scholarly journals The difference in postoperative pulmonary functional change between upper and lower thoracoscopic lobectomy

2021 ◽  
Author(s):  
Shinya Tane ◽  
Mai Kitazume ◽  
Yusuke Fujibayashi ◽  
Sanae Kuroda ◽  
Kenji Kimura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Function ◽  
Morphological Changes ◽  
Left Lung ◽  
Functional Change ◽  
Middle Lobe ◽  
Smoking History ◽  
Functional Changes ◽  
Thoracoscopic Lobectomy ◽  
The Difference

Abstract OBJECTIVES Through 3-dimensional lung volumetric and morphological analyses, we aimed to evaluate the difference in postoperative functional changes between upper and lower thoracoscopic lobectomy. METHODS A total of 145 lung cancer patients who underwent thoracoscopic upper lobectomy (UL) were matched with 145 patients with lung cancer who underwent thoracoscopic lower lobectomy (LL) between April 2012 and December 2018, based on their sex, age, smoking history, operation side, and pulmonary function. Spirometry and computed tomography were performed before and 6 months after the operation. In addition, the postoperative pulmonary function, volume and morphological changes between the 2 groups were compared. RESULTS The rate of postoperative decreased and the ratio of actual to predicted postoperative forced expiratory volume in 1 s were significantly higher after LL than after UL (P < 0.001 for both). The tendency above was similar irrespective of the resected side. The postoperative actual volumes of the ipsilateral residual lobe and contralateral lung were larger than the preoperatively measured volumes in each side lobectomy. Moreover, the increased change was particularly remarkable in the middle lobe after right LL. The change in the D-value, representing the structural complexity of the lung, was better maintained in the left lung after LL than after UL (P = 0.042). CONCLUSIONS Pulmonary function after thoracoscopic LL was superior to that after UL because the upward displacement and the pulmonary reserves of the remaining lobe appeared more robust after LL.

scholarly journals Lung Cancer Presenting as Skin Metastasis of the Back and Hand: A Case Series and Literature Review

2019 ◽  
Vol 12 (2) ◽  
pp. 480-487 ◽  
Author(s):  
Misbahuddin Khaja ◽  
Daniel Mundt ◽  
Rizwan Ahmed Dudekula ◽  
Umair Ashraf ◽  
Shehriyar Mehershahi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ct Scan ◽  
Left Lung ◽  
Case Series ◽  
The United States ◽  
Middle Lobe ◽  
Skin Metastasis ◽  
Smoking History ◽  
Poorly Differentiated ◽  
The Right

Lung cancer has the highest mortality of all cancers in the United States. The incidence of lung cancer with metastases to the skin varies between 1–12%, with the highest incidence seen in men. Here, we present two cases of lung cancer presenting as skin metastasis. The first patient was an 80-year-old African American male who presented to the hospital for evaluation of a right upper back mass. A few months prior to admission, he was found to have a left lung mass on CT scan of the chest, he underwent biopsy which showed poorly differentiated SCC of the lung. He also had a skin biopsy which showed poorly differentiated carcinoma in the dermis consistent with metastatic SCC. He was started on chemotherapy, but could not tolerate it. He was accepted to hospice. The second patient was a 78-year-old Hispanic female who presented to the hospital with dyspnea, and a dry cough. Upon physical examination, a 2 × 2 cm ulcerated, wart-like nodule on the right palm was noted. Subsequent CT scan of the chest showed a partial collapse of the right middle lobe. A biopsy of the hand mass revealed well-to-moderately differentiated metastatic SCC favoring lung origin. A bronchoscopy biopsy showed invasive SCC. Subsequently her condition worsened and she passed away. Metastasis to the skin is an unusual presenting symptom of lung cancer. It is therefore essential to consider metastasis as a diagnosis in a patient with both a skin lesion and a smoking history.

Long-Term Pulmonary Function after Lobectomy for Primary Lung Cancer

2005 ◽  
Vol 13 (4) ◽  
pp. 311-315 ◽  
Author(s):  
Yasunobu Funakoshi ◽  
Shin-Ichi Takeda ◽  
Noriyoshi Sawabata ◽  
Yoshitomo Okumura ◽  
Hajime Maeda
Keyword(s):  
Lung Cancer ◽  
Pulmonary Function ◽  
Induction Therapy ◽  
Surgical Approach ◽  
Vital Capacity ◽  
Univariate Analysis ◽  
Primary Lung Cancer ◽  
Postoperative Pulmonary Function ◽  
The Difference

The aim of this study was to investigate the factors affecting long-term postoperative pulmonary function with a view to increasing the application of combined resection, bronchoplasty, and induction therapy. Results in 80 patients who underwent lobectomy for primary lung cancer were analyzed. Predicted postoperative pulmonary function was calculated using the formula: postoperative predicted function = preoperative function × [1 − (b − n) /(42 − n)], where n and b are the numbers of obstructed segments and total segments, respectively, in the resected lobe. Spirometry was performed serially on the preoperative day, and at 3, 6, 12, 18, and 24 months postoperatively. The difference between the predicted postoperative pulmonary function and the function measured at 12 months postoperatively was calculated, and clinical and therapeutic variables were analyzed. Univariate analysis revealed that the difference in vital capacity was significantly related to surgical approach, bronchoplasty, and induction therapy, while the difference in forced expiratory volume in one second (FEV1) correlated with surgical approach and induction therapy. Multiple regression analysis showed induction therapy to be the sole factor related to the differences in both vital capacity and FEV1. Lung resection after induction therapy may cause an additional loss of pulmonary function in the late phase.

