scholarly journals P849 Analysis of rectal swabs for microbiome sampling in a cohort of IBD patients during disease exacerbation. POLIBD survey results

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S654-S654
Author(s):  
R Filip ◽  
J Gruszecka
Keyword(s):  
Clostridium Difficile ◽  
Rectal Swab ◽  
Disease Exacerbation ◽  
Cross Sectional ◽  
Intestinal Infections ◽  
Rectal Swabs ◽  
Survey Results ◽  
Inflammatory Bowel ◽  
Sectional Analysis ◽  
Positive Results

Abstract Background There are only a few studies that have investigated the role of intestinal infections other than Clostridium difficile in Inflammatory Bowel Disease (IBD). Objectives: Our goal was to investigate the frequency of intestinal infections detected by rectal swabs in IBD patients during admission due to exacerbation of the disease. Methods We conducted a cross-sectional analysis of 299 patients who underwent microbiome sampling with the use of rectal swabs from January 1, 2017 to June 30, 2019, treated at a tertiary IBD centre in Poland. Our main goal was to assess the presence of any infection that could mimic or coexist with IBD exacerbation. Results A total of 299 patients were subjected to microbiological examination, including 61 patients with Crohn’s Disease (CD), 143 patients with Ulcerative Colitis (UC) and 95 patients with diarrhoea not related to IBD. Positive results of rectal swab culture were found in a total of 22 samples - in 17 patients with IBD and 5 patients without IBD. Among the IBD patients, positive rectal swab cultures were obtained in cases of UC - 13 samples, 76.5%, p <0.001, CD - 4 samples, 23.5% positive results, p = 0.001. In patients with IBD compared with patients without IBD, a higher incidence of intestinal infections was found (in patients with IBD 8.3%, p <0.001, in patients without IBD 5.2%, p < 0.001). Analysis of the results obtained showed seasonal variability in the number of positive microbiological tests found for cultures of rectal swabs in IBD patients. Positive results of rectal swabs from patients with IBD were significantly more frequent in the summer months - 12, 70.6%, p < 0.001 than in the winter months, when 5 positive test results were found (29.4%, p <0.001). Conclusion A retrospective analysis of rectal swabs for microbiome sampling collected from IBD patients during disease exacerbation treated in a tertiary IBD centre in Poland was performed. Intestinal infections, other than Clostridium difficile, were found in 17 patients with IBD symptoms. Positive results from rectal swabs of patients without symptoms of IBD were found in 5 cases. The evaluation of the obtained results shows that positive results of rectal swabs were found more often in samples taken from women (12 samples - 68.7%) than from men (5 samples - 29.3%).

scholarly journals Retrospective analysis of Clostridioides difficile and other intestinal infections in patients with Crohn’s disease and ulcerative colitis in the tertiary hospital in Poland. POLIBD survey results

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jolanta Gruszecka ◽  
Rafał Filip
Keyword(s):  
Retrospective Analysis ◽  
Rectal Swab ◽  
Tertiary Hospital ◽  
Positive Test ◽  
Test Results ◽  
Clostridioides Difficile ◽  
Intestinal Infections ◽  
Survey Results ◽  
Inflammatory Bowel ◽  
Positive Results

Abstract Background There are several studies which evaluated the number of infections caused by enteric pathogens, including Clostridioides difficile in patients with inflammatory bowel disease (IBD). Our aim was to assess the prevalence of intestinal infections among patients suffering from IBD, when admitted to the hospital due to exacerbation of the disease. Results The performed, retrospective analysis covered test results for C. difficile toxins A and B along with rectal swab cultures sampled from patients, treated in a tertiary IBD center in Poland, between 2017 and 2019. Main objective was to estimate the presence of any infection, which could imitate or co-exist along with the exacerbation of the IBD. All in all 1471 patients had microbiological tests performed, including 1112 tested for C. difficile toxins A and B; and 359 patients who had rectal swab culture. Positive test results for C. difficile toxins A and B were reported in 358 cases, positive results from rectal swab culture were confirmed altogether in case of 25 samples. As far as patients with IBD are concerned, positive results for C. difficile toxins A and B were detected in 82 cases, positive results in rectal swab culture from patients with IBD were reported in 20 cases. Conclusion Intestinal infections were reported in 14.9% of patients (102/685) with IBD symptoms. Positive test results for C. difficile toxins A and B and rectal swab cultures among patients without IBD symptoms were reported in 35.7% of cases (281/786). Intestinal superinfections may complicate the clinical picture of IBD patients, increasing the diagnostic and therapeutic burden. Appropriate early procedures are thus needed in these patients.

Prospective, Observational, Cross-Sectional Study of Intestinal Infections among Acutely Active Inflammatory Bowel Disease Patients

Digestion ◽  
2009 ◽  
Vol 80 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Mercè Navarro-Llavat ◽  
Eugeni Domènech ◽  
Isabel Bernal ◽  
Jordi Sánchez-Delgado ◽  
José M. Manterola ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Active Inflammatory Bowel Disease ◽  
Intestinal Infections ◽  
Inflammatory Bowel

scholarly journals P319 Clinical characteristics of patients with inflammatory bowel disease and metabolic syndrome

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S313-S313
Author(s):  
I V Gubonina ◽  
V Grinevich ◽  
M Poluektov ◽  
T Kolodin ◽  
S Lapteva ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Clinical Characteristics ◽  
Clinical Course ◽  
Insufficient Evidence ◽  
Cross Sectional ◽  
Pathologic Process ◽  
Inflammatory Bowel ◽  
Sectional Analysis

