Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells
2009 ◽
Vol 20
(23)
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pp. 4976-4984
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Keyword(s):
A Genome
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A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock–dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
2021 ◽
Keyword(s):
2017 ◽
Vol 114
(40)
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pp. E8362-E8371
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Keyword(s):