P2665An observational study assessing the impact of a cardiac arrest centre on patient outcome

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T N Jones ◽  
M D Kelham ◽  
K S Rathod ◽  
O Guttmann ◽  
A Proudfoot ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Hospital Mortality ◽  
The United States ◽  
Demographic Characteristics ◽  
Admission Criteria ◽  
Before And After ◽  
Cardiac Centre ◽  
The Impact ◽  
Hospital Cardiac Arrest ◽  
Baseline Demographic

Abstract Background Out-of-hospital cardiac arrest (OHCA) is a major cause of death in Europe and the United States. There has been recent literature to suggest that the centralisation of OHCA services may benefit patient outcomes. In 2015, two major tertiary cardiac centres in the UK agglomerated to form a large dedicated tertiary cardiac centre. The previous centre had strict criteria on which OHCA patients could be admitted, with the vast majority of cases being STEMI-related. After the agglomeration, admission criteria were relaxed to include all OHCA cases within geographic range with a suspected cardiac cause. Purpose This study aimed to compare the short-term mortality of patients admitted with an OHCA to a tertiary cardiac centre before-and-after a major agglomeration of services had taken place and admission criteria had been relaxed. Methods We retrospectively analysed the data of patients admitted before and after agglomeration (2015) with OHCA who were resuscitated via conventional cardiopulmonary resuscitation. Baseline demographic characteristics were recorded, along with factors relating to the cardiac arrest. Primary endpoint was in-hospital mortality. Results A total of 650 patients (189 before and 461 after the agglomeration) with an OHCA between 2013 and 2018 were analysed. Patients admitted pre merger were older (67.7 vs 62.4 years, p=0.022), otherwise there were similar baseline demographic characteristics between patients admitted before and after the agglomeration (pre vs post) in terms of gender (74.4% vs 75.9% male, p=0.827), ethnicity (66.7% vs 58.9% Caucasian, p=0.588) and existing coronary artery disease (22.8% vs 22.7%, p=0.432). There were also similar peri-arrest characteristics, with a comparable number of patients having a non-shockable rhythm (15.4% vs 25.4%, p=0.164) and similar total downtimes between the groups (33 vs 32.3 mins, p=0.883). Interestingly there was a decrease in those with cardiogenic shock on arrival (92.3% vs 57.0%, p=0.0001) and fewer patients with an ejection fraction <30% (63.2 vs 38.7%, p=0.0003) post-agglomeration. There was a greater proportion of non-ACS-related OHCA admission after the agglomeration (16.9% vs 24.1%, p=0.047) and a corresponding decrease in those admitted with a STEMI (81.5% vs 62.3%, p=0.032) and those treated with PCI (77.8% vs 54.0%, p=0.034). Despite this, in-hospital mortality was lower after the agglomeration (69.7% vs 47.1%, p=0.019), which persisted after adjustment for the previously described demographic and arrest-related characteristics using stepwise logistic regression (p=0.036) between the two groups. Conclusion Despite an increase in non-ACS-related-OHCA cases, the formation of a centralised invasive heart centre was associated with improved survival in OHCA patients. This suggests there may be a benefit for an out-of-hospital cardiac arrest-centre model of care, supporting a centralised strategy for immediate post-resuscitation care in OHCA patients. Acknowledgement/Funding None

scholarly journals An observational study assessing the impact of a cardiac arrest centre on patient outcomes after out-of-hospital cardiac arrest (OHCA)

2020 ◽  
Vol 9 (4_suppl) ◽  
pp. S67-S73
Author(s):  
Matthew Kelham ◽  
Timothy N Jones ◽  
Krishnaraj S Rathod ◽  
Oliver Guttmann ◽  
Alastair Proudfoot ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Cardiac Arrest ◽  
Hospital Mortality ◽  
Coronary Intervention ◽  
Stepwise Logistic Regression ◽  
Coronary Syndrome ◽  
Before And After ◽  
The Impact ◽  
Hospital Cardiac Arrest ◽  
Baseline Demographic

