scholarly journals Amplification of MDM2 and Loss of p16 Expression: Do They Have a Role in Malignant Transformation of Ovarian Brenner Tumor?

2020 ◽  
Vol 154 (1) ◽  
pp. 133-141 ◽  
Author(s):  
Lucy Wang ◽  
Douglas Allison ◽  
Pratibha Sharma Shukla
Keyword(s):  
Cyclin D1 ◽  
Malignant Transformation ◽  
Molecular Characteristics ◽  
Immunohistochemical Expression ◽  
Brenner Tumor ◽  
Degree Of Malignancy ◽  
Brenner Tumors ◽  
Encoding Gene ◽  
Generation Sequencing ◽  
P16 Expression

Abstract Objectives To review the significance of MDM2 and cyclin D1 expression and loss of p16 expression in malignant and borderline Brenner tumors (BTs) of the ovary. Methods We describe 2 new cases of ovarian BT, 1 malignant and 1 borderline. We studied MDM2, p16, and cyclin D1 expression by immunohistochemistry in the benign, borderline, and malignant components of these 2 cases and in 5 additional cases of benign BT. We also reviewed and summarized the literature on the clinical, immunohistochemical and molecular characteristics of borderline and malignant BTs (BdBTs and MBTs). Results Nuclear expression of MDM2 was seen only in the MBT. Loss of p16 expression was seen in both BdBT and MBT. Cyclin D1 expression was in proportion to the degree of malignancy. Amplification of MDM2, loss of CDKN2A (p16-encoding gene), and amplification of CCND1 (cyclin D1–encoding gene) were confirmed by commercial next-generation sequencing in the case of MBT. Conclusions We are the first to report immunohistochemical expression of MDM2 in an MBT. Amplification of MDM2 and loss of p16 expression may have a role in malignant transformation of BT.

Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature

2021 ◽  
pp. 106689692199945
Author(s):  
Christine J. Salibay ◽  
Valentina Zanfagnin ◽  
Heather Miller ◽  
Saloni Walia ◽  
Laurie L. Brunette ◽  
...  
Keyword(s):  
Mucinous Cystadenoma ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Features ◽  
Review Of The Literature ◽  
Epithelial Proliferation ◽  
Unique Case ◽  
Mucinous Neoplasm ◽  
Brenner Tumor ◽  
Clinical Presentations ◽  
Brenner Tumors

Ovarian Brenner tumors, accounting for ∼5% of overall ovarian epithelial neoplasm, are often reported in association with mucinous neoplasm. Histogenetically, the two tumors are thought to arise from similar precursors. To date, fewer than 60 borderline Brenner tumors alone have been reported, and the concomitant presence of atypical proliferative components in Brenner and mucinous tumors is even rarer. Therefore, the clinicopathological characteristics and prognosis of patients with the borderline Brenner tumors alone or coexisting with mucinous neoplasm are extremely limited. Herein, we report a unique case of a 53-year-old woman with a unilateral ovarian borderline Brenner tumor associated with focal atypical mucinous epithelial proliferation and her clinical presentations. The clinicopathological features of the tumor are documented and the literature review along with the clinical molecular advances are summarized in this study.

scholarly journals A Rare Case of Bilateral Malignant Brenner Tumors of the Ovaries Associated with Peritoneal Effusion

2020 ◽  
Author(s):  
Jianing Tong ◽  
Jianmin Niu ◽  
Qiaoyun Li ◽  
Li Hu ◽  
Hui Zhang
Keyword(s):  
Preoperative Diagnosis ◽  
Vaginal Bleeding ◽  
Rare Case ◽  
Clinical Symptoms ◽  
Ovarian Tumors ◽  
Case Presentation ◽  
Brenner Tumor ◽  
Peritoneal Effusion ◽  
Brenner Tumors ◽  
The Masses

