Squamous Cell Carcinoma Of Pancreas: An Exceedingly Rare Entity In A Young Female

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S54-S54
Author(s):  
J Arshi ◽  
D Rao
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Neoplasm ◽  
Rare Entity ◽  
Primary Tumors ◽  
Palpable Mass ◽  
Rare Neoplasm ◽  
Carcinoma Of Pancreas ◽  
Adequate Sampling

Abstract Introduction/Objective Squamous cell carcinoma(SqCC) of Pancreas is a vanishingly rare neoplasm with dismal survival. Only a handful of cases are ever reported as pure SqCC reportedly accounts for <1% of malignancies of exocrine pancreas. Although, few theories have been proposed in an attempt to explain origin of this tumor including the possibility of (1)common progenitor cell and (2)squamous metaplasia, none have been proven with concrete evidence. Methods Here, we are presenting a case of squamous cell carcinoma of pancreas in a 33-year-old female who presented with 2-year history of right upper quadrant abdominal pain and a palpable mass. The imaging showed a multi-lobulated cystic mass encasing cystic duct, portal vein, and superior mesenteric artery. Results Grossly the mass was 5.2 cm in the greatest dimension. The mass revealed solid and cystic areas and was filled with hemorrhagic debris. On microscopy, the cyst wall was infiltrated by malignant neoplasm composed of irregular tongues and cords of malignant cells with nests of central keratinization. The tumor was consistent with squamous cell carcinoma. Foci of high grade cells with oval to spindled hyperchromatic nuclei, with many prominent nucleoli were also noted. There was no evidence of glandular component despite adequate sampling. The differential diagnoses of pancreatoblastoma and metastatic squamous cell carcinoma were considered and excluded. Conclusion SqCC of Pancreas is an exceedingly rare neoplasm of Pancreas. The diagnosis is made after extensive work up, adequate sampling and ruling out other common primary tumors and the possibility of metastasis. It usually follows an aggressive course with resistance to conventional neoadjuvant therapy. During the recent years, survival rates have shown some improvement with respectability and low to intermediate grade emerging as favorable prognostic factors. However, to further validate such findings noted in published case reports of this rare entity, collaborative studies with pooled data are deemed necessary.

scholarly journals Rural profile of oral squamous cell carcinoma (OSCC) survival patients attending in tertiary level hospital in Bogura: a hospital based retrospective observational study.

2020 ◽  
Vol 10 (1) ◽  
pp. 3-5
Author(s):  
Parometa Barma ◽  
Ibrahim Khalil ◽  
Tanzima Yeasmin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Neoplasm ◽  
P Value ◽  
Oral Epithelium ◽  
Tertiary Level ◽  
Total Cancer ◽  
Grade Ii

Developing country like Bangladesh among 90% of oral malignant neoplasm are arising from squamous layer of oral epithelium which are third leading of this country with severe disfiguration, functiolaesa, psychological impairments and socio-economic hardship. In this study we found the prevalence of OSCC was 6.5% among total cancer patients in the two tertiary level hospitals of Bogura. Male (70%) are affected more than in females (30%). In response to male and female parameter, sex distribution ratio was 2.3:1. The prevalent average age was 55.40 years. About 80% of ulcer site was buccal mucosa then 10 % were lip mucosa. About 80% people were habituated by betel nut, leaf with tobacco chewers. Moreover 46.7% of them were maltreated by quack doctors before. Majority of the patient was in Grade II (56.7%). Correlation between variable in respect of age and cancer grading was explained. According to these study OSCC patients in north bangle region like Bogura was quite high on ( significant p-value ≤ 0.05). Description of oral squamous cell carcinoma on the basis of demographic and clinical profile was the major aim . Most of the cases report with intermediate grade of the disease which often leads to decrease the chance of survival of a patient. So new strategies should be considered to overcome the present situation must be undertaken by oral health programs for the early diagnosis and prevention, build up awareness and management and follow up of oral cancer. Update Dent. Coll. j: 2020; 10 (1): 3-5

scholarly journals Matched-Pair Analysis of Survival in the Patients with Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma Treated with Induction Chemotherapy Plus Chemo-Radiation or Total Laryngectomy

