scholarly journals Assessing Human Iron Nutritional Status by Analyzing Its Frequency Distribution Properties in the Hair with a Median Derivatives Bioassay (P10-109-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Berislav Momčilović ◽  
Juraj Prejac ◽  
Ninoslav Mimica
Keyword(s):  
Nutritional Status ◽  
Frequency Distribution ◽  
Whole Blood ◽  
Therapeutic Option ◽  
Human Nutrition ◽  
Similar Amount ◽  
Linear Segment ◽  
Cross Sectional ◽  
Funding Sources ◽  
Sigmoid Curve

Abstract Objectives Iron is the essential trace element (TE) in human nutrition, but also the most frequently observed deficient element in the human nutrition. The aim of this study was to assess human iron nutritional status by assessing its frequency distribution in the hair with a median derivatives bioassay. Methods In this prospective, observational, cross-sectional, exploratory, and epidemiological study we have analyzed hair Fe (HFe) in 1073 apparently healthy adults (339 men M and, 734 women, W) from Zagreb, Croatia. Whole blood iron (WBFe) was assessed in a subsample of this population in 143 Women and 91 Men. Both hair and whole blood samples were analyzed for iron with the ICP MS at the Center for Biotic Medicine, Moscow, Russia. Hair Fe natural frequency distribution was analyzed with the median derivatives bioassay logistic sigmoid curve for men and women separately. The range of values below the linear segment of the sigmoid curve (adequate intake) was considered to reflect Fe deficiency, whereas values above that range indicate Fe dietary excess. Results Women and men have almost identical amount of HFe (median ♂12.72 µg·g-1 vs median ♀ 12.428 µg·g-1). The physiologically adequate HFe linear segment range of the sigmoid curve was 6.09–32.19 µg·g-1 for Men and 6.11 - 28.23 µg·g-1 for Women. Similarly, both women and men have very similar amount of WBFe (median ♂535.6 µg∙g-1 vs median ♀4880 µg∙g-1). The physiologically adequate WBFe linear range of the sigmoid curve was 386.4–606.1 µg∙g-1 for ♀ and 470.4–631.0 µg∙g-1 for ♂. Conclusions Human nutritional status of Fe may be reliably assessed by analyzing its frequency distribution in the hair with median derivatives bioassay. Hair iron is a rare case between the bioelements we have tested thusafar where wholeblood concentrations were higher than that in the hair. Our exploration indicates that the so called iron subclinical deficiency may be adequately quantified. Indeed, continuous subliminal iron supplementation may be a better therapeutic option than current supplementation with high doses associated with the unwanted side effects. Funding Sources Institute for Research and Development of Sustainable Ecosystems, Zagreb, Croatia.

scholarly journals Assessing Human Manganese Nutritional Status by Analyzing Its Frequency Distribution Properties in the Hair with a Median Derivatives Bioassay (P10-110-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Berislav Momčilović ◽  
Juraj Prejac ◽  
Ninoslav Mimica
Keyword(s):  
Nutritional Status ◽  
Frequency Distribution ◽  
Whole Blood ◽  
Biological Indicator ◽  
Linear Range ◽  
Similar Amount ◽  
Linear Segment ◽  
Cross Sectional ◽  
Funding Sources ◽  
Sigmoid Curve

Abstract Objectives Manganese (Mn) is the essential trace element (TE) in human nutrition, but high doses of Mn are toxic to the human mentation and induce brain extrapyramidal system. The main source of manganese is our diet, but there no availale long-term biological indicator for assessing the Mn nutritional status.The aim of this study was to assess human manganese nutritional status by assessing its frequency distribution in the hair with a median derivatives bioassay. Methods In this prospective, observational, cross-sectional, exploratory, and epidemiological study we have analyzed hair Mn (HMn) in 1073 apparently healthy adults (339 men, M and 734 women, W) from Zagreb, Croatia. Whole blood manganese (WBMn) was assessed in a subsample of this population in 143 Women and 91 Men. Both hair and whole blood (short-term biological indicator) samples were analyzed for iron with the ICP MS at the Center for Biotic Medicine, Moscow, Russia: an ISO certified bioelements analytical laboratory. Hair Mn natural frequency distribution was analyzed with the median derivatives bioassay logistic sigmoid curve for men and women separately. The range of values below the linear segment of the sigmoid curve (adequate intake) was considered to reflect Mn deficiency, whereas values above that linear range indicate Mn dietary excess. Results Women and men have almost identical amount of HMn (median ♂0.234 µg·g-1 vs. median ♀ 0.208 µg·g-1). The physiologically adequate HMn linear segment range of the sigmoid curve was 0.090–0.749 µg·g-1 for Men and 0.091–0.628 µg·g-1 for Women. Similarly, both women and men have very similar amount of WBMn (median ♂0.0109 µg∙g-1 vs median ♀0.0118 µg∙g-1). The physiologically adequate WBMn linear range of the sigmoid curve was 0.0084–0.0169 µg∙g-1 for ♀ and 0.0079–0.0179 µg∙g-1 for ♂. Conclusions Human nutritional status of Mn in the population may be reliably assessed by analyzing its frequency distribution in the hair with the median derivatives bioassay. Our exploration indicates how it is possible to diagnose the subclinical states of both manganese nutritional deficiency and excess. When the Mn nutritional status is expressed in a range format it became possible to study simultaneously the subtle and complex multi-bioelement profile interactions within the adequate range of a bioelement intake. Funding Sources Institute for Research and Development of Sustainable Ecosystems, Zagreb, Croatia.

