A Unique Personalized Nutrition Program Facilitates Lifestyle Behavior Changes: Novel Insights from HABIT's Personalized Approach to Health (PATH) Study (P15-020-19)

Abstract Objectives A key to a successful personalized nutrition (PN) strategy is tailoring the behavior intervention to achieve sustained behavior change consistent with desired health outcomes. The objective of this study was to evaluate the impact of a digitally-delivered, systems biology-based PN program (Habit, LLC, Oakland, CA), that included nutrition and behavior advice, and meals. Methods In this single-arm, multi-phase, open-label study (clinicaltrials.gov: NCT03424395), participants (n = 107; 67% female), 30–59 years of age, were provided a Fitbit® Activity Tracker and instructions to complete an at-home kit that included collection of DNA and capillary blood before and after (30 and 120 min) consuming a mixed macronutrient challenge beverage. Lifestyle behavior data and activity levels were collected at baseline. Participants completed a 10-week control phase and a 10-week PN program intervention phase that included tailored nutrition and behavior advice, and meals (2 meals/day, 5 days/week). Validated quality of life, perceived stress, diet self-efficacy, and eating behavior questionnaires were administered to assess behavior before and after the intervention. Data from 73 compliant participants (66% female) were included in the analysis. Anthropometric and biological results were used to categorize participants into subgroups including Protein Seekers (PS) and Range Seekers (RS). Results Participants reported feeling fuller faster after the intervention, relative to before (P = 0.002), which could be linked to the dietary recommendations and behavior advice. Analysis by gender showed men reported more control over their eating patterns during negative events at baseline, compared to women (P = 0.005). This difference was not evident at the end of the intervention with women reporting slightly more, and men slightly less control. PS entered the study with a higher weight and BMI (P < 0.001 for both) and reported eating more quickly than RS (P = 0.003). This difference diminished, and by the end of the intervention PS did not differ from RS which could reflect the tailored advice provided. Conclusions These and other data provide novel insights on how a tailored personalized intervention that targeted food behavior may help drive positive changes in health outcomes. Funding Sources Habit, LLC.

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A Novel Personalized Nutrition Program Improves Health and Lifestyle Behaviors: Subgroup Analysis Results from Habit's Personalized Approaches to Health (PATH) Study (P15-019-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz037.p15-019-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Barbara Winters ◽

Suzan Wopereis ◽

Sabina Bijlsma ◽

Tanja Krone ◽

Tim Van den Broek ◽

...

Keyword(s):

Weight Loss ◽

Saturated Fat ◽

Resistance Index ◽

Hepatic Insulin Resistance ◽

Personalized Nutrition ◽

Monounsaturated Fat ◽

Dietary Recommendations ◽

Open Label ◽

And Behavior ◽

The Impact

Abstract Objectives This study evaluates the impact of a digitally-delivered systems biology-based personalized nutrition (PN) program (Habit LLC, Oakland, CA), that included nutrition and behavior advice, and meals. Methods In this single-arm, multi-phase, open-label study (clinicaltrials.gov: NCT03424395), participants (n = 107; 67% female) were provided a Fitbit® Activity Tracker and completed an at-home kit that included collection of DNA and capillary blood before and after (30 and 120 min) consuming a mixed macronutrient challenge beverage. Participants completed a 10-week run-in and 10-week PN program intervention phase. The intervention included personalized nutrition and behavior advice and meals (2 meals/day; 5 days/week) tailored to dietary subgroups. Here we report on changes in diet, anthropometrics, and biomarkers of two subgroups (Range Seekers [RS] and Protein Seekers [PS]) that differed in anthropometrics and biological measures at baseline and were provided different dietary recommendations. Results At baseline, there were no differences between groups in nutrients assessed, however, compared to RS (n = 48), PS (n = 22) had higher BMI, weight, body fat %, waist and hip circumference (all P < 0.0001), HOMA-IR, age, (both P < 0.01), muscle mass, diastolic blood pressure, hepatic insulin resistance index and c-peptide (all P < 0.05). After the intervention, both groups reduced intakes of calories (P < 0.001) and % calories from saturated fat and monounsaturated fat (both P < 0.05). Intakes of total fat, saturated fat, and sodium (all P < 0.001) as well as carbohydrate and total sugars (both P < 0.05) were also reduced. RS and PS increased vitamin C and fiber intakes (P < 0.001). PS, but not RS, received advice to increase protein intake, accordingly % calories from protein increased in PS by 28% (P < 0.001). PS also increased intake of b-carotene and vitamin A (P < 0.01). BMI and weight decreased in both groups (P < 0.001) after the intervention, with greater extent of weight loss observed in PS. In addition to weight loss in PS, a reduction in total and LDL cholesterol (P < 0.001) was observed. Conclusions Together, these results support the efficacy of a digitally-delivered PN program, differentiated by subtype, in improving dietary patterns and health indicators. Funding Sources Habit, LLC.

