Examining the impact of mental disease on type 2 diabetes outcomes: results from the EpiChron Cohort

Abstract Background Type 2 diabetes mellitus (T2D) is often accompanied by other chronic diseases, including mental diseases (MD). This work aimed at studying MD prevalence in T2D patients and analyse its impact on T2D health outcomes. Methods Retrospective, observational study of individuals of the EpiChron Cohort aged 18 and over with prevalent T2D at baseline (2011) in Aragón, Spain (n = 63,365). Participants were categorized by the existence or absence of MD, defined as the presence of depression, anxiety, schizophrenia or substance abuse. MD prevalence was calculated, and a logistic regression model was performed to analyse the likelihood of the four studied health outcomes (4-year all-cause mortality, all-cause hospitalization, T2D-hospitalization, and emergency room visits) based on the presence of each type of MD, after adjusting by age, sex and number of comorbidities. Results Mental diseases were observed in 19% of T2D patients, with depression being the most frequent condition, especially in women (20.7% vs. 7.57%). Mortality risk was significantly higher in patients with MD (odds ratio -OR- 1.24; 95% confidence interval -CI- 1.16-1.31), especially in those with substance abuse (OR 2.18; 95% CI 1.84-2.57) and schizophrenia (OR 1.82; 95% CI 1.50-2.21). The presence of MD also increased the risk of T2D-hospitalization (OR 1.51; 95% CI 1.18-1.93), emergency room visits (OR 1.26; 95% CI 1.21-1.32) and all-cause hospitalization (OR 1.16; 95% CI 1.10-1.23). Conclusions The high prevalence of MD among T2D patients, and its association with health outcomes, underscores the importance of providing integrated, person-centred care and early detection of comorbid mental diseases in T2D patients to improve disease management and health outcomes. Key messages Comprehensive care of T2D should include specific strategies for prevention, early detection, and management of comorbidities, especially mental disorders, in order to reduce their impact on health. Substance abuse was the mental disease with the highest risk of T2D-hospitalization, emergency room visits and all-cause hospitalization.

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DB2 RACIAL DIFFERENCES IN EMERGENCY ROOM VISITS ASSOCIATED WITH MEDICATION USE IN MEDICAID ENROLLEES WITH TYPE 2 DIABETES

Value in Health ◽

10.1016/s1098-3015(10)68583-x ◽

2007 ◽

Vol 10 (3) ◽

pp. A17 ◽

Cited By ~ 1

Author(s):

R Shenolikar ◽

R Balkrishnan

Keyword(s):

Type 2 Diabetes ◽

Emergency Room ◽

Racial Differences ◽

Medication Use ◽

Emergency Room Visits

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The Impact of Health Education Intervention for Prevention and Early Detection of Type 2 Diabetes in Women with Gestational Diabetes

Journal of Community Health ◽

10.1007/s10900-016-0282-7 ◽

2016 ◽

Vol 42 (3) ◽

pp. 500-510 ◽

Cited By ~ 7

Author(s):

Mirella Youssef Tawfik

Keyword(s):

Type 2 Diabetes ◽

Health Education ◽

Early Detection ◽

Gestational Diabetes ◽

Education Intervention ◽

Prevention And Early Detection ◽

Health Education Intervention ◽

The Impact

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Evaluating the Impact of Mobile Phone Technology on Health Outcomes for Latinos with Type 2 Diabetes

Journal of Racial and Ethnic Health Disparities ◽

10.1007/s40615-020-00810-x ◽

2020 ◽

Author(s):

Laura V. Jackson ◽

Diane M. Carpenter ◽

Debbie A. Postlethwaite ◽

Lorena C. Castro ◽

Eileen Kim ◽

...

Keyword(s):

Type 2 Diabetes ◽

Health Outcomes ◽

Mobile Phone ◽

Mobile Phone Technology ◽

The Impact

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Mobile messaging support versus usual care for people with type 2 diabetes in sub-Saharan Africa: a protocol for a multicentre randomized controlled trial (StAR2D) (Preprint)

10.2196/preprints.12377 ◽

2018 ◽

Author(s):

Andrew Farmer ◽

Kirsten Bobrow ◽

Natalie Leon ◽

Nicola Williams ◽

Enita Phiri ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cost Effectiveness ◽

