The Joint Associations of Sedentary Time and Physical Activity With Mobility Disability in Older People: The NIH-AARP Diet and Health Study

AbstractObjectiveTo examine the independent and joint associations thigh-worn accelerometry assessed sedentary time and moderate to vigorous physical activity with cardiometabolic health markers.DesignCross-sectional study embedded in the age-46 wave an established birth cohort, the 1970 British Birth Cohort.SettingPopulation-based sample from Great Britain (England, Scotland, and Wales).MethodsOutcome measures included: body mass index, waist-to-hip ratio, blood pressure, glycated hemoglobin, high-density lipoprotein cholesterol, total cholesterol, triglycerides, and c-reactive protein. Sedentary behavior and other physical activity exposures, recorded by a thigh-worn activPAL3 accelerometry, included: daily sedentary time, breaks in sedentary time, daily time spent in moderate-to-vigorous physical activity. Multiple linear regression analyses, multiple logistic regression analyses, and general linear models were conducted as applicable.Results4,634 participants were available for the final analysis. After adjusting for potential confounders and moderate-to-vigorous physical activity, daily sedentary time was positively associated with triglycerides (β=0.052 [0.015, 0.089]) and inversely associated with high-density lipoprotein cholesterol (β=-0.015 [-0.022, -0.010]). Daily prolonged sedentary time (≥ 60 minutes) was positively associated with both glycated hemoglobin and log-transformed c-reactive protein (β=0.240 [0.030, 0.440] and 0.026 [0.007, 0.045], respectively) and inversely associated with systolic blood pressure and high-density lipoprotein cholesterol (β=-0.450 [-0.760, -0.150] and -0.013 [-0.022, -0.003], respectively). After adjusting for potential confounders and daily sedentary time, daily breaks in sedentary time were inversely associated with glycated hemoglobin (β=-0.020 [-0.037, -0.003]), and positively associated with both triglycerides and systolic blood pressure (β=0.006 [0.002, 0.010] and 0.030 [0.002, 0.050], respectively). The joint associations of prolonged sedentary time and moderate-to-vigorous physical activity with the prevalence of diabetes were not statistically significant.ConclusionProlonged sedentary time (≥ 60 minutes) and daily breaks in sedentary time were deleteriously associated with glycated hemoglobin, although we found no evidence that there were joint moderate-to-vigorous physical activity and sitting associations.

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Joint associations between weekday and weekend physical activity or sedentary time and childhood obesity

International Journal of Obesity ◽

10.1038/s41366-019-0329-9 ◽

2019 ◽

Vol 43 (4) ◽

pp. 691-700 ◽

Cited By ~ 5

Author(s):

Nan Li ◽

◽

Pei Zhao ◽

Chengming Diao ◽

Yijuan Qiao ◽

...

Keyword(s):

Physical Activity ◽

Childhood Obesity ◽

Sedentary Time ◽

Joint Associations

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Joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals

British Journal of Sports Medicine ◽

10.1136/bjsports-2020-103270 ◽

2020 ◽

Vol 54 (24) ◽

pp. 1499-1506

Author(s):

Ulf Ekelund ◽

Jakob Tarp ◽

Morten W Fagerland ◽

Jostein Steene Johannessen ◽

Bjørge H Hansen ◽

...

Keyword(s):

Physical Activity ◽

Proportional Hazards ◽

Sedentary Time ◽

Meta Analysis ◽

Cox Proportional Hazards ◽

Older Individuals ◽

Risk Of Death ◽

All Cause Mortality ◽

Reported Data ◽

Joint Associations

ObjectivesTo examine the joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality.MethodsWe conducted a harmonised meta-analysis including nine prospective cohort studies from four countries. 44 370 men and women were followed for 4.0 to 14.5 years during which 3451 participants died (7.8% mortality rate). Associations between different combinations of moderate-to-vigorous intensity physical activity (MVPA) and sedentary time were analysed at study level using Cox proportional hazards regression analysis and summarised using random effects meta-analysis.ResultsAcross cohorts, the average time spent sedentary ranged from 8.5 hours/day to 10.5 hours/day and 8 min/day to 35 min/day for MVPA. Compared with the referent group (highest physical activity/lowest sedentary time), the risk of death increased with lower levels of MVPA and greater amounts of sedentary time. Among those in the highest third of MVPA, the risk of death was not statistically different from the referent for those in the middle (16%; 95% CI 0.87% to 1.54%) and highest (40%; 95% CI 0.87% to 2.26%) thirds of sedentary time. Those in the lowest third of MVPA had a greater risk of death in all combinations with sedentary time; 65% (95% CI 1.25% to 2.19%), 65% (95% CI 1.24% to 2.21%) and 263% (95% CI 1.93% to 3.57%), respectively.ConclusionHigher sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30–40 min of MVPA per day attenuate the association between sedentary time and risk of death, which is lower than previous estimates from self-reported data.