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Enhancing Patient Motivation through Intelligibility in Cardiac Tele-rehabilitation

Interacting with Computers ◽

10.1093/iwc/iwz008 ◽

2019 ◽

Vol 31 (2) ◽

pp. 122-137

Author(s):

Supraja Sankaran ◽

Kris Luyten ◽

Dominique Hansen ◽

Paul Dendale ◽

Karin Coninx

Keyword(s):

Medication Adherence ◽

Exercise Training ◽

Physical Exercise ◽

Health Outcomes ◽

Cardiac Rehabilitation ◽

Field Studies ◽

Activity Levels ◽

Patient Motivation ◽

Physical Exercise Training ◽

The Impact

Abstract Physical exercise training and medication compliance are primary components of cardiac rehabilitation. When rehabilitating independently at home, patients often fail to comply with their prescribed medication and find it challenging to interpret exercise targets or be aware of the expected efforts. Our work aims to assist cardiac patients in understanding their condition better, promoting medication adherence and motivating them to achieve their exercise targets in a tele-rehabilitation setting. We introduce a patient-centric intelligible visualization approach to present prescribed medication and exercise targets to patients. We assessed efficacy of intelligible visualizations on patients’ comprehension in two lab studies. We evaluated the impact on patient motivation and health outcomes in field studies. Patients were able to adhere to medication prescriptions, manage their physical exercises, monitor their progress and gained better self-awareness on how they achieved their rehabilitation targets. Patients confirmed that the intelligible visualizations motivated them to achieve their targets better. We observed an improvement in overall physical activity levels and health outcomes of patients. Research Highlights Presents challenges currently faced in cardiac tele-rehabilitation. Demonstrates how intelligibility was applied to two core aspects of cardiac rehabilitation- promoting medication adherence and physical exercise training. Lab., field and clinical studies to demonstrate efficacy of intelligible visualization, impact on patient motivation and resultant health outcomes. Reflection on how similar HCI approaches could be leveraged for technology-supported management of critical health conditions such as cardiac diseases.

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The impact of certolizumab pegol treatment on the incidence of anterior uveitis flares in patients with axial spondyloarthritis: 48-week interim results from C-VIEW

RMD Open ◽

10.1136/rmdopen-2019-001161 ◽

2020 ◽

Vol 6 (1) ◽

pp. e001161 ◽

Cited By ~ 2

Author(s):

Irene van der Horst-Bruinsma ◽

Rianne van Bentum ◽

Frank D Verbraak ◽

Thomas Rath ◽

James T Rosenbaum ◽

...

Keyword(s):

Incidence Rate ◽

Anterior Uveitis ◽

Poisson Regression ◽

Axial Spondyloarthritis ◽

Certolizumab Pegol ◽

Tnf Inhibitor ◽

Open Label ◽

Before And After ◽

History Of ◽

The Impact

BackgroundAcute anterior uveitis (AAU) is the most common extra-articular manifestation in patients with axial spondyloarthritis (axSpA). C-VIEW investigates the impact of the Fc-free TNF inhibitor certolizumab pegol (CZP) on AAU flares in patients with active axSpA at high risk of recurrent AAU.MethodsC-VIEW (NCT03020992) is a 96-week ongoing, multicentre, open-label, phase 4 study. Included patients had an axSpA diagnosis, a history of recurrent AAU (≥2 AAU flares, ≥1 flare in the year prior to study entry), HLA-B27 positivity, active disease, and failure of ≥2 non-steroidal anti-inflammatory drugs. Patients received CZP 400 mg at Weeks 0/2/4, then 200 mg every 2 weeks up to 96 weeks. This 48-week pre-planned interim analysis compares AAU flare incidence in the 48 weeks before and after initiation of CZP treatment, using Poisson regression to account for possible within-patient correlations.ResultsIn total, 89 patients were included (male: 63%; radiographic/non-radiographic axSpA: 85%/15%; mean axSpA disease duration: 8.6 years). During 48 weeks’ CZP treatment, 13 (15%) patients experienced 15 AAU flares, representing an 87% reduction in AAU incidence rate (146.6 per 100 patient-years (PY) in the 48 weeks pre-baseline to 18.7 per 100 PY during CZP treatment). Poisson regression analysis showed that the incidence rate of AAU per patient reduced from 1.5 to 0.2 (p<0.001). No new safety signals were identified.ConclusionsThere was a significant reduction in the AAU flare rate during 48 weeks of CZP treatment, indicating that CZP is a suitable treatment option for patients with active axSpA and a history of recurrent AAU.

