Telomere Length as a Biomarker for Race-Related Health Disparities

Disparities between the races have been well documented in health and disease in the USA. Recent studies show that telomere length, a marker of aging, is associated with obesity and obesity-related diseases, such as heart disease and diabetes. The current study aimed to evaluate the connection between telomere length ratio, blood pressure, and childhood obesity. The telomere length ratio was measured in 127 children from both European American (EA) and African American (AA) children, aged 6–10 years old. AA children had a significantly high relative telomere to the single copy gene (T/S) ratio compared to EA children. There was no significant difference in the T/S ratio between normal weight (NW) and overweight/obese (OW/OB) groups of either race. Blood pressure was significantly elevated in AA children with respect to EA children. Hierarchical regression analysis adjusted for race, gender, and age expressed a significant relationship between the T/S ratio and diastolic pressure. Low T/S ratio participants showed a significant increase in systolic pressure, while a high T/S ratio group showed an increase in diastolic pressure and heart rate of AA children. In conclusion, our findings show that AA children have high T/S ratio compared to EA children. The high T/S ratio is negatively associated with diastolic pressure.

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Evaluation of blood pressure in school children aged 12-16 years

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20172607 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1218

Author(s):

Balakrishnan Nadesan ◽

Mani Madhavan Sachithananthamoorthi ◽

Sivaraman Thirumalaikumarasamy ◽

Ezhilarasu Ramalingam

Keyword(s):

Blood Pressure ◽

Family History ◽

Diastolic Blood Pressure ◽

School Children ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Cross Sectional ◽

Significant Difference ◽

History Of ◽

Family History Of Hypertension

Background: Hypertension is considered as a major health issue in developed as well as developing countries and its possible origin during childhood prompts pediatricians to routinely include measurement of blood pressure (BP) as an integral part of pediatric physical examination. The objectives of the study were to evaluate the normal range of blood pressure in adolescent school going students of 12-16 years, prevalence of hypertension and relationship of BP with variables like age, body mass index (BMI), socioeconomic status and family history of hypertension.Methods: A cross sectional study was undertaken for a period of one year in adolescent school children in age groups between 12-16 years. Detailed clinical examination was done in 1060 adolescent school children and BP was recorded in right upper limb and correlation of BP with BMI, family history of hypertension and diabetes were studied.Results: Mean systolic and diastolic pressure showed linear relationship with age. There was a highly statistically significant difference between mean systolic and diastolic blood pressure between lower and middle socio-economic class. Prevalence of obesity in our study was 1.13%, overweight was 7.83%. Prevalence of hypertension in obese children was 33.33% and in overweight children 18.07%. Family history of hypertension and diabetes carry a significant correlation with elevated systolic and diastolic blood pressure in adolescents.Conclusions: This study revealed that socio economic factors play a significant role in determining the blood pressure of the individual. Children of middle class have significantly elevated mean systolic pressure and mean diastolic pressure than low socio-economic groups.

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PENGARUH MASSAGE AROMATHERAPHY LAVENDER TERHADAP PERUBAHAN TEKANAN DARAH PADA IBU HAMIL DENGAN PREEKLAMPSIA DI PBM. LILIS SURYAWATI DESA SAMBONG DUKUH KECAMATAN JOMBANG KABUPATEN JOMBANG

Jurnal Ilmiah Kebidanan (Scientific Journal of Midwifery) ◽

10.33023/jikeb.v5i2.329 ◽

2019 ◽

Vol 5 (2) ◽

pp. 27-34

Author(s):

