A twin study of C-Reactive Protein compared to other risk factors for coronary heart disease

2003 ◽  
Vol 169 (2) ◽  
pp. 279-282 ◽  
Author(s):  
Lars Retterstol ◽  
Lars Eikvar ◽  
Kåre Berg
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Twin Study ◽  
C Reactive Protein ◽  
Reactive Protein

Lipoprotein(a) and high-sensitive C-reactive protein as risk factors of coronary heart disease

2019 ◽  
Vol 10 (2) ◽  
pp. 189
Author(s):  
DebasisDebadatta Behera ◽  
Bratati Singh ◽  
SureshKumar Behera ◽  
Subhashree Ray ◽  
KamalLochan Das
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
C Reactive Protein ◽  
Lipoprotein A ◽  
Reactive Protein

scholarly journals Factors of raised C-reactive protein as a potential determinant of Diabetic patients and Risk factor for Coronary Heart Disease

2018 ◽  
Vol 5 (3) ◽  
pp. 3656-3661
Author(s):  
Sharma Sushil Kumar ◽  
Rastogi Parag
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Type 1 Diabetes ◽  
Heart Disease ◽  
Research Work ◽  
Islet Autoimmunity ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein

Elevated C-reactive protein (CRP) levels have previously been described before the onset of type 1 diabetes and gestational diabetes. We hypothesized that inflammation, as reflected by elevated CRP levels, can help predict development of islet autoimmunity or type 1 diabetes. The outcome of this research is to establish potential determinants of raised CRP concentrations in type 1 diabetic patients. Sensitive assay showed ‘low-level’ CRP concentrations in 147 type 1 patients (83M, 64F, median age 30 years, range 13–67). We have done step by step variant examination to relate these CRP levels to known cardiovascular risk factors and demographic data. Only four patients had established Coronary Heart Disease (median CRP 3.43 mg/l vs. 0.85 mg/l, p=0.035). In subjects without overt CHD, multivariate analysis revealed increase in subject age (p=0.0027), BMI (p=0.001) and HbA1 (p=0.013) to be associated with a higher CRP concentration, as was female sex (p=0.025) and a history of CHD in a first-degree relative (p=0.018, n=58). Elevated CRP levels were positively associated with cardiovascular and renal risk factors: age, body mass index, blood pressure, serum cholesterol level, smoking, plasma glucose level and elevated urinary albumin excretion and presence of hypertension were unrelated. This research work advises that certain of the risk factors connected with CHD in type 1 patients are also individually predictive of high CRP concentrations. The reasons for this, and whether intervention would prove valuable, require further analysis

Risk factors for coronary heart disease in miners with anthracosilicosis

2021 ◽  
Vol 61 (3) ◽  
pp. 161-167
Author(s):  
Nikolay I. Panev ◽  
Natalya A. Evseeva ◽  
Sergey N. Filimonov ◽  
Olga Yu. Korotenko ◽  
Olga N. Blazhina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Significant Risk ◽  
Morphological Type ◽  
Coal Industry ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein

Introduction. There are data on the effects of dust on the respiratory system and the cardiovascular system. The main measures for preventing diseases of the circulatory system aimed to identify and eliminate risk factors. However, the prevalence of risk factors for coronary heart disease among coal mine workers with anthracosilicosis has not been sufficiently studied, determining the study's relevance. The study aimed to learn the frequency of risk factors for coronary heart disease in coal industry workers with anthracosilicosis. Materials and methods. We examined 269 miners working in conditions of dustiness exceeding the maximum permissible concentration by ten or more times: 139 miners with a previously established diagnosis of anthracosilicosis and 130 miners of the control group without dust pathology of the lungs. All of them underwent a comprehensive clinical, instrumental, and laboratory examination of the respiratory and cardiovascular systems to detect anthracosilicosis and coronary heart disease, as well as to assess its risk factors. Results. In miners with anthracosilicosis, coronary heart disease was 3.5 times more common (30.94%) than in the control group (8.46%). We have identified a high incidence of coronary heart disease in the age group of 45 and more years and with the experience of working in dust conditions of 20 and more years. In miners with anthracosilicosis combined with coronary heart disease, arterial hypertension was 1.6 times more common (58.14%) than without concomitant coronary heart disease - 35.42%. Miners with a combination of anthracosilicosis and coronary heart disease were three times more likely (20.93%) than those without coronary heart disease (6.25%) to have a metabolic syndrome. According to the Tanner index, significant risk factors for coronary heart disease were the presence of an andromorphic constitutional-morphological type and the formation of a complication of anthracosilicosis - respiratory failure. The evaluation of biochemical blood tests showed that the most significant markers of coronary heart disease risk were hyperhomocysteinemia, increased levels of C-reactive protein, fibrinogen, and soluble fibrin-monomer complexes. Conclusions. We found that the most significant risk of developing coronary heart disease in miners is 45 years and older. There are also other risk factors: work experience in harmful working conditions of 20 years or more; the presence of arterial hypertension; metabolic syndrome; andromorphic constitutional-morphological type according to the Tanner index. Risk factors are respiratory failure, hyperhomocysteinemia, hyperfibrinogenemia, increased soluble fibrin-monomer complexes, and C - reactive protein. It is necessary to consider all risks in developing programs of medical and preventive measures for employees of the coal industry.

scholarly journals Compare and correlate the levels of lipoprotein (a) and high-sensitive C-reactive protein in coronary heart disease with control

2019 ◽  
Vol 6 (3) ◽  
pp. 691
Author(s):  
Kamal Lochan Behera ◽  
Ashok Vankayala ◽  
Suresh Babu Sayana ◽  
D. S. S. K. Raju
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Inflammatory Marker ◽  
Case Control ◽  
C Reactive Protein ◽  
Lipoprotein A ◽  
Reactive Protein ◽  
Patients With Diabetes ◽  
Hs Crp

Background: The incidence of ischemic heart disease/ myocardial infarction is rapidly increasing in India. However, the traditional risk factors alone could not explain this excess of Coronary Heart Disease (CHD). So, we are in need of a tool to assess the severity and prognosis of these acute coronary syndromes. Lipoprotein (a) [Lp(a)] and High Sensitive C-Reactive Protein (hs-CRP) have been recognised as independent risk factors for CHD in many retrospective case control studies. As the data shows inconsistency in the prediction of risk by Lp(a) and hs-CRP, the study is carried out to compare and correlate the levels of Lp(a) and hs-CRP in coronary heart disease patients with controls.Methods: An observational case control study was conducted at Maharaja’s Institute of Medical Sciences, Nellimarla, with 120 participants. 80 admitted with CHD were categorised as type 2 diabetic and non-diabetic. Remaining 40 participants were age matched controls, who have attended the OP for general health check-up. Samples collected from the participants were analysed for Lp(a), hs-CRP and HbA1c.Results: Lp(a) levels were significantly elevated in CHD patients with diabetes (69.2±27.5) and non-significant in CHD patients without diabetes (50.4±24.3) as compared to their controls (36.6±22.5). There was significant correlation and elevation of hs-CRP in CHD patients with diabetes (6.0±2.6) and without diabetes (3.7±2.0) as compared to their controls (0.7±0.4).Conclusions: The present study shows a lack of association of Lp(a) levels in CHD patients with and without diabetes. A strong correlation of the inflammatory marker, hs-CRP was observed between the CHD patients with and without diabetes and even as compared to their controls. It may be concluded that hs-CRP is a better and independent marker than Lp(a) in patients with CHD.

High C-reactive protein and low paraoxonase1 in diabetes as risk factors for coronary heart disease

2006 ◽  
Vol 186 (2) ◽  
pp. 396-401 ◽  
Author(s):  
Bharti Mackness ◽  
David Hine ◽  
Patrick McElduff ◽  
Michael Mackness
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
C Reactive Protein ◽  
Reactive Protein

A system for predicting the development of coronary heart disease in miners with anthracosilicosis

2021 ◽  
Vol 61 (6) ◽  
pp. 365-370
Author(s):  
Nikolay I. Panev ◽  
Natalya A. Evseeva ◽  
Sergey N. Filimonov ◽  
Olga Yu. Korotenko ◽  
Igor P. Danilov
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Preventive Measures ◽  
Significant Risk ◽  
Excess Body Weight ◽  
C Reactive Protein ◽  
Bicycle Ergometry ◽  
Reactive Protein ◽  
The Impact

