scholarly journals Cumulative sugar-sweetened beverage consumption is associated with higher concentrations of circulating ceramides in the Framingham Offspring Cohort

2019 ◽  
Vol 111 (2) ◽  
pp. 420-428 ◽  
Author(s):  
Maura E Walker ◽  
Vanessa Xanthakis ◽  
Lynn L Moore ◽  
Ramachandran S Vasan ◽  
Paul F Jacques
Keyword(s):  
Offspring Cohort ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Blood Concentrations ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Diabetes Status ◽  
Independent Variable ◽  
Stratified Analysis

ABSTRACT Background Ceramides have been implicated in the pathogenesis of type 2 diabetes and cardiovascular disease. Limited data exist on how habitual dietary intake of foods that can alter hepatic lipid metabolism may influence circulating ceramide concentrations. Objectives We investigated the cross-sectional association of cumulative sugar-sweetened beverage (SSB) consumption with concentrations of 3 circulating ceramides and ceramide ratios. Methods We examined participants from the Framingham Heart Study's Offspring Cohort who had 3 ceramides measured (n  = 1561, mean age 66 y, 59% women). SSB consumption was measured 4 times over ∼14 y. Participants were categorized by cumulative SSB intake as nonconsumers (0 to <1 SSB serving/mo) and occasional (1 SSB serving/mo to <1 serving/wk), frequent (1 SSB serving/wk to <1 serving/d), and daily (≥1 SSB serving/d) consumers. Multivariable linear regression models were used to relate cumulative SSB consumption (independent variable) to blood concentrations of ceramides (C16:0, C22:0, and C24:0) and ceramide ratios (C22:0/C16:0 and C24:0/C16:0). Results In adjusted models, more frequent cumulative SSB consumption was positively associated with concentrations of the C16:0 and C22:0 ceramides (Ptrend < 0.05). Compared with nonconsumers, daily consumers had 0.01 μg/mL (95% CI: 0.002, 0.017 µg/mL) and 0.06 µg/mL (95% CI: 0.018, 0.092 µg/mL) higher mean concentrations of the C16:0 and C22:0 ceramides, respectively. Results were consistent when modeling continuous cumulative SSB consumption per 1 serving/d. We observed effect modification by diabetes status in the relation between cumulative SSB consumption and concentrations of the C24:0 ceramide (Pinteraction = 0.014). In a stratified analysis, more frequent cumulative SSB consumption was positively associated with concentrations of the C24:0 ceramide only in individuals with prediabetes or diabetes (Ptrend = 0.001). Conclusions Our study raises the possibility that higher concentrations of distinct ceramide species, previously associated with adverse metabolic health, may be one mechanism by which SSB consumption contributes to higher risk of cardiometabolic diseases.

scholarly journals Associations between multimorbidity and glycaemia (HbA1c) in people with type 2 diabetes: cross-sectional study in Australian general practice

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e039625
Author(s):  
Jason I Chiang ◽  
John Furler ◽  
Frances Mair ◽  
Bhautesh D Jani ◽  
Barbara I Nicholl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
General Practice ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Linear Regression Models ◽  
Sectional Study ◽  
Cross Sectional ◽  
Long Term Conditions ◽  
Australian General Practice

ObjectivesTo explore the prevalence of multimorbidity as well as individual and combinations of long-term conditions (LTCs) in people with type 2 diabetes (T2D) attending Australian general practice, using electronic health record (EHR) data. We also examine the association between multimorbidity condition count (total/concordant(T2D related)/discordant(unrelated)) and glycaemia (glycated haemoglobin, HbA1c).DesignCross-sectional study.SettingAustralian general practice.Participants69 718 people with T2D with a general practice encounter between 2013 and 2015 captured in the MedicineInsight database (EHR Data from 557 general practices and >3.8 million Australian patients).Primary and secondary outcome measuresPrevalence of multimorbidity, individual and combinations of LTCs. Multivariable linear regression models used to examine associations between multimorbidity counts and HbA1c (%).ResultsMean (SD) age 66.42 (12.70) years, 46.1% female and mean (SD) HbA1c 7.1 (1.4)%. More than 90% of participants with T2D were living with multimorbidity. Discordant conditions were more prevalent (83.4%) than concordant conditions (69.9 %). The three most prevalent discordant conditions were: painful conditions (55.4%), dyspepsia (31.6%) and depression (22.8%). The three most prevalent concordant conditions were hypertension (61.4%), coronary heart disease (17.1%) and chronic kidney disease (8.5%). The three most common combinations of conditions were: painful conditions and hypertension (38.8%), painful conditions and dyspepsia (23.1%) and hypertension and dyspepsia (22.7%). We found no associations between any multimorbidity counts (total, concordant and discordant) or combinations and HbA1c.ConclusionsMultimorbidity was common in our cohort of people with T2D attending Australian general practice, but was not associated with glycaemia. Although we did not explore mortality in this study, our results suggest that the increased mortality in those with multimorbidity and T2D observed in other studies may not be linked to glycaemia. Interestingly, discordant conditions were more prevalent than concordant conditions with painful conditions being the second most common comorbidity. Better understanding of the implications of different patterns of multimorbidity in people with T2D will allow more effective tailored care.

