Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men

Abstract No data exist on hepatitis B virus (HBV) incidence among African men who have sex with men (MSM). We tested plasma samples archived between 2005 and 2014 for HBV core antibody or surface antigen seroconversion in a cohort of 312 initially human immunodeficiency virus (HIV)-1-negative MSM with no evidence of prior HBV infection. Hepatitis B virus incidence was 6.0/100 person-years (95% confidence interval [CI], 3.9–9.1). Hepatitis B virus acquisition was associated with being uncircumcised (adjusted incidence rate ratio [aIRR], 5.0; 95% CI, 1.5–16.8), recent HIV-1 acquisition (aIRR, 2.9; 95% CI, 1.1–7.7), rape (aIRR, 5.0; 95% CI, 1.2–20.4), and any tertiary education (aIRR, 3.2; 95% CI, 1.1–9.7). African MSM have a substantial risk of HBV acquisition and require vaccination urgently.

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The prevalence of hepatitis B and C co-infections among people with HIV-1 in Bulgaria: 2010–2015

Future Virology ◽

10.2217/fvl-2019-0092 ◽

2019 ◽

Vol 14 (12) ◽

pp. 791-798

Author(s):

Ivailo Alexiev ◽

Elitsa Golkocheva-Markova ◽

Asya Kostadinova ◽

Reneta Dimitrova ◽

Lora Nikolova ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B ◽

Hepatitis B Surface Antigen ◽

Hcv Rna ◽

B Virus ◽

Sex With Men ◽

Multiple Risk Behavior ◽

Hiv 1 ◽

Hiv Aids

Aim: To evaluate hepatitis B virus (HBV) and hepatitis C virus (HCV) among individuals with HIV/AIDS in Bulgaria diagnosed between 2010 and 2015. Materials & methods: A total of 1158 individuals were diagnosed with HIV/AIDS during the study period. Different transmission groups were tested with ELISA and real-time PCR for HBV and HCV markers. Results: Hepatitis B surface antigen and hepatitis C virus antiboby were found in 9.3 and 23.2% of the tested. HBV DNA and HCV RNA has been found in 47.4 and 69.6%. Hepatitis B and C co-infections were predominant in multiple risk behavior groups, including people who inject drugs, men who have sex with men, prisoners and Roma individuals. Conclusion: HIV prevalence in Bulgaria is low but the rates of hepatitis B and C co-infections among these patients fall within the upper range reported in Europe.

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Hepatitis B virus infection among men who have sex with men and transgender women living with or at risk for HIV: a cross sectional study in Abuja and Lagos, Nigeria

BMC Infectious Diseases ◽

10.1186/s12879-021-06368-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Olusegun A. Adeyemi ◽

Andrew Mitchell ◽

Ashley Shutt ◽

Trevor A. Crowell ◽

Nicaise Ndembi ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Condomless Sex ◽

B Virus ◽

Hbv Prevalence ◽

Sex With Men ◽

Living With Hiv

Abstract Background Despite the development of a safe and efficacious hepatitis B vaccine in 1982, the hepatitis B virus (HBV) remains a public health burden in sub-Saharan Africa. Due to shared risk factors for virus acquisition, men who have sex with men (MSM) and transgender women (TGW) living with HIV are at increased risk of HBV. We estimated the prevalence of HBV and associated factors for MSM and TGW living with or without HIV in Nigeria. Methods Since March 2013, TRUST/RV368 has recruited MSM and TGW in Abuja and Lagos, Nigeria using respondent driven sampling. Participants with HIV diagnosis, enrollment as of June 2015, and available plasma were selected for a cross-sectional study and retrospectively tested for hepatitis B surface antigen and HBV DNA. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for factors associated with prevalent HBV infection. Results A total of 717 MSM and TGW had a median age of 25 years (interquartile range [IQR]: 21–27), 5% self-reported HBV vaccination, 61% were living with HIV, 10% had prevalent HBV infection and 6% were HIV-HBV co-infected. HIV mono-infected as compared to HIV-HBV co-infected had a higher median CD4 T cell count [425 (IQR: 284–541) vs. 345 (IQR: 164–363) cells/mm3, p = 0.03] and a lower median HIV RNA viral load [4.2 (IQR: 2.3–4.9) vs. 4.7 (IQR: 3.9–5.4) log10copies/mL, p < 0.01]. The only factor independently associated with HBV was self-report of condomless sex at last anal intercourse (OR: 2.2, 95% CI: 1.3, 3.6). HIV infection was not independently associated with HBV (OR: 1.0, 95% CI: 0.7–1.6). Conclusion HBV prevalence was moderately high but did not differ by HIV in this cohort of MSM and TGW. Recent condomless sex was associated with elevated HBV risk, reinforcing the need to increase communication and education on condom use among key populations in Nigeria. Evaluating use of concurrent HIV antiretroviral therapy with anti-HBV activity may confirm the attenuated HBV prevalence for those living with HIV.

