Pilot study of a screening test for peripheral arterial disease in middle aged men: fibrinogen as a possible risk factor

1988 ◽  
Vol 22 (4) ◽  
pp. 300-302 ◽  
Author(s):  
K. BAXTER ◽  
S. WISEMAN ◽  
J. POWELL ◽  
R. GREENHALGH
Keyword(s):  
Risk Factor ◽  
Pilot Study ◽  
Peripheral Arterial Disease ◽  
Screening Test ◽  
Arterial Disease ◽  
Middle Aged ◽  
Peripheral Arterial

Lanarkshire Oximetry Index as a Diagnostic Tool for Peripheral Arterial Disease in Type 2 Diabetes: A Pilot Study

Angiology ◽  
2010 ◽  
Vol 61 (4) ◽  
pp. 388-391 ◽  
Author(s):  
N. Papanas ◽  
D. Kakagia ◽  
K. Papatheodorou ◽  
D. Papazoglou ◽  
M. Alexandridou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pilot Study ◽  
Peripheral Arterial Disease ◽  
Diagnostic Tool ◽  
Arterial Disease ◽  
Peripheral Arterial

Lipoprotein(a) as a unique primary risk factor for early atherosclerotic peripheral arterial disease

2021 ◽  
Vol 14 (6) ◽  
pp. e243231
Author(s):  
John Mayo ◽  
Thomas Hoffman ◽  
Ryan Smith ◽  
Dwight Kellicut
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Common Condition ◽  
Elevated Plasma ◽  
Early Screening ◽  
Lipoprotein A ◽  
Peripheral Arterial ◽  
Primary Risk Factor

Elevated plasma lipoprotein(a) is a relatively common condition that contributes to many cardiovascular diseases. However, the awareness and testing for this condition remain low. Herein, we present a case of an otherwise healthy and active man who developed symptoms of peripheral arterial disease starting at age 49, and was found to have hyper-lipoprotein(a) as his only notable risk factor. Diagnosis was not made until years later, after an extensive workup. Upon further screening, he was also found to have subclinical coronary and carotid artery atherosclerotic disease. The patient was treated with aspirin, statin, niacin and angioplasty to bilateral superficial femoral arteries with good symptom resolution. Early screening of his son also revealed a similarly elevated lipoprotein(a) level. It is important to raise awareness of this condition and its relationship to early-onset peripheral arterial disease so patients and their families can be appropriately identified, counselled and treated.

Effects of Alpha-Lipoic Acid Supplementation in Peripheral Arterial Disease: A Pilot Study

2007 ◽  
Vol 13 (5) ◽  
pp. 577-584 ◽  
Author(s):  
Heather K. Vincent ◽  
Cheryl M. Bourguignon ◽  
Kevin R. Vincent ◽  
Ann G. Taylor
Keyword(s):  
Pilot Study ◽  
Peripheral Arterial Disease ◽  
Lipoic Acid ◽  
Arterial Disease ◽  
Alpha Lipoic Acid ◽  
Acid Supplementation ◽  
Peripheral Arterial

Metabolic Response to Claudication in Peripheral Arterial Disease: A Microdialysis Pilot Study

2019 ◽  
Vol 58 ◽  
pp. 134-141 ◽  
Author(s):  
David T. McGreevy ◽  
Sinan Dogan ◽  
Victoria Oscarsson ◽  
Marco Vergari ◽  
Ken Eliasson ◽  
...  
Keyword(s):  
Pilot Study ◽  
Peripheral Arterial Disease ◽  
Metabolic Response ◽  
Arterial Disease ◽  
Peripheral Arterial

Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

Vascular ◽  
2020 ◽  
pp. 170853812094724
Author(s):  
Ufuk Turan Kursat Korkmaz ◽  
Ahmet Yuksel ◽  
Ayhan Cetinkaya ◽  
Yusuf Velioglu ◽  
Erhan Renan Ucaroglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Peripheral Arterial Disease ◽  
Laboratory Data ◽  
Arterial Disease ◽  
Control Group ◽  
Study Group ◽  
Total Thiol ◽  
Peripheral Arterial ◽  
Study Participants

Objective To examine dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Methods One hundred patients with lower extremity peripheral arterial disease (a study group) and 100 control subjects were included in this prospective case–control study. Participants’ baseline clinical characteristics and laboratory data including some oxidant/antioxidant status parameters such as albumin, ferroxidase and myeloperoxidase, and thiol/disulphide homeostasis parameters such as native thiol, total thiol and disulphide, as well as native thiol/total thiol, disulphide/native thiol and disulphide/total thiol ratios were all recorded and then compared between the groups. Results Mean albumin and ferroxidase, and median myeloperoxidase levels were found to be significantly higher in patients with the peripheral arterial disease than in control group ( p = 0.045, p = 0.000 and p = 0.000, respectively). Mean native thiol and total thiol, and median disulphide levels were found to be significantly lower in the study group as compared with the control group ( p = 0.000, p = 0.000 and p = 0.037, respectively). According to the results of logistic regression analysis, systolic blood pressure, ferroxidase and myeloperoxidase levels were detected to be the independent predictors of peripheral arterial disease. Conclusion Our report is the first one in the literature investigating dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in peripheral arterial disease. Dynamic thiol/disulphide homeostasis metrics may be used as a valuable risk factor of oxidative stress in patients with the peripheral arterial disease since it is readily available, easily calculated and relatively cheap.

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