scholarly journals Effect of Maternal Vitamin D Supplementation on Iron Status During Pregnancy

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1054-1054
Author(s):  
Karen O'Callaghan ◽  
Ulaina Tariq ◽  
Alison Gernand ◽  
Maria Tinajero ◽  
Akpevwe Onoyovwi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Ferritin ◽  
Iron Status ◽  
Geometric Mean ◽  
Vitamin D Supplementation ◽  
Late Gestation ◽  
Double Blind ◽  
Maternal Vitamin ◽  
Few Data

Abstract Objectives Vitamin D may have an adjunctive role in the prevention and treatment of iron deficiency (ID) through its proposed role in the regulation of erythropoiesis and circulating hepcidin concentrations. Observational studies have shown associations between low vitamin D and iron status; however, there are few data from intervention trials. In participants of the Maternal Vitamin D for Infant Growth Trial (MDIG; NCT01924013), among whom the baseline prevalence of vitamin D deficiency was 64%, we examined the effect of prenatal vitamin D supplementation on iron status during pregnancy by testing the effect of vitamin D supplementation on serum ferritin concentrations. Methods In this double-blind, dose-response, randomized trial in Dhaka, Bangladesh, women were recruited at 17–24 weeks’ gestation and randomly assigned to receive a prenatal vitamin D3 dose of 4200, 16,800, 28,000 IU/week or placebo. Serum ferritin was quantified using an electro-chemiluminescence immunoassay. Plasma C-reactive protein (CRP) was analysed by enzyme-linked immunoassay. Linear regression was used to test the hypothesized effect of vitamin D supplementation on serum ferritin (n = 1011 of 1300 enrolled). In a sensitivity analysis, we adjusted for concurrent CRP to correct for inflammation (n = 920). Regression correction was used to generate an inflammation-corrected estimate of the prevalence of ID (n = 920). Results Prevalence of ID (serum ferritin <15 µg/L) was high overall (27% corrected for inflammation; 12% uncorrected). Geometric mean (95% confidence interval) serum ferritin concentrations were lower in each of the vitamin D supplementation groups [43.1 (38.1, 48.7), 44.8 (40.4, 49.7) and 45.1 (41.5, 49.1) µg/L in the 4200, 16,800 and 28,000 IU/week groups, respectively] compared to the placebo group [50.3 µg/L (45.0, 56.2)], although none of the pairwise differences between each vitamin D group and placebo were statistically significant at the P < 0.05 threshold. Adjusting for CRP did not change the inferences. Conclusions In a population with concurrently high prevalence rates of iron and vitamin D deficiency, prenatal vitamin D supplementation did not lead to improvements in iron status by late gestation. The possibility of a negative effect of vitamin D supplementation on iron status should be further explored. Funding Sources The Bill and Melinda Gates Foundation.

scholarly journals Vitamin D Supplementation Modestly Reduces Serum Iron Indices of Healthy Arab Adolescents

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1870 ◽  
Author(s):  
Mohammad Masoud ◽  
Majed Alokail ◽  
Sobhy Yakout ◽  
Malak Khattak ◽  
Marwan AlRehaili ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Iron ◽  
Iron Status ◽  
Group Analysis ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Post Intervention ◽  
King Saud University ◽  
Deficiency Type

Vitamin D deficiency has been shown to affect iron status via decreased calcitriol production, translating to decreased erythropoiesis. The present study aimed to determine for the first time whether vitamin D supplementation can affect iron levels among Arab adolescents. A total of 125 out of the initial 200 Saudi adolescents with vitamin D deficiency (serum 25(OH)D < 50 nmol/L) were selected from the Vitamin D-School Project of King Saud University in Riyadh, Saudi Arabia. Cluster randomization was done in schools, and students received either vitamin D tablets (1000 IU/day) (N = 53, mean age 14.1 ± 1.0 years) or vitamin D-fortified milk (40IU/200mL) (N = 72, mean age 14.8 ± 1.4 years). Both groups received nutritional counseling. Anthropometrics, glucose, lipids, iron indices, and 25(OH)D were measured at baseline and after six months. Within group analysis showed that post-intervention, serum 25(OH)D significantly increased by as much as 50%, and a parallel decrease of −42% (p-values <0.001 and 0.002, respectively) was observed in serum iron in the tablet group. These changes were not observed in the control group. Between-group analysis showed a clinically significant increase in serum 25(OH)D (p = 0.001) and decrease in iron (p < 0.001) in the tablet group. The present findings suggest a possible inhibitory role of vitamin D supplementation in the iron indices of healthy adolescents whose 25(OH)D levels are sub-optimal but not severely deficient, implying that the causal relationship between both micronutrients may be dependent on the severity of deficiency, type of iron disorder, and other vascular conditions that are known to affect hematologic indices. Well-designed, randomized trials are needed to confirm the present findings.