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Hepatitis B virus genotype distribution in HIV-1 coinfected patients

Gastroenterology ◽

10.1016/j.gastro.2003.03.006 ◽

2003 ◽

Vol 125 (5) ◽

pp. 1559-1560 ◽

Cited By ~ 14

Author(s):

Gianguglielmo Zehender ◽

Chiara De Maddalena ◽

Laura Milazzo ◽

Manuela Piazza ◽

Massimo Galli ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Genotype Distribution ◽

Virus Genotype ◽

B Virus ◽

Hiv 1

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Prevalence and Determinants of Hepatitis B Virus (HBV) Infection in a Cohort of HIV-1 Discordant Couples in Western Kenya: Implications for HIV Care

AIDS Research and Human Retroviruses ◽

10.1089/aid.2014.5632.abstract ◽

2014 ◽

Vol 30 (S1) ◽

pp. A280-A280

Author(s):

Dismas C.O. Oketch ◽

Eunice Kaguiri ◽

Nereo Murgor ◽

Cosmas Apaka ◽

Paul Ayuo ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Hbv Infection ◽

Hiv Care ◽

Western Kenya ◽

B Virus ◽

Discordant Couples ◽

Hiv 1

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The changing prevalence of hepatitis B virus infection among men who have sex with men who attended a sexually transmitted infections clinic in Edinburgh, Scotland between 1989 and 2003

International Journal of STD & AIDS ◽

10.1258/095646206778145613 ◽

2006 ◽

Vol 17 (8) ◽

pp. 539-542 ◽

Cited By ~ 3

Author(s):

Alexander McMillan

Keyword(s):

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Sexually Transmitted Infections ◽

Hepatitis B Virus Infection ◽

Sexually Transmitted ◽

B Virus ◽

Sex With Men

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Acute hepatitis B virus infection with simultaneous high HBsAg and high anti-HBs signals in a previously HBV vaccinated HIV-1 positive patient

Journal of Clinical Virology ◽

10.1016/j.jcv.2009.12.003 ◽

2010 ◽

Vol 47 (3) ◽

pp. 293-296 ◽

Cited By ~ 4

Author(s):

Laura van Dommelen ◽

Annelies Verbon ◽

H. Rogier van Doorn ◽

Valère J. Goossens

Keyword(s):

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Acute Hepatitis ◽

Positive Patient ◽

Hepatitis B Virus Infection ◽

B Virus ◽

Acute Hepatitis B ◽

Hiv 1

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Factors associated with self-reported hepatitis B virus vaccination status among men who have sex with men in the Netherlands

Sexual Health ◽

10.1071/sh20082 ◽

2020 ◽

Vol 17 (5) ◽

pp. 444

Author(s):

C. Den Daas ◽

P. C. G. Adam ◽

K. Vermey ◽

W. Zuilhof ◽

J. B. F. de Wit

Keyword(s):

Health Promotion ◽

Hepatitis B Virus ◽

Hepatitis B ◽

The Netherlands ◽

Vaccination Status ◽

Factors Associated ◽

Hbv Vaccination ◽

B Virus ◽

Sex With Men ◽

Health Promotion Interventions

Background Reducing the number of new acute hepatitis B virus (HBV) infections to zero by 2022 is an important goal in the Netherlands. Free HBV vaccination is available for population groups at higher risk of infection, including men who have sex with men (MSM). Identifying correlates of HBV vaccination among MSM can guide the development of health promotion interventions to increase coverage of HBV vaccination. Methods: We assessed factors associated with the HBV vaccination status of 4270 MSM in the Netherlands. Data were collected through the 2018 online Men & Sexuality survey. Results: Multinomial regression analysis showed that lower education level, having never tested for HIV, not recently diagnosed with a sexually transmissible infection, recently having had sex abroad and unknown HBV testing status were associated with higher odds of being unvaccinated as opposed to fully vaccinated. Living in Amsterdam and testing HBV negative were associated with lower odds of being unvaccinated as opposed to fully vaccinated. Age (25–39 years vs younger ages), living in Amsterdam and using pre-exposure prophylaxis decreased the odds to be partly vaccinated as opposed to fully vaccinated; having a migration background increased these odds. Conclusions: HBV vaccination rates among MSM will not reduce HBV transmission to zero. HBV promotion should focus on MSM outside of Amsterdam who are likely less connected with sexual health services and may be at lower (perceived) risk. The factors identified related to HBV vaccination status provide guidance for health promotion interventions to increase uptake and vaccination completion among MSM.

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