Background: Out-of-hospital cardiac arrest (OHCA) is a major cause of death worldwide. Recent guidelines recommend the centralisation of OHCA services in cardiac arrest centres to improve outcomes. In 2015, two major tertiary cardiac centres in London merged to form a large dedicated tertiary cardiac centre. This study aimed to compare the short-term mortality of patients admitted with an OHCA before-and-after the merger of services had taken place and admission criteria were relaxed, which led to managing OHCA in higher volume. Methods: We retrospectively analysed the data of OHCA patients pre- and post-merger. Baseline demographic and medical characteristics were recorded, along with factors relating to the cardiac arrest. The primary endpoint was in-hospital mortality. Results: OHCA patients ( N =728; 267 pre- and 461 post-merger) between 2013 and 2018 were analysed. Patients admitted pre-merger were older (65.0 vs. 62.4 years, p=0.027), otherwise there were similar baseline demographic and peri-arrest characteristics. There was a greater proportion of non-acute coronary syndrome-related OHCA admission post-merger (10.1% vs. 23.4%, p=0.0001) and a corresponding decrease in those admitted with ST-elevation myocardial infarction (80.2% vs. 57.0%, p=0.0001) and those treated with percutaneous coronary intervention (78.8% vs. 54.0%, p=0.0001). Despite this, in-hospital mortality was lower post-merger (63.7% vs. 44.3%, p=0.0001), which persisted after adjustment for demographic and arrest-related characteristics using stepwise logistic regression ( p=0.036) between the groups. Conclusion: Despite an increase in non-acute coronary syndrome-related OHCA cases, the formation of a centralised invasive heart centre was associated with improved survival in OHCA patients. This suggests there may be a benefit of a cardiac arrest centre model of care.

scholarly journals In-hospital Death Following Successful OHCA Resuscitation: Causes of early and late mortality and the impact of withdrawal of care

2020 ◽  
Author(s):  
Shu Li ◽  
Christos Lazaridis ◽  
Fernando D. Goldenberg ◽  
Atman P. Shah ◽  
Katie Tataris ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Hospital Mortality ◽  
Human Study ◽  
Early Death ◽  
Organ Injury ◽  
Neurological Injury ◽  
Hospital Death ◽  
Categorization System ◽  
The Impact ◽  
Hospital Cardiac Arrest

AbstractObjectiveIn-hospital mortality in patients successfully resuscitated following out-of-hospital cardiac arrest (OHCA) is high. The factors and timings of these deaths is not well known. To better understand in hospital post-OHCA mortality we developed a novel categorization system of in hospital death and studied the factors and timings associated with these deaths.MethodsThis was a single-centered retrospective observational human study in adult non-traumatic OHCA patients in a university affiliated hospital. Through an expert consensus process, a novel classification system of hospital death was developed.ResultsTwo hundred and forty-one patients were enrolled in the study. Death was categorized as due to withdrawal of life sustaining treatment (WOLST) 159 (66.0%), recurrent in-hospital cardiac arrest 51 (21.1%), or due to neurological criteria 31 (12.9%). Subcategorization of factors associated with WOLST into 7 categories was done by defined criteria. Inter-reliability of this system was 0.858. 50% of WOLST decisions were due to neurological injury. Early death (≤ 3 days) was associated with recurrent in-hospital cardiac arrest and WOLST in the setting of refractory shock or multi-organ injury. Late in-hospital death (> 3 days) was primarily due to WOLST decisions in the setting of isolated neurological injury.ConclusionsOHCA in hospital mortality occurred in a bimodal pattern with early deaths due to recurrent arrest and multiorgan injury while late deaths were due to isolated neurological injury. The majority of deaths occurred in the setting of WOLST decisions. Further study of the influence of these factors on post OHCA survival are needed.

P1709A comprehensive meta-analysis on the impact of cardiopulmonary resuscitation guideline changes on outcomes after in- and out-of-hospital cardiac arrest

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Nas ◽  
R Te Grotenhuis ◽  
J L Bonnes ◽  
J Thannhauser ◽  
J Furlaneto ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Positive Impact ◽  
Guideline Development ◽  
Meta Analysis ◽  
Spontaneous Circulation ◽  
Improved Outcomes ◽  
Resuscitation Guidelines ◽  
Before And After ◽  
The Impact ◽  
Hospital Cardiac Arrest

