P4473Baseline insulin levels are associated with need for revascularization among diabetic patients with high risk vascular disease: insights from the ACCELERATE trial

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

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A cross sectional study on assessment of risk of diabetes mellitus using Indian diabetic risk score in a medical college teaching hospital

International Journal of Pharmacometrics and Integrated Biosciences ◽

10.26452/ijpib.v5i2.1292 ◽

2020 ◽

Vol 5 (2) ◽

pp. 32-40

Author(s):

Singam Sivasankar Reddy ◽

Syeda Rahath ◽

Rakshitha H N ◽

Godson K Lal ◽

Swathy S ◽

...

Keyword(s):

Diabetes Mellitus ◽

High Risk ◽

Risk Score ◽

Hospital Setting ◽

College Teaching ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Cross Sectional ◽

Patient Counselling ◽

Related Quality

The objective of the study was to evaluate the risk of diabetes mellitus in elderlywith age above 20 years in a hospital setting using Indian Diabetes risk score and to provide patient counselling regarding their life style modifications and health related quality of life among participants with high risk of developing diabetes.A total of 125 non diabetic patients were interviewed with a pre designed selfstructured questionnaire (IDRS). Participants were chosen voluntarily and a written consent was obtained before the administration of the questionnaire from individual patients. In our study we observed that out of 125 patients,males 26[59%]and 18[41%] females were at high risk, males 39[58.2%] and 28[41.8%] females were at moderate risk, males 5[35.7%] and 9[64.3%] females were at low risk of developing diabetes mellitus.

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Faculty Opinions recommendation of Improved survival in asymptomatic diabetic patients with high-risk SPECT imaging treated with coronary artery bypass grafting.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11375.468863 ◽

2006 ◽

Author(s):

Richard Underwood

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

High Risk ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Spect Imaging ◽

Diabetic Patients ◽

Bypass Grafting ◽

Artery Bypass Grafting

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Role of Inflammatory Markers in Elderly Type 2 Diabetic Patients with Mild Cognitive Impairment

Current Diabetes Reviews ◽

10.2174/1573399814666180423113341 ◽

2019 ◽

Vol 15 (3) ◽

pp. 247-253 ◽

Cited By ~ 2

Author(s):

Salwa S. Hosny ◽

Ahmed M. Bahaaeldin ◽

Mohamed S. Khater ◽

Meram M. Bekhet ◽

Hayam A. Hebah ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Elderly Patients ◽

Vascular Disease ◽

Plasma Glucose ◽

Serum Levels ◽

Diabetic Patients ◽

Hs Crp ◽

And Control

<P>Background: Type 2 diabetes (T2DM) is a risk factor for Alzheimer’s disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. </P><P> Objectives: To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI). Methods: Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were divided into Group І, 30 patients with T2DM and mild cognitive impairment, group ІІ, 30 patients with T2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They were subjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke’s Cognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c, lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP. Results: Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher (946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27 ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderly patients with MCI were significantly higher than as diabetic elderly patients without cognitive impairment and control with (P=0.005). Conclusion: Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation than other groups.</P>

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