scholarly journals Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mathilde His ◽  
Vivian Viallon ◽  
Laure Dossus ◽  
Julie A. Schmidt ◽  
Ruth C. Travis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lower Risk ◽  
Positive Association ◽  
Blood Collection ◽  
Linear Regression Models ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Blood Concentrations ◽  
Exogenous Hormones ◽  
Negatively Associated

Abstract Background Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2). Methods To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786). Results For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed. Conclusions These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.

scholarly journals Correlates of sugar-sweetened beverage intake among low-income women during the first 1000 days

2020 ◽  
pp. 1-6
Author(s):  
Erika R Cheng ◽  
Elizabeth Batista ◽  
Ling Chen ◽  
Kelsey Nichols ◽  
Sohyun Park ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
Low Income ◽  
Postpartum Women ◽  
Median Regression ◽  
Cross Sectional ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Sweetened Beverages ◽  
Supplemental Nutrition Program

Abstract Objective: To describe prenatal and postpartum consumption of water, cows’ milk, 100 % juice and sugar-sweetened beverages (SSB) among women enrolled in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) programme in New York City (NYC) and to identify correlates of SSB intake in this population. Design: Cross-sectional data were collected from structured questionnaires that included validated beverage frequency questionnaires with the assistance of container samples. The association of maternal and household factors and non-SSB consumption with habitual daily energetic (kJ (kcal)) intake from SSB was assessed by using multivariable median regression. Setting: WIC programme in NYC, NY. Data were collected in 2017. Participants: 388 pregnant or postpartum women (infant aged <2 years) from the NYC First 1000 Days Study. Results: Median age was 28 years (interquartile range (IQR) 24–34); 94·1 % were Hispanic/Latina, and 31·4 % were pregnant. Overall, 87·7 % of pregnant and 89·1% of postpartum women consumed SSB ≥ once weekly, contributing to a median daily energetic intake of 410 kJ (98 kcal) (IQR (113–904 kJ) 27–216) and 464 kJ (111 kcal) (IQR (163–1013 kJ) 39–242), respectively. In adjusted analyses, only consumption of 100 % juice was associated with greater median energetic intake from SSB (adjusted β for each additional ounce = 13; 95% CI 8, 31 (3·2; 95 % CI 2·0, 7·3). Conclusions: Among pregnant and postpartum women in WIC-enrolled families, interventions to reduce SSB consumption should include reduction of 100 % juice consumption as a co-target of the intervention.

scholarly journals Sugar-sweetened beverage consumption and association with weight status in Irish children: a cross-sectional study prior to the introduction of a government tax on sugar-sweetened beverages

2020 ◽  
Vol 23 (12) ◽  
pp. 2234-2244
Author(s):  
Janas M Harrington ◽  
Catherine Perry ◽  
Eimear Keane ◽  
Ivan J Perry
Keyword(s):  
Energy Intake ◽  
Weight Status ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Sectional Study ◽  
Daily Energy Intake ◽  
Cross Sectional ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Daily Energy

AbstractObjective:To provide baseline evidence of sugar-sweetened beverage (SSB) consumption in a sample of Irish children prior to the introduction of the SSB tax; to identify the energy contribution of SSB to daily energy intake; and to explore the association between SSB consumption and overweight/obesity.Design:Cross-sectional study.Setting:Primary schools in Cork, Ireland in 2012.Participants:1075 boys and girls aged 8–11 years. SSB consumption was assessed from 3-d food diaries. BMI was used to define obesity (International Obesity Taskforce definitions). Plausible energy reporters (n 724, 68 % of total sample) were classified using Schofield equation.Results:Eighty-two per cent of children with plausible energy intake consumed SSB. Mean energy intake from SSB was 485 kJ (6 % of total kJ). Mean kilojoules from SSB increased with weight status from 443 kJ for normal-weight children to 648 kJ for children with overweight/obesity (5·8 and 7·6 % of total kJ, respectively). Mean SSB intake was significantly higher in children with overweight/obesity than normal-weight children (383 and 315 ml/d). In adjusted analyses, children consuming >200 ml/d had an 80 % increased odds of overweight/obesity compared to those consuming <200 ml/d (OR 1·8, 95 % CI 1·0, 3·5). Family socioeconomic status and lifestyle determinants, including frequency of takeaway consumption and TV viewing, were also significantly associated with SSB consumption.Conclusions:SSB account for a substantial proportion of daily energy intake and are significantly associated with child overweight/obesity. This study provides baseline data from a sample of children from which the impact of the SSB tax can be benchmarked.