Any Isro'aini

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Diastolic Pressure ◽

Blood Pressure Reduction ◽

Systolic Pressure ◽

Pharmacological Therapy ◽

Control Group ◽

P Value ◽

Significant Difference ◽

Experimental Group

Hypertension in preeclampsia is found in pregnant women with gestational age> 20 weeks. Hypertension is defined where systolic pressure above 140 mmHg and diastolic pressure above 90 mmHg. Handling hypertension in pregnant women up to now is still using pharmacological therapy or drugs by 100%. One nonpharmacological therapy that can lower blood pressure is aromatherapy lavender massage therapy. The purpose of this study was to determine the effect of lavender aromatherapy massage on blood pressure reduction in pregnant women with preeclampsia.The design of this study used the Quasy Experiment Design with the Control Time Series Design research design, where the study used two groups divided into experimental groups and control groups. In this study both groups were pre-tested and after being given treatment in the experimental group a post-test was carried out in both groups. The research sample amounted to 50 respondents, of which 25 respondents became the experimental group and 25 became the control group. This research took place at PBM. Lilis Suryawati, Sambong village, Dukuh, Jombang District, Jombang Regency. This research was conducted from February to April 201. The results showed a significant difference between the blood pressure of the experimental group who were treated and the control group that was not treated. The systolic blood pressure of both groups p-value 0.003 and the value of Z -4.007. While diastolic blood pressure in both groups p-value 0,000 and Z value -5,559. It is expected that the midwifery profession can provide information about the importance of aromatherapy lavender massage to reduce blood pressure in pregnant women with preeclampsia, so that it can minimize the occurrence of complications in pregnant women with preeclampsia.

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Blood Pressure Screening Campaign in the Adult Population

Health Scope ◽

10.5812/jhealthscope.110707 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Seyed Farzad Jalali ◽

Mostafa Javanian ◽

Reza Ghadimi ◽

Ali Bijani ◽

Simin Mouodi

Keyword(s):

Blood Pressure ◽

Diastolic Pressure ◽

Screening Program ◽

Adult Population ◽

Systolic Pressure ◽

World Health ◽

Historical Cohort ◽

Urban Regions ◽

Significant Difference ◽

The Impact

Background: World Health Organization estimated that 1 in 4 men and 1 in 5 women have hypertension (HTN). Considering the impact of high blood pressure (BP) identification to prevent its related complications. Objectives: this study was performed to describe the first national BP screening program conducted in Babol, north of Iran. Methods: In this historical cohort carried out at Babol University of Medical Sciences, data related to the 2019 BP screening mass campaign in adult people ≥ 30 years were collected. BP less than 120/80 mm Hg was considered as normal, and mean BP ≥ 140/90 mm Hg or taking antihypertensive medication was defined as hypertension. When the systolic pressure was 120 - 139 or the diastolic pressure was 80 - 90 mm Hg, the person was classified as a prehypertensive case. Results: Totally, 220,241 adult people, with a mean age of 49.82 ± 14.26 years were screened, of whom 42,107 cases (19.1%; 95% CI: 18.95 - 19.28%) had hypertension, 112,406 cases (51.0%) had normal BP, and 65,728 cases (29.8%) were diagnosed as prehypertensive cases. After controlling for demographic covariates, the logistic regression models showed significantly higher odds of hypertension for married individuals (adjusted OR = 1.23; 95% CI: 1.19 - 1.27; P < 0.0001) and those living in urban regions (adjusted OR = 1.84; 95% CI: 1.79 - 1.88; P < 0.0001). The prevalence of hypertension showed no significant difference between men and women (P = 0.476). Conclusions: As nearly one in five adults had hypertension, and nearly 30% were diagnosed as prehypertensive individuals, a continuous BP screening program is recommended in this region. High BP was observed more in older and married cases and in people living in urban regions.

