Lipid profile in a population with coronary artery disease in Madeira Island

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
MR Santos ◽  
A Pereira ◽  
M Temtem ◽  
F Mendonca ◽  
JA Sousa ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Risk Patient ◽  
Mean Value ◽  
Funding Sources ◽  
Coronary Patients ◽  
Study Population ◽  
Esc Guidelines ◽  
Artery Disease ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. We know that plasma level of LDL cholesterol (LDL-C) is strongly associated with atherosclerosis, and its reduction with statins has led to a decrease in the incidence and complications of CAD. According to the 2019 ESC guidelines, in high-risk patient the aim is to achieve an absolute LDL-C treatment goal of <55mg/dL. 2016 ESC guidelines purposed, in the same patients, a LDL-C level of <70mg/dL. Objective To evaluate the degree of LDL-C control in coronary artery disease patients according to ESC guidelines. Materials and Methods Study analyses of 1687 patients selected from GENEMACOR study population, with at least one > 75% coronary stenosis by angiography (median age 53.3 ± 3 years and 54.8% men). LDL-C was determined by chemical methods and all patients were statin treated. The population was divided in four groups according to LDL-C levels: inferior to 55mg/dL, inferior to 70mg/dL, inferior to 115mg/dL and superior to 115mg/dL. Results LDL-C mean value was 108.7mg/dL, median 105.1mg/dL (P25 83.0 and P75 127.4mg/dL). 150 (8.9%) patients had LDL-C < 55mg/dL vs 1537 (91.1%) with LDL-C ≥ 55 mg/dl. 275 (16.3%) patients had LDL-C < 70 mg/dL vs 1412 (83.7%) with LDL-C ≥ 70 mg/dL.  1084 (64.3%%) patients had LDL < 115 mg/dL vs 603 (35.7%) with LDL-C  ≥ 115 mg/dL. Conclusion In our population LDL-C control levels was low, with 91.1% patients with LDL-C ≥ 55mg/dL and 83.7% patients with LDL ≥ 70 mg/dL. It is interesting to note that most of our patients have LDL-C levels above the recommend by the newest and, surprisingly, the 2016 dyslipidemia guidelines. It is therefore important to implement a more intensive treatment strategy of dyslipidemia in coronary patients.

Types of remodeling and assessment of myocardial diastolic function in patients with ACS and CCS

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
VI Maslovskyi ◽  
IA Mezhiievska
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Functional Condition ◽  
World Medical Association ◽  
Coronary Syndrome ◽  
Funding Sources ◽  
Concentric Hypertrophy ◽  
Artery Disease ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Objective to study the features of the structural and functional condition of the myocardium in patients with various forms of coronary artery disease. Methods. 165 patients with various forms of coronary artery disease were examined. On average, patients NSTEMI - 90, NSTE-ACS - 25, STEMI - 25, chronic coronary syndrome (CCS) - 25. Features of  structural and functional condition of the myocardium were determined by echocardiography in M-, B,  and D-modes. All of research corresponding to the principles of the Declaration of Helsinki of the World Medical  Association. Results. Evaluation of the nature of structural-geometric remodeling of the left ventricle (Fig. 1) revealed the predominance of normal geometry in patients with NSTEMI in comparison with STEMI (8 (8.9%) vs. 2 (8.0%), p= 0.06), and in the group with NSTE-ACS in comparison with STEMI (0 (0) vs. 2  (8.0%), p = 0.02). Concentric remodeling was significantly more common in the group of patients with NSTEMI compared with STEMI (23 (25.6%) vs. 2 (8.0%), p = 0.06), and in the group with NSTE-ACS compared with STEMI (9 ( 36.0%) vs. 2 (8.0%), p = 0.02). Analysis of the nature of diastolic transmitral blood flow revealed the following changes normal type - 5 vs. 0 in the groups of NSTE-ACS and STEMI, respectively (p = 0.02), the type of relaxation disorder - 58 against 19 in the groups NSTEMI and NSTE-ACS, respectively (p = 0.02), 58 vs. 13 in the NSTEMI and STEMI groups, respectively (p = 0.03), 19 vs. 13 in the NSTE-ACS and STEMI groups, respectively (p <0.0001), 19 vs. 16 in the NSTE-ACS and CCS groups, respectively (p= 0.04), by type of pseudonormalization - 23 against 1 in the groups NSTEMI and NSTE-ACS, respectively (p =0.02), 23 against 12 in the groups NSTEMI and STEMI, respectively (p = 0.03), 1 against 12 in the groups NSTE-ACS and STEMI, respectively (p <0.0001), 1 vs. 6 in the groups NSTE-ACS and CCS, respectively (p = 0.04). Conclusions. The highest degree of concentric remodeling was found in patients with NSTE-ACS, concentric hypertrophy in the CCS group, excentric hypertrophy in the STEMI group. Changes in transmitral blood flow by type of relaxation disorder prevailed in the NSTE-ACS group, by type of pseudonormalization in STEMI patients. In patients with NSTEMI, transmitral blood flow prevailed as a type of relaxation disorder. Abstract Figure. Fig. 1