Do we need to perform pulmonary function tests in non-small cell lung cancer patients never diagnosed as COPD?

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. TPS9151-TPS9151
Author(s):  
Narongwit Nakwan ◽  
Sarayut Lucien Geater
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Pulmonary Function ◽  
Cancer Patients ◽  
Pulmonary Function Tests ◽  
Small Cell ◽  
Smoking History ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Function Tests

TPS9151 Background: Although chronic obstructive pulmonary disease (COPD) and lung cancer share a common risk factor, namely smoking, health care providers usually overlook the symptom of COPD in the management of lung cancer. Should, then, lung cancer patients undergo pulmonary function tests (PFT) to identify the presence of COPD? Our study was performed to describe the results of pulmonary function tests and define risk factors for COPD in non-small cell lung cancer (NSCLC) patients. Methods: A total of 31 eligible patients with NSCLC but no obvious symptoms of COPD participated. We collected baseline characteristics and conducted a detailed assessment of pulmonary function, particularly spirometry, lung volume measurement, and diffusing capacity of carbon monoxide (DLCO). Dyspnea was assessed using modified Borg (mBorg) and modified Medical Research Council (mMRC) scores. Results: Twelve patients had airflow limitation (FEV1/FVC<0.7). These patients had mean percent predicted FEV1, RV and DLCO of 52%, 143% and 66% respectively, and a mean RV/TLC of 0.55. Being male, and having a smoking history, low body mass index and squamous cell carcinoma were significantly associated with obstruction in univariate analysis. However, obstruction was not more common in advanced stage than in locally advanced NSCLC. Neither mBorg nor mMRC differed between obstructive and non-obstructive groups. Discussion: COPD was found in patients with NSCLC who had never been diagnosed as, or showed symptoms of, COPD. Male, smoking history, low BMI and squamous cell carcinoma were significantly associated with obstruction.

scholarly journals Ebola virus is evolving but not changing: no evidence for functional change in EBOV from 1976 to the 2014 outbreak

2015 ◽  
Author(s):  
Abayomi S Olabode ◽  
Xiaowei Jiang ◽  
David L Robertson ◽  
Simon C Lovell
Keyword(s):  
Genetic Variation ◽  
Protein Structure ◽  
Amino Acid ◽  
West Africa ◽  
Ebola Virus ◽  
Functional Change ◽  
Minimal Effect ◽  
Functional Changes ◽  
Epidemiological Factors ◽  
The Difference

The Ebola epidemic is having a devastating impact in West Africa. Sequencing of Ebola viruses from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to the human host and accounting for the scale of the 2014 outbreak. We show that so far there is no evidence for adaptation of EBOV to humans. We analyze the putatively functional changes associated with the current and previous Ebola outbreaks, and find no significant molecular changes. Observed amino acid replacements have minimal effect on protein structure, being neither stabilizing nor destabilizing. Replacements are not found in regions of the proteins associated with known functions and tend to occur in disordered regions. This observation indicates that the difference between the current and previous outbreaks is not due to the observed evolutionary change of the virus. Instead, epidemiological factors must be responsible for the unprecedented spread of EBOV.

scholarly journals Relationships between pulmonary function test parameters and quantitative computed tomography measurements of emphysema in subjects with chronic obstructive pulmonary disease

2018 ◽  
Vol 24 (4) ◽  
pp. 209-218
Author(s):  
Virginija Šileikienė ◽  
Marius Urbonas ◽  
Mindaugas Matačiūnas ◽  
Jolita Norkūnienė
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Left Lung ◽  
Middle Lobe ◽  
Quantitative Ct ◽  
Ct Measurements ◽  
Function Tests ◽  
Test Parameters ◽  
Right Middle Lobe ◽  
The Right

Objective. CT is able to precisely define the pathological process in COPD. There are a number of previous articles discussing the distribution of emphysema and its connection with pulmonary function tests. However, the results obtained by the researchers are not identical. Purpose. To assess relationships between emphysema and pulmonary function test parameters in COPD patients. Materials and methods. Fifty-nine patients diagnosed to have COPD underwent chest CT examinations and pulmonary function tests. For the quantitative assessment, percentages of low attenuation volume LAV950 HU (%) of a both lungs, the right lung, the left lung, and each lobe were obtained. Quantitative CT measurements were compared with forced expiratory volume in 1 s (FEV1), the ratio of FEV1 to forced vital capacity (FEV1/FVC), the diffusing capacity for carbon monoxide (DLco) and total lung capacity (TLC). Results. Except for the right middle lobe and the right upper lobe, respectively, all the quantitative CT measurements showed weak to moderate negative correlations with diffusing capacity (DLco) (r = –0.35 to –0.61, p < 0.05) and weak positive correlations with TLC (r = 0.34 to 0.44, p < 0.05). Group analysis indicated that LAV–950 HU (%) values of both lungs, right lung, left lung, and each lobe, except for right middle lobe, were increased in patients with GOLD stages 3 and 4 of COPD compared to GOLD stages 1 and 2 (p < 0.05). Conclusion. CT measurements of emphysema are significantly related to pulmonary function tests results, particularly DLco.

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