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Noninvasive measurement of systolic and diastolic blood pressure in swine

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1982.242.1.h127 ◽

1982 ◽

Vol 242 (1) ◽

pp. H127-H130 ◽

Cited By ~ 4

Author(s):

B. C. Hodgkin ◽

D. E. Burkett ◽

E. B. Smith

Keyword(s):

Blood Pressure ◽

Diastolic Blood Pressure ◽

Doppler Ultrasound ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Ulnar Artery ◽

Arterial Blood ◽

Significant Difference ◽

Sample Correlation ◽

The Difference

Arterial blood pressure was measured noninvasively using Doppler ultrasound and an occluding cuff. The subjects were 28 domestic pigs (10-49 kg) anesthetized with pentobarbital sodium (25 mg/kg). Indirect pressure measurements were made with the Doppler unit placed over the radial or the ulnar artery proximal to the carpal joint. Comparison was made with directly measured pressure to determine the reliability and reproducibility of the indirect method. Direct systolic pressures between 73 and 230 mmHg and diastolic pressures between 52 and 165 mmHg were measured. There was no significant difference between directly and indirectly measured systolic pressure (P greater than 0.20). Indirectly measured diastolic pressure tended to be lower than direct diastolic pressure, the difference by the paired t test being significant to P = 0.06. For systolic pressure the sample correlation coefficient was 0.94, and for diastolic pressure, 0.88. Both systolic and diastolic blood pressure can be accurately measured in the anesthetized pig using Doppler ultrasound and an occluding cuff.

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Use of Multiple Visits to Increase Blood Pressure Tracking Correlations in Childhood

PEDIATRICS ◽

10.1542/peds.87.5.708 ◽

1991 ◽

Vol 87 (5) ◽

pp. 708-711

Author(s):

Matthew W. Gillman ◽

Bernard Rosner ◽

Denis A. Evans ◽

Laurel A. Smith ◽

James O. Taylor ◽

...

Keyword(s):

Blood Pressure ◽

Diastolic Blood Pressure ◽

Correlation Coefficient ◽

Diastolic Pressure ◽

Pearson Correlation ◽

Systolic Pressure ◽

Pearson Correlation Coefficient ◽

Increase Blood Pressure ◽

Multiple Visit

Previous studies of childhood blood pressure have shown tracking correlations, which estimate the magnitude of association between initial and subsequent measurements, to be lower than corresponding adult values. Inasmuch as this disparity could arise from failing to account for a larger week-to-week variability in children, blood pressure was measured for 4 successive years, on four weekly visits in each year, and with three measurements at each visit, using a random-zero sphygmomanometer, in a cohort of 333 schoolchildren aged 8 through 15 at entry. Ninety percent of subjects had measurements in 1 or more years of follow-up. For all follow-up periods (1, 2, and 3 years from baseline), the Pearson correlation coefficient (r) for both systolic and diastolic blood pressure rose substantially with the number of weekly visits used to calculate each subject's yearly blood pressure (P < .0001). For systolic pressure, the 3-year r values for 1, 2, 3, and 4 visits were .45, .55, .64, and .69, respectively. For diastolic pressure (Korotkoff phase 4), the corresponding values were .28, .41, .47, and .54. These higher multiple-visit estimates of tracking approximate published adult values and raise the possibility that prediction of adult blood pressure from childhood measurements may be improved by averaging readings from multiple weekly visits.

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Comparison of Ropivacaine-Fentanyl with Bupivacaine-Fentanyl for Labour Epidural Analgesia

The Open Anesthesiology Journal ◽

10.2174/2589645802014010108 ◽

2020 ◽

Vol 14 (1) ◽

pp. 108-114

Author(s):