scholarly journals Assessing Human Molybdenum Nutritional Status by Analyzing Frequency distribution Properties in the Hair and Whole Blood with a Median Derivatives Bioassay

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1455-1455
Author(s):  
Berislav Momčilović ◽  
Juraj Prejac ◽  
Ninoslav Mimica
Keyword(s):  
Nutritional Status ◽  
Frequency Distribution ◽  
Whole Blood ◽  
Biological Indicator ◽  
Linear Range ◽  
Linear Segment ◽  
Cross Sectional ◽  
Funding Sources ◽  
Sigmoid Curve ◽  
Ultra Trace

Abstract Objectives Molybdenum is the essential trace element in human nutrition since it is a part of a pterin coenzyme which is essential for the activity of various oxidases. High doses of Mo are neurotoxic to the human brain. The safe adequate intake of Mo is set at 75–200 µg·g−1, but there is no available long-term biological indicator tissue to assess the Mo nutritional status. The aim of this study was to assess human Mo nutritional status with a median derivatives bioassay. Methods We analyzed frequency distribution of hair Mo (HMo) in a prospective, observational, cross sectional and exploratory epidemiological study of 1073 apparently healthy adults (339 men, M and 734 women, W) from Zagreb, CROATIA. Whole blood Mo (WBMo) was assessed in a population subsample of 143 W and 91 M. Both hair and whole blood, a long- and short-term biological indicator, respectively were analyzed for Mo with the ICP MS at the Center for Biotic Medicine, Moscow, Russia: an ISO certified bioelement (electrolytes, trace- and ultra-trace elements) analytical laboratory. Hair Mo natural frequency distribution was analyzed with the aid of median derivatives bioassay logistic sigmoid curve for men and women separately. The range of values below the linear segment of the sigmoid curve (the adequate Mo intake) was considered to reflect Mo deficiency, whereas the values above that linear range indicate Mo dietary excess. The adequate linear range may be further subdivided into marginal (subclinical), true adequate, and ample region with a 30:60:10 ratio, respectively. Results The linear segment of the hair Mo deposition was distinctly different (ng·g−1) and higher in M (34–75) than W (27–57) with the observed median ♀/♂ ratio 0.82. The marginal (subclinical) interval ranges are M 34–46.3, W 27–36). However, there were no difference in the WBMo confidence intervals between M (455–1380) and W (480–1145); the Median ♀/♂ observed ratio is 0.93. Conclusions Adequate human population Mo nutritional status may be accurately assessed by analyzing hair Mo frequency distribution with the median derivatives bioassay. Apparently, there is gender dependent delay of Mo hair saturation in the men hair. For the first time it was possible to differentiate the subclinical levels of sparsely adequate dietary Mo. Funding Sources Institute for Research and Development of Sustainable Eco Systems, 10,000 Zagreb, Croatia.

scholarly journals Nutritional Profile of Patients with Colorretal Cancer Candidates for Big Surgery (P05-035-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ana Paula Rocha Trotte ◽  
Rosana Oliveira Macedo ◽  
Thaiza Fragoso Nunes ◽  
Danielly Rodrigues Wassita da Rocha ◽  
Maria Eliza De Gouvêa Marti Ferrão
Keyword(s):  
Colorectal Cancer ◽  
Weight Loss ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
Nutritional Risk ◽  
Cross Sectional ◽  
Nutritional Profile ◽  
Funding Sources ◽  
Nrs 2002

