Reactive oxygen species and their consequences on the structure and function of mammalian spermatozoa

2021 ◽  
Author(s):  
Joel R Drevet ◽  
Jorge Hallak ◽  
Mohammad Hossein Nasr-Esfahani ◽  
Robert John Aitken
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Structure And Function ◽  
Oxygen Species ◽  
And Function ◽  
Mammalian Spermatozoa

Counteraction of the deleterious effects of reactive oxygen species on hemoglobin structure and function by ellagic acid

2017 ◽  
Vol 182 ◽  
pp. 1-7 ◽  
Author(s):  
Masoumeh Valipour ◽  
Parvaneh Maghami ◽  
Mehran Habibi-Rezaei ◽  
Mostafa Sadeghpour ◽  
Mohamad Ali Khademian ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ellagic Acid ◽  
Reactive Oxygen ◽  
Structure And Function ◽  
Oxygen Species ◽  
And Function

Shear Stress, Reactive Oxygen Species, and Arterial Structure and Function

2009 ◽  
Vol 11 (7) ◽  
pp. 1699-1709 ◽  
Author(s):  
Hanke L Matlung ◽  
Erik N.T.P. Bakker ◽  
Ed VanBavel
Keyword(s):  
Reactive Oxygen Species ◽  
Shear Stress ◽  
Reactive Oxygen ◽  
Structure And Function ◽  
Oxygen Species ◽  
Arterial Structure ◽  
And Function

Reactive Oxygen Species and Nitric Oxide Production, Regulation and Function During Defense Response

2019 ◽  
pp. 573-590
Author(s):  
Eliana Molina‐Moya ◽  
Laura C. Terrón‐Camero ◽  
Leyre Pescador‐Azofra ◽  
Luisa M. Sandalio ◽  
María C. Romero‐Puertas
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Defense Response ◽  
Reactive Oxygen ◽  
Nitric Oxide Production ◽  
Oxygen Species ◽  
Oxide Production ◽  
And Function

Free radicals, lipid peroxidation and sperm function

1995 ◽  
Vol 7 (4) ◽  
pp. 659 ◽  
Author(s):  
RJ Aitken
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Reactive Oxygen ◽  
Human Spermatozoa ◽  
Sperm Function ◽  
Oxygen Species ◽  
Normal Sperm ◽  
Oxidative Processes ◽  
Mammalian Spermatozoa

The cellular generation of reactive oxygen species was first observed in mammalian spermatozoa in the late 1940s. The field then remained dormant for 30 years until Thaddeus Mann and Roy Jones published a series of landmark papers in the 1970s in which the importance of lipid peroxidation as a mechanism for damaging mammalian spermatozoa was first intimated. The subsequent demonstration that human spermatozoa produce reactive oxygen species and are susceptible to peroxidative damage has triggered intense interest in the role of oxidative stress in the aetiology of male infertility. Moreover, data have recently been obtained to indicate that, although excessive exposure to reactive oxygen species may be harmful to spermatozoa, in physiological amounts these molecules are of importance in the control of normal sperm function. This review considers the dualistic role of reactive oxygen species and sets out the current understanding of the importance of oxidative processes in both the physiology and the pathology of the human spermatozoon. Extra keywords: human spermatozoa, reactive oxygen species.

scholarly journals Exposure to Copper Compromises the Maturational Competency of Porcine Oocytes by Impairing Mitochondrial Function

2021 ◽  
Vol 9 ◽  
Author(s):  
Jingyue Chen ◽  
Zhaokang Cui ◽  
Yawei Qiu ◽  
Xingxing Zhang ◽  
Fang Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Reactive Oxygen ◽  
Oocyte Quality ◽  
Actin Dynamics ◽  
Oxygen Species ◽  
Cortical Granules ◽  
Porcine Oocyte ◽  
Mitochondrial Distribution ◽  
And Function

Copper (Cu) is an essential trace element for animals, and also an important nutritional component for the normal physiology and metabolism of animal reproductive systems. An excess or lack of Cu will directly or indirectly affect animal reproductive activities. However, the effect of Cu, in particular excessive Cu, on the reproductive performance of sows has not been studied. Here, we report that excessive Cu had negative effects on oocyte maturation and organelle functions. We showed that Cu exposure perturbed porcine oocyte meiotic maturation and impaired spindle/chromosome structure, resulting in a defective spindle assembly, as well as the abnormal distribution of actin dynamics and cortical granules. In addition, single-cell transcriptome analysis identified the target effectors of Cu actions in porcine oocytes, further demonstrating that Cu exposure affects the mitochondrial distribution and function, leading to the high levels of reactive oxygen species, DNA damage, and early apoptosis of porcine oocytes. These findings demonstrate that Cu exposure causes abnormalities in the mitochondrial distribution and function, resulting in the increased oxidative stress and levels of reactive oxygen species, DNA damage, and apoptosis, ultimately leading to a decreased porcine oocyte quality.

scholarly journals Essential Role of NADPH Oxidase-Dependent Reactive Oxygen Species Generation in Regulating MicroRNA-21 Expression and Function in Prostate Cancer

2013 ◽  
Vol 19 (16) ◽  
pp. 1863-1876 ◽  
Author(s):  
Sarvesh Jajoo ◽  
Debashree Mukherjea ◽  
Tejbeer Kaur ◽  
Kelly E. Sheehan ◽  
Sandeep Sheth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Essential Role ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
And Function
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