scholarly journals Sampling Trial Showed S-equol Supplementation Helped Relieve Menopausal Symptoms (P06-111-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
LeeCole Legette ◽  
Chioma Ikonte ◽  
Susan Mitmesser
Keyword(s):  
Weight Gain ◽  
Hair Loss ◽  
Sexual Desire ◽  
Sleep Disturbances ◽  
Hot Flashes ◽  
Menopausal Symptoms ◽  
Menopausal Transition ◽  
Memory Problems ◽  
Night Sweats ◽  
The Impact

Abstract Objectives Women experience a variety of symptoms during each stage of the menopausal transition (perimenopause, menopause, and post menopause) and search out various approaches for relief including complementary and alternative treatments such as phytoestrogens. Phytoestrogens are plant compounds that have a similar chemical structure to that of estrogen. Common examples include red clover and soy isoflavones. S-equol, a metabolite of soy isoflavone daidzein, is naturally produced by intestinal bacteria following soy consumption. However, only 20–30% of the US population are equol producers, indicating that many may benefit from S-equol supplementation. The aim of this sampling trial was to assess the impact of a dietary S-equol supplement on menopausal symptoms. Methods Perimenopausal and menopausal women were recruited into an open label trial on a rolling basis; subjects were provided a four week supply of a S-equol supplement 3 times resulting in 12 week supplementation. Participants were instructed to consume a 5 mg S-equol tablet twice daily for total of 10 mg S-equol daily. Participants completed an online survey at weeks 0, 3, 7, and 12 during the trial. They reported on the occurrence of various menopausal symptoms including: anxiety, change in sexual desire, depression, fatigue, hair loss, hot flashes, mood swings, memory problems, night sweats, sleep disturbances, and weight gain. Results Baseline survey (n = 1164) showed common menopausal transition symptoms include: anxiety (78%), change in sexual desire (83%), depression (70%), fatigue (89%), hair loss (57%), hot flashes (97%), mood swings (85%), memory problems (86%), night sweats (95%), sleep disturbances (95%), and weight gain (81%). After 12 weeks of S-equol supplementation (n = 247), 90% of women noted a difference in one or more menopausal symptoms. Among individuals that noted any difference in one or more symptoms (n = 223), 82%, 71% and 40% noticed a difference in hot flashes, night sweats, and sleep disturbances, respectively. Over 90% of the differences observed for hot flashes, night sweats, and sleep disturbances were reported as improvements. Conclusions Following 12 week supplementation of 10 mg S-equol per day, over 90% of women identified an effect on 1 or more menopausal symptom. For the most common symptoms (hot flashes, night sweats, and sleep disturbances), over 90% were reported as improved. Funding Sources This study was funded by Pharmavite LLC.

scholarly journals Intersection between gonadal function and vascular aging in women

2018 ◽  
Vol 125 (6) ◽  
pp. 1881-1887 ◽  
Author(s):  
Kerrie L. Moreau
Keyword(s):  
Risk Factors ◽  
Sleep Disturbances ◽  
Hot Flashes ◽  
Vascular Wall ◽  
Menopausal Transition ◽  
Vascular Aging ◽  
Gonadal Function ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
The Impact

Vascular aging, characterized by endothelial dysfunction and large elastic arterial stiffening, is a major risk factor for age-associated cardiovascular disease (CVD). Although women have a lower prevalence of CVD until midlife, prevalence rates increase rapidly coincident with the menopausal transition to match those observed in men. The menopausal transition, or perimenopause, is a chaotic period that is associated with increased symptoms (e.g., hot flashes, depressed mood, anxiety, sleep disturbances) and CVD risk factors due to changes in the hormonal environment. Because these quality of life factors and CVD risk factors also change with aging, the arteries of women appear to endure a double insult. Our laboratory has been investigating how changes in gonadal function and hormone levels with the menopause transition impacts the vascular aging process in healthy women. Our work has shown that vascular endothelial function progressively declines, and large elastic arterial stiffness is greater across the stages of the menopausal transition. This acceleration in vascular aging may be due to the loss of vasodilatory, antioxidant, anti-inflammatory, and antiproliferative effects of estradiol on the vascular wall. This minireview discusses the impact of changes in gonadal function and hormones with the menopausal transition on vascular aging in women and areas for investigations to further our understanding of the intersection between gonadal function and vascular aging.