scholarly journals Lifestyle related risk factors of coronary artery disease patients in Nepal

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
P Gaudel ◽  
M Kaunonen ◽  
S Neupane ◽  
K Joronen ◽  
A M Koivisto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Categorical Variables ◽  
Dietary Habit ◽  
Total Study Population ◽  
Related Risk ◽  
Study Population ◽  
Artery Disease

Abstract Background Coronary Artery Disease (CAD) is a leading cause of morbidity and mortality and serious health problem worldwide. It is important to observe lifestyle related risk factors in patients with CAD for effective planning and implementation of secondary prevention strategies. The aim of this study is to describe the prevalence of lifestyle related risk factor habits among the patients with CAD. Methods A cross-sectional study was conducted among CAD patients in a tertiary care national heart center in Kathmandu, Nepal. Six lifestyle related factors (dietary habit, smoking, alcohol consumption, stress, physical activity and adherence to medication) and Body Mass Index were used as the risk factors of CAD in this study. Individual face-to-face structured interview was conducted using culturally validated standard instruments. The descriptive characteristics were presented as frequencies and percentages for categorical variables and as mean ± standard deviation (SD) or median and interquartile range (IQR) otherwise. Results In total study population, the mean age of the patients was 59.9 years and 76% were male. Patients having any three risk factors out of seven were the most common (36%) followed by two risk factors (25%) and four risk factors (22%). About 32% of study population were current smokers, whereas 29% were former smokers. Likewise, 31% of the total were physically inactive. Majority of the patients 95% had perceived moderate stress. Conclusions The prevalence of lifestyle related risk factors is high among CAD patients in study population. Combination of any three lifestyle related risk factors were the most common among patients. Therefore, studies focusing on lifestyle risk factor modification intervention on particular groups is recommended. Key messages Need to improve awareness about lifestyle related risk factors among CAD patients. Highlight the importance of lifestyle counselling.

scholarly journals Acute Myocardial Infarction during Pregnancy

2018 ◽  
Vol 03 (02/03) ◽  
pp. 098-107
Author(s):  
Jyotsna Maddury ◽  
Indrani Garre
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Maternal Age ◽  
Heart Diseases ◽  
Review Article ◽  
Esc Guidelines ◽  
Artery Disease ◽  
European Society Of Cardiology

AbstractBecause of increase in the incidence of coronary artery disease (CAD) in younger population with increasing maternal age of pregnancy, the topic of acute myocardial infarction (AMI) during pregnancy has gained importance. Pathophysiologically AMI during pregnancy occurs more frequently due to coronary dissection, which is different in detection and management when compared with the atherosclerotic CAD. Dual antiplatelet drugs that are mandatory following AMI require modification before labor. In this review article, authors discuss in detail about the detection and management of AMI at different stages of pregnancy with the risk stratification and recommendations, including 2018 European Society of Cardiology (ESC) guidelines on “heart diseases during pregnancy.”

Impact of race and gender on antithrombotic therapy

2010 ◽  
Vol 104 (09) ◽  
pp. 471-484 ◽  
Author(s):  
Davide Capodanno ◽  
Dominick Angiolillo
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Antithrombotic Therapy ◽  
Clinical Presentation ◽  
Randomised Trials ◽  
Antithrombotic Drugs ◽  
Race And Gender ◽  
Study Population ◽  
Artery Disease ◽  
And Gender

SummaryLarge randomised trials support the use of a variety of antithrombotic drugs for treatment of atherothrombotic disease processes leading to cardiovascular disease. The heterogeneous case-mix of patients enrolled in these trials, however, hamper the attempt to generalise their findings to subgroups which are not sufficiently represented in the study population, such as women and ethnic minorities. Sex- and race-specific disparities in the clinical presentation, management, and outcomes of coronary artery disease may relate to underlying differences in thrombotic profiles and response to antithrombotic therapies. The present manuscript provides an overview of the currently available data on the epidemiology of coronary artery disease based on gender and race as well as the biological considerations for their differences in thrombosis and haemostasis and effects of antithrombotic therapy.

