The Sperm Specific Form of Lactate Dehydrogenase (LDHC4) is Required for Fertility and is an Attractive Target for Male Contraception (A Review)

2020 ◽  
Author(s):  
Erwin Goldberg
Keyword(s):  
Lactate Dehydrogenase ◽  
Hormonal Contraception ◽  
Marked Change ◽  
Glycolytic Enzyme ◽  
Specific Form ◽  
Innovative Technology ◽  
Male Contraceptive ◽  
Lactate Dehydrogenase C ◽  
Gates Foundation ◽  
Development Paths

Abstract There has been a recent upsurge in interest about contraceptive development, evidenced by the Contraceptive Special Issue of Biology of Reproduction [1], with research funding from the Male Contraceptive Initiative (MCI), and the Bill and Melinda Gates Foundation. Support from the Contraceptive Research Branch of the Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD) continues with a marked change in focus in the funding announcements. This has motivated me to reflect on research, mostly from my laboratory starting in the 1960’s to the present, on the development of a male contraceptive based on the sperm specific glycolytic enzyme, Lactate Dehydrogenase C (LDHC4). This review considers the rationale behind this research, the development paths pursued, obstacles encountered and the renewed interest in going forward toward development of a male contraceptive mediated by inhibition of the sperm specific form of Lactate dehydrogenase (LDHC). I will address how some papers published many years ago are relevant to present goals of non-hormonal contraception and will mention innovative technology now available that can advance this project. This review presumably will serve as an instructive guide for a research program with a focused program related to contraception. As an aside, many of the citations in this review are to most of the 26 publications in Biology of Reproduction co-authored by this investigator and collaborators from 1974 through 2020 not long after the first issue of BOR which was published in April 1969.

P–047 Knowledge, professional attitudes and training of health professionals on male contraceptive methods

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
J Perrin ◽  
J Tcherdukian ◽  
A Netter ◽  
E Lechevalier ◽  
F Bretelle ◽  
...  
Keyword(s):  
General Practitioners ◽  
Health Professionals ◽  
Large Scale ◽  
Hormonal Contraception ◽  
Male Contraception ◽  
Contraceptive Methods ◽  
Medical Specialties ◽  
Professional Attitudes ◽  
Male Contraceptive ◽  
And Training

Abstract Study question Among health professionals involved in contraceptive prescribing, what are the knowledge, professional attitudes and training on male contraceptive methods? Summary answer The health professionals involved in prescribing contraception are not sufficiently trained in male contraception and almost all of them want more. What is known already The most recent large-scale studies show that 70% of couple contraception is provided by women and that the majority of men and women would be willing to adopt male contraception as couple contraception. The medicalization of contraception places the medical profession at the forefront of the acceptability of and information regarding a contraceptive method. However, only one study have evaluated health professionals’ knowledge of the various methods of male contraception (MC), including male hormonal contraception (MHC) and male thermal contraception (MTC). Study design, size, duration Between April 2020 and June 2020, we carried out a descriptive prospective multicentre study in a medical population of 2243 prescribers of couple contraception in France. Participants/materials, setting, methods The participants were obstetrician-gynaecologists, medical gynaecologists, general practitioners or midwives. They completed a three-part numerical questionnaire, including i) sociodemographic characteristics and personal experiences with contraception, ii) knowledge and professional attitudes about male contraception and iii) training on male contraception. Main results and the role of chance The overall participation rate was 19% (340/2243). Condoms and withdrawal were known by 98% and 89% of the population, respectively. Vasectomy was known by 75% of the population and significantly better known by obstetrician-gynaecologists than by medical gynaecologists and general practitioners (p = 0.026). Male hormonal contraception (MHC) and male thermal contraception (MTC) were known by 10% and 23% of the population, respectively, and were significantly better known by medical gynaecologists and general practitioners than by other specialties (p < 0.001). More than half (55%) of the population never or infrequently offered MC during a couple’s contraceptive request consultation. Female practitioners offered MC significantly more often than male practitioners (48% vs. 26%; p = 0.033). Only 14% of the population had ever participated in training on MC, 96% wished to be better trained on MC, and 86% expressed a willingness to participate in such a training. Limitations, reasons for caution The population was mainly representative of medical health practitioners of southeastern France. There was an over-representation of women in all medical specialties, except for midwives. Wider implications of the findings: Our study shows that health professionals involved in contraception have limited knowledge about MC and are eager to have more information about it. To advance the acceptability and dissemination of such contraceptive methods, it seems imperative to provide health professionals with an adapted training program on male contraception. Trial registration number 2020–01–23–03

scholarly journals Lactate Dehydrogenase C and Energy Metabolism in Mouse Sperm

2011 ◽  
Vol 85 (3) ◽  
pp. 556-564 ◽  
Author(s):  
F. Odet ◽  
S. A. Gabel ◽  
J. Williams ◽  
R. E. London ◽  
E. Goldberg ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Energy Metabolism ◽  
Mouse Sperm ◽  
Lactate Dehydrogenase C

scholarly journals Contraceptive Choices: Is the Future with Men?

