scholarly journals Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: endocrine aspects

2001 ◽  
Vol 16 (8) ◽  
pp. 1603-1610 ◽  
Author(s):  
T. Sir-Petermann
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Ovarian Function ◽  
Ovarian Syndrome

scholarly journals ASSESSMENT OF THE EFFICACY OF SPECIFIC YOGASANASA - SINGLE CASE STUDY ON PCOS

2020 ◽  
Vol p4 (05) ◽  
pp. 2450-2452
Author(s):  
Sushma 1 ◽  
Shivani Chaudhary ◽  
Satish Jalihal
Keyword(s):  
Metabolic Disorders ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Function ◽  
Single Case ◽  
Primordial Follicle ◽  
Cystic Changes ◽  
Diet And Lifestyle ◽  
Day By Day ◽  
Ovarian Syndrome

Due to sedentary lifestyle and stress, the incidence of metabolic disorders is increasing day by day. Among these, polycystic ovarian syndrome (PCOS) is one of them. PCOS is a disease, which is related to cystic changes in the ovary. The follicles develop from primordial follicle, but the development stops at an early antral stage due to disturbed ovarian function. Women with PCOS have irregular menstrual cycle, excess of androgen, anovulation, acne, hirsutism and infertility. According to Ayurveda, this type of clinical features is found in Pushpagni, Jataharni and Artavakshaya. It can be considered as rasa Medodhatuvikara and has to be managed depending on Doshadushya vitiation. Ayurvedic management principles as Amaha-rachikitsa, Shodhana and Samana therapies along with Vata-Kaphahara Dravyas. Diet and lifestyle modi-fications are also proving to be beneficial in PCOS. The present study highlights the effect of Samana ther-apy in PCOS.

scholarly journals Laparoscopic ovarian drilling in clomiphene citrate resistant polycystic ovarian syndrome patients

2018 ◽  
Vol 5 (10) ◽  
pp. 3230
Author(s):  
M. Sridhar ◽  
Chillamherla Susmitha
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Ovarian Function ◽  
Surgical Intervention ◽  
Clomiphene Citrate ◽  
Reproductive Age ◽  
Transvaginal Sonography ◽  
Polycystic Ovarian Disease ◽  
Laparoscopic Ovarian Drilling ◽  
Ovarian Drilling ◽  
Ovarian Syndrome

Background: Polycystic ovarian disease (PCOD) or polycystic ovarian syndrome (PCOS) is a common endocrine disorder which commonly affects women in their reproductive age, often leading to anovulatory infertility. There has been a resurgence of surgical intervention with the advent of ovarian drilling. This study was performed to assess the surgical management for patients with PCOS resistant to hormonal therapy.Methods: A thorough history and demographic details were taken from all the patients. A detailed clinical examination, along with transvaginal sonography was done. Laparoscopic ovarian drilling was performed on the patients under general anesthesia.Results: Most of the women were in the 3rd decade of their life and majority of the women had attained menarche at 13 years. The chief complaint of the patients was irregular periods experienced by 80%. 44.4% of the patents had normal BMI, while 31.5% were underweight. Most of the patients (6.7%) showed no evidence of hyperandrogenism, while 20% had hirsutism, 11% had acne.Conclusions: Polycystic ovarian syndrome is quite prevalent among the women of reproductive age. The effective treatment for PCOS which are resistant to hormonal therapy is laparoscopic drilling of the ovaries which results in ovarian function.

scholarly journals Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway

Reproduction ◽  
2020 ◽  
Vol 159 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Fang-Ju Wu ◽  
Ying-Wen Wang ◽  
Ching-Wei Luo
Keyword(s):  
Bone Morphogenetic Proteins ◽  
Granulosa Cells ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Function ◽  
Cell Function ◽  
Type I ◽  
Type Ii ◽  
Related Gene ◽  
Inhibitory Effects ◽  
Ovarian Syndrome

Bone morphogenetic proteins (BMPs) are known to play an indispensable role in preventing the precocious luteinization of granulosa cells within growing ovarian follicles. In this study, we found that the transcripts of BMP8 genes are enriched in the ovaries of humans and rodents. When analyzing transcriptomic datasets obtained from human mature granulosa cells, we further found that the BMP8 transcripts not only show the highest abundance among the searchable BMP-related ligands but also decrease significantly in women of advanced age or women with polycystic ovarian syndrome. The correlation between the BMP8 levels in granulosa cells and the decline in ovarian function in these subjects suggests that BMP8 protein may be involved in the regulation of granulosa cell function(s). Using a rat model, we demonstrated that human BMP8A protein activates the SMAD1/5/8 and the SMAD2/3 pathways simultaneously in both immature and mature granulosa cells. Furthermore, the expression of potential type I and type II receptors used by BMP8 in rat granulosa cells was characterized. We found that BMP8A treatment can significantly inhibit gonadotropin-induced progesterone production and steroidogenesis-related gene expression in granulosa cells. Pathway dissection using receptor inhibitors further revealed that such inhibitory effects occur specifically through the BMP8-activated SMAD1/5/8, but not SMAD2/3, pathway. Taken together, considering its abundance and possible functions in granulosa cells, we suggest that BMP8 may act as a novel luteinization inhibitor in growing follicles.