Serum Selenium and Glutathione Peroxidase Concentrations in Iranian Patients with Angiography-Defined Coronary Artery Disease

Angiology ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 186-191 ◽  
Author(s):  
Parizadeh Seyyed Mohammad Reza ◽  
Mohsen Moohebati ◽  
Fahimeh Ghafoori ◽  
Majid Ghayour-Mobarhan ◽  
Seyyed Mohammad Reza Kazemi-Bajestani ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Glutathione Peroxidase ◽  
Fasting Blood Glucose ◽  
Mean Value ◽  
Control Group ◽  
Serum Selenium ◽  
Artery Disease ◽  
The Relationship ◽  
Iranian Patients

This study investigated the relationship between serum selenium (Se) and glutathione peroxidase (GPx) levels and the presence of coronary artery disease (CAD) among Iranian patients. Three groups were compared: patients undergoing angiography with angiographically defined CAD, individuals with a normal angiogram, and apparently healthy controls with no evidence of overt CAD. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profiles, serum Se and GPx measurements, and angiographic assessment were carried out using standard protocols. Mean serum Se concentrations were not significantly different between patients with and without CAD and the control group. The mean value of serum GPx in the control group was significantly higher than in patients with or without CAD. Selenium status did not differentiate between patients with and without CAD, which may be related to the fact that angiography is not a very sensitive index of global atherosclerosis, and it is possible that patients who were CAD negative by angiogram still have significant disease. It may also be that Se is not a good marker of CAD.

scholarly journals STUDY OF THE RISK FACTORS FOR CORONARY ARTERY DISEASE AND THEIR CORRELATION WITH THYROID HORMONE PROFILE AMONGST WOMEN WITH ST SEGMENT ELEVATION IN ACUTE MYOCARDIAL INFARCTION

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Jitendra Kodilkar ◽  
Dr Jeetendra Singh ◽  
Dr. Akash Berad ◽  
Dr. Mayur Babras ◽  
Dr. Imran Pinjari ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Thyroid Hormone ◽  
St Segment Elevation ◽  
Hormone Profile ◽  
St Segment ◽  
Study Population ◽  
Artery Disease

Background: To assess risk factors for coronary artery disease and their correlation with thyroid hormone profile amongst women with ST segment elevation in acute myocardial infarction. Method: A total number of 78 females having ST elevation myocardial infarction diagnosed through detailed clinical history and ECG evaluations were included after they satisfy the eligibility criteria. Patients were subsequently evaluated for presence of risk factors of ischemic heart disease such age, marital status, parity, and menopause, use of oral contraceptives, family history, obesity, diabetes mellitus, hypertension, hypercholesterolemia and hypertriglyceridemia. Their thyroid hormone profiles (T3, T4, TSH) were done and were correlated with risk factors for ischemic heart disease. Result: A total 78 patient included in the study. Most of the study population belongs to the age group of 40 to 50 years (43.6 %). Hypertension was the most common clinical features amongst study population (59%) followed by Diabetes (50%). most of the study population had Normal Thyroid status (57.69%) followed by Hypothyroidism (25.64%) and Hyperthyroidism (16.67%). and SERUM TSH is the most sensitive test for evaluation. Diabetes Mellitus was statistically significant risk factor (p value <0.05) in patients with STEMI with different levels of thyroid. Conclusion: Patients with coronary artery disease especially in the presence of other risk factors should be screened for diabetes and also for thyroid dysfunction as in our study cases of Hypothyroidism was seen in 25.64% of the population under study. Hence it can be postulated that hypothyroidism may be a predictor for myocardial injury in STEMI. Here we recommend that tests for thyroid disorders in acute coronary syndrome can give predictor for risk of morbidity and mortality in those subjects. These results also may warrant further larger study to investigate whether reversing the hypothyroidism could benefit the STEMI patients. Keywords: STEMI- ST segment elevation myocardial infarction, MI- Myocardial Infarction, Hyperthyroidism, Hypothyroidism, TSH- Thyroid Stimulating Hormone

scholarly journals The Management of Co-Morbidities in Patients with Heart Failure – Angina and Coronary Disease