25-OHD response to vitamin D supplementation in children: effect of dose but not GC haplotype

2021 ◽  
Author(s):  
Christine A. Simpson ◽  
Jane H. Zhang ◽  
Dirk Vanderschueren ◽  
Lei Fu ◽  
Teresita C. Pennestri ◽  
...  
Keyword(s):  
At Risk ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Randomized Study ◽  
Vitamin D Supplementation ◽  
Children At Risk ◽  
Double Blind ◽  
Baseline Levels ◽  
To Receive

Objective: GC/DBP effects on response to vitamin D supplementation have not been well-studied. Thus we assessed free and total 25-OHD after vitamin D treatment across the 6 common GC haplotypes. Design: This double-blind, randomized study compared two vitamin D3 doses in healthy, urban-dwelling 6-month to 10-year-old children at-risk for vitamin D deficiency. Randomization was stratified by GC haplotype. Methods: Children were randomized to receive 2800 or 7000 International Units of vitamin D3 weekly. 25-OHD and 1,25(OH)2D were sampled at baseline and after 1 and 6 months of supplementation. Results and Conclusions: 192 of 225 enrolled subjects completed the study. After one month, total 25-OHD increased with both doses, and were higher with 7000 IU/week (85.5 ± 22.8 nmol/L) compared to 2800 IU/week (76.8 ± 18.0 nmol/L), despite equivalent baseline levels. No further significant increase occurred at 6 months (89.8 ± 35.5 and 74.3 ± 18.3 nmol/L, respectively). Free 25-OHD similarly changed. 25-OHD differed among GC groups at baseline. Although no significant effects of individual GC haplotypes on incremental changes were evident, a trend towards an effect of combined “at risk” GC alleles on response was evident (P=0.06). Total 1,25(OH)2D showed modest increases, moreso with the larger dose. In urban-dwelling children at-risk for vitamin D deficiency, one month of vitamin D3 2800 IU/week increased 25-OHD across all GC haplotype groups, and somewhat enhanced with 7000 IU/week with no further significant increases after 6 months of supplementation. Free 25-OHD measures offer no monitoring advantage over total 25-OHD.

scholarly journals Maternal Vitamin D Deficiency and Fetal Growth

2015 ◽  
Vol 9 (3) ◽  
pp. 223-229
Author(s):  
Christos Ioannou
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Vitamin D Deficiency ◽  
Fetal Growth ◽  
Vitamin D Supplementation ◽  
Skeletal Growth ◽  
Vitamin D Status ◽  
Femur Length ◽  
Maternal Vitamin ◽  
Randomized Controlled

ABSTRACT There is increasing incidence of vitamin D deficiency in pregnancy in developed countries. Dark skinned women who have migrated and live in higher latitudes are at greatest risk. Vitamin D supplementation is now recommended in several countries, yet its impact on fetal growth remains unclear. Observational studies suggest a possible correlation between maternal serum vitaminD and birth weight. However, differences in birth weight can be confounded by soft-tissue growth and placental function. The effect on vitamin D on bone mineral indices using dual energy X-ray absorptiometry is difficult to ascertain in the neonatal period and therefore remains unclear. Prenatal ultrasound is a safe and practical modality for assessing skeletal growth, yet very few studies have investigated fetal growth in the context of vitamin D status: one study has demonstrated no correlation with femur length, whereas two studies have shown positive correlations with femur length and femur volume respectively. The effect of vitamin D supplementation on birth weight has been investigated in seven interventional studies. However, there is considerable methodological heterogeneity and high risk of bias among some of them. Meta-analysis of well conducted randomized controlled trials (RCTs) has not demonstrated a significant effect on birth weight. The effect of vitamin D supplementation on ultrasound markers of fetal growth has not been reported to date. In summary, there is weak evidence that maternal vitamin D status may have a positive association with measures of fetal skeletal growth. However, if such an association exists, it is not clear whether it is causal or spurious. Randomized controlled trials of vitamin D supplementation are needed, where fetal ultrasound and neonatal bone mineral indices will be reported as primary outcome measures. How to cite this article Ioannou C. Maternal Vitamin D Deficiency and Fetal Growth. Donald School J Ultrasound Obstet Gynecol 2015;9(3):223-229.

scholarly journals Correlation of Vitamin D Serum Level of Mothers and Their Newborns