Kalpana Kulkarni ◽

Rahul Patil

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Epidural Analgesia ◽

Diastolic Blood Pressure ◽

Diastolic Pressure ◽

Vas Score ◽

Group I ◽

Significant Difference ◽

Labour Epidural Analgesia ◽

Group Ii

Background: Bupivacaine with opioid is commonly used for labour epidural analgesia. Ropivacaine is considered as an alternative to bupivacaine due to its lower cardiovascular complications. However, there is a controversy regarding the efficacy of these drugs as some studies suggest equivalent action, whereas others report that ropivacaine produces less motor blockade. The study aimed to compare the effect of ropivacaine-fentanyl and bupivacaine-fentanyl for labour analgesia. Materials and Methods: The prospective randomized study was performed on 60 parturients, divided into two groups of 30 subjects each. Group I received 10ml of bupivacaine 0.1% + fentanyl 2µg/ml and Group II received 10ml of ropivacaine 0.1% + fentanyl 2µg/ml by epidural catheter. Pre-anaesthetic evaluation was performed on all the participants and all were administered metoclopramide 0.25mg/kg and ondansetron 0.08-0.1mg/kg intravenously as premedication. The baseline and post anaesthesia systolic, diastolic blood pressure, heart rate, VAS score, degree of motor block, sedation and APGAR score of the baby were recorded. The data were tabulated and statistically analyzed. Results: When compared, there was no significant difference in systolic/diastolic blood pressure in two groups except at 360 min where diastolic pressure was low in group II. Significantly higher heart rate at 30 min (P=0.0003), 120 min (0.006), and 300 min (P=0.001) was observed in group I subjects. VAS score was significantly less at 180 min (P=0.019) and 300 min (P=0.019) in group II. Adverse effects such as fetal bradycardia, nausea/vomiting and hypotension observed were clinically insignificance when compared in two groups. Conclusion: Bupivacaine and ropivacaine produce an equal degree of analgesia and hemodynamic stability in 0.1% of concentration when added with 2µg/ml fentanyl . However, heart rate was well maintained with lower VAS scores in group II receiving ropivacaine. No significant difference in the side effects between the two groups. Hence, Ropivacaine can be used as a safe alternative to bupivacaine for labour epidural analgesia.

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Comparison of The Effect of Breads Containing Milled Sesame or Flaxseed on Blood Pressure of Patient in Stage I Hypertension

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v28i10.4925 ◽

2020 ◽

Author(s):

Moneyreh Modarres Mosadegh ◽

Mozhgan Modarresi ◽

Seyedeh Mahdieh Nemayandeh ◽

Masoud Mirzaei ◽

Mahdieh Jabinzadeh ◽

...

Keyword(s):

Blood Pressure ◽

Diastolic Blood Pressure ◽

Eating Habits ◽

Systolic Pressure ◽

Physical Activities ◽

Abdominal Circumference ◽

Type I ◽

Demographic Information ◽

Significant Difference ◽

Single Blind

Introduction: Flaxseed and sesame both are capable of reducing blood pressure, but no studies have been done to compare their effects on hypertension. The purpose of this study was to compare the effect of breads containing either milled sesame or flaxseed on blood pressure of patients with type I hypertension. Methods: This was a randomized, single blind clinical trial study. Demographic information was obtained from 100 eligible patients and they were randomly allocated to flaxseed or sesame groups. They received breads containing 30 g of either flaxseed or sesame for 14 weeks. Blood pressure, abdominal circumference, and BMI (body mass index) were measured at the beginning, seventh week, and at the end of study. Questionnaires regarding their eating habits and physical activities were also completed at these times. Data was analyzes by SPSS version 16 and independent sample t test and repeated measurement test. Results: Both sesame and flaxseed significantly reduced systolic and diastolic blood pressure (p=0.001) and there was no significant difference. On average, systolic pressure decreased by 9.5 mmHg with sesame and 10 mmHg with flaxseed. Likewise, diastolic blood pressure decreased by 5.05 mmHg with sesame and 5.8 mmHg with flaxseed. BMI and abdominal circumference reduced in both flaxseed (p= 0.001 and 0.001, respectively) and sesame (p=0.01 and 0.02, in order). No difference was observed between these groups. Conclusion: Both sesame and flaxseed could similarly decrease systolic and diastolic blood pressure, abdominal circumference, and BMI. Therefore, they could be used as supplements in reducing blood pressure.

