Metastatic Alveolar Soft Part Sarcoma to the Breast: A Case Report

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S27-S27
Author(s):  
A Cheriyan ◽  
A Bousamra
Keyword(s):  
Differential Diagnosis ◽  
Tumor Cells ◽  
Soft Part ◽  
Left Breast ◽  
Alveolar Soft Part Sarcoma ◽  
Primary Tumors ◽  
Palpable Mass ◽  
Keratin 5 ◽  
Left Base ◽  
The Right

Abstract Introduction/Objective Metastases to the breast are rare (less than 3% of all breast malignancies). In adults, malignant melanoma is the most common type of metastasis followed by carcinomas from various primary sites. Here, we describe a case of metastatic alveolar soft part sarcoma (ASPS) to the breast. Only a handful similar presentations are reported in the literature. Methods Here we describe the case of a 43-year-old female patient with a recent diagnosis of left base of tongue alveolar soft part sarcoma (in an outside hospital), presenting with a palpable mass in her left breast. Sonographic study of the left breast demonstrated a 1.4 cm oval hypoechoic mass with partially microlobulated margins at 1 o’clock. Results Histopathologic examination of the ultrasound guided core biopsy showed a “pink” neoplasm, composed of plump epithelioid tumor cells with an eosinophilic and granular cytoplasm, round to oval nuclei and conspicuous nucleoli. They are arranged in organoid nests separated by sinusoidal spaces. An immunohistochemical study shows the tumor cells to be negative for keratin AE1/AE3, keratin 7, keratin 5/6, GATA-3, Pax-8, estrogen receptor, HER2, p63, S100 and CD117. FISH test for TFE3 (Xp 11.23) is positive. PAS with diastase staining highlights the intracytoplasmic granules. Theses morphologic, clinical and molecular findings confirm the diagnosis of metastatic ASPS. Conclusion The differential diagnosis of “pink” tumors of the breast include primary tumors like secretory carcinoma and apocrine carcinoma and metastatic lesions of renal, thyroid, skin (melanoma), oral cavity and soft tissue. Although extremely rare, in the right clinical context, metastatic ASPS to the breast can occur and should be included in the differential diagnosis.

Malignant Deciduoid Mesothelioma: A Diagnostic Challenge

2005 ◽  
Vol 129 (3) ◽  
pp. 403-406 ◽  
Author(s):  
Najat Mourra ◽  
Cecilede Chaisemartin ◽  
Isabelle Goubin-Versini ◽  
Rolland Parc ◽  
Jean-Francois Flejou
Keyword(s):  
Differential Diagnosis ◽  
Cesarean Section ◽  
Tumor Cells ◽  
Elderly People ◽  
Young Women ◽  
Poor Prognosis ◽  
Diagnostic Challenge ◽  
Keratin 5 ◽  
The Poor ◽  
Rare Phenotype

Abstract Malignant deciduoid mesothelioma, a rare phenotype of epithelioid mesothelioma, arises more commonly from the peritoneum of young women, but it is also reported in the pleura of elderly people. We report a case of malignant deciduoid mesothelioma that occurred in a 41-year-old woman after cesarean section and was initially misdiagnosed as pseudotumoral deciduosis. Microscopically, the tumor was entirely composed of deciduoid areas, and only scattered tumor cells were positive for calretinin and keratin 5/6. The patient died 14 months after the first operation. This observation confirms the poor prognosis of this entity and the importance of the differential diagnosis of pseudotumoral deciduosis.

scholarly journals Alveolar soft part sarcoma of the right calf

Medicine ◽  
2020 ◽  
Vol 99 (5) ◽  
pp. e18952
Author(s):  
Bin Wang ◽  
Huanhuan Wang ◽  
Jinlong Wei ◽  
Limei Qu ◽  
Lingbin Meng ◽  
...  
Keyword(s):  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
The Right

Alveolar Soft Part Sarcoma of the Pituitary Gland with Secondary Involvement of the Right Cerebral Ventricle

1988 ◽  
Vol 2 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Gerard Th. A. M. Bots ◽  
Cornelis C. Tijssen ◽  
Douwe Wijnalda ◽  
Johannes L. J. M. Teepen
Keyword(s):  
Pituitary Gland ◽  
Soft Part ◽  
Cerebral Ventricle ◽  
Alveolar Soft Part Sarcoma ◽  
The Right

scholarly journals Lung Metastasis of Primary Alveolar Soft-Part Sarcoma Occurring 20 Years after Initial Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
R. F. Falkenstern-Ge ◽  
M. Kimmich ◽  
M. Wohlleber ◽  
A. Grabner ◽  
G. Friedel ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Lung Metastasis ◽  
Lung Tumor ◽  
Lung Metastases ◽  
Soft Part ◽  
Lower Limbs ◽  
Alveolar Soft Part Sarcoma ◽  
Malignant Soft Tissue Tumor ◽  
Previously Treated ◽  
The Right

A 30-year old woman was referred to our center because of suspicion of a primary lung tumor of the right upper lobe. Histological examination of the lung lesion revealed lung metastasis of a previously treated alveolar soft part sarcoma of the musculus vastus medialis of the right femur, which was resected 20 years ago. Alveolar soft-part sarcoma is a rare malignant tumor that occurs most often in the soft tissue of lower limbs. It is a slow-growing malignant soft tissue tumor arising in muscle tissue, usually in young adults. Due to pleural and extensive mediastinal infiltration with bilateral lung metastases, a systemic treatment with chemotherapy doxorubicin and ifosfamide was initiated. Late metastases from previously treated alveolar part sarcoma should be considered in patients with suspicious lung lesions even if surgical treatment was performed a long time ago.

Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma

2009 ◽  
Vol 190 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Makiko Hoshino ◽  
Akira Ogose ◽  
Hiroyuki Kawashima ◽  
Tomohiro Izumi ◽  
Tetsuo Hotta ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Peripheral Blood ◽  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Molecular Analyses

scholarly journals PRIMARY EWING'S SARCOMA OF THE NASAL CAVITY IN PEDIATRIC PRACTICE

2021 ◽  
Vol 06 (01) ◽  
pp. 102-103
Author(s):  
Bekisheva Aigul Bekisheva Aigul ◽  
Makhneva Anna Makhneva Anna ◽  
Bulegenova Minira Bulegenova Minira ◽  
Abyov Galyjan Abyov Galyjan ◽  
Remkulova Mahabbat Remkulova Mahabbat
Keyword(s):  
Differential Diagnosis ◽  
Nasal Cavity ◽  
Tumor Cells ◽  
Paranasal Sinuses ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Diagnostic Methods ◽  
Pelvic Bone ◽  
Radiological Features ◽  
The Right

Introduction: Ewing's sarcoma (ES) is an aggressive tumor occuring more frequently in childhood and adolescence, mainly observed during the first three decades of life. Microscopically consists of small round cells, with a high nuclear cytoplasmic index, originating from primitive neuroectodermal cells. Most often such tumor occurs in early childhood or adolescence. [1] Ewing's sarcoma refers to tumors of the bone tissue : the limbs, ribs, and pelvic bone, but also it may occur in soft tissues, which means any localization in the human body. Among extra-skeletal localities, ES rarely occurs in the head and neck (2-3% of all ES) and extremely rare in the nasal cavity or paranasal sinuses [1,2,3]. Diagnosis the primary of ES nasal localization is complex and mainly depends on histopathological research, as visual diagnostic methods (x-ray, CT, MRI) do not identify the type of tumor. MRI examination of tumors of such localization may suggest a malignant nature, so further differential diagnosis should exclude the following: malignant lymphoma, rhabdomyosarcoma, moderately differentiated carcinomas, and ES. These tumors have common radiological features, so they require additional research [4,5]. From abovementioned, the following clinical case of primary Ewing's sarcoma in the nasal cavity in a 14-year-old girl seemed to be interesting . The patient complained on the difficulty of breathing, swelling in the right half of the nose wing. MRI showed a large neopasm of the facial skull on the right (pterygoid and subterranean fossa, right half of the nose, nasopharynx, latticed bone and paranasal sinuses). Histological examination of the samples revealed a solid neoplastic tissue consisting of monomorphic small circular or oval cells with a high nuclear-cytoplasmic index. Some exapnsion of the tumor cells around the vessels was observed, while part of epithelial lining and glandular structures were preserved in the same places. Foci of necrosis and extensive hemorrhages were visualized. The immunohistochemical study with the CD99 antibody showed a total positive membrane reaction with the closure of the stained membranes ( with the presence of membranes ring staining ). The reaction with anti Fli1 revealed total nuclear staining of tumor cells, except for the stromal cells. Thus: as primary Ewing's sarcoma affects the sinus tract very rarely, diagnosis of the tumor in this location is difficult. MRI and other visual methods in these cases are not informative, because a number of tumors have common radiological features, that make the differential diagnosis very difficult. In this regard, the pathomorphological study including immunohistochemical research is the main method of diagnosing ES.

scholarly journals Successful use of three-dimensional conformal radiotherapy as adjuvant treatment for alveolar soft part sarcoma. A case report

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Eliana Evelina Ocolotobiche ◽  
Esteban Pérez-Duhalde ◽  
Alba Mabel Güerci
Keyword(s):  
Adjuvant Radiotherapy ◽  
Soft Part ◽  
Three Dimensional ◽  
Conformal Radiotherapy ◽  
Metastatic Tumor ◽  
Local Relapse ◽  
Alveolar Soft Part Sarcoma ◽  
Genetic Characteristics ◽  
Three Dimensional Conformal Radiotherapy ◽  
The Right

