March, September and December months with the greatest influence of atmospheric pressure on blood pressure in patients with hypertension

Abstract Objectives For a long time, science has searched for the relationship between weather and human health. Atmospheric pressure is the most objective weather factor because, regardless of whether the objects are outdoors or indoors, it affects all objects in the same way. In cardiology, we often look for factors that worsen blood pressure control. Could atmospheric pressure be one of them? The main objective of our research was to assess the relationship between atmospheric pressure and blood pressure in patients with treated hypertension in different months in the moderate climate of Central Poland. Material and methods The study group consisted of 4191 patients with arterial hypertension, divided into 2 near equal groups due to a lower or higher average value of atmospheric pressure when blood pressure was recorded. Blood pressure was monitored by a means of 24-h ABPM. Atmospheric pressure was recorded with the frequency of 1 measurement per minute using a meteorological station. The observations were conducted in the years 2009–2019. Comparisons between blood pressure values in the 2 groups were performed using the Mann-Whitney U test. Results We observed a significant difference in blood pressure recorded during the periods of lower and higher atmospheric pressure: for systolic blood pressure during the days of September (125.01±14.99 vs 120.14±12.83, p<0.001) and December (124.22±15.45 vs 127.50±14.35, p<0.05), for diastolic pressure during the days of March (72.24±10.92 vs 69.81±9.13, p<0.02) and for diastolic pressure during the nights of March (61.53±8.96 vs 59.58±9.17, p<0.04). Conclusions A significant inverse relationship between atmospheric pressure and blood pressure was observed; during March days and nights for diastolic blood pressure and during September and December days for systolic blood pressure. This finding may be important for the understanding of why during some months the pharmacological control of blood pressure is poor, and of the consequences of this fact. FUNDunding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): own resources

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Influence of baseline systolic blood pressure on the relationship between intensive blood pressure control and cardiovascular outcomes in the Systolic Blood Pressure Intervention Trial (SPRINT)

Clinical Research in Cardiology ◽

10.1007/s00392-018-1353-9 ◽

2018 ◽

Vol 108 (3) ◽

pp. 273-281 ◽

Cited By ~ 1

Author(s):

Xiuting Sun ◽

Yue Guo ◽

Zhiqiang Nie ◽

Jing Cheng ◽

Huimin Zhou ◽

...

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Blood Pressure Control ◽

Pressure Control ◽

Cardiovascular Outcomes ◽

Intervention Trial ◽

Baseline Systolic Blood Pressure ◽

The Relationship ◽

Intensive Blood Pressure

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Faculty Opinions recommendation of Intensive vs standard blood pressure control in adults 80 years or older: A secondary analysis of the systolic blood pressure intervention trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737098090.793573249 ◽

2020 ◽

Author(s):

Wilbert Aronow

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Blood Pressure Control ◽

Secondary Analysis ◽

Pressure Control ◽

Intervention Trial

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Determination of vertical dimension of occlusion by using the phonetic vowel "O" and "E"

Vojnosanitetski pregled ◽

10.2298/vsp1502123i ◽

2015 ◽

Vol 72 (2) ◽

pp. 123-131 ◽

Cited By ~ 6

Author(s):

Marko Igic ◽

Nebojsa Krunic ◽

Ljiljana Aleksov ◽

Milena Kostic ◽

Aleksandra Igic ◽

...

Keyword(s):

