A review on magnetic and spintronic neurostimulation: challenges and prospects

2022 ◽  
Author(s):  
Renata Saha ◽  
Kai Wu ◽  
Robert Bloom ◽  
Shuang Liang ◽  
Denis Tonini ◽  
...  

Abstract In the treatment of neurodegenerative, sensory and cardiovascular diseases, electrical probes and arrays have shown quite a promising success rate. However, despite the outstanding clinical outcomes, their operation is significantly hindered by non-selective control of electric fields. A promising alternative is micromagnetic stimulation (μMS) due to the high permeability of magnetic field through biological tissues. The induced electric field from the time-varying magnetic field generated by magnetic neurostimulators is used to remotely stimulate neighboring neurons. Due to the spatial asymmetry of the induced electric field, high spatial selectivity of neurostimulation has been realized. Herein, some popular choices of magnetic neurostimulators such as microcoils (μcoils) and spintronic nanodevices are reviewed. The neurostimulator features such as power consumption and resolution (aiming at cellular level) are discussed. In addition, the chronic stability and biocompatibility of these implantable neurostimulator are commented in favor of further translation to clinical settings. Furthermore, magnetic nanoparticles (MNPs), as another invaluable neurostimulation material, has emerged in recent years. Thus, in this review we have also included MNPs as a remote neurostimulation solution that overcomes physical limitations of invasive implants. Overall, this review provides peers with the recent development of ultra-low power, cellular-level, spatially selective magnetic neurostimulators of dimensions within micro- to nano-range for treating chronic neurological disorders. At the end of this review, some potential applications of next generation neuro-devices have also been discussed.

2003 ◽  
Vol 10 (1/2) ◽  
pp. 45-52 ◽  
Author(s):  
R. E. Ergun ◽  
L. Andersson ◽  
C. W. Carlson ◽  
D. L. Newman ◽  
M. V. Goldman

Abstract. Direct observations of magnetic-field-aligned (parallel) electric fields in the downward current region of the aurora provide decisive evidence of naturally occurring double layers. We report measurements of parallel electric fields, electron fluxes and ion fluxes related to double layers that are responsible for particle acceleration. The observations suggest that parallel electric fields organize into a structure of three distinct, narrowly-confined regions along the magnetic field (B). In the "ramp" region, the measured parallel electric field forms a nearly-monotonic potential ramp that is localized to ~ 10 Debye lengths along B. The ramp is moving parallel to B at the ion acoustic speed (vs) and in the same direction as the accelerated electrons. On the high-potential side of the ramp, in the "beam" region, an unstable electron beam is seen for roughly another 10 Debye lengths along B. The electron beam is rapidly stabilized by intense electrostatic waves and nonlinear structures interpreted as electron phase-space holes. The "wave" region is physically separated from the ramp by the beam region. Numerical simulations reproduce a similar ramp structure, beam region, electrostatic turbulence region and plasma characteristics as seen in the observations. These results suggest that large double layers can account for the parallel electric field in the downward current region and that intense electrostatic turbulence rapidly stabilizes the accelerated electron distributions. These results also demonstrate that parallel electric fields are directly associated with the generation of large-amplitude electron phase-space holes and plasma waves.


2016 ◽  
Vol 34 (1) ◽  
pp. 55-65 ◽  
Author(s):  
A. D. M. Walker ◽  
G. J. Sofko

Abstract. When studying magnetospheric convection, it is often necessary to map the steady-state electric field, measured at some point on a magnetic field line, to a magnetically conjugate point in the other hemisphere, or the equatorial plane, or at the position of a satellite. Such mapping is relatively easy in a dipole field although the appropriate formulae are not easily accessible. They are derived and reviewed here with some examples. It is not possible to derive such formulae in more realistic geomagnetic field models. A new method is described in this paper for accurate mapping of electric fields along field lines, which can be used for any field model in which the magnetic field and its spatial derivatives can be computed. From the spatial derivatives of the magnetic field three first order differential equations are derived for the components of the normalized element of separation of two closely spaced field lines. These can be integrated along with the magnetic field tracing equations and Faraday's law used to obtain the electric field as a function of distance measured along the magnetic field line. The method is tested in a simple model consisting of a dipole field plus a magnetotail model. The method is shown to be accurate, convenient, and suitable for use with more realistic geomagnetic field models.