scholarly journals Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Patrice Carter ◽  
Danielle H. Bodicoat ◽  
Lauren M. Quinn ◽  
Francesco Zaccardi ◽  
David R. Webb ◽  
...  
Keyword(s):  
Population Based ◽  
Glucose Regulation ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Screening Study ◽  
Multiethnic Population ◽  
Baseline Characteristics ◽  
Sectional Analysis

Introduction. Previous observational studies have shown conflicting results between plasma K+concentrations and risk of type 2 diabetes. To help clarify the evidence we aimed to determine whether an association existed between serum K+and glucose regulation within a UK multiethnic population.Methods. Participants were recruited as part of the ADDITION Leicester study, a population based screening study. Individuals from primary care between the age of 40 and 75 years if White European or 25 and 75 years if South Asian or Afro Caribbean were recruited. Tests for associations between baseline characteristics and K+quartiles were conducted using linear regression models.Results. Data showed individuals in the lowest K+quartile had significantly greater 2-hour glucose levels (0.53 mmol/L, 95% CI: 0.36 to 0.70,P≤0.001) than those in the highest K+quartile. This estimation did not change with adjustment for potential confounders. Conversely, participants in the lowest K+quartile had a 0.14% lower HbA1c (95% CI −0.19 to −0.10:P≤0.001) compared to those in the highest K+quartile.Conclusion. This cross-sectional analysis demonstrated that lower K+was associated with greater 2 hr glucose. The data supports the possibility that K+may influence glucose regulation and further research is warranted.

scholarly journals Trends in sugar-sweetened beverage consumption among California children

2020 ◽  
Vol 23 (16) ◽  
pp. 2864-2869 ◽  
Author(s):  
Amy L Beck ◽  
Suzanna Martinez ◽  
Anisha I Patel ◽  
Alicia Fernandez
Keyword(s):  
African American ◽  
Ethnic Disparities ◽  
Health Behaviours ◽  
Population Level ◽  
California Health Interview Survey ◽  
Cross Sectional ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Sports Drinks ◽  
Racial Ethnic

AbstractObjective:To assess trends in consumption of soda, sweetened fruit drinks/sports drinks and any sugar-sweetened beverage (SSB) from 2013 to 2016 among all children in California aged 2–5 and 6–11 years and by racial-ethnic group.Design:Serial cross-sectional study using the California Health Interview Survey (CHIS).Setting:CHIS is a telephone survey of households in California designed to assess population-level estimates of key health behaviours. Previous research using CHIS documented a decrease in SSB consumption among children in California from 2003 to 2009 coinciding with state-level policy efforts targeting child SSB consumption.Participants:Parents of children in California aged 2–11 years (n 4901 in 2013–2014; n 3606 in 2015–2016) were surveyed about the child’s consumption of soda and sweetened fruit drinks/sports drinks on the day prior.Results:Among 2–5-year-olds, consumption of soda, sweetened fruit drinks/sports drinks and any SSB remained stable. Sweetened fruit drink/sports drink consumption was higher than soda consumption in this age group. Latino 2–5- year-olds were more likely to consume any SSB in both 2013–2014 and 2015–2016 compared with Whites. Among 6–11-year-olds, consumption of soda, sweetened fruit drinks/sports drinks and any SSB also remained stable over time. Latino and African-American 6–11-year-olds were more likely to consume an SSB in 2013–2014 compared with White children.Conclusions:SSB consumption among children in California was unchanged from 2013 to 2016 and racial-ethnic disparities were evident. Increased policy efforts are needed to further reduce SSB consumption, particularly among children of Latino and African-American backgrounds.

scholarly journals The Association between the Availability of Sugar-Sweetened Beverage in School Vending Machines and Its Consumption among Adolescents in California: A Propensity Score Matching Approach

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Lu Shi
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
California Health Interview Survey ◽  
Cross Sectional ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Vending Machines ◽  
Adolescent Sample ◽  
Interview Survey ◽  
Propensity Score Stratification

There is controversy over to what degree banning sugar-sweetened beverage (SSB) sales at schools could decrease the SSB intake. This paper uses the adolescent sample of 2005 California Health Interview Survey to estimate the association between the availability of SSB from school vending machines and the amount of SSB consumption. Propensity score stratification and kernel-based propensity score matching are used to address the selection bias issue in cross-sectional data. Propensity score stratification shows that adolescents who had access to SSB through their school vending machines consumed 0.170 more drinks of SSB than those who did not (). Kernel-based propensity score matching shows the SSB consumption difference to be 0.158 on the prior day (). This paper strengthens the evidence for the association between SSB availability via school vending machines and the actual SSB consumption, while future studies are needed to explore changes in other beverages after SSB becomes less available.

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