2021 ◽  
Vol 18 (2) ◽  
Author(s):  
Hassan Boskabadi ◽  
Elahe Heidari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
High Rate ◽  
Cross Sectional ◽  
Maternal Vitamin ◽  
Premature Newborns ◽  
Vitamin D Levels

Background: The possibility of vitamin D deficiency is high among mothers and their premature newborns. Objectives: Due to the high rate of vitamin D deficiency in Iranian women, this study aimed to determine the association between the serum levels of vitamin D in the blood of premature newborns and their mothers in the Iranian population. Methods: This cross-sectional study was conducted on 324 mothers and their 324 newborns with gestational age less than 37 weeks, who were referred to Ghaem Hospital affiliated to Mashhad University of Medical Sciences, Mashhad, Iran, during 2016-2020. After clamping, 1.5 cc blood samples were obtained through the umbilical cord to determine the neonates’ vitamin D levels. Finally, the serum levels of vitamin D were measured, and the correlation between the levels of vitamin D of mothers and their newborns was calculated. Results: The mean vitamin D levels of newborns and mothers were 15.75 ± 11.18 and 20.16 ± 13.41 ng/mL, respectively. Moreover, there was a high correlation between the vitamin D levels of mothers and their newborns (r = 0.672; P < 0.001). Furthermore, a significant correlation was observed between the vitamin D levels of mothers, who used vitamin D supplementation during pregnancy and their neonates’ levels (r = 0.773; P < 0.001). Conclusions: The findings suggest a positive correlation between neonatal and maternal vitamin D levels. Moreover, it seems that maternal vitamin D levels can predict neonatal vitamin D deficiency.

scholarly journals High Dose Vitamin-D-substitution in patients with COVID-19: study protocol for a randomized, double blind, placebo controlled, multi-centre study- VitCov Trial

2021 ◽  
Author(s):  
Fabienne Jaun ◽  
Giorgia Lüthi-Corridori ◽  
Kristin Abig ◽  
Anja Makhdoomi ◽  
Philippe Haas ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Series ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Double Blind ◽  
Multi Centre Study ◽  
Treatment As Usual ◽  
Centre Study ◽  
High Dose Vitamin

Abstract BackgroundThe Coronavirus disease 19 (Covid-19) pandemic has caused more than a million deaths and new treatments are urgently needed. Factors associated with a worse Covid-19 prognosis include old age (> 65 years), ethnicity, male sex, obesity and people with comorbidities such as hypertension, diabetes, cardiovascular disease, and respiratory diseases. Further, vitamin D deficiency has been reported to be a predictor of poor prognosis in patients with acute respiratory failure due to Covid-19. Vitamin D deficiency is a modifiable risk factor, which - according to a recent clinical case series – has the prospect of reducing hospital stay, intensive care and fatal outcomes. Vitamin D has potent immunomodulatory property sand its supplementation might improve important outcomes in critically ill and vitamin D deficient Covid-19 patients. Despite the evidence that supports an association between vitamin D deficiency and Covid-19 severity, there is uncertainty about the direct link. The aim of the trial is therefore to assess if high dose vitamin D supplementation has a therapeutic effect in vitamin D deficient patients with Covid-19.MethodsRandomized, placebo-controlled double blind, multi-centre study trial to compare a high single dose of vitamin D (140’000 IU) followed by treatment as usual (TAU) (VitD + TAU) with treatment as usual only (placebo + TAU) in patients with Covid-19 and vitamin D deficiency.DiscussionVitamin D substitution in patients with Covid-19 and vitamin D deficiency should be investigated for efficacy and safety. The objective of the study is to test the hypothesis that patients with vitamin D deficiency suffering from Covid-19 treated under standardized conditions in hospital will recover faster when additionally treated with high dose vitamin D supplementation. Latest studies suggest, that vitamin D supplementation in patients with Covid-19 is highly recommended to positively influence the course of the disease. With this randomised controlled trial, a contribution to new treatment guidelines shall be made.Trial registration: clinicaltrials.gov: NCT04525820 and SNCTP: 2020 − 01401

Maternal vitamin D supplementation in pregnancy and offspring outcomes: a double-blind randomized placebo-controlled trial

2016 ◽  
Vol 35 (4) ◽  
pp. 464-471 ◽  
Author(s):  
Saroj Kumar Sahoo ◽  
Kishore Kumar Katam ◽  
Vinita Das ◽  
Anjoo Agarwal ◽  
Vijayalakshmi Bhatia
Keyword(s):  
Vitamin D ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Double Blind ◽  
Maternal Vitamin ◽  
In Pregnancy
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