Abstract Background Studies on international registries report improved outcomes after in- and out-of-hospital cardiac arrest over the last decade. The 2015 resuscitation guidelines incorporate initiatives derived from both guidelines 2005 and 2010, respectively. Purpose In order to assess the impact of these respective updates, we aim to provide the most comprehensive quantitative summary of comparative studies that specifically focused on outcomes before and after guideline updates. Methods PubMed, Web-of-Science, Embase and The Cochrane Libraries were searched for studies that compared clinical outcomes of patients resuscitated in the period before and after introduction of guidelines 2010 and 2005, respectively. Results For studies on guidelines 2010 vs. 2005 (n=6; 1,002 patients), the pooled estimate did not indicate a difference [OR 1.29 (95% CI 0.74–2.25) p=0.372] in return of spontaneous circulation (ROSC). For survival to discharge a significant benefit [OR 1.70 (1.01–2.84) p=0.045] was observed for patients resuscitated according to guideline 2010. As for guidelines 2005 vs. 2000 (n=23; 40,859 patients), the pooled estimates for ROSC, survival to admission, to discharge and favourable neurologic outcome consistently indicated benefit for guideline 2005 [OR 1.21 (1.04–1.42) p=0.014; OR 1.34 (1.09–1.65) p=0.005; OR 1.46 (1.25–1.70) p<0.001; OR 1.35 (1.01–1.81) p=0.040]. Conclusions This comprehensive meta-analysis quantifies the positive impact of resuscitation guideline updates on outcomes and supports the current way of guideline development. While there is robust evidence for improved overall outcomes after guidelines 2005, the 2010 guideline benefit was restricted to improved survival to discharge. In terms of quality control, our findings call for continued initiatives to monitor outcomes after guideline updates. Acknowledgement/Funding None

scholarly journals The Impact of Hypoxic Hepatitis on Clinical Outcomes after Extracorporeal Cardiopulmonary Resuscitation

2020 ◽  
Vol 9 (9) ◽  
pp. 2994
Author(s):  
Yun Im Lee ◽  
Min Goo Kang ◽  
Ryoung-Eun Ko ◽  
Taek Kyu Park ◽  
Chi Ryang Chung ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Renal Replacement Therapy ◽  
Cardiopulmonary Resuscitation ◽  
Hospital Mortality ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Clinical Outcomes ◽  
Hypoxic Hepatitis ◽  
The Impact ◽  
Hospital Cardiac Arrest

Although there have been several reports regarding the association between hypoxic hepatic injury and clinical outcomes in patients who underwent conventional cardiopulmonary resuscitation (CPR), limited data are available in the setting of extracorporeal CPR (ECPR). Patients who received ECPR due to either in- or out-of-hospital cardiac arrest from May 2004 through December 2018 were eligible. Hypoxic hepatitis (HH) was defined as an increased aspartate aminotransferase or alanine aminotransferase level to more than 20 times the upper normal range. The primary outcome was in-hospital mortality. In addition, we assessed poor neurological outcome defined as a Cerebral Performance Categories score of 3 to 5 at discharge and the predictors of HH occurrence. Among 365 ECPR patients, 90 (24.7%) were identified as having HH. The in-hospital mortality and poor neurologic outcomes in the HH group were significantly higher than those of the non-HH group (72.2% vs. 54.9%, p = 0.004 and 77.8% vs. 63.6%, p = 0.013, respectively). As indicators of hepatic dysfunction, patients with hypoalbuminemia (albumin < 3 g/dL) or coagulopathy (international normalized ratio > 1.5) had significantly higher mortalities than those of their counterparts (p = 0.005 and p < 0.001, respectively). In multivariable logistic regression, age and acute kidney injury requiring continuous renal replacement therapy were predictors for development of HH (p = 0.046 and p < 0.001 respectively). Furthermore age, arrest due to ischemic heart disease, initial shockable rhythm, out-of-hospital cardiac arrest, lowflow time, continuous renal replacement therapy, and HH were significant predictors for in-hospital mortality. HH was a frequent complication and associated with poor clinical outcomes in ECPR patients.

scholarly journals P075: Impact of pit-crew CPR following out-of-hospital cardiac arrest in Saskatoon