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Impact of a structured, group-based running programme on clinical, cognitive and social function in youth and adults with complex mood disorders: a 12-week pilot study

BMJ Open Sport & Exercise Medicine ◽

10.1136/bmjsem-2019-000521 ◽

2019 ◽

Vol 5 (1) ◽

pp. e000521

Author(s):

Laura E Keating ◽

Suzanna Becker ◽

Katie McCabe ◽

Jeff Whattam ◽

Laura Garrick ◽

...

Keyword(s):

Quality Of Life ◽

Mood Disorders ◽

Exercise Intervention ◽

Bodily Pain ◽

Cognitive Outcomes ◽

Open Label ◽

Mood Symptoms ◽

Before And After ◽

The Impact

BackgroundIndividuals with mood disorders often report lingering health-related quality of life (HRQOL) and social and cognitive impairments even after mood symptoms have improved. Exercise programmes improve mood symptoms in patients, but whether exercise improves functional outcomes in patients with difficult-to-treat mood disorders remains unknown.DesignWe evaluated the impact of a 12-week structured running programme on cognitive, social and quality-of-life outcomes in participants with difficult-to-treat mood disorders.MethodsIn a prospective, open-label study, patients referred to the St Joseph’s Healthcare HamiltonTeam Unbreakablerunning programme for youth and adults with mood disorders completed a comprehensive assessment battery before and after the 12-week exercise intervention.ResultsWe collected preintervention and postintervention data from 18 participants who improved on the general health, vitality, role of emotions, social functioning and mental health (all p≤0.01) HRQOL subscales. Performance improved on cognitive tests that assessed working memory and processing speed (p≤0.04); there were no improvements in complex executive functioning tasks. Regression analyses indicated that younger age, shorter illness duration and reduced bodily pain predicted social and cognitive outcomes.ConclusionParticipation in a group-based, structured running programme was associated with improved HRQOL and social and cognitive function.

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The impact of digital health interventions on health-related outcomes in the workplace: A systematic review

Digital Health ◽

10.1177/2055207618770861 ◽

2018 ◽

Vol 4 ◽

pp. 205520761877086 ◽

Cited By ~ 24

Author(s):

Ana Howarth ◽

Jose Quesada ◽

Jessica Silva ◽

Stephanie Judycki ◽

Peter R Mills

Keyword(s):

Systematic Review ◽

Health Outcomes ◽

Positive Impact ◽

Digital Health ◽

Controlled Trial ◽

Health Interventions ◽

Activity Levels ◽

Standardized Measures ◽

Health Related ◽

The Impact

Background The impact of employee health on productivity in the workplace is generally evidenced through absenteeism and presenteeism. Multicomponent worksite health programmes, with significant online elements, have gained in popularity over the last two decades, due in part to their scalability and low cost of implementation. However, little is known about the impact of digital-only interventions on health-related outcomes in employee groups. The aim of this systematic review was to assess the impact of pure digital health interventions in the workplace on health-related outcomes. Methods Multiple databases, including MEDLINE, EMBASE, PubMed and PsycINFO, were used to review the literature using PRISMA guidelines. Results Of 1345 records screened, 22 randomized controlled trial studies were found to be eligible. Although there was a high level of heterogeneity across these studies, significant improvements were found for a broad range of outcomes such as sleep, mental health, sedentary behaviours and physical activity levels. Standardized measures were not always used to quantify intervention impact. All but one study resulted in at least one significantly improved health-related outcome, but attrition rates ranged widely, suggesting sustaining engagement was an issue. Risk of bias assessment was low for one-third of the studies and unclear for the remaining ones. Conclusions This review found modest evidence that digital-only interventions have a positive impact on health-related outcomes in the workplace. High heterogeneity impacted the ability to confirm what interventions might work best for which health outcomes, although less complex health outcomes appeared to be more likely to be impacted. A focus on engagement along with the use of standardized measures and reporting of active intervention components would be helpful in future evaluations.