Geophysics ◽  
2004 ◽  
Vol 69 (5) ◽  
pp. 1192-1202 ◽  
Author(s):  
Michael Commer ◽  
Gregory Newman

A parallel finite‐difference algorithm for the solution of diffusive, three‐dimensional (3D) transient electromagnetic field simulations is presented. The purpose of the scheme is the simulation of both electric fields and the time derivative of magnetic fields generated by galvanic sources (grounded wires) over arbitrarily complicated distributions of conductivity and magnetic permeability. Using a staggered grid and a modified DuFort‐Frankel method, the scheme steps Maxwell's equations in time. Electric field initialization is done by a conjugate‐gradient solution of a 3D Poisson problem, as is common in 3D resistivity modeling. Instead of calculating the initial magnetic field directly, its time derivative and curl are employed in order to advance the electric field in time. A divergence‐free condition is enforced for both the magnetic‐field time derivative and the total conduction‐current density, providing accurate results at late times. In order to simulate large realistic earth models, the algorithm has been designed to run on parallel computer platforms. The upward continuation boundary condition for a stable solution in the infinitely resistive air layer involves a two‐dimensional parallel fast Fourier transform. Example simulations are compared with analytical, integral‐equation and spectral Lanczos decomposition solutions and demonstrate the accuracy of the scheme.


2007 ◽  
Vol 21 (10) ◽  
pp. 1715-1720 ◽  
Author(s):  
NANA METREVELI ◽  
ZAUR KACHLISHVILI ◽  
BEKA BOCHORISHVILI

The transverse runaway (TR) is a phenomenon whereby for a certain combination of energy and momentum scattering mechanisms of hot electrons, and for a certain threshold of the applied electric field, the internal (total) field tends to infinity. In this work, the effect of the magnetic field on the transverse runaway threshold is considered. It is shown that with increasing magnetic field, the applied critical electric fields relevant to TR decrease. The obtained results are important for practical applications of the TR effect as well as for the investigation of possible nonlinear oscillations that may occur near the TR threshold.


Geophysics ◽  
1982 ◽  
Vol 47 (7) ◽  
pp. 1068-1077 ◽  
Author(s):  
G. M. Hoversten ◽  
H. F. Morrison

The electric field induced within four layered models by a repetitive current wave form in a circular loop transmitter is presented along with the resulting magnetic fields observed on the surface. The behavior of the induced electric field as a function of time explains the observed sign reversal of the vertical magnetic field on the surface. In addition, the differences between magnetic field responses for different models are explained by the behavior of the induced electric fields. The pattern of the induced electric field is shown to be that of a single “smoke ring,” as described by Nabighian (1979), which is distorted by layering but which remains a single ring system rather than forming separate smoke rings in each layer.


1967 ◽  
Vol 22 (12) ◽  
pp. 1890-1903
Author(s):  
F. Karger

In a previous paper31 discrepancies between theory and experiment were found on investigating the positive column in a curved magnetic field. The approximation derived in 31 for the torus drift in a weakly ionized magnetoplasma is therefore checked here (Part I) with a refined theory which also yields the transverse electric field strength. Experimentally, both the transverse electric fields and the density profiles in the DC discharge were determined in addition to the longitudinal electric field strength.The discrepancies occurring in 31 are ascribed to the fact that the plasma concentrates at the cathode end of the magnetic field coils, this effect having a considerable influence on the form of the transverse density profile and on the stability behaviour. Part II later will show how the influence of this concentration can be eliminated and what effect in the current-carrying toroidal plasma causes a marked reduction of the charge carrier losses.


