ECG markers of malignant arrhythmias risk in patients with arterial hypertension hospitalized for COVID-19 pneumonia

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Changes in the myocardium in patients with arterial hypertension (AH) can cause fatal arrhythmias. The effects of inflammation and drugs on the heart in COVID-19 pneumonia can also increase the risk of sudden arrhythmic death. The aim of the paper is to study interrelationship of ECG markers of malignant arrhythmias and clinical and laboratory findings in patients with AH and COVID-19 pneumonia. Methods. 48 patients with AH hospitalized for COVID-19 pneumonia (32 women aged 34 to 83, 16 men aged 48-80) were included in the study in October-November 2020. Exclusion criteria: congestive heart failure, previous myocardial infarction, reduced ejection fraction, valvular disease, life-threatening COVID-19 and other serious diseases. Main clinical characteristics and recommended laboratory findings were taken into account. Corrected QT and Tpeak-Tend were analyzed. Results. The QTc fluctuations were from 353 ms to 494 ms. The QTc values were higher than normal in 28%. The QTc duration correlated with C-reactive protein level (Kendall R = 0.59) and NYHA class (Gamma = 0.48). The Tpeak-Tend value correlated with coronary heart disease (Gamma 0.65), C-reactive protein (Kendall R = 0.57) and taking dexamethasone (Gamma 0.44) and fluoroquinolones (Gamma 0.58). Multivariate analysis has showed that high level of C-reactive protein (Wald = 7.4) and the presence of heart failure (Wald = 5.2) were independent predictors of QTc increase. Coronary heart disease (Wald = 4,8) and taking respiratory fluoroquinolones (Wald= 3.7) were independent predictors of Tpeak-Tend increase. Age, SatO2, taking betablockers and other analyzed indicators were not significantly related to QTc and Tpeak-Tend. Conclusion. Systemic inflammatory response, heart diseases and taking respiratory fluoroquinolones can adversely affect the myocardial repolarization indicators associated with the risk of sudden death in patients with AH hospitalized for COVID-19 pneumonia.

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Faculty Opinions recommendation of C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1165500.628495 ◽

2009 ◽

Author(s):

Deborah R Korenstein

Keyword(s):

Systematic Review ◽

Coronary Heart Disease ◽

Risk Factor ◽

Heart Disease ◽

Task Force ◽

Preventive Services ◽

C Reactive Protein ◽

Reactive Protein ◽

Meta Analyses ◽

The U.S

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Lipoprotein complexed C-reactive protein in patients with coronary heart disease

Thrombosis and Haemostasis ◽

10.1160/th05-05-1111 ◽

2005 ◽

Vol 94 (11) ◽

pp. 1111-1112 ◽

Cited By ~ 1

Author(s):

Thorsten Kälsch ◽

Martin Borggrefe ◽

Carl-Erik Dempfle ◽

Elif Elmas

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

C Reactive Protein ◽

Reactive Protein

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The Case for C-Reactive Protein as a Risk Marker for Coronary Heart Disease

Annals of Internal Medicine ◽

10.7326/0003-4819-152-6-201003160-00020 ◽

2010 ◽

Vol 152 (6) ◽

pp. 406 ◽

Cited By ~ 1

Author(s):

Nancy R. Cook

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Risk Marker ◽

C Reactive Protein ◽

Reactive Protein

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Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2004.08.007 ◽

2005 ◽

Vol 178 (1) ◽

pp. 115-121 ◽

Cited By ~ 85

Author(s):

Jerome L. Abramson ◽

W. Craig Hooper ◽

Dean P. Jones ◽

Salman Ashfaq ◽

Steven D. Rhodes ◽

...