Abstract Background: Malignant ovarian Brenner tumors are extremely rare worldwide, accounting for only 1% of malignant ovarian tumors. Their clinical symptoms and pathology are complex and erratic, and the images are mostly non-specific. This poses difficulties in preoperative diagnosis and distinguishing them from other cystic solid ovarian tumors. Here this study has reported on a case of bilateral malignant ovarian Brenner tumor with peritoneal effusion. Case presentation: A 54-year-old woman presented with intermittent vaginal bleeding for more than two months and abdominal pain for one month. Two hard mass of five centimeters with poor movement could be touched at each side of the ovarian areas. The CT findings indicated the presence of two large cystic and solid masses in both adnexal regions. The operation had watched the size of the masses in the bilateral ovarian was both 6cmx6cmx5cm and their surface ulceration showed rotten fleshy tissue. After the operation, combined with morphological and immunohistochemical features, the ovarian specimens were consistent with bilateral ovarian malignant Brenner tumors.Conclusions: Although the incidence of bilateral malignant OBT is extremely low and this disease is extremely rare clinically, the gynecologists should be more informed of its diagnosis and treatment.

scholarly journals Immunohistochemical expression of cyclin D1 in invasive breast carcinoma and its correlation with clinicopathological parameters

2020 ◽  
Vol 63 (3) ◽  
pp. 376
Author(s):  
SiddhiGaurish Sinai Khandeparkar ◽  
PranotiVitthalrao Lengare ◽  
AvinashR Joshi ◽  
BageshriP Gogate ◽  
SmitaGaneshrao Solanke ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cyclin D1 ◽  
Invasive Breast Carcinoma ◽  
Clinicopathological Parameters ◽  
Immunohistochemical Expression

Detection of a novel gene mutation, ERBB2 exon 20 insertion, in bronchial adenoma using next-generation sequencing and a review of the literature

2020 ◽  
Author(s):  
Qian Wu ◽  
Lin Li ◽  
Ke Zheng ◽  
Yuan Tang ◽  
Lili Jiang
Keyword(s):  
Computed Tomography ◽  
Next Generation Sequencing ◽  
Biological Behavior ◽  
Molecular Characteristics ◽  
Neoplastic Disease ◽  
Next Generation ◽  
Computed Tomography Images ◽  
Exon 20 ◽  
Generation Sequencing ◽  
Bronchial Adenoma

Abstract Objectives: Ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor and is a subtype of bronchial adenoma (BA). Although recent studies have suggested that BA is a neoplastic disease, the complete histogenesis of BA is not fully understood and molecular data are limited. Methods: We examined the clinicopathological features of four patients with BA and performed immunohistochemical analysis and next-generation sequencing to characterize the molecular features of BA. A review of the previous literature was also undertaken to comprehensively conclude the molecular characteristics of this disease. Results: From previous studies and the present study, 99 BA /CMPT cases have been reported to date, with most of the patients from East Asia (77/99, 77.8%). The median age was 64 years old and the ages ranged from 19 to 84 years. The proportion of males and females was close, being approximately 1:1.3. From the computed tomography images, the BA /CMPT tumor usually presented as a peripheral solid mass, part-solid nodules, or ground-glass opaque with an irregular border and occasional central cavities. ERBB2, EGFR, BRAF, and AKT1 mutations were found on the computed tomography images of the BAs. To the best of our knowledge, this is the first study to report about ERBB2 exon 20 insertion in BA. Conclusion: BA /CMPT is a rare pulmonary disease that mainly affects elderly Asian patients. Many abnormal molecular changes were found, which confirmed the neoplastic nature of BA /CMPT. However, it also added to the debate regarding the biological behavior of BA /CMPT.

scholarly journals A rare presentation of benign Brenner tumor of ovary: a case report

2018 ◽  
Vol 7 (7) ◽  
pp. 2971
Author(s):  
Sumathi Periasamy ◽  
Subha Sivagami Sengodan ◽  
Devipriya . ◽  
Anbarasi Pandian
Keyword(s):  
Abdominal Pain ◽  
Ovarian Tumor ◽  
Ovarian Neoplasms ◽  
Pelvic Mass ◽  
Ovarian Tumors ◽  
Pathological Examination ◽  
Rare Presentation ◽  
Brenner Tumor ◽  
Benign Nature ◽  
Brenner Tumors