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The difference in pediatric blood pressure between middle childhood and late childhood prior to dental treatment

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol25no1.15426 ◽

2018 ◽

Vol 25 (1) ◽

Author(s):

Fitri Anissa Syaimima Syaiful Azim ◽

Arlette Suzy Puspa Pertiwi ◽

Rosiliwati Wihardja

Keyword(s):

Blood Pressure ◽

Middle Childhood ◽

Dental Treatment ◽

Systolic Pressure ◽

The Body ◽

Late Childhood ◽

Test Analysis ◽

Mean Values ◽

Significant Difference ◽

The Difference

Every child will go through several stages in his or her life. They are different from each other as they are in the process of development of cognition, physics, emotion, and personality. For many children, a visit to the dentist can raise their anxiety. This anxiousness will lead to stress that influences the cardiovascular function in the body. The purpose of this research was to determine the difference in pediatric blood pressure between middle childhood and late childhood prior to dental treatment. This research was a clinical trial, pure experimental study. The sample consisted of 30 children within the range of 4-12 years old where they were divided into two groups of age; middle childhood (4-7 years old) and late childhood (8-12 years old). The blood pressures were measured before any dental treatment began and the values were recorded. The data were then analyzed using the One-Sample T-Test analysis. The results of blood pressure in middle childhood and late childhood were compared to the average mean values for each age group. It showed that there was a significant difference in the systolic pressure, which was found higher in the middle childhood group compared to the late childhood. From the result can be concluded that there was a difference in the pediatric blood pressure between middle childhood and late childhood prior to dental treatment.

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Hubungan kadar natrium dengan tekanan darah pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara

Jurnal e-Biomedik ◽

10.35790/ebm.4.2.2016.14862 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Rivanli Polii ◽

Joice N.A. Engka ◽

Ivonny M. Sapulete

Keyword(s):

Blood Pressure ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Extracellular Fluid ◽

Sampling Technique ◽

Cross Sectional Study ◽

Coastal Areas ◽

The Body ◽

Cross Sectional ◽

Purposive Sampling

Abstract: Sodium is an extracellular fluid cation which is the highest in amount, 35-40% sodium (Na) is found in the body skeleton. The function of sodium is the regulation of fluid volume, the regulation of fluid balance, the regulation of osmolarity, and the regulation of blood pressure. Blood pressure is the force that is needed to keep the blood flowing inside the blood vessel and circulates to reach all the tissues in human body. Blood pressure consists of two components, the systolic pressure and diastolic pressure. According to the study conducted by Riset Kesehatan Dasar on 2007, it was found that the Natuna Islands (coastal areas) has the highest prevalence of hypertension, which is 53,3%, while the highlands of Jayawijaya has the lowest prevalence of hypertension, which is 6,8%. The North Bolaang Mongondow regency, especially West Bolangitang district is an area which is conditioned around the coastal areas. Adolescents, according to WHO, are those aged 12-24 years old. This was an analytical descriptive research is conducted with a cross sectional study design. Afterward, the collected datas are processed using the help of SPSS software. The population is all of the students in SMAN 1 Bolangitang Barat, North Bolaang Mongondow regency and the samples were collected with purposive sampling technique. The results showed that the number of respondents who follow the research were 60 students, consisting 16 boy and 44 girl by spearman’s correlation statistical test.This study shows no correlation between the levels of sodium and blood pressure on adolescents in West Bolangitang district North Bolaang Mongondow regency. Conclusion: there is no correlation between the levels of sodium and blood pressure on adolescents in West Bolangitang district, North Bolaang Mongondow regency. Keywords: sodium, blood pressure, adolescent Abstrak: Natrium ialah kation terbanyak dalam cairan ekstrasel , 35-40% natrium (Na) ada didalam kerangka tubuh. Fungsi natrium untuk mengatur volume cairan, mengatur keseimbangan cairan, mengatur osmolaritas, dan mengatur tekanan darah. Tekanan darah adalah kekuatan yang diperlukan agar darah dapat mengalir di dalam pembuluh darah dan beredar mencapai semua jaringan tubuh manusia. Tekanan darah terdiri atas 2 bagian tekanan sistolik dan tekanan diastolik. Berdasarkan data yang dilakukan Riset Kesehatan Dasar tahun 2007 didapatakan bahwa prevalensi hipertensi tertinggi di Kepulauan Natuna (wilayah pantai) sebanyak 53,3 % sedangkan prevalensi hipertensi terendah di pegunungan jayawijaya sebanyak 6,8%. Kabupaten Bolaang mongondow utara khususnya Kecamatan Bolangitang Barat merupakan suatu wilayah yang terletak disekitaran pesisir pantai, Remaja menurut WHO adalah mereka yang berumur 12-24 tahun. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang. Data diolah dengan menggunakan program SPSS. Populasi ialah semua siswa/i SMAN 1 Bolangitang Barat Kabupaten Bolaang Mongondow Utara dan sampel diambil dengan cara purposive sampling. Hasil uji korelasi Spearman menunjukkan tidak terdapat hubungan antara kadar natrium dengan tekanan darah pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara. Simpulan: Tidak terdapat hubungan antara kadar natrium dengan tekanan darah pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara.Kata kunci: natrium, tekanan darah, remaja

