Reactive Oxygen Species in intestinal stem cell metabolism, fate and function

2021 ◽  
Vol 166 ◽  
pp. 140-146
Author(s):  
Otto Morris ◽  
Heinrich Jasper
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Cell Metabolism ◽  
Reactive Oxygen ◽  
Intestinal Stem Cell ◽  
Oxygen Species ◽  
Stem Cell Metabolism ◽  
And Function

scholarly journals Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics

2011 ◽  
Vol 135 (3) ◽  
pp. 293-304 ◽  
Author(s):  
Wanakee J. Carr ◽  
Rebecca E. Oberley-Deegan ◽  
Yuping Zhang ◽  
Christopher C. Oberley ◽  
Larry W. Oberley ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Side Population ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antioxidant Proteins

scholarly journals A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

2017 ◽  
Vol 46 (38) ◽  
pp. 12785-12789 ◽  
Author(s):  
C. Lu ◽  
K. Laws ◽  
A. Eskandari ◽  
K. Suntharalingam
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Schiff Base ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Cyclooxygenase 2 ◽  
Oxygen Species

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties,1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency.

Reactive Oxygen Species and Nitric Oxide Production, Regulation and Function During Defense Response

2019 ◽  
pp. 573-590
Author(s):  
Eliana Molina‐Moya ◽  
Laura C. Terrón‐Camero ◽  
Leyre Pescador‐Azofra ◽  
Luisa M. Sandalio ◽  
María C. Romero‐Puertas
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Defense Response ◽  
Reactive Oxygen ◽  
Nitric Oxide Production ◽  
Oxygen Species ◽  
Oxide Production ◽  
And Function

scholarly journals A reactive oxygen species-generating, cancer stem cell-potent manganese(ii) complex and its encapsulation into polymeric nanoparticles

2019 ◽  
Vol 10 (33) ◽  
pp. 7792-7800 ◽  
Author(s):  
Arvin Eskandari ◽  
Kogularamanan Suntharalingam
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Polymeric Nanoparticles ◽  
Reactive Oxygen ◽  
Breast Cancer Stem Cell ◽  
Oxygen Species ◽  
Inflammatory Drug ◽  
Phenanthroline Complex

Here we report the breast cancer stem cell (CSC) potency of a reactive oxygen species (ROS)-generating manganese(ii)-phenanthroline complex bearing diclofenac, a nonsteriodial anti-inflammatory drug.

scholarly journals Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Parthive H. Patel ◽  
Clothilde Pénalva ◽  
Michael Kardorff ◽  
Marianne Roca ◽  
Bojana Pavlović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Nadph Oxidase ◽  
Bacterial Infection ◽  
Intestinal Stem Cell ◽  
Oxygen Species ◽  
Damage Sensing ◽  
Mechanical Insult ◽  
Adult Drosophila

Abstract Epithelia are exposed to diverse types of stress and damage from pathogens and the environment, and respond by regenerating. Yet, the proximal mechanisms that sense epithelial damage remain poorly understood. Here we report that p38 signaling is activated in adult Drosophila midgut enterocytes in response to diverse stresses including pathogenic bacterial infection and chemical and mechanical insult. Two upstream kinases, Ask1 and Licorne (MKK3), are required for p38 activation following infection, oxidative stress, detergent exposure and wounding. Ask1-p38 signaling in enterocytes is required upon infection to promote full intestinal stem cell (ISC) activation and regeneration, partly through Upd3/Jak-Stat signaling. Furthermore, reactive oxygen species (ROS) produced by the NADPH oxidase Nox in enterocytes, are required for p38 activation in enterocytes following infection or wounding, and for ISC activation upon infection or detergent exposure. We propose that Nox-ROS-Ask1-MKK3-p38 signaling in enterocytes integrates multiple different stresses to induce regeneration.

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