Introduction. Among underground miners, the pathology of the cardiovascular system is much more common than among workers on the surface, which indicates the negative role of the impact of harmful production factors. There is evidence of a high prevalence of traditional risk factors for the development of coronary heart disease among miners with dust pathology of the lungs. Preventive measures for coronary heart disease exist for the timely detection and elimination of risk factors. In this regard, it is relevant to optimize methods for predicting the risk of developing coronary heart disease in coal mine workers. The study aims to develop a system for predicting the probability of developing coronary heart disease in miners with anthracosilicosis based on determining the most significant risk factors. Materials and methods. The experts studied the frequency of coronary heart disease and its risk factors in 139 employees of the primary professions of coal mines. The scientists performed daily ECG monitoring, bicycle ergometry according to the Rose questionnaire. They also studied the indicators of lipid metabolism, hemostasis, the level of homocysteine, C-reactive protein, glycemia, the presence of excess body weight, constitutional and morphological types according to Rice-Eysenck and Tanner. The experts developed a predictive system using the Bayes method. We calculated a predictive coefficient for each factor. Scientists determined the probability of coronary heart disease by the value of the sum of prognostic coefficients. Results. Workers aged 45 years and older have the highest risk of developing coronary heart disease. The experience of working in harmful working conditions for 20 years or more, the presence of arterial hypertension, metabolic syndrome, respiratory failure, andromorphic constitutional-morphological type according to the Tanner index, as well as the presence of hyperhomocysteinemia, hyperfibrinogenemia, increased levels of soluble fibrin-monomer complexes and C-reactive protein - all these are the risks of developing coronary heart disease in miners with anthracosilicosis. Conclusions. The developed system of personalized prediction of the probability of developing coronary heart disease in miners with anthracosilicosis allows us to identify a group of high-risk workers for timely treatment and preventive measures for them.

A Healthy Nordic diet score and risk of incident coronary heart disease among men: the Kuopio Ischaemic Heart Disease Risk Factor Study

2021 ◽  
pp. 1-23
Author(s):  
Hanna-Mari Tertsunen ◽  
Sari Hantunen ◽  
Tomi-Pekka Tuomainen ◽  
Jukka T. Salonen ◽  
Jyrki K. Virtanen
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Carotid Atherosclerosis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nordic Diet ◽  
Chd Risk ◽  
Chd Risk Factors ◽  
Diet Score

Abstract Healthy Nordic diet has been beneficially associated with coronary heart disease (CHD) risk factors, but few studies have investigated risk of developing CHD. We investigated the associations of healthy Nordic diet with major CHD risk factors, carotid atherosclerosis, and incident CHD in middle-aged and older men from eastern Finland. A total of 1981 men aged 42-60 years and free of CHD at baseline in 1984-1989 were investigated. Diet was assessed with 4-d food recording and the healthy Nordic diet score was calculated based on the Baltic Sea Diet Score. Carotid atherosclerosis was assessed by ultrasonography of the common carotid artery intima-media thickness in 1053 men. Analysis of covariance and Cox proportional hazards regression analyses were used for analyses. Healthy Nordic diet score associated with lower serum C-reactive protein concentrations (multivariable-adjusted extreme-quartile difference 0.69 mg/L, 95% confidence interval 0.15-1.22 mg/L), but not with serum lipid concentrations, blood pressure, or carotid atherosclerosis. During the average follow-up of 21.6 years (SD 8.3 years), 407 men had a CHD event, of which 277 were fatal. The multivariable-adjusted hazard ratios (95% confidence interval) in the lowest vs. the highest quartile of the healthy Nordic diet score were 1.10 (0.85-1.45) for any CHD event (P-trend 0.429) and 1.38 (0.95-2.00) (P-trend 0.119) for fatal CHD event. We did not find evidence that adherence to a healthy Nordic diet would be associated with a lower risk of CHD or with carotid atherosclerosis or major CHD risk factors, except for an inverse association with serum C-reactive protein concentrations.

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