scholarly journals Fat Mass Loss Predicts Gain in Physical Function With Intentional Weight Loss in Older Adults

2012 ◽  
Vol 68 (1) ◽  
pp. 80-86 ◽  
Author(s):  
K. M. Beavers ◽  
M. E. Miller ◽  
W. J. Rejeski ◽  
B. J. Nicklas ◽  
S. B. Kritchevsky
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Mass Loss ◽  
Physical Function ◽  
Fat Mass ◽  
Intentional Weight Loss ◽  
Fat Mass Loss

scholarly journals Restricting Calories on Low-Carbohydrate vs Low-fat Diets for Weight Loss: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1609-1609
Author(s):  
Anthony Basile ◽  
Michael Renner ◽  
Jessica Scillian ◽  
Karen Sweazea
Keyword(s):  
Systematic Review ◽  
Weight Loss ◽  
Mass Loss ◽  
Fat Mass ◽  
Meta Analysis ◽  
Low Fat ◽  
Fat Loss ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Fat Mass Loss

Abstract Objectives As the never-ending macronutrient debate for weight loss continues, conflicting evidence persist. Per the carbohydrate-insulin hypothesis, a low-carbohydrate diet (LC) should produce a greater weight/fat loss compared to a low-fat/calorie diet (LF) by releasing less of the anabolic hormone insulin. However, from a ‘calories in, calories out’ perspective, does restricting calories on a LC diet produce a greater weight/fat loss compared to a LF diet? Methods A systematic review and meta-analysis of LC vs LF trials for weight loss was conducted and data were collected from 53 studies. Weight loss data were converted to kcals (1 kg = 3500 kcals) and a ratio was produced for each individual diet (ID-Ratio: weight loss in kcals/restricted dietary kcals) where a ratio of 1 indicates that one dietary kcal restriction equals one kcal of weight loss. Next, to compare the two diets, a comparison ratio (DC-Ratio: LC ID-Ration/LF ID-Ratio) was produced where a ratio greater than 1 indicates greater weight loss per dietary calorie restricted with LC diet. These calculations were repeated for body fat loss for full duration (n = 30 trials) and time of greatest weight loss (TGWL; Weight Loss: n = 19 trials; Fat Mass Loss: n = 4 trials). Results LC diets produced a greater weight loss (Full Duration: 6.10 kg vs 4.86 kg; n = 53 trials; P = 0.024; TGWL: 6.29 kg vs 4.34 kg; n = 19 trials; P = 0.024), however no difference was found for the amount of restricted calories or fat mass loss for either duration. No difference was found for the LC and LF ID-Ratios for weight or fat mass loss for either duration. The mean weight loss DC-Ratio was greater than 1 (Full Duration Mean: 1.61, SD: 1.71, n = 53 studies, P = 0.004; TGWL Mean: 1.74, SD: 1.0, n = 19 trails, P = 0.010) indicating a greater weight loss per calorie restricted with a LC diet. However, the fat loss DC-Ratio was not different from 1 (Full Duration Mean: 1.74, SD: 1.09, n = 30 trials, P = 0.552; TGWL Mean: 1.25, SD: 0.53, n = 4 trials, P = 0.428). Conclusions From a ‘calories in, calories out’ perspective, restricting calories on a LC diet produced a greater weight loss for the full duration of the trails and at the time of greatest weight loss compared to a LF diet. As no effect was seen on LC diets and fat mass loss, these results do not support the carbohydrate-insulin hypothesis of obesity. Funding Sources School of Life Sciences, Arizona State University.

High intake of dairy during energy restriction does not affect energy balance or the intestinal microflora compared with low dairy intake in overweight individuals in a randomized controlled trial

2018 ◽  
Vol 43 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Line Quist Bendtsen ◽  
Trine Blædel ◽  
Jacob Bak Holm ◽  
Janne Kunchel Lorenzen ◽  
Alicja Budek Mark ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Mass Loss ◽  
Fat Mass ◽  
Calcium Intake ◽  
Energy Restriction ◽  
Calcium Excretion ◽  
Fecal Fat ◽  
Fat Excretion ◽  
Fat Mass Loss

