  
Dan Shao ◽  
Juan Yue ◽  
...  

2020 ◽  
Vol 146 (4) ◽  
pp. 875-882
Author(s):  
Maonan Wang ◽  
Lishan Wang ◽  
Huan Feng ◽  
Hui Jiang ◽  
Jiahua Zhou ◽  
...  

2016 ◽  
Vol 7 (9) ◽  
pp. 6232-6237 ◽  
Author(s):  
S. Paterson ◽  
S. A. Thompson ◽  
J. Gracie ◽  
A. W. Wark ◽  
R. de la Rica

A new method is introduced for self-assembling citrate-capped gold nanoparticles into supraparticles with crystallographically aligned building blocks.


2017 ◽  
Vol 5 (38) ◽  
pp. 7831-7838 ◽  
Author(s):  
Yan-Hui Li ◽  
Min Guo ◽  
Shu-Wen Shi ◽  
Qian-Ling Zhang ◽  
Shi-Ping Yang ◽  
...  

A multifunctional nanoplatform is capable of targeting liver cancer cells for NIR-light-controlled NO-release, and achieving both photodynamic and photothermal therapies.


ACS Nano ◽  
2019 ◽  
Vol 13 (6) ◽  
pp. 7345-7354 ◽  
Author(s):  
Tingting Sun ◽  
Jinfeng Han ◽  
Shi Liu ◽  
Xin Wang ◽  
Zhi Yuan Wang ◽  
...  

2021 ◽  
Vol 22 (2) ◽  
pp. 738
Author(s):  
Bartosz F. Grześkowiak ◽  
Damian Maziukiewicz ◽  
Agata Kozłowska ◽  
Ahmet Kertmen ◽  
Emerson Coy ◽  
...  

The development of multifunctional drug delivery systems combining two or more nanoparticle-mediated therapies for efficient cancer treatment is highly desired. To face this challenge, a photothermally active polydopamine (PDA) nanoparticle-based platform was designed for the loading of chemotherapeutic drug and targeting of cancer cells. PDA spheres were first functionalized with polyamidoamine (PAMAM) dendrimers followed by the conjugation with polyethylene glycol (PEG) moieties and folic acid (FA) targeting ligand. The anticancer drug doxorubicin (DOX) was then absorbed on the particle surface. We performed the physico-chemical characterization of this versatile material and we assessed further its possible application in chemo- and photothermal therapy using liver cancer cell model. These nanoparticles exhibited high near-infrared photothermal conversion efficacy and allowed for loading of the drug, which upon release in specifically targeted cancer cells suppressed their growth. Using cell proliferation, membrane damage, apoptosis, and oxidative stress assays we demonstrated high performance of this nanosystem in cancer cell death induction, providing a novel promising approach for cancer therapy.


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