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1735
Author(s):  
Patricia García-Cabo ◽  
Fernando López ◽  
Mario Sánchez-Canteli ◽  
Laura Fernández-Vañes ◽  
César Álvarez-Marcos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Matched Pair ◽  
Primary Tumors ◽  
Free Survival ◽  
Tumor Node Metastasis Stage ◽  
Significant Difference

Background: We performed a comparative analysis between an organ-preservation protocol and surgery followed by radiotherapy in patients with locally advanced squamous cell carcinoma of the larynx and hypopharynx; Methods: 60 previously untreated patients who were treated with induction chemotherapy followed by chemoradiotherapy in responders were compared with a control group of 60 patients treated with up-front surgery. Both groups were statistically comparable, according to the subsite, TNM (tumor-node-metastasis) stage, age, and sex; Results: Mean age was 58 years and 92% were male. No significant statistical difference was observed for overall survival (OS) (HR 0.75; 95% CI 0.48–1,18; P = 0.22) and disease-specific survival (DSS) (HR 0.98; 95% CI 0.52–1.83, P = 0.96). Also, there was no significant difference for recurrence-free survival (HR 0.931; 95% CI 0.57–1.71; P = 0.81), metastases-free survival (HR 2.23; 95% CI 0.67–7.41; P = 0.19), and the appearance of second primary tumors (HR 1.22; 95% CI 0.51–2.88; P = 0.64); Conclusions: The results of the organ-preservation approach did not appear inferior to those of surgery plus (chemo)radiotherapy for patients with T3/T4a larynx and T2–T4a hypopharynx cancer with respect to OS and DSS, locoregional control and metastases-free survival.

scholarly journals Synchronous primary malignancy of ovary and cervix with different histopathology: A rare case report

2016 ◽  
Author(s):  
Alok Tiwari ◽  
Dhananjay Gughe ◽  
Radhika Dureja ◽  
Satinder Kaur
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Contrast Enhancement ◽  
Squamous Cell ◽  
Pap Smear ◽  
Ca 125 ◽  
Post Contrast ◽  
Palpable Mass ◽  
Diffusion Restriction

Concurrent different histopathological types of gynecologic tumors arise rarely. We present ovarian serous and cervical squamous cell carcinoma formed synchronously. A 51-year-old woman with a poor general condition was admitted with gradual distension of abdomen for 1 year with gradual loss of weight and appetite for the last three months and pain in the abdomen and irregular vaginal bleeding for the last two months. There was no family history of malignancy of genital tract, breast or colon. On examination she was cachexic, pale, dehydrated, tachypnoeic and had edema over feet. Per abdomen examination revealed solid, non-mobile palpable mass arising from pelvis. Per vaginal examination revealed large mass in pelvis and uterus can not be felt separately on per speculum examination there was small endocervical erosion, hypertrophied cervix. On per rectal examination bilateral parametria were free. Her tumor marker were evaluated and CA-125 was found to be raised (CA 125: 915.6 u/ml U/mL); rest tumor markers were normal. Cervical punch biopsy was suggestive of moderately differentiated carcinoma and pap smear was also suggestive of cervical cancer. MRI findings revealed a mass of altered signal intensity 2.5 × 1.5 × 2.2 cm with diffusion restriction and post contrast enhancement in the anterior lip of cervix and another large, lobulated predominantly solid mass, hypo intense on T1, intermediate on T2 with diffusion restriction and post contrast enhancement in the right adnexal region abutting the small bowel and sigmoid colon optimal debulking surgery with standard protocol was done. Histopathology report revealed squamous cell carcinoma of cervix, grade III and high grade serous cystadenocarcinoma of ovary. Tumour deposits from ovary were seen on right fallopian tube and right parametrium. Squamous cell carcinoma cervix involved ectocervix, endocervix and infiltrated near full thickness of cervical stroma, endomyometrium, vaginal cuff, paracervical tissue omentum and appendix were free of tumour. Twenty five right pelvic lymphnodes dissected were free of tumour, (00/25). One out of fifteen lymphnode dissected were involved with extra capsular extent, 01/15 and thirteen para aortic lymph node dissected were free of tumor. Immunohistochemistry markers: Ovarian mass-tumour cell expressed ck, vimentin, wt-1 with focal Ck positivity, no expression of ck20, p63, ck5/6 and CEA seen. Cervical tumour-tumour cells expressed ck, ck7, p63 and ck5/6 no expression of ck20, wt-1. Based on our case report we need to keep in mind that even if patient presents with symptoms pertaining to a single malignancy; still the rare possibility of synchronous malignancies should be looked for by doing proper investigations. In our case, patient had symptoms pertaining to ovarian malignancy; whereas cervical malignancy was diagnosed after investigating the patient. Histologic examination should be done properly as the prognosis depends on the malignancies being metastatic or synchronous one appropriate management should be offered in all such cases. Long term follow up of such patients should be maintained to determine the prognosis.