Cognitive Functions ◽

Complete Denture ◽

Reference Points ◽

Vertical Dimension ◽

Entire Sample ◽

Average Value ◽

Significant Difference ◽

The Relationship

Background/Aim. The vertical dimension of occlusion is a very important parameter for proper reconstruction of the relationship between the jaws. The literature describes many methods for its finding, from the simple, easily applicable clinically, to quite complicated, with the use of one or more devices for determination. The aim of this study was to examine the possibility of determining the vertical dimension of occlusion using the vocals ?O? and ?E? with the control of values o btained by applying cognitive functions. Methods. This investigation was performed with the two groups of patients. The first group consisted of 50 females and 50 males, aged 18 to 30 years. In this group the distance between the reference points (on top of the nose and chin) was measured in the position of the mandible in the vertical dimension of occlusion, the vertical dimension at rest and the pronunciation of the words ?OLO? and ?ELE?. Checking the correctness of the particular value for the word ?OLO? was also performed by the phonetic method with the application of cognitive exercises when the patients counted from 89 to 80. The obtained difference in the average values i n determining the vertical dimension of occlusion and the ?OLO? and ?ELE? in the first group was used as the reference for determining the vertical dimension of occlusion in the second group of patients. The second group comprised of 31 edentulous persons (14 females and 17 males), aged from 54 to 85 years who had been made a complete denture. Results. The average value obtained for the vertical dimension of rest for the entire sample was 2.16 mm, for the word ?OLO? for the entire sample was 5.51 mm and for the word ?ELE? for the entire sample was 7.47 mm. There was no statistically significant difference between the genders for the value of the vertical dimension at rest, ?ELE? and ?OLO?. There was a statistically significant difference between the values f or the vertical dimension at rest, ?OLO? and ?ELE? for both genders. There was a statistically significant correlation between the value for the vertical dimension at rest, ?OLO? and ?ELE?, for both groups of subjects. Conclusion. Determining the vertical dimension of occlusion requires 5.5 mm subtraction from the position of the mandible in pronunciation of the word ?OLO? or 7.5 mm in pronunciation of the word ?ELE?.

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Telomere Length as a Biomarker for Race-Related Health Disparities

Genes ◽

10.3390/genes12010078 ◽

2021 ◽

Vol 12 (1) ◽

pp. 78

Author(s):

Vaithinathan Selvaraju ◽

Megan Phillips ◽

Anna Fouty ◽

Jeganathan Ramesh Babu ◽

Thangiah Geetha

Keyword(s):

Blood Pressure ◽

Telomere Length ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Single Copy ◽

Normal Weight ◽

Length Ratio ◽

Hierarchical Regression ◽

Significant Difference ◽

The Usa

Disparities between the races have been well documented in health and disease in the USA. Recent studies show that telomere length, a marker of aging, is associated with obesity and obesity-related diseases, such as heart disease and diabetes. The current study aimed to evaluate the connection between telomere length ratio, blood pressure, and childhood obesity. The telomere length ratio was measured in 127 children from both European American (EA) and African American (AA) children, aged 6–10 years old. AA children had a significantly high relative telomere to the single copy gene (T/S) ratio compared to EA children. There was no significant difference in the T/S ratio between normal weight (NW) and overweight/obese (OW/OB) groups of either race. Blood pressure was significantly elevated in AA children with respect to EA children. Hierarchical regression analysis adjusted for race, gender, and age expressed a significant relationship between the T/S ratio and diastolic pressure. Low T/S ratio participants showed a significant increase in systolic pressure, while a high T/S ratio group showed an increase in diastolic pressure and heart rate of AA children. In conclusion, our findings show that AA children have high T/S ratio compared to EA children. The high T/S ratio is negatively associated with diastolic pressure.

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Blood pressure level and laboratory indicators of disease severity in patients with arterial hypertension and COVID-19

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.166 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

K Popov ◽

A Novitskiy ◽

Y Shvarts

Keyword(s):