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Information Architecture of Web-Based Interventions to Improve Health Outcomes: Systematic Review (Preprint)

10.2196/preprints.7867 ◽

2017 ◽

Author(s):

Jillian Pugatch ◽

Emily Grenen ◽

Stacy Surla ◽

Mary Schwarz ◽

Heather Cole-Lewis

Keyword(s):

Health Behavior ◽

Health Outcomes ◽

Digital Health ◽

Behavioral Outcomes ◽

Evidence Base ◽

Information Architecture ◽

Site Condition ◽

Behavior Outcomes ◽

And Behavior ◽

The Impact

BACKGROUND The rise in usage of and access to new technologies in recent years has led to a growth in digital health behavior change interventions. As the shift to digital platforms continues to grow, it is increasingly important to consider how the field of information architecture (IA) can inform the development of digital health interventions. IA is the way in which digital content is organized and displayed, which strongly impacts users’ ability to find and use content. While many information architecture best practices exist, there is a lack of empirical evidence on the role it plays in influencing behavior change and health outcomes. OBJECTIVE Our aim was to conduct a systematic review synthesizing the existing literature on website information architecture and its effect on health outcomes, behavioral outcomes, and website engagement. METHODS To identify all existing information architecture and health behavior literature, we searched articles published in English in the following databases (no date restrictions imposed): ACM Digital Library, CINAHL, Cochrane Library, Google Scholar, Ebsco, and PubMed. The search terms used included information terms (eg, information architecture, interaction design, persuasive design), behavior terms (eg, health behavior, behavioral intervention, ehealth), and health terms (eg, smoking, physical activity, diabetes). The search results were reviewed to determine if they met the inclusion and exclusion criteria created to identify empirical research that studied the effect of IA on health outcomes, behavioral outcomes, or website engagement. Articles that met inclusion criteria were assessed for study quality. Then, data from the articles were extracted using a priori categories established by 3 reviewers. However, the limited health outcome data gathered from the studies precluded a meta-analysis. RESULTS The initial literature search yielded 685 results, which was narrowed down to three publications that examined the effect of information architecture on health outcomes, behavioral outcomes, or website engagement. One publication studied the isolated impact of information architecture on outcomes of interest (ie, website use and engagement; health-related knowledge, attitudes, and beliefs; and health behaviors), while the other two publications studied the impact of information architecture, website features (eg, interactivity, email prompts, and forums), and tailored content on these outcomes. The paper that investigated IA exclusively found that a tunnel IA improved site engagement and behavior knowledge, but it decreased users’ perceived efficiency. The first study that did not isolate IA found that the enhanced site condition improved site usage but not the amount of content viewed. The second study that did not isolate IA found that a tailored site condition improved site usage, behavior knowledge, and some behavior outcomes. CONCLUSIONS No clear conclusion can be made about the relationship between IA and health outcomes, given limited evidence in the peer-reviewed literature connecting IA to behavioral outcomes and website engagement. Only one study reviewed solely manipulated IA, and we therefore recommend improving the scientific evidence base such that additional empirical studies investigate the impact of IA in isolation. Moreover, information from the gray literature and expert opinion might be identified and added to the evidence base, in order to lay the groundwork for hypothesis generation to improve empirical evidence on information architecture and health and behavior outcomes.

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Palatability of Liquid Anti-Infectives: Clinician and Student Perceptions and Practice Outcomes

The Journal of Pediatric Pharmacology and Therapeutics ◽

10.5863/1551-6776-12.4.216 ◽

2007 ◽

Vol 12 (4) ◽

pp. 216-223

Author(s):

Stacy C. Gee ◽

Tracy M. Hagemann

Keyword(s):

Student Perceptions ◽

Health Care Professionals ◽

Patient Counseling ◽

Open Label ◽

Taste Test ◽

Medication Counseling ◽

Before And After ◽

Oral Liquid ◽

The Individual ◽

The Impact

Oral liquid medications with poor palatability may lead to non-compliance, especially among children. Often, prescribers are not aware of the palatability of the agent that they are prescribing. Eighty-six health-care professionals participated in an open-label taste test of 24 anti-infectives in stock at a pediatric teaching hospital. A sample of the product was placed on a plastic spoon and participants were asked to evaluate their overall impression based on taste, texture, smell, and aftertaste. Participants were then asked to rank the individual products on a visual analog scale. Certain anti-infective formulations were perceived as being much more palatable than others. As a follow-up study, surveys were sent out to assess the impact of the taste test. Participants were asked to evaluate their prescribing and patient counseling habits both before and after the taste test. We found that half of the volunteers had altered their prescribing and/or medication counseling habits as a result of the taste test.