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Abstract P332: Socio-environmental Influences on Youth Total Sedentary Time: Results From the Hispanic Community Health Study / Study of Latino Youth

Circulation ◽

10.1161/circ.137.suppl_1.p332 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Melawhy L Garcia ◽

Sheila F Castaneda ◽

Linda C Gallo ◽

Maria Lopez-Gurrola ◽

Krista M Perreira ◽

...

Keyword(s):

Physical Activity ◽

Environmental Factors ◽

Sedentary Behavior ◽

Sedentary Time ◽

Latino Youth ◽

Self Report ◽

Health Study ◽

Future Research ◽

Linear Regression Models ◽

Sampling Weights

Introduction: Sedentary behavior (SED) is associated with higher obesity and cardiometabolic risk in youth, independent of physical activity. Studies showing the association between screen time and SED among Hispanics/Latinos, have primarily focused on Mexican-origin Hispanics. Additional research is needed to examine other socio-environmental factors that can influence SED among diverse Hispanics/Latinos. This cross-sectional study examined the home-, neighborhood-, and school- environment to identify factors associated with total sedentary time among youth. Methods: Data from 1,104 youth ages 8-16 years and 728 caregivers (mean age 43.1 ± 8.2 years) from four U.S. cities, who participated in the Study of Latino Youth (2012-2014), were examined. Associations between socio-environmental factors (measured by self-report) and total sedentary time (measured by one-week Actical accelerometry) were examined in linear regression models that included MVPA minutes/day, demographic covariates, and accounted for the complex survey design and sampling weights. Results: Mean sedentary time was 10.1 ± 1.8 hours/day. Home environment factors, such as electronics in the bedroom and parent limit setting, were not associated with total sedentary time. Presence of barriers to physical activity in the neighborhood (e.g., muggings, gangs) was associated with 13.4 more minutes of sedentary time per day. Attending a school that never/rarely compared to sometimes offered after school physical activity opportunities was associated with more sedentary time (B=38.0 minutes/day; 95% Confidence Interval: 13.5-62.4). Conclusions: The study findings highlight the need for future research to investigate other sources of sedentary behavior in the home for interventionist to focus on specific SED-based strategies to decrease sedentary time among youth. Minimizing barriers by identifying safe places to be active in participant’s neighborhoods may also support youth to spend less time indoors where sedentary time is prevalent.

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Addressing the Nonexercise Part of the Activity Continuum: A More Realistic and Achievable Approach to Activity Programming for Adults With Mobility Disability?

Physical Therapy ◽

10.2522/ptj.20110284 ◽

2012 ◽

Vol 92 (4) ◽

pp. 614-625 ◽

Cited By ~ 86

Author(s):

Patricia J. Manns ◽

David W. Dunstan ◽

Neville Owen ◽

Genevieve N. Healy

Keyword(s):

Physical Activity ◽

Light Intensity ◽

Sedentary Behavior ◽

Sedentary Time ◽

Metabolic Health ◽

Moderate Intensity ◽

Future Research ◽

Mobility Disability ◽

Activity Promotion ◽

Cord Injury

Abstract Participation in physical activity is fundamental for the maintenance of metabolic health and the prevention of major chronic diseases, particularly type 2 diabetes and cardiovascular disease. A whole-of-day approach to physical activity promotion is increasingly advocated and includes not only increasing moderate-intensity physical activity but also reducing sedentary time and increasing light-intensity activity (the “nonexercise” part of the activity continuum). This whole-of-day approach to tackling the challenge of inactivity may be particularly relevant for adults with mobility disabilities, who are among the most inactive segment of the population. Focusing on nonexercise activity by striving to reduce sedentary time and increase light-intensity activity may be a more successful place to begin to change behavior in someone with mobility disability. This article discusses what is known about the metabolic health consequences of sedentary behavior and light-intensity activity in adults with and without mobility disability. The concept of inactivity physiology is presented, along with possible applications or evidence from studies with adults with mobility disability. Mobility disability discussions and examples focus on stroke and spinal cord injury. Finally, clinical implications and future research directions related to sedentary behavior in adults with mobility disability are discussed.

