scholarly journals Spin-Echo Resting-State Functional Connectivity in High-Susceptibility Regions: Accuracy, Reliability, and the Impact of Physiological Noise

2016 ◽  
Vol 6 (4) ◽  
pp. 283-297 ◽  
Author(s):  
Yasha B. Khatamian ◽  
Ali M. Golestani ◽  
Don M. Ragot ◽  
J. Jean Chen
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Spin Echo ◽  
High Susceptibility ◽  
Resting State Functional Connectivity ◽  
Physiological Noise ◽  
The Impact

scholarly journals Attention network modulation via tRNS correlates with attention gain

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Federica Contò ◽  
Grace Edwards ◽  
Sarah Tyler ◽  
Danielle Parrott ◽  
Emily Grossman ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Large Scale ◽  
Random Noise ◽  
Cognitive Capacity ◽  
Resting State Functional Connectivity ◽  
Attention Network ◽  
Transcranial Random Noise Stimulation ◽  
The Impact ◽  
Behavioral Improvement

Transcranial random noise stimulation (tRNS) can enhance vision in the healthy and diseased brain. Yet, the impact of multi-day tRNS on large-scale cortical networks is still unknown. We investigated the impact of tRNS coupled with behavioral training on resting-state functional connectivity and attention. We trained human subjects for 4 consecutive days on two attention tasks, while receiving tRNS over the intraparietal sulci, the middle temporal areas, or Sham stimulation. We measured resting-state functional connectivity of nodes of the dorsal and ventral attention network (DVAN) before and after training. We found a strong behavioral improvement and increased connectivity within the DVAN after parietal stimulation only. Crucially, behavioral improvement positively correlated with connectivity measures. We conclude changes in connectivity are a marker for the enduring effect of tRNS upon behavior. Our results suggest that tRNS has strong potential to augment cognitive capacity in healthy individuals and promote recovery in the neurological population.

scholarly journals Differential resting state connectivity responses to glycemic state in type 1 diabetes

2019 ◽  
Author(s):  
Lisa Parikh ◽  
Dongju Seo ◽  
Cheryl Lacadie ◽  
Renata Belfort-DeAguiar ◽  
Derek Groskreutz ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Functional Connectivity ◽  
Resting State ◽  
Medical Center ◽  
Academic Medical Center ◽  
Angular Gyrus ◽  
Resting State Functional Connectivity ◽  
The Impact ◽  
Resting State Connectivity

Abstract Context Individuals with type 1 diabetes (T1DM) have alterations in brain activity which have been postulated to contribute to the adverse neurocognitive consequences of T1DM; however, the impact of T1DM and hypoglycemic unawareness on the brain’s resting state activity remains unclear. Objective To determine whether individuals with T1DM and hypoglycemia unawareness (T1DM-Unaware) had changes in the brain resting state functional connectivity compared to healthy controls (HC) and those with T1DM and hypoglycemia awareness (T1DM-Aware). Design Observational study Setting Academic medical center Participants 27 individuals with T1DM and 12 healthy control volunteers participated in the study. Intervention All participants underwent BOLD resting state fMRI brain imaging during a 2-step hyperinsulinemic euglycemic (90 mg/dl)-hypoglycemic (60mg/dl) clamp. Outcome Changes in resting state functional connectivity Results Using two separate methods of functional connectivity analysis, we identified distinct differences in the resting state brain responses to mild hypoglycemia amongst HC, T1DM-Aware and T1DM-Unaware participants, particularly in the angular gyrus, an integral component of the default mode network (DMN). Furthermore, changes in angular gyrus connectivity also correlated with greater symptoms of hypoglycemia (r = 0.461, P = 0.003) as well as higher scores of perceived stress (r = 0.531, P = 0.016). Conclusion These findings provide evidence that individuals with T1DM have changes in the brain’s resting state connectivity patterns, which may be further associated with differences in awareness to hypoglycemia. These changes in connectivity may be associated with alterations in functional outcomes amongst individuals with T1DM.

The impact of childhood trauma on thalamic functional connectivity in patients with obsessive–compulsive disorder

2020 ◽  
pp. 1-10
Author(s):  
Minyi Chu ◽  
Tingting Xu ◽  
Yi Wang ◽  
Pei Wang ◽  
Qiumeng Gu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Obsessive Compulsive Disorder ◽  
Childhood Trauma ◽  
Resting State ◽  
Healthy Controls ◽  
Resting State Functional Connectivity ◽  
Obsessive Compulsive ◽  
Predisposing Factor ◽  
Compulsive Disorder ◽  
The Impact

