P5259Evaluation of functional impairment and cardiac remodelling in isolated left branch bundle block using magnetic resonance imaging

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Salatzki ◽  
T Fischer ◽  
M Ochs ◽  
P Fortner ◽  
K Hirschberg ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Negative Correlation ◽  
Myocardial Strain ◽  
Lateral Wall ◽  
Left Ventricular ◽  
Lv Function ◽  
Positive Correlation ◽  
Systolic Volume ◽  
End Diastolic Volume ◽  
Qrs Duration

Abstract Introduction Left bundle-branch block (LBBB) is associated with underlying cardiovascular abnormalities, such as dilated cardiomyopathy and coronary heart disease. However, an isolated LBBB can be found in individuals without detectable cardiovascular disease. Echocardiographic studies demonstrated a reduced left ventricular (LV) ejection fraction (EF) and an increased LV cavity volume and mass in patients with isolated LBBB. Recent studies have shown larger cavity volumes (end-diastolic volume – EDV; end-systolic volume – ESV) and lower LVEF using CMR. However, there is still limited data on cardiac function, volumes and mass and the correlation between the parameters and the QRS duration (QRS) in patients with isolated LBBB. Purpose In this retrospective study LV function, volume, mass, T1-values and myocardial strain were measured and correlation between QRS duration in patients with isolated LBBB was identified using CMR. Methods Potential cases were identified from our local database, who underwent CMR during 2015–2018. We excluded patients with echocardiographic abnormalities besides abnormal septal motion or greater than a mild valve disease, known cardiovascular disease (coronary artery disease, cardiomyopathy or arrhythmia), history of potential cardiotoxic chemotherapy. We could identify 26 adults, who underwent CMR in a 1.5- or 3-Tesla scanner. LBBB was confirmed by ECG prior to CMR by a cardiologist. T1-values (MOLLI) were available in 19 patients. Myocardial strain (tissue tracking) could be performed in 23 patients. Associations were tested using Pearson's correlation analysis. Results 26 patients (age 61.5±9.6 years, 19 women, BMI 25.4 (18.2–38.1)) with isolated LBBB were included (QRS duration: 138±12ms). CMR results in the cohort revealed a reduced LVEF (53.4±3,8%) and slightly enlarged LV cavity when corrected to body-surface area (BSA) (LV-EDV/BSA: 83.7±13.8ml/m2; LV-ESV/BSA: 39.3±8.6ml/m2), when compared to normal values from the study center. There is a negative correlation between LVEF and QRS duration (r=−0.550, p<0.05) and a positive correlation between QRS duration and LV-EDV/BSA (r=0.627, p<0.05) as well as between QRS and LV-ESV/BSA (r=0.661, p<0.05). In addition, there is a positive correlation between QRS duration and myocardial mass (r=0.645, p<0.05), septal myocardial thickness (r=0.405, p<0.05) and lateral wall thickness (r=0.495, p<0.05). In addition, there is a positive correlation between LV longitudinal strain and QRS (r=0.449, p<0.05). T1-values were in normal range. There is no correlation between QRS and T1-values. Conclusion Using CMR a negative correlation between LV function and QRS duration and the positive correlation between LV volumes and QRS duration in patients with isolated LBBB could be identified. The absence of significant myocardial fibrosis with normal T1-values indicates an electromechanical dissociation rather than an underlying myocardial abnormality as an explanation for the reduced LVEF.

scholarly journals 561 Targeting septal work and viability identifies responders to cardiac resynchronization therapy

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
J Aalen ◽  
E Donal ◽  
C K Larsen ◽  
J Duchenne ◽  
M Cvijic ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Myocardial Strain ◽  
Lateral Wall ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Lv Function ◽  
Resynchronization Therapy ◽  
Entire Study ◽  
Systolic Volume ◽  
Crt Response