Abstract Objectives To identify the nutritional profile of adult and elderly patients with colorectal cancer admitted to a Proctology ward for large elective surgeries. Methods A cross-sectional and retrospective study was performed with 31 patients of both genders, aged 39 to 77 years with colorectal cancer. The nutritional screening parameters used were the percentage of weight loss and Nutrition Risck Screening (NRS 2002). The data (percentage of weight loss and NRS 2002) were collected through a nutritional assessment form completed in the care routine, applied within 72 hours after the patient's hospitalization. Results The study included 13 adults (41.9%) and 18 elderly (58.1%). The evaluation of the percentage of weight loss showed that 7 patients (22.5%) had weight loss greater than 15% in a period of less than or equal to 6 months. In the nutritional risk assessment based on the NRS 2002, we observed that 9 patients (29%) scored 2, while 22 patients (71%) achieved a score equal to or greater than 3. Conclusions The nutritional profile of the evaluated patients showed a considerable prevalence of malnutrition, considering a weight loss of more than 15% in a period of 6 months, which is associated to a decrease in survival in patients with cancer, and is a very relevant data to help in the classification of nutritional status. The classification by the NRS 2002, showed a high prevalence of patients at nutritional or malnourished risk. Variation in the classification of nutritional status using several parameters reinforces the need for them to be used in a complementary way. Funding Sources Hospital Federal dos Servidores do Estado, Ministerio da Saude.

scholarly journals A Systematic Review of the Nutritional Status of Children Living in Institutionalized Care

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 822-822
Author(s):  
Emily De Lacey ◽  
Cally Tann ◽  
Nora Groce ◽  
Maria Kett ◽  
Michael Quiring ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nutritional Status ◽  
Children With Disabilities ◽  
Micronutrient Deficiencies ◽  
Older Children ◽  
Cross Sectional ◽  
Funding Sources ◽  
Micronutrient Status ◽  
Prevention And Treatment ◽  
Nutritional Status Of Children

Abstract Objectives An estimated 2.7 million children live within institutionalized care worldwide. This systematic review aimed to evaluate available data on the nutritional status of children living within institutionalized care. Methods Four databases were searched for articles published between January 1990 to January 2019. Studies were eligible for inclusion if they contained information on anthropometry or micronutrient status of children living within institutionalized care. The review is registered on PROSPERO: CRD42019117103. Results We screened 3602 titles and reviewed 98 full texts, from which 25 papers were determined eligible. The majority of studies were cross sectional (88%). Low birth weight ranged from 25 to 39%. Five (20%) studies included information on children with disabilities reporting prevalence from 8 to 75%. Prevalence of undernutrition varied between ages, sites and countries: stunting ranged from 9 to 72%; wasting from 0 to 27%; underweight from 7 to 79%; low BMI from 5 to 27%. Overweight/obesity ranged between 10 to 32% and small head circumference from 17 to 41%. The prevalence of HIV was between 2 to 23% and anemia from 3 to 90%. Skin conditions or infections ranged between 10 to 31% and parasites from 6 to 76%. Institution-based children were more malnourished than community peers and younger children were more malnourished than older children. A high risk of bias was found in the studies. Conclusions Addressing the nutrition needs of this underrepresented vulnerable population of children is important in the fight against malnutrition worldwide. Prevention and treatment of poor nutrition in this population can have far reaching impacts but there is limited research on their nutritional status. Children in institutions were commonly malnourished; affected by undernutrition, overnutrition and micronutrient deficiencies. Few studies described disabilities, despite disabilities being common in this population and having a big potential impact on nutritional status. Together, these findings suggest a need for greater focus on prevention and treatment of malnutrition in this population, especially for younger children and children with disabilities. More information is needed to support the millions of children living within institutionalized care to address their rights and needs for healthy development. Funding Sources No funding.

scholarly journals Assessing Calcium and Magnesium Nutritional Status With the Hair Median Derivatives Bioassay

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1063-1063
Author(s):  
Berislav Momčilović ◽  
Juraj Prejac ◽  
Ninoslav Mimica
Keyword(s):  
Nutritional Status ◽  
Human Body ◽  
Biological Indicator ◽  
Saturation Curve ◽  
Reference Ranges ◽  
Linear Segment ◽  
Funding Sources ◽  
Icp Ms ◽  
Metabolic Difference