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Abstract 278: Diet-Induced Leukocyte Telomere Shortening Correlates with Extent of Atherosclerosis

Circulation Research ◽

10.1161/res.115.suppl_1.278 ◽

2014 ◽

Vol 115 (suppl_1) ◽

Author(s):

GENESIO KARERE ◽

Shifra Birnbaum ◽

Clint Christensen ◽

Michael Mahaney ◽

John VandeBerg ◽

...

Keyword(s):

Telomere Length ◽

Pearson Correlation ◽

Single Copy ◽

Developed Countries ◽

Primate Model ◽

Telomere Shortening ◽

Atherosclerotic Lesions ◽

Potential Biomarker ◽

Significant Difference ◽

Before And After

Introduction: Cardiovascular disease, the leading cause of death in developed countries, is commonly due to atherosclerosis. Studies have demonstrated association between leukocyte telomere shortening (LTS), extent of atherosclerotic lesions and accelerated cell senescence. Further LTS is associated with dietary intake. However, efforts to link LTS, diet and extent of lesions have been unsuccessful in humans due to difficulties controlling diet in large human population studies. To begin addressing these critical issues, we controlled dietary fat (high-fat, HF) in baboons for 2yrs - a well-developed primate model of human atherosclerosis. This is the first study in primates showing correlation of LTS with both chronic HF diet and atherosclerotic lesions. Hypothesis: We hypothesized that leukocyte telomere length decreased with chronic HF diet in baboons and is correlated with extent of atherosclerotic lesions. Methods and Results: A cohort of pedigreed baboons (n=107; females=46, males=61) was fed a HF diet for 2yrs. Absolute leukocyte telomere lengths (LTL; kb/diploid genome) were quantified by qPCR before and after diet challenge. Total telomere length was calculated by computing the ratio of telomere quantity per single copy gene quantity (baboon LIPG). Mean LTL was significantly shorter after feeding baboons a HF diet for 2 yrs (paired t test, p=0.03). Baboons (n=232) maintained on a low fat diet for 2yrs showed no significant difference in LTL (p=0.47). These findings suggest that a HF diet accelerates LTS. Further we quantified the extent of atherosclerotic lesions in baboons after 2yr HF diet and found that LTL, adjusted for age and sex, were correlated with lesions in descending aorta (Pearson correlation, r=0.19; p=0.03). Interestingly this correlation was significant in females but not in males after adjusting for age (r=0.27, p=0.03). Conclusions: LTS correlates with chronic feeding with a HF diet in baboons, is significantly correlated with arterial lesions and the correlation is sex-specific. These findings suggest that LTS may be a potential biomarker of extent of atherosclerosis.

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