scholarly journals Native American mitochondrial DNA analysis indicates that the Amerind and the Nadene populations were founded by two independent migrations.

Genetics ◽  
1992 ◽  
Vol 130 (1) ◽  
pp. 153-162 ◽  
Author(s):  
A Torroni ◽  
T G Schurr ◽  
C C Yang ◽  
E J Szathmary ◽  
R C Williams ◽  
...  
Keyword(s):  
Native American ◽  
American Indians ◽  
Sequence Variation ◽  
Dna Analysis ◽  
Restriction Analysis ◽  
Divergence Time ◽  
Divergence Times ◽  
South American ◽  
Genetic Stock ◽  
Mitochondrial Dnas

Abstract Mitochondrial DNAs (mtDNAs) from 167 American Indians including 87 Amerind-speakers (Amerinds) and 80 Nadene-speakers (Nadene) were surveyed for sequence variation by detailed restriction analysis. All Native American mtDNAs clustered into one of four distinct lineages, defined by the restriction site variants: HincII site loss at np 13,259, AluI site loss at np 5,176, 9-base pair (9-bp) COII-tRNA(Lys) intergenic deletion and HaeIII site gain at np 663. The HincII np 13,259 and AluI np 5,176 lineages were observed exclusively in Amerinds and were shared by all such tribal groups analyzed, thus demonstrating that North, Central and South American Amerinds originated from a common ancestral genetic stock. The 9-bp deletion and HaeIII np 663 lineages were found in both the Amerinds and Nadene but the Nadene HaeIII np 663 lineage had a unique sublineage defined by an RsaI site loss at np 16,329. The amount of sequence variation accumulated in the Amerind HincII np 13,259 and AluI np 5,176 lineages and that in the Amerind portion of the HaeIII np 663 lineage all gave divergence times in the order of 20,000 years before present. The divergence time for the Nadene portion of the HaeIII np 663 lineage was about 6,000-10,000 years. Hence, the ancestral Nadene migrated from Asia independently and considerably more recently than the progenitors of the Amerinds. The divergence times of both the Amerind and Nadene branches of the COII-tRNA(Lys) deletion lineage were intermediate between the Amerind and Nadene specific lineages, raising the possibility of a third source of mtDNA in American Indians.

scholarly journals Mitochondrial DNA analysis suggests a Chibchan migration into Colombia

2015 ◽  
Vol 20 (2) ◽  
pp. 261 ◽  
Author(s):  
Maria Claudia Noguera-Santamaría ◽  
Carl Edlund Anderson ◽  
Daniel Uricoechea ◽  
Clemencia Durán ◽  
Ignacio Briceño-Balcázar ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Native American ◽  
Dna Analysis ◽  
Human Genetics ◽  
Human Populations ◽  
South American ◽  
Indigenous Groups ◽  
Genetic Structures

The characterization of mitochondrial DNA (mtDNA) allows the establishment of genetic structures and phylogenetic relationships in human populations, tracing lineages far back in time. We analysed samples of mtDNA from twenty (20) Native American populations (700 individuals) dispersed throughout Colombian territory. Samples were collected during 1989-1993 in the context of the program Expedición Humana (“Human Expedition”) and stored in the Biological Repository of the Institute of Human Genetics (IGH) at the Pontificia Universidad Javeriana (Bogotá, Colombia). Haplogroups were determined by analysis of RFLPs. Most frequent was haplogroup A, with 338 individuals (48.3%). Haplogroup A is also one of the most frequent haplogroups in Mesoamerica, and we interpret our finding as supporting models that propose Chibchan-speaking groups migrated to northern Colombia from Mesoamerica in prehistoric times. Haplogroup C was found in 199 individuals (28.4%), while less frequent were B and D, with 113 and 41 (16% and 6%) individuals, respectively. The haplogroups of nine (9) individuals (1.3%) could not be determined due to the low quality of the samples of DNA. Although all the sampled populations had genetic structures that fit broadly into the patterns that might be expected for contemporary Central and South American indigenous groups, it was found that haplogroups A and B were more frequent in northern Colombia, while haplogroups C and D were more frequent in southern and south-western Colombia.

scholarly journals The structure of Brazilian Amazonian gut microbiomes in the process of urbanisation