Abstract Objectives Short-term biological indicator of urinary Mg and Ca excretion helps us to assess human body Mg and Ca nutritional status. In this study, we used the long-term biological indicator tissue of hair to assess Mg and Ca human body nutritional status. Methods Hair Mg and Ca were analyzed in 1073 healthy white adult Caucasians [734 women (♀) and 339 men (♂)] consuming common mid-European diet, with the ICP MS. The log transformed data on hair magnesium and calcium were analyzed with median derivatives bioassay. Results The median values (μg·g−1) were ♀Mg 137.2 and ♂Mg 47.1, and ♀Ca 1721.4 and ♂Ca 492.0, respectively. The linear (adequate) reference ranges of the sigmoid saturation curve for magnesium were ♀Mg 29.7–270.6 and ♂Mg 20.5–90.2, whereas these ranges for calcium were ♀Ca 487.7–4426.8 and ♂Ca 261.1–816.4. The magnesium to calcium (Mg/Ca) ratio in women appears fairly constant along the sigmoid linear segment range (about 0.067), and in difference to the constantly increasing Mg/Ca ratio in men - from 0.078 at the start of the linear segment to 0.096 at the median and 0.1105 before leveling at the top of the curve. Conclusions Women tend to accumulate much more Ca in their hair than men. The results suggest how hair Mg concentration should not be below 29.7 and 20.5 or above 270.6 and 90.2 μg·g−1 in women and men, respectively. Similarly, Ca hair concentrations should be not below 487.7 and 261.1 and higher than 4456.8 and 816.4 in women and men, respectively. The possible health effects of the observed sex related metabolic difference between men and women remains to be elucidated. Funding Sources The authors received no specific funding for this work.

Assessing the boron nutritional status by analyzing its cummulative frequency distribution in the hair and whole blood

2018 ◽  
Vol 45 ◽  
pp. 50-56 ◽  
Author(s):  
Juraj Prejac ◽  
Andrey A. Skalny ◽  
Andrei R. Grabeklis ◽  
Suzana Uzun ◽  
Ninoslav Mimica ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Frequency Distribution ◽  
Whole Blood

Assessing lithium nutritional status by analyzing its cumulative frequency distribution in the hair and whole blood

2019 ◽  
Vol 36 (07) ◽  
pp. 113-119
Author(s):  
Ninoslav Mimica ◽  
Juraj Prejac ◽  
Andrey A. Skalny ◽  
Andrei R. Grabeklis ◽  
Berislav Momčilović
Keyword(s):  
Nutritional Status ◽  
Frequency Distribution ◽  
Whole Blood ◽  
Cumulative Frequency ◽  
Cumulative Frequency Distribution

scholarly journals Entanglement of Hair Iodine and Selenium Nutritional Status

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1456-1456
Author(s):  
Berislav Momčilović ◽  
Ninoslav Mimica ◽  
Juraj Prejac
Keyword(s):  
Thyroid Gland ◽  
Nutritional Status ◽  
Dietary Intake ◽  
Frequency Distribution ◽  
Single Element ◽  
Nutrition Environment ◽  
Thyroid Gland Function ◽  
Funding Sources ◽  
Hair Samples ◽  
Gland Function

Abstract Objectives Iodine and selenium are two essential trace elements intimately associated with the thyroid gland function. The aim of this study was to assess the combined hair iodine and selenium frequency distribution in the hair to assess their nutritional status and their mutual ratio. Methods Hair was collected in 1073 healthy adult subjects (339 men and 729 women) living in Zagreb, CROATIA. Hair samples were analyzed for Se and I by the ICP-MS at the CBM, Moscow, RUSSIA, an internationally ISO certified analytical laboratory. I and Se were detected in all the 1073 hair samples. The frequency distribution of hair I and Se was statisticaly analyzed with the median derivative bioassay method of the log transformed data. Results The adequate nutritional status of iodine and selenium in the hair is shown by the linear response interval on ther sigmoid curves. The adequate nutritional status was associated with the hair iodine and selenium (µg·g−1) of men (M) and women (W), respectively. Iodine was M 0.506 W 9.482, and selenium M 0.346 and W 0.269, Over the same linear (adequate) interval of the responsive sigmoid curve of the combined iodine and selenium dietary intake (I&Se) the adequate dietary interval was (µg·g−1) 0.209–2.433 (r2 0.90); their combined ratio was also constant at (log µg·g−1) 0.740 within the ±2% difference between men and women. Conclusions Iodine and selenium deposition into the hair are closely entangled over the adequate interval of their dietary intake. The iodine to selenium mutual ratio should be also kept constant to provide the most optimal nutrition environment for the thyroid gland function. Single element supplementation should be always viewed on how it may affect the rest of the elements in our body. Funding Sources Institute for Research and Development of Sustainable Eco Systems, 10,000 Zagreb, Croatia.

