Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middle-aged white strict vegetarians

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

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Low Serum Levels of 25-hydroxyvitamin D Accompany Severe COVID-19 Because it is a Negative Acute Phase Reactant

The American Journal of the Medical Sciences ◽

10.1016/j.amjms.2021.06.005 ◽

2021 ◽

Author(s):

Maria Antonelli ◽

Irving Kushner

Keyword(s):

Acute Phase ◽

Serum Levels ◽

Acute Phase Reactant ◽

Hydroxyvitamin D ◽

Phase Reactant ◽

25 Hydroxyvitamin D ◽

Low Serum

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Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants

European Journal of Pediatrics ◽

10.1007/s00431-014-2405-4 ◽

2014 ◽

Vol 174 (3) ◽

pp. 365-372 ◽

Cited By ~ 7

Author(s):

Gloria Moreno-Solís ◽

Fernando Fernández-Gutiérrez ◽

Javier Torres - Borrego ◽

Ricardo Torcello-Gáspar ◽

José Luis Gómez-Chaparro Moreno ◽

...

Keyword(s):

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Low Serum

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Association between low serum 25-hydroxyvitamin D and depression in a large sample of Chinese patients with type 2 diabetes mellitus

Journal of Affective Disorders ◽

10.1016/j.jad.2016.10.040 ◽

2017 ◽

Vol 224 ◽

pp. 56-60 ◽

Cited By ~ 6

Author(s):

Yuhong Wang ◽

Hui Yang ◽

Pan Meng ◽

Yuanshan Han

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Chinese Patients ◽

Large Sample ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Low Serum

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Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis

Frontiers in Nutrition ◽

10.3389/fnut.2021.660420 ◽

2021 ◽

Vol 8 ◽

Author(s):

Mohammad Rizki Akbar ◽

Arief Wibowo ◽

Raymond Pranata ◽

Budi Setiabudiawan

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Secondary Outcome ◽

Control Group ◽

Hydroxyvitamin D ◽

Literature Searches ◽

25 Hydroxyvitamin D ◽

Meta Regression Analysis ◽

Embase Database ◽

Low Serum

Background: This systematic review and meta-analysis aimed to assess whether low serum 25-hydroxyvitamin D (25-OHD) level is associated with susceptibility to COVID-19, severity, and mortality related to COVID-19.Methods: Systematic literature searches of PubMed, Scopus, and Embase database up until 9 December 2020. We include published observational prospective and retrospective studies with information on 25-OHD that reported main/secondary outcome. Low serum 25-OHD refers to participants with serum 25-OHD level below a cut-off point ranging from 20 to 30 ng/mL. Other cut-off values were excluded to reduce heterogeneity. The main outcome was mortality defined as non-survivor/death. The secondary outcome was susceptibility and severe COVID-19.Results: There were 14 studies comprising of 999,179 participants. Low serum 25-OHD was associated with higher rate of COVID-19 infection compared to the control group (OR = 2.71 [1.72, 4.29], p < 0.001; I2: 92.6%). Higher rate of severe COVID-19 was observed in patients with low serum 25-OHD (OR = 1.90 [1.24, 2.93], p = 0.003; I2: 55.3%), with a sensitivity of 83%, specificity of 39%, PLR of 1.4, NLR of 0.43, and DOR of 3. Low serum 25-OHD was associated with higher mortality (OR = 3.08 [1.35, 7.00], p = 0.011; I2: 80.3%), with a sensitivity of 85%, specificity of 35%, PLR of 1.3, NLR of 0.44, and DOR of 3. Meta-regression analysis showed that the association between low serum 25-OHD and mortality was affected by male gender (OR = 1.22 [1.08, 1.39], p = 0.002), diabetes (OR = 0.88 [0.79, 0.98], p = 0.019).Conclusion: Low serum 25-OHD level was associated with COVID-19 infection, severe presentation, and mortality.

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