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ana Paula Schaan ◽  
Dionison Sarquis ◽  
Giovanna C. Cavalcante ◽  
Leandro Magalhães ◽  
Eliene R. P. Sacuena ◽  
...  
Keyword(s):  
Native American ◽  
Ribosomal Rna ◽  
Gut Microbiome ◽  
Brazilian Amazon ◽  
American People ◽  
South American ◽  
Subsistence Strategy ◽  
Urban Populations ◽  
Gradual Loss ◽  
Agricultural Societies

AbstractShifts in subsistence strategy among Native American people of the Amazon may be the cause of typically western diseases previously linked to modifications of gut microbial communities. Here, we used 16S ribosomal RNA sequencing to characterise the gut microbiome of 114 rural individuals, namely Xikrin, Suruí and Tupaiú, and urban individuals from Belém city, in the Brazilian Amazon. Our findings show the degree of potential urbanisation occurring in the gut microbiome of rural Amazonian communities characterised by the gradual loss and substitution of taxa associated with rural lifestyles, such as Treponema. Comparisons to worldwide populations indicated that Native American groups are similar to South American agricultural societies and urban groups are comparable to African urban and semi-urban populations. The transitioning profile observed among traditional populations is concerning in light of increasingly urban lifestyles. Lastly, we propose the term “tropical urban” to classify the microbiome of urban populations living in tropical zones.

scholarly journals Using a GTR+Γ substitution model for dating sequence divergence when stationarity and time-reversibility assumptions are violated

2020 ◽  
Vol 36 (Supplement_2) ◽  
pp. i884-i894
Author(s):  
Jose Barba-Montoya ◽  
Qiqing Tao ◽  
Sudhir Kumar
Keyword(s):  
Divergence Time ◽  
Sequence Divergence ◽  
Molecular Dating ◽  
Divergence Times ◽  
Time Reversibility ◽  
Sequence Alignments ◽  
Divergence Time Estimates ◽  
Time Estimates ◽  
Substitution Process ◽  
The Impact

Abstract Motivation As the number and diversity of species and genes grow in contemporary datasets, two common assumptions made in all molecular dating methods, namely the time-reversibility and stationarity of the substitution process, become untenable. No software tools for molecular dating allow researchers to relax these two assumptions in their data analyses. Frequently the same General Time Reversible (GTR) model across lineages along with a gamma (+Γ) distributed rates across sites is used in relaxed clock analyses, which assumes time-reversibility and stationarity of the substitution process. Many reports have quantified the impact of violations of these underlying assumptions on molecular phylogeny, but none have systematically analyzed their impact on divergence time estimates. Results We quantified the bias on time estimates that resulted from using the GTR + Γ model for the analysis of computer-simulated nucleotide sequence alignments that were evolved with non-stationary (NS) and non-reversible (NR) substitution models. We tested Bayesian and RelTime approaches that do not require a molecular clock for estimating divergence times. Divergence times obtained using a GTR + Γ model differed only slightly (∼3% on average) from the expected times for NR datasets, but the difference was larger for NS datasets (∼10% on average). The use of only a few calibrations reduced these biases considerably (∼5%). Confidence and credibility intervals from GTR + Γ analysis usually contained correct times. Therefore, the bias introduced by the use of the GTR + Γ model to analyze datasets, in which the time-reversibility and stationarity assumptions are violated, is likely not large and can be reduced by applying multiple calibrations. Availability and implementation All datasets are deposited in Figshare: https://doi.org/10.6084/m9.figshare.12594638.

scholarly journals Sequence Analysis of Mitochondrial DNAs of 12S rRNA, 16S rRNA, and Cytochrome Oxidase Subunit 1(COI) Regions in Slow Lorises (Genus Nycticebus) May Contribute to Improved Identification of Confiscated Specimens

ISRN Zoology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Hiroko Somura ◽  
Hiroshi Hori ◽  
Yoshinobu Manome
Keyword(s):  
16S Rrna ◽  
Cytochrome Oxidase ◽  
Dna Analysis ◽  
12S Rrna ◽  
Cytochrome Oxidase Subunit ◽  
Slow Loris ◽  
Oxidase Subunit ◽  
Mitochondrial Dnas ◽  
Cytochrome Oxidase Subunit 1 ◽  
Rrna 16S