During weight loss, dairy calcium is proposed to accelerate weight and fat-mass loss through increased fecal fat excretion. The primary objective was to investigate if a high-dairy energy-restricted diet is superior to low dairy in terms of changes in body weight, body composition, and fecal fat excretion over 24 weeks. Secondary objectives included fecal energy and calcium excretion, resting energy expenditure, blood pressure, lipid metabolism, and gut microbiota. In a randomized, parallel-arm intervention study, 11 men and 69 women (body mass index, 30.6 ± 0.3 kg/m2; age, 44 ± 1 years) were allocated to a 500-kcal (2100 kJ) –deficit diet that was either high (HD: 1500 mg calcium/day) or low (LD: 600 mg calcium/day) in dairy products for 24 weeks. Habitual calcium intake was ∼1000 mg/day. Body weight loss (HD: –6.6 ± 1.3 kg, LD: –7.9 ± 1.5 kg, P = 0.73), fat-mass loss (HD: –7.8% ± 1.3%, LD: –8.5% ± 1.1%, P = 0.76), changes in fecal fat excretion (HD: –0.57 ± 0.76 g, LD: 0.46 ± 0.70 g, P = 0.12), and microbiota composition were similar for the groups over 24 weeks. However, total fat-mass loss was positively associated with relative abundance of Papillibacter (P = 0.017) independent of diet group. Consumption of a high-dairy diet did not increase fecal fat or accelerate weight and fat-mass loss beyond energy restriction over 24 weeks in overweight and obese adults with a habitual calcium intake of ∼1000 mg/day. However, this study indicates that Papillibacter is involved in body compositional changes.

scholarly journals Divergent Benefits of a Diet Plus Exercise Obesity Intervention by Race (black/white): Preliminary Cognitive and Functional Outcomes in Obese Older Adults (P21-045-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Marshall Miller ◽  
Kathryn Porter Starr ◽  
Connie Bales
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Body Weight ◽  
Physical Function ◽  
Protein Intake ◽  
The United States ◽  
Functional Improvement ◽  
Physical And Mental Health ◽  
Intentional Weight Loss ◽  
Race Time

Abstract Objectives Obesity affects a growing number of older adults, contributing to poor physical and mental health outcomes; meanwhile, treatments to reduce obesity in older adults are complicated by a relatively limited treatment window and potential loss of lean mass. Furthermore, obesity's prevalence is unevenly distributed and highest among black and Hispanic older adults, thus contributing to ongoing health disparities. Recent research from our laboratory shows that higher protein intake (≥30 g/meal) enhances functional improvement during intentional weight loss but it is not yet known whether these effects are consistent across race. Methods In an ancillary pilot study, change in body weight, physical function (Short Physical Performance Battery), and cognitive function (Trail Making Test, TMT; Symbol Digit Modalities, SMD) was assessed among obese black and white older adults with mild to moderate functional impairment (n = 10) following 3 months of weight loss intervention at one of two protein intake levels (RDA 0.8 vs 1.2 g/kg/d and (≥30 g/meal) and moderate exercise. Results Significant weight loss (P = 0.009) and improvement in physical function (SPPB; P = 0.008) were observed at 3 months. While protein effects were not observed in this subset, trends toward race*time interactions showing greater weight loss among white participants (P = 0.062) and greater function improvement among black participants (P = 0.067) were observed. Additionally, cognitive assessment revealed a race*time interaction on TMT performance (TrailsB-A; P = 0.012), which correlated with changes in body weight and physical function. Conclusions These preliminary findings suggest that obesity reduction interventions benefited older adults across multiple health domains and underscore the need for further research to characterize potentially divergent benefits of intentional weight loss within these populations. Funding Sources This study was funded by the National Dairy Council and received additional support from the United States (U.S.) Department of Veterans Affairs Rehabilitation Research and Development Service Program and the National Institute of Aging.

scholarly journals DOES PHYSICAL FUNCTION RESPONSE TO INTENTIONAL WEIGHT LOSS IN OLDER ADULTS VARY BY SEX-GENDER?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S686-S687
Author(s):  
Kristen Beavers ◽  
Rebecca Neiberg ◽  
Daniel P Beavers ◽  
Eliza Dewey ◽  
Dalane Kitzman ◽  
...  
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Weight Gain ◽  
Physical Function ◽  
Grip Strength ◽  
Intentional Weight Loss ◽  
High Loss ◽  
Individual Level ◽  
Level Data ◽  
Baseline Bmi

Abstract The purpose of this study is to explore whether the effect of intentional weight loss on physical function in older adults varies by sex/gender. Individual level data from 1369 older, (67.7±5.4 years), obese (BMI: 33.9±4.4 kg/m2), adults (30% male, 21% African American) who participated in eight randomized controlled trials of weight loss were pooled. All studies were 5-6 months in duration and collected baseline demographic and pre/post gait speed (n=1296), short physical performance battery (SPPB; n=866), and grip strength (n=401) data. Treatment effects were generated by weight loss assignment [weight loss (WL; n=764) versus non-weight loss (NWL; n=605)], as well as categorical amount of weight change (high loss: >-7%, moderate loss: -7 to -3%, and weight gain/stability: <-3%). Analyses were adjusted for age, race/ethnicity, study, education, baseline BMI, and baseline value of the outcome measure of interest. Sex/gender stratified results were presented if the interaction term was p≤0.10. A sex/gender*weight loss assignment interaction was observed for SPPB (p=0.07), with women experiencing greater weight loss-associated improvement in SPPB score (WL: 0.42±0.08 versus NWL: 0.10±0.09; p=0.02) compared to men (WL: 0.30±0.11 versus NWL: 0.30±0.13). A sex/gender*weight loss amount interaction was observed for grip strength (p=0.05), with no difference observed across categories in women; however, greatest grip strength improvement was seen in men experiencing moderate weight loss compared to high loss and weight gain/stability categories. Weight loss-associated improvement in SPPB score is greater in women than men; grip strength gains in men are greatest among those achieving moderate weight loss.