Abstract Funding Acknowledgements The study was supported by Center for Cardiological Innovation. Introduction Septal dysfunction is the dominant mechanism of left ventricular (LV) failure in left bundle branch block (LBBB). We hypothesize that, provided septum is viable, septal function can recover and hence LV function improve after cardiac resynchronization therapy (CRT). Purpose To determine if combined assessment of septal function and viability identifies responders to CRT. Methods In a prospective multicenter study of 200 unselected patients referred for CRT, we measured myocardial strain by speckle-tracking echocardiography and regional work by pressure-strain analysis before and 7 ± 1 months after CRT. Viability was assessed by late gadolinium enhancement cardiac magnetic resonance imaging (n = 123). CRT response was defined as ≥15% reduction in LV end-systolic volume. Results Before CRT, septal work was 258 ± 463 and LV lateral wall work 1469 ± 674 mmHg·% (p &lt; 0.0001). In CRT responders, septal work was restored to 1243 ± 495 mmHg·%, whereas non-responders showed less marked improvement (p &lt; 0.0001). The figure illustrates a typical CRT responder with negative septal work and a large difference between work in the LV lateral wall and septum (panel A). There was no septal scar (panel B) and, after 6 months with CRT, septal work was recovered (panel C). Pressure-strain loops illustrate that CRT converted inefficient septal contractions with substantial negative (wasted) work to positive work throughout systole. For the entire study population, the difference between work in the LV lateral wall and septum predicted CRT response with area under the curve (AUC) 0.75 (95% CI: 0.68-0.83) and was feasible in 98% of patients. Furthermore, septal scar predicted non-response to CRT with AUC 0.76 (95% CI: 0.65-0.86). Combining work difference and septal viability improved AUC for CRT response to 0.85 (95% CI: 0.76-0.94) (figure panel D). The AUC was similar for QRS 120-150 and &gt;150 ms. Conclusions The proposed combined approach with assessment of septal work and viability identified CRT responders with high precision. Abstract 561 Figure.

Abstract 15314: Left Ventricular Dysfunction in Children and Adolescents With Arrhythmogenic Right Ventricular Cardiomyopathy

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Paweena Chungsomprasong ◽  
Robert Hamilton ◽  
Wietske Luining ◽  
Shi-Joon Yoo ◽  
Meena Fatah ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Task Force ◽  
Myocardial Dysfunction ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Myocardial Strain ◽  
Young Patients ◽  
Left Ventricular ◽  
Lv Function ◽  
Ventricular Cardiomyopathy ◽  
End Diastolic Volume

Background: Involvement of the left ventricle (LV) is increasingly recognized in adults with arrhythmogenic right ventricular cardiomyopathy (ARVC) but it is unclear whether LV function is compromised in children with this condition. The aim of this study was examine myocardial contractility in pediatric patients with suspected ARVC. Methods: For this retrospective study, patients with a work-up for ARVC were classified into ‘no’, ‘possible’, ‘borderline’ or ‘definite’ ARVC according to the revised Task Force Criteria (rTFC). Ventricular size and function as well as LV myocardial strain and torsion were measured by cardiac magnetic resonance (CMR). Results: A total of 142 patients were enrolled, of whom 58 (41%) had no, 32 (23%) possible, 29 (20%) borderline and 23 (16%) definite ARVC. The groups were similar in age at CMR. With higher rTFC score, z scores (Z) of right ventricular (RV) ejection fraction (EF) were lower (p<0.001) while z-RV end diastolic volume (EDV) and z-LV EDV were larger (p=0.002 and 0.013, respectively). LV EF did not differ between rTFC categories. Global circumferential strain (GCS) of the LV was lower in patients in higher rTFC categories (p=0.018). Z-LVEDV correlated with z-RVEDV (r2 = 0.69, p<0.001) and z- LVEF correlated with z-RVEF (r2 = 0.55, p <0.001). Z-LVEF and z-RVEF correlated with LV GCS (r2 = 0.48, p<0.001 and r2 = 0.46, p<0.001, respectively) and torsion (r2 = 0.21, p=0.032 for both). Forty-two patients had a follow-up CMR, after a median interval of 2.6 years (0.4- 8.4). The rate of deterioration of LV or RV EF or EDV did not differ between rTFC categories. A more rapid increase of z-RVEDV was associated with a faster decline in z-RVEF (r2 = -0.383, p=0.004) and z-LVEF (r2 = -0.45, p=0.001). A decline of z-LVEF over time correlated with that of z-RVEF (r2 = 0.60, p<0.001) and z-LVEDV increase correlated with z-RVEDV increase (r2 = 0.84, p<0.001). Conclusion: LV myocardial dysfunction is present in young patients with suspected or confirmed ARVC. Quantification of myocardial mechanics with CMR may be a useful tool to detect early LV involvement in ARVC. Progressive LV dysfunction and enlargement appear to parallel those of the RV.