Abstract Background Currently the incidence of patients with Metabolic Syndrome (MS) tends to increase among patients with inflammatory bowel disease (IBD). The purpose of the study is to investigate the course of IBD depending on the presence of MS. Methods This cross-sectional analysis was performed on the database of patients with IBD to estimate the frequency of MS presence and study the clinical course (extension of pathologic process, severity and phenotype) of Crohn’s disease (CD) and ulcerative colitis (UC). Results 347 patients with IBD were included in the investigation: 259 patients with UC and 88 patients with CD. MS was revealed with the same frequency among patients with UC (26 patients, 10.04%) and CD (9 patients, 10.23%). Proctitis (48 patients, 20.6%) and left-sided colitis (121 patients, 51.93%) are usually found among patients with UC without MS while total colitis is significantly more frequent among patients with underlying MS (12, 46.15%, p < 0,05). It was found that patients without MS more often suffered from mild UC (116 patients, 49.79%, p < 0,01) while among patients with MS severe UC occurred more frequently (6 patients, 23.08%, p < 0.05). Among patients with CD and MS, there was no significant correlation between underlying MS and localisation, severity and course of CD. Conclusion Patients with UC and MS suffer from a more severe course of UC (as to both the extension of pathologic process and severity) in comparison with the patients with UC without MS. Due to the small quantity of patient with CD and MS insufficient evidence for the influence of MS on the course of CD has been obtained.

scholarly journals Assessment of rectal Chlamydia trachomatis viable load in women by viability-PCR

2019 ◽  
Vol 96 (2) ◽  
pp. 85-88 ◽  
Author(s):  
Kevin J H Janssen ◽  
Petra Wolffs ◽  
Mayk Lucchesi ◽  
Nicole H T M Dukers-Muijrers ◽  
Christian J P A Hoebe
Keyword(s):  
Chlamydia Trachomatis ◽  
Nucleic Acid Amplification ◽  
Test Results ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Public Health Implication ◽  
Significant Difference ◽  
Rectal Swabs ◽  
The Mean ◽  
Positive Results

ObjectivesIn recent years, studies have demonstrated frequent rectal Chlamydia trachomatis (CT) detection in women, irrespective of reported anal sex or rectal symptoms. However, the clinical relevance and public health implication of rectal CT detection in women remain under debate. Therefore, evaluating CT viability may provide more insight into the relevance of standard routine nucleic acid amplification test (NAAT)–positive results.MethodsIn this cross-sectional explorative study, a convenience sample of female patients at our STI clinic aged 18 years or older, diagnosed with vaginal and/or rectal CT, were invited to participate. On return for treatment, rectal CT-diagnosed women were instructed to self-collect rectal swab samples before being treated. Standard COBAS 4800 CT/NG routine NAAT testing was applied for CT diagnosis. Rectal viable CT load was evaluated by using viability-PCR (V-PCR).Results53 women with rectal CT were included in this study; 86.8% (46/53) had a quantifiable rectal total CT load. Of women with quantifiable samples, 52.2% (24/46) had viable CT detected from rectal swabs by V-PCR, with a mean rectal viable CT load of 3.31 log10 CT/mL (range 1.16–6.22). No statistically significant difference (p=0.73) was observed in the mean rectal viable CT load of women with an indication for rectal testing (n=9) and without (n=15), 3.20 log10 CT/mL (range 2.06–4.36) and 3.38 log10 CT/mL (range 1.16–6.22), respectively. CT culture yielded positive test results from rectal swabs in 22.6% (12/53) of rectal CT NAAT-diagnosed women. Of women with viable rectal CT by V-PCR (n=24), 50% (12/24) were positive by CT culture.ConclusionsOverall, the detection of high rectal viable CT loads in this study indicates that rectal CT in some women might represent a currently ongoing infection rather than just the presence of remnant DNA from dead bacteria or only contamination from an active vaginal CT infection.

scholarly journals Conflicts of Interest in Inflammatory Bowel Disease Articles on UpToDate

2019 ◽  
Author(s):  
Rishad Khan ◽  
Juana Li ◽  
Michael A Scaffidi ◽  
Nikko Gimpaya ◽  
Bianca Pivetta ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Clinical Decision Making ◽  
Conflicts Of Interest ◽  
Point Of Care ◽  
Clinical Decision ◽  
Cross Sectional ◽  
Inflammatory Bowel ◽  
Sectional Analysis ◽  
Open Payments

Abstract Background Financial conflicts of interest (FCOIs) are widespread in inflammatory bowel disease (IBD) and may be particularly important in point-of-care (POC) resources, such as UpToDate, that are used to aid clinical decision making. In this study, we determined the prevalence of industry payments from companies making biologic medications for IBD to contributors of UpToDate articles on IBD. Methods This cross-sectional analysis included UpToDate articles that mention the use of biologic medications for IBD. We collected the names of the contributors (authors and editors) and their disclosures on UpToDate. We then searched for their names on the Center for Medicare and Medicaid Open Payments database and compared the payment information from 2013 to 2018 with UpToDate's disclosures. We presented data per episode, which describes one instance of participation by one person in one article, regardless of whether that person contributed to multiple articles. Results We identified 23 articles on the treatment of Crohn's disease and ulcerative colitis that mentioned the use of biologic medications, with 86 total episodes. Sixty-two (72%) episodes involved FCOIs. The median payment associated with each episode was $$55 (interquartile range = $44 to $145,241). Contributors did not fully disclose FCOIs in 41 (48%) episodes. Deputy editors, who are required to be free of FCOIs, in general did not have substantial episodes involving FCOI. Conclusions We found that UpToDate articles on inflammatory bowel disease involve substantial FCOI, many of which are not disclosed. The presence of these FCOIs may hamper trust in the objectivity of treatment recommendations.

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