scholarly journals Experience of Menopause and Menopausal Transition among Middle aged Women Attending A Periurban Hospital

2017 ◽  
Vol 31 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Saria Tasnim ◽  
Md Abidul Haque ◽  
Summyia Nazmeen
Keyword(s):  
Significant Proportion ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Menopausal Symptoms ◽  
Menopausal Transition ◽  
Middle Aged ◽  
Health Seeking ◽  
Cross Sectional ◽  
Hot Flush ◽  
Night Sweats

Objective (s): The objective was to explore frequency of menopause related symptoms among middle aged women and their perception about menopause,Materials and Methods: This was a cross sectional study carried during March to May 2013 among women aged 45-60 years at the out patient Department of Obstetrics and Gynaecology of a tertiary hospital using structured questionnaire. Information was sought regarding menstrual pattern, self reported menopausal symptoms and attitude towards menopausal transition. Data analysis was done using SPSS version 16.Results: Total 106 women were interviewed, The mean age of the respondents was 50.3± 53 years, and 58.5% were post menopausal and 41.5% in menopausal transition. More than half (59.4%) were illiterate, 32% were working. Common menopausal symptoms were insomnia 51.8%, body ache 44.3% and feeling sad 31.3%. Hot flush and night sweats were reported by 50% and 33% respectively. Half of them regard menopause as normal and health seeking for menopausal problems was 42.5%.Conclusion: A significant proportion of women were suffering from vasomotor and psychosomatic symptoms but most of them did not seek treatment. To ensure quality of life health needs of middle aged women should be identified and their views towards menopause incorporated in formulating services for themBangladesh J Obstet Gynaecol, 2016; Vol. 31(1) : 10-15

PP12  A survey-based evaluation of the impact of menopause transition on female ambulance staff in one UK ambulance service

2020 ◽  
Vol 37 (10) ◽  
pp. e6.3-e7
Author(s):  
Theresa Foster ◽  
Larissa S Prothero ◽  
Debra Winterson
Keyword(s):  
Emergency Services ◽  
Energy Levels ◽  
Well Being ◽  
Menopausal Symptoms ◽  
Ambulance Service ◽  
Staff Support ◽  
Convenience Sample ◽  
Night Sweats ◽  
Menopause Transition ◽  
The Impact

BackgroundMenopausal symptoms can have a significant impact on workplace attendance and performance, yet limited evidence regarding the menopause transition in the emergency services exists. The aim of this study was to explore work and personal impacts of the menopause on female staff in the ambulance setting.MethodsA purpose-designed, online 20-question survey, based on the British Menopause Society Survey (2016), was developed to understand menopausal symptoms and their impact on female staff in one UK ambulance service. Disseminated during July 2019, it resulted in a convenience sample of 522 responses (22% of female workforce), which were analysed using quantitative (descriptive) and qualitative (thematic) approaches.ResultsTypically, respondents were either pre-menopausal (33%; n=171) or peri-menopausal (24%; n=126). Approximately one third (31%; n=161) were menopausal or post-menopausal. Over half worked in operational emergency service delivery (58%; n=301), and typically worked shifts/unsocial hours (75%; n=391). For those who had experienced menopause symptoms (64%; n=336), wide-ranging symptoms were reported: tiredness/low energy levels, difficulty sleeping/insomnia, mood changes (including anxiety and depression), musculoskeletal problems, and hot flushes and/or night sweats were most common. The majority (61%; n=205) stated they had not expected the symptoms they experienced, which had impacted on their well-being (51%; n=171); work life (45%; n=151), some requiring time off work (21%; n=71); and home life (44%; n=148). Only 12% (n=40) of respondents felt supported at work. Of most concern to respondents was lack of awareness of menopause symptoms, and their impact throughout the service, in particular those in managerial roles and male staff.ConclusionsAll women will experience the menopause and will work through and beyond this life phase. For those who experience menopausal symptoms, the impact can be significant. Yet menopause awareness in the ambulance service is limited and there is clear scope for initiatives for improved staff support and well-being.

