Association of Single Nucleotide Polymorphisms inTNFAandIL10Genes with Disease Severity in Influenza A/H1N1pdm09 Virus Infections: A Study from Western India

2018 ◽  
Vol 31 (10) ◽  
pp. 683-688 ◽  
Author(s):  
Manohar Lal Choudhary ◽  
Kalichamy Alagarasu ◽  
Urmila Chaudhary ◽  
Samruddhi Kawale ◽  
Prachi Malasane ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Influenza A ◽  
Western India ◽  
Nucleotide Polymorphisms ◽  
Virus Infections ◽  
Single Nucleotide

Intronic single-nucleotide polymorphisms in Bcl-2 are associated with chronic obstructive pulmonary disease severity

Respirology ◽  
2007 ◽  
Vol 12 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Makoto SATA ◽  
Noriaki TAKABATAKE ◽  
Sumito INOUE ◽  
Yoko SHIBATA ◽  
Shuichi ABE ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Single Nucleotide Polymorphisms ◽  
Pulmonary Disease ◽  
Disease Severity ◽  
Chronic Obstructive ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Obstructive Pulmonary Disease

Single nucleotide polymorphisms in the dystroglycan gene do not correlate with disease severity in hereditary inclusion body myopathy

2005 ◽  
Vol 86 (1-2) ◽  
pp. 244-249 ◽  
Author(s):  
Emily Gottlieb ◽  
Carla Ciccone ◽  
Daniel Darvish ◽  
Shahrouz Naiem-Cohen ◽  
Marinos C. Dalakas ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Inclusion Body ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Inclusion Body Myopathy ◽  
Hereditary Inclusion Body Myopathy

scholarly journals T2 Single nucleotide polymorphisms in the ficolin-2 gene predispose to Pseudomonas aeruginosa infection and disease severity in non-cystic fibrosis bronchiectasis

Thorax ◽  
2011 ◽  
Vol 66 (Suppl 4) ◽  
pp. A1-A2 ◽  
Author(s):  
J. D. Chalmers ◽  
D. C. Kilpatrick ◽  
B. J. McHugh ◽  
M. P. Smith ◽  
J. R. W. Govan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Pseudomonas Aeruginosa Infection

scholarly journals TNFA and IL10 Polymorphisms and IL-6 and IL-10 Levels Influence Disease Severity in Influenza A(H1N1)pdm09 Virus Infected Patients

Genes ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1914
Author(s):  
Kalichamy Alagarasu ◽  
Himanshu Kaushal ◽  
Pooja Shinde ◽  
Mahadeo Kakade ◽  
Urmila Chaudhary ◽  
...  
Keyword(s):  
Disease Severity ◽  
Influenza A ◽  
Severe Disease ◽  
Fatal Outcome ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Mild Disease ◽  
Pdm09 Virus ◽  
Potential Biomarker ◽  
Influenza A H1n1

Cytokines are key modulators of immune response, and dysregulated production of proinflammatory and anti-inflammatory cytokines contributes to the pathogenesis of influenza A(H1N1)pdm09 virus infection. Cytokine production is impacted by single nucleotide polymorphisms (SNPs) in the genes coding for them. In the present study, SNPs in the IL6, TNFA, IFNG, IL17A, IL10, and TGFB were investigated for their association with disease severity and fatality in influenza A(H1N1)pdm09-affected patients with mild disease (n = 293) and severe disease (n = 86). Among those with severe disease, 41 patients had fatal outcomes. In a subset of the patients, levels of IL-2, IL-4, IL-6, IL-10, TNF, IFN-γ, and IL-17 were assayed in the plasma for their association with severe disease. The frequency of TNFA rs1800629 G/A allele was significantly higher in severe cases and survived severe cases group compared to that of those with mild infection (OR with 95% for mild vs. severe cases 2.95 (1.52–5.73); mild vs. survived severe cases 4.02 (1.84–8.82)). IL10 rs1800896-rs1800872 G-C haplotype was significantly lower (OR with 95% 0.34 (0.12–0.95)), while IL10 rs1800896-rs1800872 G-A haplotype was significantly higher (OR with 95% 12.11 (2.23–76.96)) in fatal cases group compared to that of the mild group. IL-6 and IL-10 levels were significantly higher in fatal cases compared to that of survived severe cases. IL-6 levels had greater discriminatory power than IL-10 to predict progression to fatal outcome in influenza A(H1N1)pdm09 virus-infected patients. To conclude, the present study reports the association of TNFA and IL10 SNPs with severe disease in Influenza A(H1N1)pdm09 virus-infected subjects. Furthermore, IL-6 levels can be a potential biomarker for predicting fatal outcomes in Influenza A(H1N1)pdm09 virus infected subjects.

Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis

2010 ◽  
Vol 16 (6) ◽  
pp. 652-659 ◽  
Author(s):  
Madeleine H Sombekke ◽  
David Arteta ◽  
Mark A van de Wiel ◽  
J Bart A Crusius ◽  
Diego Tejedor ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Clinical Data ◽  
Severity Score ◽  
Interleukin 2 ◽  
Dna Chip ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Clinical Variables

Multiple sclerosis is a heterogeneous neurological disease with varying degrees of severity. The common hypothesis is that susceptibility to multiple sclerosis and its phenotype are caused by a combination of environmental and genetic factors. The genetic part exerts its effect through several genes, each having modest effects. We evaluated whether disease severity could be predicted by a model based on clinical data and data from a DNA chip. The DNA chip was designed containing several single nucleotide polymorphisms in 44 genes, previously described to be associated with multiple sclerosis. A total of 605 patients with multiple sclerosis were included in this analysis, using gender, onset type and age at onset as clinical covariates. We correlated 80 single nucleotide polymorphisms to the degree of disease severity using the following three outcome measures: linear Multiple Sclerosis Severity Score, dichotomous Multiple Sclerosis Severity Score (using a cut-off point of 2.5) and time to reach Expanded Disability Status Scale score 6. Sixty-nine single nucleotide polymorphisms were included in the analysis. No individual single nucleotide polymorphism showed a significant association; however, a combination of single nucleotide polymorphisms significantly improved the prediction of disease severity in addition to the clinical variables. In all three models the Interleukin 2 gene was included, confirming a previously reported modest effect on disease severity. The highest power was obtained using the dichotomized Multiple Sclerosis Severity Score as outcome. Several single nucleotide polymorphisms showed their added predictive value over the clinical data in the predictive models. These results support our hypothesis that disease severity is determined by clinical variables and genetic influences (through several genes with small effects) in concert.

scholarly journals CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity

2004 ◽  
Vol 5 (1) ◽  
Author(s):  
Carol J Blaisdell ◽  
Timothy D Howard ◽  
Augustus Stern ◽  
Penelope Bamford ◽  
Eugene R Bleecker ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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