scholarly journals Retinal vascular changes and right ventricular structure and function: the MESA-Right Ventricle and MESA-Eye studies

2018 ◽  
Vol 9 (1) ◽  
pp. 204589401881978 ◽  
Author(s):  
Anthony C. Chyou ◽  
Barbara E.K. Klein ◽  
Ronald Klein ◽  
R. Graham Barr ◽  
Mary Frances Cotch ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Right Ventricle ◽  
Retinal Vessel ◽  
Left Ventricular ◽  
Inverse Association ◽  
Systolic Volume ◽  
End Diastolic Volume ◽  
Retinal Arterioles ◽  
Mri Scans ◽  
And Function

Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM), end-diastolic volume (RVEDV), end-systolic volume (RVESV), stroke volume (RVSV), and ejection fraction (RVEF) were assessed using cardiac magnetic resonance imaging (MRI) scans of 4204 participants without clinical cardiovascular disease at the baseline examination; retinal photography was obtained at the second examination. Mean diameters of retinal arterioles and venules were measured and summarized as central retinal vein and artery equivalents (“veins” and “arteries,” respectively). After adjusting for covariates, wider veins were associated with greater RVEDM and RVEDV in women ( P = 0.04 and P = 0.02, respectively), whereas there was an inverse association with RVEDV in men ( P = 0.02). In both sexes, narrower arteries were associated with lower RVEDM ( P < 0.001 in women and P = 0.002 in men) and smaller RVEDV ( P < 0.001 in women and P = 0.04 in men) in adjusted models. Narrower arteries were also associated with lower RVEF in men but this was of borderline significance after adjusting for the LVEF ( P = 0.08). Wider retinal venular diameter was associated with sex-specific changes in RVEDM and RVEDV in adults without clinical cardiovascular disease. Narrower retinal arteriolar diameter was associated with significantly lower RVEDM and smaller RVEDV in both sexes.

scholarly journals Agreement in Left Ventricular Function Measured by Echocardiography and Cardiac Magnetic Resonance in Patients With Chronic Coronary Total Occlusion

2021 ◽  
Vol 8 ◽  
Author(s):  
Jiahui Li ◽  
Lijun Zhang ◽  
Yueli Wang ◽  
Huijuan Zuo ◽  
Rongchong Huang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Pearson Correlation ◽  
Left Ventricular ◽  
Lv Function ◽  
Total Occlusion ◽  
Systolic Volume ◽  
End Diastolic Volume ◽  
End Systolic Volume ◽  
The Difference ◽  
Ventricular Motion