2017 ◽  
Vol 10 ◽  
Author(s):  
Ilaria Spoletini ◽  
Petar Seferovic
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Essential Element ◽  
Patients With Heart Failure ◽  
Esc Guidelines ◽  
Artery Disease ◽  
European Society Of Cardiology

Co-morbidities are particularly relevant in the management of HF as they may confound HF diagnosis, worsen symptomatology, impact quality of life and aggravate the prognosis. According to the most recent European Society of Cardiology (ESC) guidelines, treatment of co- morbidities is an essential element of the comprehensive care of HF. Angina and coronary artery disease (CAD), in particular are common disorders associated with HF. The pharmacological and surgical management of angina according to the ESC guidelines is reviewed in this article.

scholarly journals Association of ABO blood group with CAD in patients undergoing CAG in Cardiology Department of Dhaka Medical College and Hospital

2015 ◽  
Vol 10 (2) ◽  
pp. 81-84 ◽  
Author(s):  
Md Nazmul Hasan ◽  
Abdul Wadud Chowdhury ◽  
Lahani Md Tajul Islam ◽  
Mohammad Safiuddin ◽  
Mostashirul Haque ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Medical College ◽  
Cardiology Department ◽  
Study Population ◽  
Artery Disease ◽  
Group B

There are many reports regarding association between ABO and Rhesus blood groups and coronary artery disease. This study has been designed to see the association of ABO blood group with coronary artery disease in patient who were admitted in Cardiology Department of Dhaka Medical College and Hospital and undergoing coronary angiography. A total of 680 patients were studied in this retrospective study. ABO blood group, gender and standard cardiovascular risk factors were determined. In our study 17.5% of the study population were female with mean age of 49.94±10.37 years and 82.5% were male with a mean age 49.68±10.45 years . Most of the patients belonged to blood group B (33.4%) .Our results demonstrated the prevalence of CAD in blood group B is much higher than other blood groups which is in contrast with other studies in few other countries including one study done on small groups of people in Bangladesh. Geographical distribution may explain the variation in results among countries.University Heart Journal Vol. 10, No. 2, July 2014; 81-84

scholarly journals Apolipoprotein A-I and B levels in Bangladeshi patients with coronary artery disease

2016 ◽  
Vol 9 (1) ◽  
pp. 31-33
Author(s):  
Ashesh K Chowdhury ◽  
Abu Mohammed Shafique ◽  
Zeenat F Rahman
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Large Scale ◽  
Control Group ◽  
Total Study Population ◽  
Apo B ◽  
Apolipoprotein A ◽  
Study Population ◽  
The Mean ◽  
Artery Disease

Coronary arteay disease (CAD) is an important cause of morbidity and mortality in developed as well as developing countries like Bangladesh. In this study, the status of serum apolipoprotein A-I (Apo A-1) and apolipoprotein B (Apo B) levels were assessed in Bangladeshi patients with coronary artery diseases. The study was carried out in the Department of Cardiology, University Cardiac Centre (UCC), Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Total study population was 100, of which 50 were patients with CAD and 50 were individuals without CAD (control). The patients with CAD and controls were enrolled following the inclusion and exclusion criteria. About 5 ml blood was collected by venepuncture from each individual and apolipoprotein A-1 and B were determined by automated nephelometry. The mean age of total study population was 51.4 ± 10.8 years while the mean age of the patients and control was 51.3 ± 10.9 and 51.4 ± 10.9 years respectively. The Apo A-I level was significantly (p<0.01) different in CAD patients compared to control group (95.10 ± 20.50 mg/dl vs 113.47 ± 20.96 mg/dl). The ratio of Apo B and Apo A1 was also significantly higher (p<0.01) in CAD patients than that of controls (1.25 ± 0.40 vs 0.95 ± 0.26 while Apo B levels was not different among the two groups. The study revealed significant alteration of serum Apo A-I level and Apo B/Apo A-I ratio in patients with CAD compared to those without CAD. Further large-scale study is needed to evaluate the exact influence of apolipoproteins on coronary artery disease in Bengali ethnic population.Ibrahim Med. Coll. J. 2015; 9(1): 31-33

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