scholarly journals Biochemical Indicators of Malnutrition in Children with Chronic Kidney Disease on Peritoneal Dialysis, Hemodialysis and Post-Transplant Kidney

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1150-1150
Author(s):  
Edgar Vazquez Garibay ◽  
Julieta García De Alba Verduzco ◽  
Erika Hurtado López ◽  
Z Consuelo Ponton Vazquez ◽  
Adriana De La Torre Serrano ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Nutritional Status ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
National Council ◽  
Chi Square ◽  
Cross Sectional ◽  
Biochemical Indicators ◽  
Funding Sources ◽  
Stage Renal Disease

Abstract Objectives To demonstrate differences in the profile of biochemical indicators of nutritional status in children with End-stage renal disease (ESRD) between peritoneal dialysis (PD), hemodialysis (HD), and renal transplantation (RT). Methods Analytical cross-sectional study. A total of 130 children and adolescents between 6 and 18 years of age with ESRD were included: 49 children in RT, 33 in PD, and 48 in HD. The biochemical indicators (hemoglobin, glucose, albumin, total cholesterol, and triglycerides) and anthropometric indicators of nutritional status were obtained. ANOVA, T-student, and Pearson correlation were performed. For nonparametric variables, Chi-square, U-Mann Whitney, Kruskal-Wallis, and odds ratio were used. Results The frequency of hypoalbuminemia was higher in the PD group than in the RT group [OR = 56.4 (6.9, 459) P < 0.001] and the HD group [OR = 10.08 (3.1, 319) P < 0.001]. Anemia was higher in the HD group compared with the RT group [OR = 4.9 (2.1, 11.2) P < 0.001] and the PD group [OR = 3.0 (1.3, 7.7), P = 0.02]. Cholesterol serum concentration was higher in the PD group compared to the RT group [OR = 27.4 (3.3, 225), P < 0.01] and the HD group [OR = 26.2 (3.2, 215), P < 0.001]. Patients in the PD group had a higher risk of hypertriglyceridemia than the RT group [OR = 5.5 (1.9, 15.7), P = 0.002] and the HD group [OR = 2.3 (1.1, 5.4), P = 0.04]. Albumin correlated with tricipital skinfold and mid-upper arm circumference (MUAC) in the RT group; with subscapular skinfold (SSF) in the HD group; and with height, SSF, and MUAC in PD group. Conclusions There are substantial differences in the biochemical indicators of nutritional status depending on the renal substitution program. Funding Sources Project supported by the National Council of Science and Technology of Mexico.

THE RELATIONSHIP OF NUTRITIONAL STATUS TO URIC ACID LEVEL IN COMMUNITY OF PONDOK PESANTREN AL-HIDAYAH, NGAWI

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Marselli Widya Lestari ◽  
Tri Wahyuni Bintarti
Keyword(s):  
Uric Acid ◽  
Nutritional Status ◽  
Gouty Arthritis ◽  
Extracellular Fluid ◽  
Boarding School ◽  
Clinical Syndrome ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Knowledge And Attitude ◽  
Cross Sectional Design

Gout or Gouty Arthritis is a degenerative disease. Gouty arthritis is a clinical syndrome that is caused by deposition of purine crystals in the tissues, due to levels of uric acid (hyperuricemia) in the extracellular fluid that passes through saturation. The etiology of gout arthritis included age, sex, history of medication, obesity, consumption of purine and alcohol. Aging is an important risk factor for men and women. This study uses an analytical-descriptive approach with cross-sectional design. This study was conducted to obtain a relationship between nutritional status and uric acid levels in the community in the area of ​​Al-Hidayah Islamic Boarding School, Ngawi. This research was conducted in Majasem Village, Kendal District, Ngawi Regency, starting from 7 June - 31 August 2018. The results showed that there was a relationship between nutritional status and uric acid levels in the community in the area of ​​Al-Hidayah Islamic Boarding School, Ngawi (p=0,008). Suggestions for further research are bivariate analysis based on gender, knowledge and attitude to response to diet so that other factors that influence can be seen clearly

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