Health Outcomes ◽

Usual Care ◽

Text Messaging ◽

Sub Saharan Africa ◽

Sub Saharan ◽

The Impact ◽

Sms Text Messaging

UNSTRUCTURED Background: Health outcomes for people treated for type 2 diabetes could be substantially improved in sub-Saharan Africa. Failure to take medicines regularly to treat diabetes has been identified as a major problem. Resources to identify and support patients who are not making best use of medicine in low and middle-income settings are scarce. Mobile phones are widely available in these settings including among people with diabetes, and linked technologies such as SMS-text messaging have shown promise in delivering low-cost interventions efficiently. However, evidence that these interventions will work when carried out at a larger scale, and of the extent to which they will improve health outcomes when added to usual care is limited. Methods: We will carry out a randomised clinical trial in two contrasting settings in sub-Saharan Africa, Cape Town in South Africa and Lilongwe in Malawi, to provide information about the impact of sending brief automated messages via SMS text-messaging. The messages will advise people about the benefits of their diabetes treatment and offer motivation and encouragement around lifestyle and use of medication. We will allocate patients using a randomly-generated assignment plan to receive either intervention messages, or an active control. We will follow up people for twelve months measuring important risk factors for poor health outcomes and complications in diabetes so we can estimate potential health benefits, including HbA1c as a marker for long-term blood glucose control and blood pressure control, We will record the costs of doing this, and estimate cost-effectiveness. We will also capture collection of medication and assess the reception of the intervention by participants and health care workers. Discussion: The knowledge gained will have wide application and advance the evidence base for effectiveness of mobile-phone based brief text-messaging on clinical outcomes and in large-scale, operational settings. It will provide evidence for cost-effectiveness that will further inform policy development and decision-making. We will work with a wide network that includes patients, clinicians, academics, industry, and policy makers to help us identify opportunities for informing people about the work and raise awareness of what is being developed and studied. Trial Registration: ISRCTN70768808 (Registered on 3 August 2015)

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PCV3 THE IMPACT OF MYOCARDIAL PERFUSION IMAGING FOR DETECTION OF CORONARY ARTERY DISEASE ON THE HEALTH OUTCOMES OF ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES

Value in Health ◽

10.1016/s1098-3015(10)64673-6 ◽

2006 ◽

Vol 9 (3) ◽

pp. A119

Author(s):

PJ Marangos ◽

FJ Papatheofanis

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Myocardial Perfusion Imaging ◽

Myocardial Perfusion ◽

Health Outcomes ◽

Asymptomatic Patients ◽

Artery Disease ◽

The Impact

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COVID-19, Type-2 Diabetes, and Associated Health Outcomes in China: Results from a Nationwide Survey of 10,545 Adults

10.1101/2020.10.07.20207282 ◽

2020 ◽

Author(s):

Zumin Shi ◽

Alice Yan ◽

Paul Zimmet ◽

Xiaoming Sun ◽

Nayla Cristina do Vale Moreira ◽

...

Keyword(s):

Type 2 Diabetes ◽

Social Media ◽

Health Outcomes ◽

Preventive Measures ◽

Development Program ◽

World Health ◽

Increased Risk ◽

Health Related ◽

The Impact

AbstractObjectiveThis study examined the associations between type-2 diabetes (T2DM) and self-reported/familial COVID-19 infection and investigated health-related outcomes among those with diabetes during China’s nationwide quarantine.MethodsThe 2020 China COVID-19 Survey was administered anonymously via social media (WeChat) across China. It was completed by 10,545 adults in all of mainland China’s 31 provinces. The survey consisted of 74 items covering sociodemographic characteristics, preventive measures for COVID-19, lifestyle behaviors, and health-related outcomes during the period of quarantine. Regression models examined associations among study variables, adjusting for covariates.ResultsDiabetes was associated with a six-fold increased risk of reporting COVID-19 infection among respondents or their family members. Among patients with diabetes, individuals who rarely wore masks had double the risk of suspected COVID-19 infection compared with those who always wore masks, with an inverse J-shaped relationship between face mask wearing and suspected COVID-19 infection. People with T2DM tended to have both poor knowledge of COVID-19 and poor compliance with preventive measures, despite perceiving a high risk of personal infection (40.0% among respondents reporting T2DM and 8.0% without T2DM). Only 54-55% of these respondents claimed to consistently practice preventive measures, including wearing face masks. Almost 60% of those with T2DM experienced food or medication shortages during the quarantine period, which was much higher than those without T2DM. Importantly, respondents who experienced medication shortages reported a 63% higher COVID-19 infection rate.ConclusionsT2DM was associated with an increased risk of self-reported personal and family member COVID-19 infection, which is mitigated by consistent use of face masks.FundingThe project is supported in part by research grants from the China Medical Board (Grant number: 16-262), the National Key Research and Development Program of China (Grant Number: 2017YFC0907200 & 2017YFC0907201), the University Alliance of the Silk Road (Grant number: 2020LMZX002), and Xi’an Jiaotong University Global Health Institute.Research in ContextEvidence before this studyDuring the COVID-19 pandemic, it has become increasingly clear that the risk factors for initial infection and subsequent poor health outcomes include, but are not limited to, social vulnerability, economic status, older age, and obesity. While community-wide masking has been recommended by the World Health Organization to control COVID-19, its overall effectiveness has not been clearly evaluated.Added value of this studyThrough an anonymous survey disseminated and promoted through WeChat, the largest social media platform in China, we sought to understand the impact of COVID-19 on the health, wellbeing, and health-related behaviors of adults in China. Specifically, this study examined how individuals with chronic diseases managed the threat, including their COVID-19 related knowledge, attitudes, and adherence to preventive measures such as wearing face masks, and their disease-related self-care.Implications of the available evidenceThis study demonstrates that type-2 diabetes mellitus is associated with an increased risk of COVID-19 infection, which is mitigated by consistent use of face masks.

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