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An Investigation of the Effect of Retraining Courses on the Knowledge, Attitude and Performance of Health Workers in the Field of Malaria

10.53350/pjmhs211561598 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1598-1601

Author(s):

Roghaye Ershad Sarabi ◽

Rafigh Dehvari Mohammadi ◽

Aziollah Arbabisarjou

Keyword(s):

Health Center ◽

Health Workers ◽

Demographic Data ◽

Knowledge Score ◽

Before And After ◽

The Face ◽

Level Of Knowledge ◽

And Performance ◽

And Behavior ◽

The Impact

Background: Malaria is considered one of the most important parasitic diseases in Iran. With regard to malaria, Sistan and Baluchestan province ranks first among the country's provinces. Aim: To investigate the impact of education on malaria knowledge, attitude and behavior among health workers working in Saravan city health center. Methods: The present study is a semi-experimental study of before and after clinical trial type that was performed on 73 health workers in Saravan city. A researcher-made questionnaire was used to collect the required data. It consisted of two parts: the first part was dedicated to demographic data and the second part was about the knowledge, attitude and performance of health workers regarding malaria. The face and content validity of the questionnaire was confirmed by an expert panel. The reliability of the questionnaire was calculated using Cronbach's alpha coefficient (α=0.85). Before the start of the training, the questionnaires were given to the health workers. The trainings were presented in 49 one-hour sessions by the experts of the headquarters of Saravan Health Center in Behvarzi Center using lectures and pamphlets. One month after the training, the same questionnaires were filled in by health workers. Results: The results showed that the mean scores of health workers in the areas of knowledge, attitude and performance increased significantly after the workshop (p=0.001) so that the participants' knowledge score increased from 26.06 to 56.7. In terms of attitude, their score increased from 7.2 to 17.7, and in terms of performance, participants' score increased from 13 to 32. Conclusions: The findings revealed that the implementation of educational programs in the field of malaria can increase the level of knowledge, attitude and performance of the community regarding the preventive behaviors of malaria. Therefore, health system officials are recommended to work toward the amelioration of the knowledge, attitude and performance of the health workers. Keywords: knowledge, attitude, performance, health workers, malaria, retrainin

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Using Sustainability Reports as a Method of Cause-Related Marketing for Competitive Advantage

Marketing and Consumer Behavior ◽

10.4018/978-1-4666-7357-1.ch064 ◽

2015 ◽

pp. 1302-1318

Author(s):

John Kenneth Corley ◽

Sandra A. Vannoy ◽

Joseph A. Cazier

Keyword(s):

Consumer Behavior ◽

Purchase Intention ◽

Positive Impact ◽

Sustainability Reporting ◽

Experimental Simulation ◽

Cause Related Marketing ◽

Before And After ◽

Mp3 Players ◽

And Behavior ◽

The Impact

This study explores the impact of sustainability reporting on consumer behavior. In this study, the authors measure consumer perception and behavior using the constructs value congruence, trust, loyalty, and purchase intention. To test other research model and hypotheses they collected survey data during an online experimental simulation. During the simulation participants were presented with information about a fictional retailer of digital music, movies, and MP3 players. Consumer behavior data were collected from participants before and after presenting information about the sustainability report of the fictitious retailer. The results of the study suggest sustainability reporting has a significant and positive impact on consumer behavior. Therefore, it may prove to be an effective method of cause-related marketing used to attract conscientious consumers.

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Using Sustainability Reports as a Method of Cause-Related Marketing for Competitive Advantage

International Journal of Social Ecology and Sustainable Development ◽

10.4018/jsesd.2013040102 ◽

2013 ◽

Vol 4 (2) ◽

pp. 16-33

Author(s):

John Kenneth Corley ◽

Sandra A. Vannoy ◽

Joseph A. Cazier

Keyword(s):

Consumer Behavior ◽

Purchase Intention ◽

Positive Impact ◽

Sustainability Reporting ◽

Experimental Simulation ◽

Cause Related Marketing ◽

Before And After ◽

Mp3 Players ◽

And Behavior ◽

The Impact

This study explores the impact of sustainability reporting on consumer behavior. In this study, the authors measure consumer perception and behavior using the constructs value congruence, trust, loyalty, and purchase intention. To test otheur research model and hypotheses they collected survey data during an online experimental simulation. During the simulation participants were presented with information about a fictional retailer of digital music, movies, and MP3 players. Consumer behavior data were collected from participants before and after presenting information about the sustainability report of the fictitious retailer. The results of the study suggest sustainability reporting has a significant and positive impact on consumer behavior. Therefore, it may prove to be an effective method of cause-related marketing used to attract conscientious consumers.

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