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Abstract 32: Joint Associations of Peripheral Artery Disease and Objectively-measured Physical Activity With Mortality: The Hispanic Community Health Study / Study of Latinos

Circulation ◽

10.1161/circ.141.suppl_1.32 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Yumin Gao ◽

Simin Hua ◽

Yejin Mok ◽

Qibin Qi ◽

Guochong Chen ◽

...

Keyword(s):

Physical Activity ◽

Sedentary Time ◽

Objective Measure ◽

Activity Levels ◽

Physical Movement ◽

Physical Activity Levels ◽

Artery Disease ◽

Objectively Measured ◽

Objectively Measured Physical Activity ◽

Joint Associations

Background: Peripheral artery disease (PAD) reduces physical activity, and both PAD and lower physical activity levels have been shown to increase mortality risk. Yet, their joint contributions to mortality have not been systematically studied, especially with the objective measure of physical activity. Hypothesis: PAD and lower 1-week objectively-measured physical activity are synergistically associated with mortality. Methods: We studied 7124 Hispanic adults aged 45-74 years at baseline from the Study of Latinos who adhered to an objective measure of physical activity using wearable accelerometers. We quantified the associations of the status of PAD (ankle-brachial index [ABI] ≤0.90 [PAD], 0.91-1.39 [no PAD], and ≥1.40 [possible PAD with ankle artery calcification]) and two physical activity measures (sedentary time [tertiles] and daily physical movement counts [tertiles]) at baseline with mortality using multivariable Cox models accounting for sampling weights. Results: During a median follow-up of 7.0 years, 289 participants died. Sedentary time and daily physical movement counts were weakly correlated (r=-0.17). Both low and high ABI, longer sedentary time, and lower physical movement counts were all independently associated with increased mortality risk (marginal cells in Table ). In terms of the joint associations of PAD and physical activity with mortality, they generally demonstrated synergistic associations (e.g., hazard ratio 4.43 [95%CI, 2.44-8.03] in ABI ≤0.9 plus top tertile of sedentary time and 5.46 [2.47-12.08] in ABI ≥1.40 plus top tertile of sedentary time vs. normal ABI with shortest sedentary time) (cross-categories in Table ), with no significant interactions. Conclusions: Both low and high ABI, and lower objectively-measured physical activity levels were significantly associated with greater risk of mortality independently of each other and potential confounders. Our results suggest the importance of objectively evaluating daily physical activity levels and leg vascular condition.

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Joint Associations of Adiposity and Physical Activity With Mortality: The National Institutes of Health-AARP Diet and Health Study

American Journal of Epidemiology ◽

10.1093/aje/kwp053 ◽

2009 ◽

Vol 169 (11) ◽

pp. 1344-1351 ◽

Cited By ~ 29

Author(s):

A. Koster ◽

T. B. Harris ◽

S. C. Moore ◽

A. Schatzkin ◽

A. R. Hollenbeck ◽

...

Keyword(s):

Physical Activity ◽

National Institutes Of Health ◽

Health Study ◽

Joint Associations

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Daily Physical Activity and Sedentary Time Assessed by Acceleration Based on Mean Amplitude Deviation among Older People

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17186887 ◽

2020 ◽

Vol 17 (18) ◽

pp. 6887

Author(s):

Ying Gao ◽

Timo Rantalainen ◽

Taija Finni ◽

Erja Portegijs ◽

Johanna Eronen ◽

...

Keyword(s):

Physical Activity ◽

Older People ◽

Sedentary Behavior ◽

Sedentary Time ◽

Mean Amplitude ◽

Community Dwelling ◽

Older Individuals ◽

Self Reports ◽

Light Activity ◽

Community Dwelling Older People

Accelerometer-derived estimates of physical activity (PA) and sedentary time have been an important methodological focus. However, little is known about the daily activities among older people during their normal lives. Furthermore, some older individuals would like to be more active, yet experience an unmet PA need, which is defined as the desire to engage in more PA but without the opportunity to act on the desire. This study examined the intensity of daily PA and sedentary behavior measured with accelerometers among older people, and whether PA differs between weekdays and weekends and those with and without the experience of unmet PA need, measured with self-reports. A total of 174 community-dwelling older people (64% female) aged 75 to 90 years used an accelerometer for 7 consecutive days during waking hours, and the results were classified for sedentary behavior (thresholds of 0.0167 g), light activity (0.091 g), and moderate-to-vigorous activity (MVPA, 0.414 g) based on mean amplitude deviation (g). We found that during weekdays, older people engaged slightly more in light activity and had less sedentary time than during weekends. In total, 7.6% of the participants perceived an unmet PA need. Accordingly, those with unmet PA needs spent less time in MVPA, especially during weekdays, and they might benefit from PA-enabling interventions.

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