Abstract Background Childhood trauma is a vulnerability factor for the development of obsessive–compulsive disorder (OCD). Empirical findings suggest that trauma-related alterations in brain networks, especially in thalamus-related regions, have been observed in OCD patients. However, the relationship between childhood trauma and thalamic connectivity in patients with OCD remains unclear. The present study aimed to examine the impact of childhood trauma on thalamic functional connectivity in OCD patients. Methods Magnetic resonance imaging resting-state scans were acquired in 79 patients with OCD, including 22 patients with a high level of childhood trauma (OCD_HCT), 57 patients with a low level of childhood trauma (OCD_LCT) and 47 healthy controls. Seven thalamic subdivisions were chosen as regions of interest (ROIs) to examine the group difference in thalamic ROIs and whole-brain resting-state functional connectivity (rsFC). Results We found significantly decreased caudate-thalamic rsFC in OCD patients as a whole group and also in OCD_LCT patients, compared with healthy controls. However, OCD_HCT patients exhibited increased thalamic rsFC with the prefrontal cortex when compared with both OCD_LCT patients and healthy controls. Conclusions Taken together, OCD patients with high and low levels of childhood trauma exhibit different pathological alterations in thalamic rsFC, suggesting that childhood trauma may be a predisposing factor for some OCD patients.

The impact of genetic variation in comt and bdnf on resting-state functional connectivity

2012 ◽  
Vol 22 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Joon Hwan Jang ◽  
Je-Yeon Yun ◽  
Wi Hoon Jung ◽  
Geumsook Shim ◽  
Min Soo Byun ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
The Impact

scholarly journals Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes

2019 ◽  
Vol 105 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Lisa Parikh ◽  
Dongju Seo ◽  
Cheryl Lacadie ◽  
Renata Belfort-Deaguiar ◽  
Derek Groskreutz ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Functional Connectivity ◽  
Resting State ◽  
Academic Medical Center ◽  
Blood Oxygenation ◽  
Angular Gyrus ◽  
Resting State Functional Connectivity ◽  
The Impact ◽  
Resting State Connectivity

Abstract Context Individuals with type 1 diabetes mellitus (T1DM) have alterations in brain activity that have been postulated to contribute to the adverse neurocognitive consequences of T1DM; however, the impact of T1DM and hypoglycemic unawareness on the brain’s resting state activity remains unclear. Objective To determine whether individuals with T1DM and hypoglycemia unawareness (T1DM-Unaware) had changes in the brain resting state functional connectivity compared to healthy controls (HC) and those with T1DM and hypoglycemia awareness (T1DM-Aware). Design Observational study. Setting Academic medical center. Participants 27 individuals with T1DM and 12 HC volunteers participated in the study. Intervention All participants underwent blood oxygenation level dependent (BOLD) resting state functional magnetic brain imaging during a 2-step hyperinsulinemic euglycemic (90 mg/dL)–hypoglycemic (60 mg/dL) clamp. Outcome Changes in resting state functional connectivity. Results Using 2 separate methods of functional connectivity analysis, we identified distinct differences in the resting state brain responses to mild hypoglycemia between HC, T1DM-Aware, and T1DM-Unaware participants, particularly in the angular gyrus, an integral component of the default mode network (DMN). Furthermore, changes in angular gyrus connectivity also correlated with greater symptoms of hypoglycemia (r = 0.461, P = 0.003) as well as higher scores of perceived stress (r = 0.531, P = 0.016). Conclusion These findings provide evidence that individuals with T1DM have changes in the brain’s resting state connectivity patterns, which may be further associated with differences in awareness to hypoglycemia. These changes in connectivity may be associated with alterations in functional outcomes among individuals with T1DM.

scholarly journals Mild early‐life stress exaggerates the impact of acute stress on corticolimbic resting‐state functional connectivity

2021 ◽  
Author(s):  
Huan Wang ◽  
Judith M. C. Leeuwen ◽  
Lycia D. Voogd ◽  
Robbert‐Jan Verkes ◽  
Benno Roozendaal ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Life Stress ◽  
Early Life ◽  
Acute Stress ◽  
Early Life Stress ◽  
Resting State Functional Connectivity ◽  
The Impact

scholarly journals The impact of serotonin transporter (5-HTTLPR) genotype on the development of resting-state functional connectivity in children and adolescents: A preliminary report

NeuroImage ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 2760-2770 ◽  
Author(s):  
Jillian Lee Wiggins ◽  
Jirair K. Bedoyan ◽  
Scott J. Peltier ◽  
Samantha Ashinoff ◽  
Melisa Carrasco ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Children And Adolescents ◽  
Serotonin Transporter ◽  
Resting State ◽  
Preliminary Report ◽  
Resting State Functional Connectivity ◽  
The Impact

P4-313: THE IMPACT OF FIBER-TRACT-SPECIFIC WHITE MATTER HYPERINTENSITIES ON RESTING STATE FUNCTIONAL CONNECTIVITY IN ALZHEIMER'S DISEASE

2014 ◽  
Vol 10 ◽  
pp. P900-P901
Author(s):  
Alexander N.W. Taylor ◽  
Benno Gesierich ◽  
Lee Simon-Vermot ◽  
Lana Kambeitz-Ilankovic ◽  
Marco Duering ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Functional Connectivity ◽  
Resting State ◽  
White Matter Hyperintensities ◽  
Resting State Functional Connectivity ◽  
Fiber Tract ◽  
The Impact
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