Aims: To determine the agreement between two-dimensional transthoracic echocardiography (2DTTE) and cardiovascular magnetic resonance (CMR) in left ventricular (LV) function [including end-systolic volume (LVESV), end-diastolic volume (LVEDV), and ejection fraction (LVEF)] in chronic total occlusion (CTO) patients.Methods: Eighty-eight CTO patients were enrolled in this study. All patients underwent 2DTTE and CMR within 1 week. The correlation and agreement of LVEF, LVESV, and LVEDV as measured by 2DTTE and CMR were assessed using Pearson correlation, Kappa analysis, and Bland–Altman method.Results: The mean age of patients enrolled was 57 ± 10 years. There was a strong correlation (r = 0.71, 0.90, and 0.80, respectively, all P &lt; 0.001) and a moderately strong agreement (Kappa = 0.62, P &lt; 0.001) between the two modalities in measurement of LV function. The agreement in patients with EF ≧50% was better than in those with an EF &lt;50%. CTO patients without echocardiographic wall motion abnormality (WMA) had stronger intermodality correlations (r = 0.84, 0.96, and 0.87, respectively) and smaller biases in LV function measurement.Conclusions: The difference in measurement between 2DTTE and CMR should be noticed in CTO patients with EF &lt;50% or abnormal ventricular motion. CMR should be considered in these conditions.

scholarly journals Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Zhi Zuo ◽  
Anne Subgang ◽  
Alireza Abaei ◽  
Wolfgang Rottbauer ◽  
Detlef Stiller ◽  
...  
Keyword(s):  
Cardiac Mri ◽  
Left Ventricular ◽  
Cine Mri ◽  
Lv Function ◽  
Longitudinal Assessment ◽  
Systolic Volume ◽  
Adult Mice ◽  
End Diastolic Volume ◽  
Standardized Protocol ◽  
End Systolic Volume

The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength. A group of adult mice (n=5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters.

scholarly journals Darbepoetin-α prevents progressive left ventricular dysfunction and remodeling in nonanemic dogs with heart failure

2008 ◽  
Vol 295 (6) ◽  
pp. H2475-H2482 ◽  
Author(s):  
Sharad Rastogi ◽  
Makoto Imai ◽  
Victor G. Sharov ◽  
Sudhish Mishra ◽  
Hani N. Sabbah
Keyword(s):  
Heart Failure ◽  
Caspase 3 ◽  
Hypoxia Inducible Factor ◽  
Left Ventricular ◽  
Stem Cell Marker ◽  
Lv Function ◽  
Systolic Volume ◽  
Beneficial Effects ◽  
End Diastolic Volume ◽  
End Systolic Volume

In anemic patients with heart failure (HF), erythropoietin-type drugs can elicit clinical improvement. This study examined the effects of chronic monotherapy with darbepoetin-α (DARB) on left ventricular (LV) function and remodeling in nonanemic dogs with advanced HF. HF [LV ejection fraction (EF) ∼25%] was produced in 14 dogs by intracoronary microembolizations. Dogs were randomized to once a week subcutaneous injection of DARB (1.0 μg/kg, n = 7) or to no therapy (HF, n = 7). All procedures were performed during cardiac catheterization under general anesthesia and under sterile conditions. LV end-diastolic volume (EDV), end-systolic volume (ESV), and EF were measured before the initiation of therapy and at the end of 3 mo of therapy. mRNA and protein expression of caspase-3, hypoxia inducible factor-1α, and the bone marrow-derived stem cell marker c-Kit were determined in LV tissue. In HF dogs, EDV and ESV increased and EF decreased after 3 mo of followup. Treatment with DARB prevented the increase in EDV, decreased ESV, and increased EF. DARB therapy also normalized the expression of HIF-1α and active caspase-3 and enhanced the expression of c-Kit. We conclude that chronic monotherapy with DARB prevents progressive LV dysfunction and dilation in nonanemic dogs with advanced HF. These results suggest that DARB elicits beneficial effects in HF that are independent of the presence of anemia.

