Previous longitudinal studies have demonstrated that blood pressure measurements at home (HBP) in the wakening-
up display stronger predictive power for death, and vascular complications in patients with type 2 diabetes mellitus
(T2DM) than clinic blood pressure measurements (CBP). The leading cause of death was cancer. Patients with T2DM
have associated with cancer, and high CBP is a risk factor for cancer. Therefore, this study investigated whether HBP
or CBP is related to cancer event in patients with T2DM for 10 years. At baseline, 400 Japanese patients with T2DM
were classified as hypertensive (HT) or normotensive (NT) based on HBP and CBP. Mean (± SD) duration was 95 ± 35
months. Primary and secondary endpoints were death and cancer, respectively. Differences in outcome between HT and
NT were analyzed using survival curves from Kaplan-Meier analysis and log-rank testing. Associated risk factors were
assessed using Cox proportional hazards. On basis of HBP, death and event of cancer were significantly higher in HT than
in NT. The leading cause of death was cancer. On basis of CBP, there was no significant difference in the incidence of
death and event of cancer between patients with HT and NT at baseline. Associated risk factor for cancer was T2DM.
Home morning HT may be reflected more keenly state of cancer than clinic HT, which may be superior to clinic NT.
When we meet with such patients, it is important that cancer may be one of many causes for morning HT in Japanese patients
with T2DM.
Small dense low-density lipoprotein as a potential risk factor of nephropathy in type 2 diabetes mellitus