scholarly journals DOES PHYSICAL FUNCTION RESPONSE TO INTENTIONAL WEIGHT LOSS IN OLDER ADULTS VARY BY RACE-ETHNICITY?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S680-S680
Author(s):  
Daniel P Beavers ◽  
Rebecca Neiberg ◽  
Kristen Beavers ◽  
Dalane Kitzman ◽  
Barbara M Nicklas ◽  
...  
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
African Americans ◽  
Physical Function ◽  
Gait Speed ◽  
Intentional Weight Loss ◽  
High Loss ◽  
Individual Level ◽  
Beneficial Effects ◽  
Race Ethnicity

Abstract The purpose of this study is to explore whether the effect of weight loss on physical function in older adults varies by race/ethnicity. Individual level data from 1369 older, (67.7±5.4 years), obese (BMI: 33.9±4.4 kg/m2), adults (30% male, 21% African American) who participated in eight randomized controlled trials of weight loss were pooled. Studies were 5-6 months in duration and collected baseline demographic and pre/post gait speed (n=1296), short physical performance battery (SPPB; n=866), and grip strength (n=401) data. Treatment effects were generated by weight loss assignment [weight loss (WL; n=764) versus non-weight loss (NWL; n=605)], as well as categorical amount of weight change (high loss: >-7%, moderate loss: -7 to -3%, and weight gain/stability: <-3%). Analyses were adjusted for age, sex/gender, study, education, baseline BMI, and baseline value of the outcome measure of interest. Race/ethnicity stratified results were presented if the interaction term was p≤0.10. A race/ethnicity*weight loss assignment interaction was observed for gait speed (p=0.07), with African Americans experiencing greater weight loss-associated improvement (WL: 0.07±0.01 m/s versus NWL: 0.02±0.01 m/s; p=0.03) compared to Whites (WL: 0.08±0.01 m/s versus NWL: 0.07±0.01 m/s). A race/ethnicity*weight loss amount interaction was also observed for gait speed (p<0.01), with greater weight loss associated with greater improvement in both African Americans and Whites; although, gains were most apparent in African Americans experiencing high loss (0.12±0.02 m/s) compared to gain/stability (0.01±0.01 m/s). The beneficial effects of weight loss on gait speed appear greater in African Americans and are augmented with greater weight loss.

scholarly journals Association of PPARG and PPARGC1 polymorphism with effectiveness of exercise-induced fat mass loss

2020 ◽  
Vol 27 ◽  
pp. 196-201
Author(s):  
Iu. Iu. Mazur ◽  
S. B. Drozdovska ◽  
O. V. Andrieieva ◽  
Yu. Vinnichuk ◽  
A. Polishchuk ◽  
...  
Keyword(s):  
Weight Loss ◽  
Mass Loss ◽  
Fat Mass ◽  
Visceral Fat ◽  
Exercise Intervention ◽  
Physical Activity Intervention ◽  
Plasma Lipoproteins ◽  
Single Nucleotide ◽  
Fat Mass Loss ◽  
Pparg Expression

Aim. Peroxisome proliferator activated receptor gamma (PPARG) and PPARG coactivator 1α (PPARGC1A) is a key regulator of energy metabolism. This study examines the influence of PPARG and PPARGC1A gene polymorphisms on the PPARG expression, obesity risk, lipoprotein profile and effectiveness of the physical activity intervention for improvement of these parameters. Methods. 39 women with BMI>30 kg/m2 participated in the three-months fitness-program and followed a hypocaloric diet (1500 kCal). At the beginning and at the end of the program, the following anthropometric and biochemical parameters were measured: BMI, percentage of total and visceral fat, amount of plasma lipoproteins, cholesterol, and triglycerides. Single nucleotide polymorphisms were identified in PPARG (n=94) and PPARGC1A (n=138) genes. PPARG mRNA expression was measured through reverse transcription PCR. Results. The physical exercise intervention resulted in a significant fat mass loss in all participants (40.3±5.3% before the study vs 36.4±5.7% after the study, P<0.00001). Polymorphisms rs6442311, rs6846769, rs6846769 were associated with lower visceral fat percent, rs6442311 also correlated with PPARG expression. PPARGC1A polymorphisms rs4458444, rs2305681 were associated with plasma lipoproteins, cholesterol, and triglyceride content. Weight loss effectiveness was connected with rs17650401, rs9833097, rs12629751. Conclusions. After correction for multiple comparisons only rs17650401, of PPARGC1A gene was associated with more effective fat mass reduction. Keywords: PPARG, obesity, single nucleotide polymorphism, weight loss, exercise intervention.

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