2005 ◽  
Vol 1 (2) ◽  
pp. 183-189 ◽  
Author(s):  
R A Anderson ◽  
M J Walton
Keyword(s):  
Vas Deferens ◽  
Hormonal Contraception ◽  
Potential Method ◽  
Phase Iii ◽  
Male Contraceptive ◽  
The Future ◽  
Further Development ◽  
Phase Iii Studies

A credible, reversible male contraceptive with sufficient efficacy and convenience to rival established female methods has been eagerly awaited for some years. What are the issues surrounding its development and when is a launch likely? At present, many different approaches and targets have been identified for further development. These include spermatogenesis, unique testicular proteins, immunocontraception, the vas deferens and the potential method currently closest to fruition, hormonal contraception. This is now in Phase III studies in China and commercial studies are underway in Europe.

scholarly journals Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy

2020 ◽  
Vol 69 (3) ◽  
pp. 449-463 ◽  
Author(s):  
Remy Thomas ◽  
Hibah Shaath ◽  
Adviti Naik ◽  
Salman M. Toor ◽  
Eyad Elkord ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Cancer Immunotherapy ◽  
Lactate Dehydrogenase C ◽  
Novel Targets

Alternative Splicing of Testis-Specific Lactate Dehydrogenase C Gene in Mammals and Pigeon

2012 ◽  
Vol 23 (2) ◽  
pp. 114-123 ◽  
Author(s):  
Lin Huang ◽  
Yaqiu Lin ◽  
Suyu Jin ◽  
Wei Liu ◽  
Yaou Xu ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Lactate Dehydrogenase ◽  
Lactate Dehydrogenase C

Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5

1988 ◽  
Vol 14 (5) ◽  
pp. 515-518 ◽  
Author(s):  
Fa-Ten Kao ◽  
Kun C. Wu ◽  
Martha L. Law ◽  
Judith A. Hartz ◽  
Yun-Fai Lau
Keyword(s):  
Lactate Dehydrogenase ◽  
Human Gene ◽  
Chromosome 11 ◽  
Gene Encoding ◽  
Lactate Dehydrogenase C

scholarly journals Regional enzyme development in rat brain. Enzymes associated with glucose utilization

1984 ◽  
Vol 218 (1) ◽  
pp. 131-138 ◽  
Author(s):  
S F Leong ◽  
J B Clark
Keyword(s):  
Enzyme Activity ◽  
Lactate Dehydrogenase ◽  
Rat Brain ◽  
Brain Regions ◽  
Glycolytic Enzyme ◽  
Glycolytic Potential ◽  
Key Enzyme ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Potential Enzyme Activity ◽  
The Brain

The development of key enzyme activities concerned with glucose metabolism was studied in six regions of the rat brain in animals from just before birth (-2 days) through the neonatal and suckling period until adulthood (60 days old). The brain regions studied were the cerebellum, medulla oblongata and pons, hypothalamus, striatum, mid-brain and cortex. The enzymes whose developmental patterns were investigated were hexokinase (EC 2.7.1.1), aldolase (EC 4.1.2.13), lactate dehydrogenase (EC 1.1.1.27) and glucose-6-phosphate dehydrogenase (EC 1.1.1.49). Hexokinase, aldolase and lactate dehydrogenase activities develop as a single cluster in all the regions studied, although the timing of this development varies from region to region. Glucose-6-phosphate dehydrogenase activity, however, declines relative to glycolytic enzyme activity as the brain matures. When the different brain regions are compared, it is clear that the medulla develops its glycolytic potential, as indicated by its potential enzyme activity, considerably earlier than the other regions (hypothalamus, striatum and mid-brain), with the cortex and cerebellar activities developing even later. This enzyme developmental sequence correlates well with the neurophylogenetic development of the brain and adds support to the hypothesis that the development of the potential for glycolysis in the brain is a necessary prerequisite for the development of neurological competence.

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