Viability and functional recovery after chronic total occlusion percutaneous coronary intervention

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R De Winter ◽  
S.P Schumacher ◽  
H Everaars ◽  
W.J Stuijfzand ◽  
P.A Van Diemen ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Functional Recovery ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Lv Function ◽  
Wall Thickening ◽  
Total Occlusion ◽  
Systolic Volume ◽  
End Diastolic Volume ◽  
Percutaneous Coronary

Abstract Background Current guidelines advocate viability assessment to guide percutaneous coronary intervention (PCI) of chronic coronary total occlusions (CTO). Purpose Aim of the present study was to evaluate viability as well as global and regional functional recovery after successful CTO PCI using quantitative cardiac magnetic resonance (CMR) imaging. Methods 132 patients with sequential CMR at baseline and 3-months after successful CTO PCI were prospectively recruited between 2013 and 2018. Segmental wall thickening (SWT) and percentage late gadolinium enhancement (LGE) were quantitatively measured per segment. Viability was defined as dysfunctional myocardium (&lt;2.84mm SWT) with no or limited scar (≤50% LGE). Results Significant improvements in left ventricular (LV) ejection fraction (from 48.1±11.8 to 49.5±12.1%, p&lt;0.01), LV end-diastolic volume (from 99.1±31.8 to 95.7±30.2ml, p&lt;0.01), and LV end-systolic volume (from 54.4±30.5 to 51.2±29.3ml, p&lt;0.01) were observed after CTO PCI. CTO segments with viability (N=216, (31%)) demonstrated a significantly higher increase in SWT (0.80±1.39mm) compared to CTO segments with pre-procedural preserved function (N=456 (65%), 0.07±1.43mm, p&lt;0.01) or extensive scar (LGE &gt;50%, N=26 (4%), −0.08±1.09mm, p&lt;0.01). Improvement in SWT was comparable between segments with viability if further stratified to 0, &gt;0–25, and &gt;25–50% hyperenhancement (p=0.94). Patients with ≥2 CTO segments viability showed more SWT increase in the CTO territory compared to patients with 0–1 segment viability (0.49±0.93 vs. 0.12±0.98mm, p=0.03). Conclusions Improvements in LV function and volumes were significant but modest following CTO PCI. Detection of dysfunctional myocardial segments without extensive scar (≤50% LGE) as a marker for viability may aid in identifying subjects with significant regional functional recovery after CTO PCI. Funding Acknowledgement Type of funding source: None

scholarly journals The recent advances, drawbacks, and the future directions of CMRI in the diagnosis of IHD

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Moram A. Fagiry ◽  
Ikhlas Abdelaziz ◽  
Rob Davidson ◽  
Mustafa Z. Mahmoud
Keyword(s):  
Systolic Function ◽  
Diagnostic Value ◽  
Left Ventricular ◽  
Lv Function ◽  
Conventional Coronary Angiography ◽  
Future Directions ◽  
Systolic Volume ◽  
End Diastolic Volume ◽  
Recent Advances ◽  
The Future

AbstractIschemic heart disease (IHD), also known as coronary artery disease (CAD), is a leading cause of morbidity and mortality in adults. The aims of this research were to study the recent advances on the prognostic and diagnostic value, drawbacks, and the future directions of cardiac magnetic resonance imaging (CMRI) in the diagnosis of IHD. One hundred patients with IHD who had been clinically diagnosed were enrolled in this study prospectively. CMRI; Siemens Magnetom Sola 1.5 T MRI scanner was used to examine the patients. To confirm the diagnosis, conventional coronary angiography was used. CMRI revealed that the left ventricular (LV) volumes and systolic function of male and female patients differed by age decile were 28.9 ± 3.5%; 32 ± 1.7%, 53.3 ± 11.2; 58 ± 6.6 ml, 100.6 ± 7.1; 98.3 ± 14.7 bpm, 5.4 ± 1.4; 5.8 ± 1.5 L/min, 189 ± 14.3; 180 ± 10.9 ml, and 136 ± 3.1; 123 ± 4.4 ml for the left ventricle ejection fraction (LVEF), stroke volume (SV), heart rate, cardiac output, end diastolic volume (EDV), and end systolic volume (ESV), respectively. CMRI has sensitivity, specificity, and accuracy of 97%, 33.33%, and 95.15%, respectively. Finally, CMRI provides a comprehensive assessment of LV function, myocardial perfusion, and viability, as well as coronary anatomy.