Blood Pressure ◽

Multivariate Analysis ◽

Arterial Hypertension ◽

Negative Correlation ◽

Diastolic Pressure ◽

Negative Relationship ◽

Laboratory Parameters ◽

Acute Period ◽

Nonparametric Correlation ◽

The Relationship

Abstract Funding Acknowledgements Type of funding sources: None. Background. Many patients with COVID-19 suffer from arterial hypertension and have marked variations in blood pressure (BP) during the acute period of infection. The reasons for such changes are poorly understood. Purpose. To assess the relationship between the level of BP and the severity of changes in the main clinical and laboratory parameters in patients with arterial hypertension and with a moderate course of COVID-19 at the stage of the height of the disease. Materials and methods. The study included 86 hospitalized patients with verified coronavirus disease of moderate severity: 46 of them were male, the median age was 65 years. Patients received adequate hypertension therapy for a long time. After hospitalization, treatment was adjusted if necessary. The level of laboratory parameters in the acute period of the disease was determined, including the electrolytes, C-reactive protein (CRP), albumin, ferritin, general blood test, etc. BP measured daily. The relationship between laboratory parameters and BP level was evaluated by nonparametric correlation using the Spearman coefficient and multivariate analysis based on the "generalized nonlinear model". Results. In 67.44% of patients with hypertension, an elevated BP level (>140/90) was observed against the background of moderate COVID-19. There was a significant negative correlation between the levels of CRP and BP throughout the stay in the hospital, the most significant is the 5th day of hospitalization. At the same time, a slightly stronger relationship is observed with diastolic BP (r = -0.4425) than with systolic BP (r = -0.3525). A similar trend is observed in all BP measurements. Besides, a negative correlation was found between potassium levels and BP values. The strongest association of potassium levels is with systolic BP on the day of hospitalization (r = -0.4850) and diastolic pressure on the 1st day of hospitalization (r = -0.3561). Multivariate analysis confirmed independent and reliable "influence" of CRP (p = 0.00018) and potassium (p = 0.03921) as independent predictors of diastolic pressure. Conclusions. Most patients with hypertension and moderate COVID-19 have elevated BP levels. There is a statistically significant negative relationship between the values of BP and levels of CRP and potassium. The obtained data may correspond to the existing hypothesis about the significant role of the kinin–kallikrein system in the pathogenesis of COVID-19.

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What Physical Fitness Component Is Most Closely Associated With Adolescents' Blood Pressure?

Perceptual and Motor Skills ◽

10.1177/0031512517730414 ◽

2017 ◽

Vol 124 (6) ◽

pp. 1107-1120 ◽

Cited By ~ 1

Author(s):

Heloyse E. G. Nunes ◽

Carlos A. S. Alves ◽

Eliane C. A. Gonçalves ◽

Diego A. S. Silva

Keyword(s):

Blood Pressure ◽

Body Composition ◽

Muscle Strength ◽

Physical Fitness ◽

Systolic Blood Pressure ◽

Diastolic Blood Pressure ◽

Aerobic Fitness ◽

Pressure Control ◽

Cross Sectional ◽

Digital Pressure

This study aimed to determine which of four selected physical fitness variables, would be most associated with blood pressure changes (systolic and diastolic) in a large sample of adolescents. This was a descriptive and cross-sectional, epidemiological study of 1,117 adolescents aged 14–19 years from southern Brazil. Systolic and diastolic blood pressure were measured by a digital pressure device, and the selected physical fitness variables were body composition (body mass index), flexibility (sit-and-reach test), muscle strength/resistance (manual dynamometer), and aerobic fitness (Modified Canadian Aerobic Fitness Test). Simple and multiple linear regression analyses revealed that aerobic fitness and muscle strength/resistance best explained variations in systolic blood pressure for boys (17.3% and 7.4% of variance) and girls (7.4% of variance). Aerobic fitness, body composition, and muscle strength/resistance are all important indicators of blood pressure control, but aerobic fitness was a stronger predictor of systolic blood pressure in boys and of diastolic blood pressure in both sexes.

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Abstract P060: Angiotensin AT1A Receptors on Vasopressin-Expressing Cells are Dispensable for DOCA-salt Hypertension

Hypertension ◽

10.1161/hyp.66.suppl_1.p060 ◽

2015 ◽

Vol 66 (suppl_1) ◽

Author(s):

Jeremy A Sandgren ◽

Danny W Linggonegoro ◽

Kristin E Claflin ◽

Nicole A Pearson ◽

Gary L Pierce ◽

...