scholarly journals Clinical analysis of 12 cases of ovarian cystic mature teratoma with malignant transformation into squamous cell carcinoma

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098154
Author(s):  
Xiangyu Wang ◽  
Wenjing Li ◽  
Yan Kong ◽  
Xiangyu Liu ◽  
Zhumei Cui
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Tumor Size ◽  
Treatment Guidelines ◽  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Clinical Analysis ◽  
Palpable Mass

Objective This study aimed to examine the clinicopathological characteristics, treatment, and prognostic factors in 12 cases of malignant transformation of mature cystic teratoma of the ovary (MCTO). Methods We performed a retrospective study of 12 patients with malignant transformation of MCTO who were admitted to the Affiliated Hospital of Qingdao University from 2003 to 2019. We examined case records, clinical parameters, and biological assessments. Results The median age of the patients was 56.5 years and seven of them were postmenopausal. The average tumor size was 18.5 cm. All patients had pelvic masses at their first hospital visit. Nine of the patients had discomfort in the lower abdomen, two presented with a lower abdominal palpable mass, and three were complicated by fever. The median follow-up time was 73 months (12‒193 months). Ten patients survived with a disease-free status and two died. Conclusions There is a low incidence of malignant transformation of MCTO, and its most common histological type is squamous cell carcinoma. Age and tumor size are important factors in malignant transformation of teratomas. While there is a lack of treatment guidelines for malignant transformation of MCTO, early diagnosis and treatment may be beneficial for these patients.

scholarly journals Squamous Cell Carcinoma of Kidney and Its Prognosis: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Tapan Kumar Sahoo ◽  
Saroj Kumar Das ◽  
Chandraprava Mishra ◽  
Ipsita Dhal ◽  
Rohani Nayak ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radical Nephrectomy ◽  
Advanced Stage ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma ◽  
Review Of The Literature ◽  
Radiological Features ◽  
The Right

Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.

scholarly journals Metastatic Squamous Cell Carcinoma of the Anus to the Lung Confirmed with Allelotyping

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Rachel Roth ◽  
Susan Moffatt-Bruce ◽  
Marino E. Leon
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Palliative Chemotherapy ◽  
Primary Tumors ◽  
Appropriate Treatment ◽  
Metastatic Squamous Cell Carcinoma ◽  
Hematoxylin And Eosin

Histopathologic techniques are insufficient for distinguishing primary squamous cell carcinoma (SCC) from metastatic SCC, which is clinically important. A patient with SCC of the anus was found to also have SCC of the lung, and the question of metastatic versus synchronous primary diseases was raised. Immunohistochemical and hematoxylin and eosin (H&E) staining on sections of tissue could not discriminate between the two entities. Immunostain for p16 and chromogenicin situhybridization for human papillomavirus (HPV) type 16 were positive in both tumors. Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment. Identification can be achieved using allelotyping for loss of heterozygosity.

Sign in / Sign up

Export Citation Format

Share Document