2007 ◽  
Vol 25 (3) ◽  
pp. 453-464 ◽  
Author(s):  
L. Torrisi ◽  
D. Margarone ◽  
S. Gammino ◽  
L. Andò

Laser-generated plasma is obtained in high vacuum (10−7 mbar) by irradiation of metallic targets (Al, Cu, Ta) with laser beam with intensities of the order of 1010 W/cm2. An Nd:Yag laser operating at 1064 nm wavelength, 9 ns pulse width, and 500 mJ maximum pulse energy is used. Time of flight measurements of ion emission along the direction normal to the target surface were performed with an ion collector. Measurements with and without a 0.1 Tesla magnetic field, directed along the normal to the target surface, have been taken for different target-detector distances and for increasing laser pulse intensity. Results have demonstrated that the magnetic field configuration creates an electron trap in front of the target surface along the axial direction. Electric fields inside the trap induce ion acceleration; the presence of electron bundles not only focuses the ion beam but also increases its energy, mean charge state and current. The explanation of this phenomenon can be found in the electric field modification inside the non-equilibrium plasma because of an electron bunching that increases the number of electron-ion interactions. The magnetic field, in fact, modifies the electric field due to the charge separation between the clouds of fast electrons, many of which remain trapped in the magnetic hole, and slow ions, ejected from the ablated target; moreover it increases the number of electron-ion interactions producing higher charge states.


2012 ◽  
Vol 30 (1) ◽  
pp. 177-202 ◽  
Author(s):  
N. Yu. Ganushkina ◽  
M. W. Liemohn ◽  
T. I. Pulkkinen

Abstract. The main point of the paper is to investigate how much the modeled ring current depends on the representations of magnetic and electric fields and boundary conditions used in simulations. Two storm events, one moderate (SymH minimum of −120 nT) on 6–7 November 1997 and one intense (SymH minimum of −230 nT) on 21–22 October 1999, are modeled. A rather simple ring current model is employed, namely, the Inner Magnetosphere Particle Transport and Acceleration model (IMPTAM), in order to make the results most evident. Four different magnetic field and two electric field representations and four boundary conditions are used. We find that different combinations of the magnetic and electric field configurations and boundary conditions result in very different modeled ring current, and, therefore, the physical conclusions based on simulation results can differ significantly. A time-dependent boundary outside of 6.6 RE gives a possibility to take into account the particles in the transition region (between dipole and stretched field lines) forming partial ring current and near-Earth tail current in that region. Calculating the model SymH* by Biot-Savart's law instead of the widely used Dessler-Parker-Sckopke (DPS) relation gives larger and more realistic values, since the currents are calculated in the regions with nondipolar magnetic field. Therefore, the boundary location and the method of SymH* calculation are of key importance for ring current data-model comparisons to be correctly interpreted.


1970 ◽  
Vol 4 (3) ◽  
pp. 441-450 ◽  
Author(s):  
Barbara Abraham-Shrauner

Suppression of runaway of electrons in a weak, uniform electric field in a fully ionized Lorentz plasma by crossed magnetic and electric fields is analysed. A uniform, constant magnetic field parallel to a constant or harmonically time varying electric field does not alter runaway from that in the absence of the magnetic field. For crossed, constant fields the passage to runaway or to free motion as described by constant drift motion and spiral motion about the magnetic field is lengthened in time for strong magnetic fields. The new ‘runaway’ time scale is roughly the ratio of the cyclotron frequency to the collision frequency squared for cyclotron frequencies much greater than the collision frequency. All ‘runaway’ time scales may be given approximately by t2E Teff where tE is the characteristic time of the electric field and Teff is the ffective collision time as estimated from the appropriate component of the electrical conductivity.


2016 ◽  
Vol 34 (1) ◽  
pp. 67-73 ◽  
Author(s):  
A. D. M. Walker

Abstract. A method of mapping electric fields along geomagnetic field lines is applied to the IGRF (International Geomagnetic Reference Field) model. The method involves integrating additional sets of first order differential equations simultaneously with those for tracing a magnetic field line. These provide a measure of the rate of change of the separation of two magnetic field lines separated by an infinitesimal amount. From the results of the integration Faraday's law is used to compute the electric field as a function of position along the field line. Examples of computations from a software package developed to implement the method are presented. This is expected to be of use in conjugate studies of magnetospheric phenomena such as SuperDARN (Super Dual Auroral Radar) observations of convection in conjugate hemispheres, or comparison of satellite electric field observations with fields measured in the ionosphere.


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