CJEM ◽  
2016 ◽  
Vol 18 (S1) ◽  
pp. S103-S103
Author(s):  
S. Netherton ◽  
A. Leach ◽  
T. Hillier ◽  
R. Woods
Keyword(s):  
Cardiac Arrest ◽  
Survival Rates ◽  
The United States ◽  
Spontaneous Circulation ◽  
Full Data ◽  
Data Set ◽  
Automated External Defibrillators ◽  
Before And After ◽  
Collection Phase ◽  
Hospital Cardiac Arrest

Introduction: Between 1980 and 2008, survival rates following an out-of-hospital cardiac arrest (OHCA) have remained unchanged, averaging 7.6%. Despite the use of new and emerging technologies, new medications, and automated external defibrillators, survival remains low. Recently, a new focus in cardiopulmonary resuscitation (CPR) has shown dramatic improvements in survival post OHCA. This new model, called pit-crew CPR, focuses on minimizing interruptions in chest compressions and has each team member playing a specific role in the resuscitation, akin to the pit-crew of a car race. Certain districts in the United States and Canada have adopted the pit-crew, or a similar, high quality, maximum time-on-chest CPR model, with much success. We aim to determine whether the pit-crew model of CPR improves survival following OHCA in Saskatoon, SK. Methods: In Saskatoon, EMS and Fire crews respond to OHCAs and have been exclusively using the pit-crew model of CPR since Jan 1st, 2015. This study is a before and after retrospective chart analysis, comparing two groups - pre and post implementation of the pit-crew CPR model. The primary outcome is survival to hospital discharge post OHCA. Secondary outcomes include survival to admission and any return of spontaneous circulation (as per the Utstein definition). The inclusion criteria are patients >18 years old with a witnessed OHCA of presumed cardiac origin who receive CPR by EMS/Fire within the Saskatoon Ambulance service (MD Ambulance) catchment area. Patients were excluded if the OHCA was unwitnessed, or if there was a presumed non-cardiac cause for the arrest, e.g. trauma. Results: In the pre-pit-crew model cohort, between Jan 1st, 2011 and Sept 31st, 2014, 455 OHCAs were analyzed. In this cohort 10.5% survived to discharge, 31.9% survived to admission and ROSC was achieved in 39% of cases. The percentage of patients with initial rhythms of VF/VT, asystole or PEA were 28.5% (26%), 41.5% (1%) and 23.6% (10%) respectively, with survival to discharge shown in parentheses. The post-pit-crew cohort is still in the data collection phase. Conclusion: Our pre-pit crew cohort data has been collected and analyzed. With ongoing data acquisition for the post-pit crew cohort, we hope to have the full data set complete by the end of 2018. It will be at that time when we are able to determine whether the pit-crew model of CPR improves survival to discharge following OHCA in Saskatoon.

Abstract 315: Community Characteristics Associated With Out of Hospital Cardiac Arrest Mortality: The Intersection of Urbanicity, Poverty, and Race

Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
John Barbe ◽  
David F Gaieski ◽  
Alexis M Zebrowski ◽  
David G Buckler ◽  
Marissa N Lang ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Hospital Mortality ◽  
Urban Areas ◽  
Census Data ◽  
Community Characteristics ◽  
Suburban Communities ◽  
County Poverty ◽  
Black Populations ◽  
The Impact ◽  
Hospital Cardiac Arrest

Introduction: Variation in survival for out-of-hospital cardiac arrest (OHCA) has been described, but the intersection of urbanicity, race, and poverty and the impact on OHCA outcomes remains unclear. We sought to test whether rurality was associated with increased in-hospital mortality compared to urban and suburban communities when accounting for differences in poverty and race. Methods: We performed a retrospective analysis using 2013-2014 Medicare claims for inpatient stays originating in the emergency department. OHCA Patients (≥65 years) were identified by ICD-9-CM diagnosis code. Urbanicity was assigned based on county of residence using Rural-Urban Continuum Codes. Census data were used for county poverty and racial composition measures. Multivariate logistic regression was used to estimate the association of in-hospital mortality with urbanicity, percent of resident population in poverty, and percent black residency. Also included were individual, hospital, and community characteristics. Results: A total of 246,736 OHCA cases were identified of which 53% were male, 23% non-white, and 36% >75 years. Survival to discharge was 22%. Over 95% of OHCA patients resided in urban (85%) or suburban (11%) areas. Predicted probabilities of death (Figure) were lowest in suburban communities with moderate poverty and small black populations (0.76, CI 0.75-0.76) and highest in urban areas with moderate poverty and larger black populations (0.80, CI 0.80-0.81). All areas with high poverty and larger black populations had similar predicted probabilities (0.77-0.78), regardless of urbanicity. Conclusions: Suburban residence was associated with lower odds of mortality, even in communities with high levels of poverty. Communities with moderate poverty showed the greatest spread of outcomes in all 3 urbanicity categories. Further work should explore access to care, social determinants of health, and hospital factors that lead to the observed disparities.

