Spinal Muscle Atrophy Disease Modelling as Bayesian Network
2021 ◽
Vol 2128
(1)
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pp. 012015
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Abstract We investigate the molecular gene expressions studies and public databases for disease modelling using Probabilistic Graphical Models and Bayesian Inference. A case study on Spinal Muscle Atrophy Genome-Wide Association Study results is modelled and analyzed. The genes up and down-regulated in two stages of the disease development are linked to prior knowledge published in the public domain and co-expressions network is created and analyzed. The Molecular Pathways triggered by these genes are identified. The Bayesian inference posteriors distributions are estimated using a variational analytical algorithm and a Markov chain Monte Carlo sampling algorithm. Assumptions, limitations and possible future work are concluded.
2006 ◽
Vol 1
(3)
◽
pp. 27-50
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2019 ◽
Vol 23
(1)
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pp. 60-64
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Keyword(s):
2021 ◽
Keyword(s):