MENOPAUSAL WOMEN AND THE WORK ENVIRONMENT

1994 ◽  
Vol 22 (4) ◽  
pp. 347-354 ◽  
Author(s):  
Robert V. High ◽  
Patricia A. Marcellino
Keyword(s):  
Job Performance ◽  
Work Environment ◽  
Hot Flashes ◽  
Menopausal Symptoms ◽  
Mood Changes ◽  
Final Sample ◽  
Menopausal Women ◽  
Night Sweats ◽  
Survey Instruments ◽  
Post Menopausal

A survey was taken of working, post-menopausal women, concerning their menopausal symptoms. The survey addressed itself to any difficulties the women may have faced in the work environment as a result of their menopausal symptoms. The final sample consisted of N = 89 completed survey instruments. In addition to night sweats and hot flashes, other symptoms reported by at least 40% of the women included weight gain, irritability, depression, bloating, and mood changes. These symptoms were reported as being disruptive to their lives by 47% of the respondents, with 30% indicating that their job performance had been adversely affected. The symptoms of irritability and mood changes showed significant correlations with job performance. The sample was further analyzed with regard to whether the respondent was in a managerial or non-managerial position. Excluding the expected night sweats and hot flashes, the non-managerial group showed a significantly higher percentage reporting each symptom in seven of the eight symptoms listed.

Hormone Therapy for the Management of Menopausal Symptoms

2010 ◽  
Vol 23 (6) ◽  
pp. 540-547 ◽  
Author(s):  
C. Brock Woodis
Keyword(s):  
Hormone Therapy ◽  
Dosage Form ◽  
Hot Flashes ◽  
Menopausal Symptoms ◽  
Vasomotor Symptoms ◽  
Controlled Trials ◽  
Patient Evaluation ◽  
Health Initiative ◽  
Randomized Controlled ◽  
Night Sweats

Nearly 50 million women each year are projected to reach menopause by 2030. Many of these women will experience vasomotor symptoms such as night sweats and hot flashes as they enter the menopausal transition. Up until the release of the findings of the Women’s Health Initiative (WHI) studies, women were frequently prescribed hormone therapy (HT) to alleviate bothersome and sometimes debilitating menopausal symptoms as well as to prevent osteoporosis and coronary heart disease (CHD). Although the WHI studies were the first large, randomized, controlled trials that contradicted what was historically believed about the benefits of HT in postmenopausal women, important limitations including baseline demographics of WHI participants and investigation of only one HT strength/dosage form exist. HT may be a reasonable pharmacotherapy option for the management of menopausal symptoms following complete patient evaluation by experienced clinicians. Updated recommendations addressing management of menopausal symptoms, a new HT product containing the spironolactone-analogue drospirenone (DRSP), and discontinuation methods of HT are also discussed in this review.

scholarly journals The effect of Saliva officinalis extract on the menopausal symptoms in postmenopausal women: An RCT

2019 ◽  
Author(s):  
Fereshteh Dadfar ◽  
Kourosh Bamdad
Keyword(s):  
Postmenopausal Women ◽  
Rating Scale ◽  
Hormone Replacement ◽  
Hot Flashes ◽  
Menopausal Symptoms ◽  
Postmenopausal Symptoms ◽  
Before And After ◽  
Night Sweats ◽  
Common Problems ◽  
Menopause Rating Scale

Background: The menopausal symptoms are the most common problems in postmenopausal women. Due to the side effects of hormone replacement therapy, the use of medicinal herbs has increased for the treatment of menopausal symptoms. Objective: The aim of this study was to evaluate the effect of Saliva officinal is on the decreasing of the severity of the menopausal symptoms in postmenopausal women. Materials and Methods: The study was performed on 30 postmenopausal women aged 46–58 yr referred to the healthcare center of Darab who experienced various degrees of postmenopausal symptoms. The severity of menopausal symptoms is recorded by a Menopause Rating Scale. Participants received a 100 mg capsule of sage extract daily for 4 wk. The severity of postmenopausal symptoms was compared before and after four weeks of the consumption of sage extract. Results: The results showed the severity of hot flashes, night sweats, panic, fatigue, and concentration had significant differences before and after the consumption of sage extract. Conclusion: It was concluded that Saliva officinal is were effective to change the severity of some of the menopausal symptoms in postmenopausal women.