scholarly journals Air pollution and out-of-hospital cardiac arrest risk

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L Moderato ◽  
D Lazzeroni ◽  
A Biagi ◽  
T Spezzano ◽  
B Matrone ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cardiac Arrest ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
External Temperature ◽  
Pm 2.5 ◽  
Pm10 And Pm2.5 ◽  
Short Term Exposure ◽  
The Impact ◽  
Hospital Cardiac Arrest

Abstract Introduction Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide; it accounts for up to 50% of all cardiovascular deaths.It is well established that ambient air pollution triggers fatal and non-fatal cardiovascular events. However, the impact of air pollution on OHCA is still controversial. The objective of this study was to investigate the impact of short-term exposure to outdoor air pollutants on the incidence of OHCA in the urban area of Piacenza, Italy, one of the most polluted area in Europe. Methods From 01/01/2010 to 31/12/2017 day-by-day PM10 and PM2.5 levels, as well as climatic data, were extracted from Environmental Protection Agency (ARPA) local monitoring stations. OHCA were extracted from the prospective registry of Community-based automated external defibrillator Cardiac arrest “Progetto Vita”. OHCA data were included: audio recordings, event information and ECG tracings. Logistic regression analysis was used to estimate the association between the risk of OHC, expressed as odds ratios (OR), associated with the PM10 and PM2.5 levels. Results Mean PM10 levels were 33±29 μg/m3 and the safety threshold (50 μg/m3) recommended by both WHO and Italian legislation has been exceeded for 535 days (17.5%). Mean PM 5 levels were 33±29 μg/m3. During the follow-up period, 880 OHCA were recorded on 750 days; the remaining 2174 days without OHCA were used as control days. Mean age of OHCA patients was 76±15 years; male gender was prevalent (55% male vs 45% female; &lt;0.001). Concentration of PM10 and PM 2.5 were significantly higher on days with the occurrence of OHCA (PM10 levels: 37.7±22 μg/m3 vs 32.7±19 μg/m3; p&lt;0.001; PM 2.5 levels: 26±16 vs 22±15 p&lt;0.001). Risk of OHCA was significantly increased with the progressive increase of PM10 (OR: 1.009, 95% CI 1.004–1.015; p&lt;0.001) and PM2.5 levels (OR 1.012, 95% CI 1.007–1.017; p&lt;0.001). Interestingly, the above mentioned results remain independent even when correct for external temperature or season (PM 2.5 levels: p=0.01 – PM 10 levels: p=0.002), Moreover, dividing PM10 values in quintiles, a 1.9 fold higher risk of cardiac arrest has been showed in the highest quintile (Highest quintile cut-off: &lt;48μg/m3) Conclusions In large cohort of patients from a high pollution area, both PM10 and PM2.5 levels are associated with the risk of Out-of-hospital cardiac arrest. PM10 and PM2.5 levels and risk of OHCA Funding Acknowledgement Type of funding source: None

In-hospital mortality after out-of-hospital cardiac arrest

The Lancet ◽  
1995 ◽  
Vol 346 (8972) ◽  
pp. 417-421 ◽  
Author(s):  
N.R Grubb ◽  
K.A.A Fox ◽  
R.A Elton
Keyword(s):  
Cardiac Arrest ◽  
Hospital Mortality ◽  
Hospital Cardiac Arrest

Abstract 138: A Before and After Study of Active Compression Decompression Cardiopulmonary Resuscitation With the Impedance Threshold Device in a Large Urban Pre-Hospital System