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers

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C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women

ACC Current Journal Review ◽

10.1016/j.accreview.2005.10.017 ◽

2005 ◽

Vol 14 (11) ◽

pp. 16

Author(s):

M. Cushman ◽

A.M. Arnold ◽

B.M. Psaty

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Older Men ◽

C Reactive Protein ◽

Men And Women ◽

Reactive Protein ◽

Older Men And Women

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Relationship Between gamma-Glutamyltransferase (gamma-GT) with High Sensitive C-Reactive Protein (hs-CRP), Oxidized (Ox-LDL) and Glutathione Peroxidase (GPx) on Coronary Heart Disease (CHD) Patient

The Indonesian Biomedical Journal ◽

10.18585/inabj.v1i2.94 ◽

2009 ◽

Vol 1 (2) ◽

pp. 51 ◽

Cited By ~ 1

Author(s):

Marissa Arifin ◽

Marsetio Donosepoetro ◽

Sutomo Kasiman

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Glutathione Peroxidase ◽

Medical Center ◽

Oxidized Ldl ◽

C Reactive Protein ◽

Reactive Protein ◽

Significant Difference ◽

Hs Crp

BACKGROUND: Recent clinical studies have suggested that γ-glutamyltransferase (γ-GT) can trigger oxidative stress within the plaque. This study aimed to investigate whether serum γ-GT might be as a risk factor of coronary heart disease (CHD), and measure the associations of serum γ-GT with high sensitive C-Reactive Protein (hs-CRP), Oxidized LDL (Ox-LDL) and Glutathione Peroxidase (GPx).METHODS: This study recruited 48 patients aged 30-70 year who underwent coronary angiography at Haji Adam Malik Medical Center at Medan between February and April 2008 and who presented at least one coronary stenosis of > 50% of the luminar diameter. The sample subjects were consecutively selected.RESULTS: γ-Glutamyltransferase was positively associated (r = 0.546) with hs-CRP as a marker of chronic inflammation after careful adjustment for other established risk factors in CHD patient. But, there was no significant difference between γ-GT in male and female patients. Further, there were no correlations between γ-GT and Ox-LDL and GPx. Ratio of γ-GT/GPx was measured as well, and it was associated with hs-CRP.CONCLUSIONS: Ratio of γ-GT/GPx was associated with inflammation process in coronary heart disease patients.KEYWORDS: γ-glutamyltransferase (γ-GT), inflammation, oxidative stress, coronary heart disease

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Non-Fasting Changes of Hs-CRP Level in Chinese Patients With Coronary Heart Disease After A Daily Meal

10.21203/rs.3.rs-1195738/v1 ◽

2021 ◽

Author(s):

Ling Liu ◽

Qiu-Zhen Lin ◽

Xue-Yan Zang ◽

Yan Fu ◽

Xingyu Wen ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

High Sensitivity ◽

Chinese Patients ◽

Inflammatory Factor ◽

Fasting State ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Atherosclerotic Cardiovascular Diseases

Abstract High-sensitivity C-reactive protein (hs-CRP) is a key inflammatory factor in atherosclerotic cardiovascular diseases. In Chinese patients with coronary heart disease (CHD), the changes in hs-CRP levels after a daily meal and the effect of statins on those were never explored. A total of 300 inpatients with CHD were included. Hs-CRP levels were measured in fasting and non-fasting state at 2 hour (h) and 4h after a daily breakfast. Group with fasting hs-CRP ≤ 3mg/L had significantly higher percentage of patients with statins using ≥ 1 month (m) than that with fasting hs-CRP > 3mg/L (51.4% vs. 23.9%, P < 0.05). Hs-CRP levels were significantly higher in non-fasting state (P < 0.05). Interestingly, the hs-CRP didn’t elevate significantly in inpatients with statins using ≥ 1m in hs-CRP > 3mg/L group, but it elevated significantly after meal in inpatients without and with statins using < 1m (P < 0.05). About 32% of patients with non-fasting hs-CRP > 3mg/L came from those with fasting hs-CRP ≤ 3mg/L. In conclusion, hs-CRP levels increased significantly in CHD patients after a daily meal. When fasting hs-CRP > 3mg/L but not ≤ 3mg/L, statins work partly in reducing hs-CRP elevation in non-fasting state.

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