Keyword(s):

Blood Pressure ◽

Blood Pressure Control ◽

Specific Activity ◽

Fluorescent Microscopy ◽

Renin Angiotensin System ◽

Pressure Control ◽

Fluorescent Reporter ◽

Significant Difference ◽

Low Renin Hypertension ◽

Salt Hypertension

Increased blood pressure in the deoxycorticosterone acetate (DOCA)-salt model of low-renin hypertension is correlated with increased vasopressin (AVP) secretion, and is sensitive to inhibition of the brain renin-angiotensin system (RAS). Further, AVP-deficient Brattleboro rats are largely resistant to DOCA-salt hypertension. These findings lead us to hypothesize a role for AT1A receptors localized to AVP-expressing neurons in the control of AVP secretion, specifically in low-renin hypertension. Blood pressure was assessed via tail-cuff plesthysmography and total daily AVP secretion assessed via urine copeptin in mice with specific disruption of the AT1A gene in AVP-expressing cells (AVP-Cre x AT1Aflox/flox mice, “KO”) under both baseline and DOCA-salt treatment conditions. Specific activity of Cre-recombinase within the paraventricular and supraoptic nuclei of AVP-Cre transgenic mice was confirmed by fluorescent microscopy in brain sections from mice expressing a conditional fluorescent reporter (AVP-Cre x ROSA-stopflox-tdTomato mice). At baseline, AVP secretion (via urine copeptin) trended downward with large variation (control n=17, 363±182 vs KO n=5, 33±11 pg/day; p>0.05) but there was no significant difference in blood pressure (control n=27, 107±1.3 vs KO n=12, 111±2.2 mmHg; p>0.05) compared to littermate controls. In response to DOCA-salt, blood pressure (control n=23, +10.35±2.1 vs KO n=8, +12.91±2.0; p>0.05), urine output (control n=23, +12.65±0.8 vs KO n=9, +12.73±1.5 g/day; p>0.05), and fluid intake (control n=23, +16.17±1.3 vs KO n=9, +14.83±2.5 mL/day; p>0.05) increased normally in KO mice. Preliminary findings indicate normal or possibly exaggerated urine copeptin levels in KO mice following DOCA-salt, and an exaggerated AVP release in response to increasing serum osmolality. Collectively, these data suggest that AT1A receptors on AVP expressing cells are required to mediate baseline secretion of AVP, but that these receptors are dispensable for DOCA-salt mediated increases in circulating AVP and blood pressure.

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Old hypertensive patient: a hard challenge

Italian Journal of Medicine ◽

10.4081/itjm.2009.109 ◽

2013 ◽

pp. 109-112

Author(s):

Giuseppe Rossetti ◽

Diana Solari ◽

Maria Laura Rainoldi ◽

Stefano Carugo

Keyword(s):

Blood Pressure ◽

Cardiovascular Risk ◽

Elderly People ◽

Diastolic Pressure ◽

Beta Blockers ◽

The Elderly ◽

Pressure Control ◽

World Population ◽

Continuous Increase ◽

Hypertensive Therapy

BACKGROUND High blood pressure is one of the most important cardiovascular risk factor and its incidence is continuously increasing: on 2025 1/3 of adult world population will suffer of it. Moreover, the therapy of elderly hypertension sufferer patient is still growing up in importance for the continuous increase of world population average life. With ageing, the cardiovascular system suffers neurohormonal and haemodinamic modifications which determine the onset of isolate systolic hypertension, which is characteristic of the elderly. This pathology results linked to a higher cardiovascular risk. AIM OF THE STUDY This review aims to analyze and evaluate present and future therapeutic opportunities about anti-hypertensive therapy in elderly people. DISCUSSION AND CONCLUSIONS Also in elderly people systolic blood pressure values must be lower than 150 mmHg, but it’s also important to maintain diastolic pressure not under 70 mmHg, to avoid phenomenons of cerebral and coronary hypo-perfusion (J curve). The benefits of an effective anti-hypertensive therapy are achieved thanks to both blood pressure lowering “per se” and to the decrease of cardiovascular mortality and morbility. Blood pressure control in the elderly is a hard challenge for the low compliance to the therapy, for the importance of the comorbidity and for the supplementary risk factors. ESH-ESC 2007 guidelines recommend for elderly highblood pressure sufferer patient the use first of all of calcium-antagonists and thiazides diuretics, and for second line ACE-inhibitors, ARB and beta-blockers. In several patients combinations of two or more drugs are necessary to obtain pressure control.

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