Impaired subendocardial contractile myofiber function in asymptomatic aged humans, as detected using MRI

2006 ◽  
Vol 291 (4) ◽  
pp. H1573-H1579 ◽  
Author(s):  
Joost Lumens ◽  
Tammo Delhaas ◽  
Theo Arts ◽  
Brett R. Cowan ◽  
Alistair A. Young
Keyword(s):  
Left Ventricular ◽  
Lv Function ◽  
Aged Group ◽  
Systolic Volume ◽  
Local Loss ◽  
Functional Changes ◽  
End Diastolic Volume ◽  
Tissue Tagging ◽  
End Systolic Volume ◽  
Aged Subjects

With aging, structural and functional changes occur in the myocardium without obvious impairment of systolic left ventricular (LV) function. Transmural differences in myocardial vulnerability for these changes may result in increase of transmural inhomogeneity in contractile myofiber function. Subendocardial fibrosis and impairment of subendocardial perfusion due to hypertension might change the transmural distribution of contractile myofiber function. The ratio of LV torsion to endocardial circumferential shortening (torsion-to-shortening ratio; TSR) during systole reflects the transmural distribution of contractile myofiber function. We investigated whether the transmural distribution of systolic contractile myofiber function changes with age. Magnetic resonance tissue tagging was performed to derive LV torsion and endocardial circumferential shortening. TSR was quantified in asymptomatic young [age 23.2 (SD 2.6) yr, n = 15] and aged volunteers [age 68.8 (SD 4.4) yr, n = 16]. TSR and its standard deviation were significantly elevated in the aged group [0.47 (SD 0.12) aged vs. 0.34 (SD 0.05) young; P = 0.0004]. In the aged group, blood pressure and the ratio of LV wall mass to end-diastolic volume were mildly elevated but could not be correlated to the increase in TSR. There were no significant differences in other indexes of systolic LV function such as end-systolic volume and ejection fraction. The elevated systolic TSR in the asymptomatic aged subjects suggests that aging is associated with local loss of contractile myofiber function in the subendocardium relative to the subepicardium potentially caused by subclinical pathological incidents.

scholarly journals Agreement in left ventricular function measured by echocardiography and cardiac magnetic resonance in patients with chronic total occlusion

2020 ◽  
Author(s):  
Jiahui Li ◽  
Lijun Zhang ◽  
Yueli Wang ◽  
Huijuan Zuo ◽  
Rongchong Huang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Pearson Correlation ◽  
Left Ventricular ◽  
Lv Function ◽  
Total Occlusion ◽  
Systolic Volume ◽  
End Diastolic Volume ◽  
End Systolic Volume ◽  
The Difference ◽  
Ventricular Motion

Abstract Background: To determine the agreement between two-dimensional transthoracic echocardiography (2DTTE) and cardiovascular magnetic resonance (CMR) in left ventricular (LV) function in CTO patients: including end-systolic volume (LVESV), end-diastolic volume (LVEDV), and ejection fraction (LVEF).Methods: Eighty-eight CTO patients were enrolled in this study. All patients underwent 2DTTE and CMR within one week of each other. The correlation and agreement of LVEF, LVESV and LVEDV as measured by 2DTTE and CMR were assessed using Pearson correlation, Kappa analysis and Bland-Altman method. Results: The mean age of patients enrolled was 57 ± 10 years. There was a strong correlation (r=0.71, 0.90 and 0.80, respectively, all P<0.001) and a moderately strong agreement (Kappa=0.62, P<0.001) between the two modalities in measurement of LV function. The agreement in patients with EF≧50% was better than in those with an EF <50%. CTO patients without echocardiographic WMA had stronger intermodality correlations (r=0.84, 0.96, and 0.87, respectively) and smaller biases in LV function measurement.Conclusions: The difference in measurement between 2DTTE and CMR should be noticed in CTO patients with EF<50% or abnormal ventricular motion. CMR should be considered in these conditions.Trial registration: Retrospectively registered

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