The slow loris (Nycticebus) is a prosimian that is popular among exotic pet lovers. In Japan, many slow lorises have been imported illegally. Prosimians that have been confiscated in raids are protected in Japanese zoos, and the number of such animals has increased. In most cases, the country of origin remains unknown and even the species can be difficult to identify from the animal’s physical appearance alone. We have attempted to resolve this problem by using DNA analysis. DNA samples of five species, consisting of the Pygmy slow loris (Nycticebus pygmaeus), Bengal slow loris (Nycticebus bengalensis), Sunda slow loris (Nycticebus coucang), Javan slow loris (Nycticebus javanicus), and Bornean slow loris (Nycticebus menagensis), were extracted, amplified, and the nucleotide sequences of mitochondrial 12S rRNA, 16S rRNA, and the cytochrome oxidase subunit 1(COI) regions were compared. Differences of nucleic acid sequences of representative individuals were demonstrated.

The Epidemiology of Infectious Diseases among South American Indians: A Call for Guidelines for Ethical Research

2001 ◽  
Vol 42 (3) ◽  
pp. 425-432 ◽  
Author(s):  
Magdalena Hurtado ◽  
Kim Hill ◽  
Hillard Kaplan ◽  
Jane Lancaster
Keyword(s):  
Infectious Diseases ◽  
American Indians ◽  
South American ◽  
Ethical Research ◽  
South American Indians

Prevention of Alcohol Misuse: A Review of Health Promotion Efforts among American Indians

1995 ◽  
Vol 9 (4) ◽  
pp. 288-299 ◽  
Author(s):  
Philip A. May ◽  
James R. Moran
Keyword(s):  
Health Promotion ◽  
Native American ◽  
American Indian ◽  
American Indians ◽  
Local Community ◽  
Alcohol Misuse ◽  
Heavy Drinking ◽  
Community Empowerment ◽  
Negative Consequences ◽  
Wide Range

Purpose. The purpose of this review is to provide an overview of a wide range of potentially useful strategies to address the prevention of alcohol misuse among American Indians. This broad approach to the review is useful because the extreme heterogeneity of the American Indian population requires that health promotion professionals explore many options and tailor their activities to specific communities. Search Method. A literature search was initiated through MEDLINE using the following key words: prevention, alcohol, substance abuse, American Indian, and Native American. The search yielded 29 articles from the years 1982 through 1994. These articles, along with 45 previously identified in three overview articles, form the basis of the review and discussion in this paper. Summary of findings. As a group, American Indians experience many health problems that are related to alcohol misuse. Comparison of Indians to non-Indians shows that the age of first involvement with alcohol is younger, the frequency and amount of drinking is greater, and negative consequences are more common. Health promotion programs that address these issues must take into account American Indian heterogeneity and should use a comprehensive approach that addresses both heavy drinking and the sequelae of problems related to alcohol misuse. Major Conclusions. Important concepts for providing health promotion services to this population are: cultural relevance must be carefully planned and monitored; individuals in the local community must be involved; the drunken Indian stereotype must be addressed; and community empowerment should be an important goal.

scholarly journals Board to Page to Board

2016 ◽  
Vol 10 (1) ◽  
pp. 17-31 ◽  
Author(s):  
Philip M. Winkelman
Keyword(s):  
Native American ◽  
20Th Century ◽  
American Indians ◽  
North American ◽  
Intelligent Design ◽  
Typically Develop ◽  
North American Indians ◽  
The North ◽  
Gradual Evolution

Abstract The ways new games typically develop might be viewed as a continuum ranging from very gradual “evolution” based on mutations introduced to a single progenitor during play or recall, to sudden “intelligent design” based on a purposeful and original combination — or even invention — of ludemes independent of any particular lines of transmission. This paper argues that two proprietary 20th-century games, C.A. Neves’s Fang den Hut! and Lizzie Magie’s The Landlord’s Game, were developed in a different way, a bit outside the typical continuum. It analyzes the games’ general typologies, and specific ludemes, concluding that both games are modern adaptations of traditional Native American games encountered, not through play or even contact with players, but through the seminal ethnographic publications of Stewart Culin. Specifically, Fang den Hut! derives from Boolik via Games of the North American Indians, and The Landlord’s Game derives from Zohn Ahl via Chess and Playing-Cards.

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