Fertility (male and female) and Menopause

2012 ◽  
Vol 30 (30) ◽  
pp. 3705-3711 ◽  
Author(s):  
Kathryn J. Ruddy ◽  
Ann H. Partridge
Keyword(s):  
Hot Flashes ◽  
Symptom Burden ◽  
Reproductive Organs ◽  
Lifestyle Changes ◽  
Menopausal Symptoms ◽  
Patients With Cancer ◽  
Hypothalamic Pituitary Axis ◽  
Male Patients ◽  
Pharmacologic Agents ◽  
The Impact

The impact of oncologic treatments on fertility and menopausal symptoms is often significant for patients with cancer. Surgery, radiation, and chemotherapy can all damage the reproductive organs or the hypothalamic pituitary axis that controls them, impairing fertility and causing hormonally mediated symptoms such as hot flashes. Understanding these risks and strategies to mitigate them may substantially improve cancer survivorship care. For both female and male patients who desire a future biologic child, there are a variety of fertility preservation techniques that should be considered. For cancer survivors who experience menopausal symptoms, lifestyle changes may be beneficial, and hormonal and nonhormonal pharmacologic agents are well proven to reduce symptom burden.

Treatment of Menopause-Related Mood Disturbances

CNS Spectrums ◽  
2005 ◽  
Vol 10 (6) ◽  
pp. 489-497 ◽  
Author(s):  
Claudio N. Soares ◽  
Jennifer Prouty ◽  
Leslie Born ◽  
Meir Steiner
Keyword(s):  
Hormone Therapy ◽  
Hot Flashes ◽  
Menopausal Transition ◽  
Health Initiative ◽  
Estrogen Receptor Modulators ◽  
Increased Risk ◽  
Hormonal Fluctuations ◽  
Night Sweats ◽  
Receptor Modulators

AbstractMore than 1.7 million American women are expected to reach menopause each year. Recent Canadian statistics show that a 50-year-old woman can now expect to live until her mid-80s, which implies living at least one-third of her life after menopause. The menopausal transition is typically marked by intense hormonal fluctuations, accompanied by vasomotor symptoms (eg, hot flashes, night sweats), sleeps disturbance, and changes in sexual function, as well as increased risk for osteoporosis, cardiovascular disease, and cognitive decline. More importantly, recent studies have demonstrated a significant association between menopausal transition and a higher risk for developing depression. In the post-Women's Health Initiative Study era, physicians and patients are questioning the safety and efficacy of long-term hormone therapy use. This article reviews the current literature on the benefits and risks of using hormone therapy for the treatment of menopause-related mood disturbances and alternate strategies currently available for the management of menopause-related problems, including antidepressants, complementary and alternative medicine, and selective estrogen receptor modulators.

scholarly journals Effects of Low Estrogens: Vaginal Atrophy

2022 ◽  
Vol 6 (1) ◽  
pp. 01-03
Author(s):  
PD Gupta
Keyword(s):  
Heart Disease ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Sleep Disturbances ◽  
Hormone Replacement ◽  
Hot Flashes ◽  
Vaginal Atrophy ◽  
Facial Hair ◽  
Vaginal Dryness ◽  
Night Sweats

Estrogens are the group of hormones which makes a woman a woman. Girls at menarche start making it and under normal conditions sufficient levels are maintained in the women's body until menopause. During perimenopause, menopause and postmenopause the hormone levels start fluctuating and if maintained low for a longer period, it starts giving various problems. Fluctuating levels of estrogen causes, hot flashes, night sweats, vaginal dryness, depression, and mood swings. Sleep disturbances brain fog and may be heart disease, osteoporosis, obesity and the appearance of unwanted facial hair. These problems can be overcome by supplementing with phytoestrogens or hormone replacement therapy.

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