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_2) ◽  
Author(s):  
Johanna C Moore ◽  
Michael Grahl ◽  
Tracy Marko ◽  
Ariel Blythe-Reske ◽  
Amber Lage ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Response Time ◽  
First Responders ◽  
The United States ◽  
Threshold Device ◽  
Before And After ◽  
Mechanical Cpr ◽  
Impedance Threshold Device ◽  
Before And After Study

Introduction: Active Compression Decompression cardiopulmonary resuscitation with an impedance threshold device (ACD+ITD CPR) is available for use in the United States. However, little is known regarding integration of this CPR system into a large urban prehospital system with short response times, routine use of mechanical CPR and ITD, and transport of patients to cardiac arrest centers. This is an ongoing before and after study of the implementation of ACD+ITD CPR in non-traumatic cardiac arrest cases 6 months pre and post protocol change. Hypothesis: Neurologically intact rates of survival, defined by Cerebral Performance Category (CPC) score of 1 or 2, would be higher post protocol. Methods: Basic life support first responders (n = 420) and paramedics (n = 207) underwent training including didactic and hands-on sessions to learn ACD+ITD CPR. The protocol included ACD+ITD CPR initially, with the option to transition to mechanical CPR at 15 minutes. Demographics, response time, CPR duration, initial rhythm, signs of perfusion during CPR, and return of spontaneous circulation (ROSC) were recorded prospectively by first responders. Chart review was performed to determine survival to hospital admission and CPC score at discharge. Results: Training occurred October 2016 to March 2017, with protocol change on May 1, 2017. Cases from November 2016-April 2017 (n = 136) and May 2017-November 2017 (n= 103) were reviewed. Complete data were available for 128 subjects pre-protocol change (94%) and 96 subjects (94%) post. Age, gender, response time, rhythm, total CPR time, and rates of bystander CPR and witnessed arrest were similar between groups. Post protocol change, 87% (89/102) received ACD+ITD CPR with median ACD+ITD CPR time of 15 minutes (range 2-300). Pre-protocol, 6/128 (4.7%) subjects survived with CPC score 1 or 2, versus 8/96 (13.5%) subjects post (difference 8.8%, 95% CI 1%-17%). ROSC rates were similar (pre: 54/127, 42.5% post: 44/93, 47%, difference 4.8%, 95% CI -8% - 18%) Conclusions: The change in protocol was straightforward with a high rate of adherence of the system for the recommended duration of therapy. Results are suggestive of a higher rate of neurological survival with the routine use of ACD+ITD CPR in a small cardiac arrest patient population.

Knowledge and Skills of Lay Participants Training with Basic Life Support Program in Case of Cardiac Arrest

2021 ◽  
Vol 104 (Suppl. 1) ◽  
pp. S44-S48
Keyword(s):  
Cardiac Arrest ◽  
Training Program ◽  
Basic Life Support ◽  
Life Support ◽  
Training Session ◽  
Smartphone Application ◽  
Knowledge And Skills ◽  
Lay People ◽  
Before And After ◽  
Hospital Cardiac Arrest

Background: Out-of-hospital cardiac arrest is an important cause that leads to hospital admission and death. Improving lay people’s knowledge and skills in basic life support (BLS) may lead to reduced death associated with out-of-hospital cardiac arrest. “BLS NU KKU” is a BLS training program developed from up-to-date literature as a smartphone application used to train lay people in the community. Objective: To evaluate BLS-related knowledge and skills of participants before and after BLS training. Materials and Methods: A one group pretest-posttest design was used to implement the present study in Khon Kaen, Thailand. Participants were 350 individuals age 18 and older. An 8-hour BLS training session was offered to 10 groups of 35 participants over the period of 10 months between November 2018 and August 2019. Self-administered questionnaires were used to assess BLS knowledge and Cardiopulmonary resuscitation (CPR) skills. Results: The mean score for BLS-related knowledge significantly increased after the BLS training (mean = 15.05, SD = 2.51) compared to the scores before the training (mean = 10.47, SD = 3.43) (p<0.05). BLS skills improved from 0% to 100% (p<0.001) will all skills rated with mostly “excellent” and “good”. Satisfaction with the training program was also rated mostly with “excellent” and “good”. Conclusion: The BLS training program effectively improved participants’ knowledge and skills for basic life support. This program should be disseminated to train lay people in other settings. Keywords: Basic life support, Cardiac arrest, Mobile application

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