Introduction: Alveolar soft part sarcoma is a very rare and aggressive type of sarcoma. Although its histology and genetic characteristics have been identified, the benefits of adjuvant radiotherapy for its treatment are still being studied. Case presentation: In November 2007, a 21-year-old woman presented with a primary tumor in the right thigh, with histological and immunohistochemical confirmation of an alveolar soft part sarcoma, which was totally resected in December 2007. Also, the large size of the mass suggested an unfavorable evolution. Two years after the first surgery, two metastatic tumors were detected in the right lung, which were completely resected separately. Two years later, the patient had two independent relapse events, five months apart: a mass in the right tight, and a metastatic tumor in the adrenal gland together with relapse in the tight. All tumors were successfully resected. In June 2014, after the last local relapse, adjuvant radiotherapy was started because of the risk of thigh amputation. At the end of treatment, the patient’s general condition was good. Currently, at age 34, the patient is monitored through periodic evaluations, showing disease regression and stabilization. Conclusions: Currently, it is known that radiation not only produces cytotoxic effects on the target region, but also induces an immune system-mediated systemic response with potential antimetastatic properties. The emerging radiobiological paradigms should be considered, particularly since they could explain some encouraging and unexpected results such as those described in this case.

scholarly journals Diffuse Anterior Retinoblastoma with Sarcoidosis-Like Nodule

2015 ◽  
Vol 6 (3) ◽  
pp. 443-447 ◽  
Author(s):  
Koji Kitazawa ◽  
Kenji Nagata ◽  
Yukito Yamanaka ◽  
Yasumichi Kuwahara ◽  
Tomoko Iehara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Differential Diagnosis ◽  
Tumor Cells ◽  
Ciliary Body ◽  
Anterior Segment ◽  
Small Cells ◽  
Posterior Surface ◽  
Undifferentiated Cells ◽  
Anti Inflammatory ◽  
The Right

Background: Retinoblastomas account for 4% of malignancies in children, 1-2% of which are diffuse infiltrating retinoblastomas. Diffuse anterior retinoblastoma is rare and does not involve the retina. Here, we report on a diffuse anterior retinoblastoma with large sarcoidosis-like nodules on the iris that were responsive to anti-inflammatory therapy. Case: We present a 6-year-old girl who had anterior uveitis with white nodules on the iris and posterior surface of the cornea in her right eye. The nodules initially responded well to anti-inflammatory treatment. However, anterior segment optical coherence tomography (AS-OCT) showed that the nodules gradually grew, shrinking the iris. We then collected the aqueous humor for diagnosis. A biopsy revealed clusters of small cells with a high nuclear-to-cytoplasm ratio with partial rosette formation. Therefore, we diagnosed diffuse anterior retinoblastoma without retinal involvement and performed enucleation of the right eye. The histopathology demonstrated undifferentiated cells similar to those seen on the biopsy, and tumor cells invaded the iris stroma, posterior surface of the cornea, ciliary body, and sclera. After the enucleation, she underwent chemotherapy and remains alive. Conclusion: A differential diagnosis of retinoblastoma should be considered when white nodules refractory to anti-inflammatory therapy occur in the eye, even in the absence of obvious retinal masses. AS-OCT findings are useful in assessing retinoblastoma.

scholarly journals Alveolar soft part sarcoma of the orbit, a case report of a rare tumor

2017 ◽  
Vol 9 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Ángel Nava-Castañeda ◽  
José Luis Tovilla-Canales ◽  
Francisca Zuazo ◽  
Lourdes Rodríguez-Cabrera ◽  
Lilia Garnica-Hayashi
Keyword(s):  
Malignant Tumor ◽  
Soft Part ◽  
Extended Period ◽  
Distant Metastases ◽  
Excisional Biopsy ◽  
Lower Eyelid ◽  
Soft Tissue Tumors ◽  
Alveolar Soft Part Sarcoma ◽  
The Right

Background: Alveolar Soft Part Sarcoma is a rare malignant tumor of uncertain histogenesis, representing 0.5-1% of all soft tissue tumors. It occurs predominantly in head and neck regions, especially the orbit and the tongue, in infants, causing no specific symptoms for an extended period of time. Case: A four year old girl was brought to consultation because of persistent swelling of her left upper and lower eyelid for the past six months. A 4 mm proptosis was noted on her left eye with significant upwards displacement of the globe. A firm, not pulsating and non tender mass was palpated, and motility examination revealed deficient abduction and infraduction. Visual acuity was 20/40 and 1/200 in the right and left eye, respectively. The computed tomography revealed an extraconal mass on the inferotemporal aspect of the left orbit, with no bony erosion or globe invasion. An excisional biopsy was made, finding a tumor with nests of clusters of large polygonal cells, separated by fibrous septa and a sinusoidal vascular channel. An Alveolar Soft Part Sarcoma was diagnosed. Our patient had a favorable post-operative follow up, and oncologic evaluations have not shown metastasis or local recurrences. Observations and Conclusions: Alveolar Soft Part Sarcoma is a rare malignant tumor of indolent course, but with propensity to distant metastases, making early diagnose and long term follow up necessary. 

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