Brenner tumors are rare ovarian tumors accounting for 2-3% of all ovarian neoplasms and about 2% of these tumors are borderline (proliferating) or malignant. These tumors are commonly seen in 4th-8th decades of life with a peak in late 40s and early 50s. Benign Brenner tumors are usually small, <2cm in diameter and often detected incidentally during surgery or on pathological examination. Authors report a case of a large, calcified benign Brenner tumor in a 55-year-old postmenopausal woman who presented with complaint of abdominal pain and mass in abdomen. Imaging revealed large complex solid cystic pelvic mass -peritoneal fibrosarcoma. She underwent laparotomy which revealed huge Brenner tumor weighing 9kg arising from left uterine cornual end extending up to epigastric region. Myomectomy and hysterectomy with bilateral salphingo oophorectomy, omentectomy done and the specimen was sent for histopathological and immunohistochemistry study which revealed benign Brenner tumor. Brenner tumors are rare ovarian neoplasms accounting for 2-3% of all ovarian tumors. Benign Brenner tumors are usually small and solid whereas borderline and malignant Brenner tumors are usually larger and cystic with solid areas. But it is possible to have a completely benign large Brenner tumor. Therefore, benign nature of the lesion should not be excluded even when the ovarian tumor is very large.

Molecular differential diagnosis of uterine leiomyomas and leiomyosarcomas

2018 ◽  
Vol 101 (6) ◽  
pp. 1115-1123 ◽  
Author(s):  
Aymara Mas ◽  
Carlos Simón
Keyword(s):  
Uterine Leiomyomas ◽  
Noninvasive Detection ◽  
Molecular Characteristics ◽  
Bioinformatic Tools ◽  
Molecular Features ◽  
Genomic Markers ◽  
Potential Clinical Utility ◽  
Tumor Dna ◽  
Generation Sequencing ◽  
New Mutations

Abstract Uterine leiomyomas (LM) and leiomyosarcomas (LMS) are considered biologically unrelated tumors due to their cytogenetic and molecular disparity. Yet, these tumors share morphological and molecular characteristics that cannot be differentiated through current clinical diagnostic tests, and thus cannot be definitively classified as benign or malignant until surgery. Newer approaches are needed for the identification of these tumors, as has been done for other tissues. The application of next generation sequencing enables the detection of new mutations that, when coupled to machine learning bioinformatic tools, advances our understanding of chromosomal instability. These approaches in the context of LM and LMS could allow the discovery of genetic variants and possible genomic markers. Additionally, the potential clinical utility of circulating cell-free tumor DNA could revolutionize the noninvasive detection and monitoring of these tumors. Here, we seek to provide a perspective on the molecular background of LM and LMS, recognizing their distinct molecular features that may lead to improved diagnosis and personalized treatments, which would have a measurable impact on women's reproductive health.

scholarly journals Borderline Brenner Tumor: A Review of the Literature

2019 ◽  
Vol 143 (10) ◽  
pp. 1278-1280 ◽  
Author(s):  
Ruifang Zheng ◽  
Debra S. Heller
Keyword(s):  
World Health ◽  
Review Of The Literature ◽  
Epithelial Proliferation ◽  
Stromal Invasion ◽  
World Health Organization Classification ◽  
Ovarian Epithelial Tumors ◽  
Brenner Tumor ◽  
Pathologic Findings ◽  
Brenner Tumors ◽  
Health Organization

Brenner tumors arise from ovarian epithelium, accounting for approximately 5% of benign ovarian epithelial tumors. The World Health Organization classification groups them into benign, borderline, and malignant on the basis of proliferation and invasiveness, and borderline Brenner tumor is defined as “displaying epithelial proliferation beyond that seen in benign Brenner's tumor, but lacking stromal invasion.” Borderline Brenner tumors are rare. Fewer than 60 cases have been reported. The more recent articles mostly focus on pathogenesis. We reviewed the literature on borderline Brenner tumor and have summarized the clinical and pathologic findings, as well as the treatment, differential diagnoses, and recent advances in histogenesis and molecular pathogenesis.

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