scholarly journals Inositols in PCOS

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5566
Author(s):  
Zdravko Kamenov ◽  
Antoaneta Gateva
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Ovarian Function ◽  
Biochemical Pathways ◽  
Randomized Controlled ◽  
Metabolic Outcomes ◽  
Current Review ◽  
Reproductive Axis ◽  
Novel Method ◽  
Post Implantation ◽  
Ovarian Syndrome

(1) Background: Myoinositol (MI) and D-chiro-inositol (DCI) are involved in a number of biochemical pathways within oocytes having a role in oocyte maturation, fertilization, implantation, and post-implantation development. Both inositols have a role in insulin signaling and hormonal synthesis in the ovaries. (2) Methods: Literature search (with key words: inositols, myo-inositol, d-chiro-inositol, PCOS) was done in PubMed until Sept. 2020 and 197 articles were identified, of which 47 were of clinical trials (35 randomized controlled trials). (3) Results: Many studies have demonstrated that in patients with polycystic ovarian syndrome (PCOS) MI treatment improved ovarian function and fertility, decreased the severity of hyperandrogenism including acne and hirsutism, positively affected metabolic aspects, and modulated various hormonal parameters deeply involved in the reproductive axis function and ovulation. Thus treating with MI has become a novel method to ameliorate PCOS symptoms, improve spontaneous ovulation, or induce ovulation. The current review is focused on the effects of MI and DCI alone or in combination with other agents on the pathological features of PCOS with focus on insulin resistance and adverse metabolic outcomes. (4) Conclusions: The available clinical data suggest that MI, DCI, and their combination in physiological ratio 40:1 with or without other compound could be beneficial for improving metabolic, hormonal, and reproductive aspects of PCOS.

scholarly journals Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency

2016 ◽  
Vol 29 (5) ◽  
Author(s):  
Alessandro Ciresi ◽  
Marco C. Amato ◽  
Jessica Bianco ◽  
Carla Giordano
Keyword(s):  
Growth Hormone ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Function ◽  
Hdl Cholesterol ◽  
Treated Group ◽  
Hormone Deficiency ◽  
Childhood Growth ◽  
Group A ◽  
Group B ◽  
Ovarian Syndrome

AbstractGrowth hormone (GH) plays a role in the regulation of ovarian function but there are limited data in women with GH deficiency (GHD). Our aim was to evaluate the features of polycystic ovarian syndrome (PCOS) in women with previous GHD.Data of 22 adolescents previously GH-treated (group A) were compared with those of 22 women with classical PCOS (group B) and 20 controls (group C).: Group A showed higher testosterone (p=0.048) and prevalence of menstrual irregularities (p<0.001) than group C. Compared to the group B, group A showed lower diastolic blood pressure (p=0.004), degree of hirsutism (p=0.005), testosterone (p=0.003) and prevalence of polycsytic ovaries (POC) morphology (p=0.024), with higher HDL-cholesterol (p=0.035) and 17-β-estradiol (p=0.009).: Adolescents with previous GHD show a higher prevalence of PCOS than controls, but with milder metabolic and hormonal features than adolescents with classical PCOS. A careful long-term follow-up is advisable in these patients.

scholarly journals Association between Anti-Müllerian Hormone and other biomarkers with ovarian function in polycystic ovarian syndrome of Iraqi women

2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Huda Basim Al-Lami ◽  
Fadhil Jawad Al-Tu’ma ◽  
Wasan Ghazi Al-Safi
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Function ◽  
Fasting Blood Glucose ◽  
Normal Weight ◽  
The Body ◽  
Control Group ◽  
Total Testosterone ◽  
Iraqi Women ◽  
Ovarian Syndrome

Objectives: The current study aimed to investigate the role of of Anti-Müllerian hormone and other hormonal biomarkers and insulin resistance in pathogenesis of polycystic ovarian syndrome of Iraqi women with various ages and BMI. Method: The sublects include 50 cases of polycystic ovarian syndrome obtained from gynecological and obstetric teaching hospital, Kerbala health directorate / Kerbala – Iraq and another 50 apparently healthy women as a control group. with age ranged between (18-37) years during the period from Dec. 2019 to June, 2020 which was divided into two groups depending upon their age; first group with age (18-27) years and the second with age (28-37) years, also they divided into three subgroups depending upon the body mass index, normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), obesity (30-34.9 kg/m2) and  measurement of various hormonal levels were performed including LH, FSH, insulin, insulin resistance, total testosterone and anti-müllerian hormone. Results: A significant elevated levels of each of Anti-Müllerian hormone (AMH), insulin, LH, total testosterone, prolactin, fasting blood glucose, FBG and insulin resistance while, a non-significant differences was found in FSH levels in women with PCOS as compared with control group. Conclusion: A significant high levels of the all hormonal parameters including anti-müllerian hormone, LH, prolactin and total testosterone  was found in women with PCOS as compared with the control, except the FSH values.

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