385Prospective associations between serum homocysteine, folate, vitamin B12 and risk of metabolic syndrome

Abstract Background Both elevated homocysteine (Hcy) and metabolic syndrome (MetS) are associated with cardio-metabolic disease. However, the potential causality in the association between Hcy and MetS is unclear, and there is uncertainty about the importance of serum level of folate and vitamin B12 for MetS. The aim of this study was to determine the prospective associations between serum homocysteine, folate and vitamin B12, and incidence of MetS in a community-based cohort of Korean adults aged ≥ 40 years. Methods We measured serum Hcy, folate and vitamin B12 in 2,895 participants (1,187 men and 1,708 women) who did not have MetS. During follow-up (10,043 person-years), 471 MetS cases were newly diagnosed. Results Higher Hcy levels were positively associated with risk of MetS (adjusted incidence rate ratio, IRR 1.87; 95% CI, 1.07–3.25 for ≥15 compared with <10 μmol/L of Hcy in men; IRR 1.81; 95% CI, 1.06–3.08 for ≥10 compared with <5 μmol/L of Hcy in women). However, serum folate was not associated with MetS, and higher serum vitamin B12 levels were associated with a statistically significant protection of MetS in men only (IRR 0.61; 95% CI, 0.42–0.90; P for trend=0.0082 in the highest tertile). Conclusions Hcy levels were positively associated in men and women, and serum vitamin B12 was inversely associated with risk of MetS in men but not in women. Serum folate do not seem to be a protective marker for MetS. Key messages Our results extend previously reported associations of Hcy with MetS, and the absence of associations of folate with MetS.

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VITAMIN B12 AND FOLIC ACID VALUES IN PREMATURE INFANTS

PEDIATRICS ◽

10.1542/peds.50.4.584 ◽

1972 ◽

Vol 50 (4) ◽

pp. 584-589

Author(s):

Ambadas Pathak ◽

Herman A. Godwin ◽

Luis M. Prudent

Keyword(s):

Folic Acid ◽

Vitamin B12 ◽

Premature Infants ◽

Serum Vitamin ◽

Serum Folate ◽

Born Infant ◽

Low Concentrations ◽

Folate And Vitamin B12 ◽

Relationship Of ◽

The Relationship

The relationship of serum vitamin B12 and folic acid was studied in 24 premature infants. In 14 of the 24, low serum vitamin B12 values were found around 40 days of age. Serum folic acid concentrations were less frequently depressed and were usually associated with normal red cell folate values. No correlation between hematocrits and vitamin B12 or folate levels was found. It is suggested that low concentrations of serum folate and vitamin B12 result from low dietary intake coupled with increased demand by the prematurely born infant.

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Plasma Total Homocysteine, Folate, and Vitamin B12 Status and Hospitalizations for Cardiovascular Disease

Pteridines ◽

10.1515/pteridines.2007.18.1.122 ◽

2007 ◽

Vol 18 (1) ◽

pp. 122-127

Author(s):

Bakhouche Houcher ◽

Mirande Candito ◽

Pierre Gibelin

Keyword(s):

Vitamin B12 ◽

Serum Vitamin ◽

Inverse Correlation ◽

Serum Folate ◽

Plasma Thcy ◽

Total Homocysteine ◽

Group 2 ◽

Folate And Vitamin B12 ◽

Plasma Total Homocysteine ◽

Group 1

Abstract Elevated plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease (CVD). Also known is that plasma folate and vitamin B12 influence homocysteine metabolism as cosubstrate and cofactor, respectively. This population-based study was conducted to evaluate the plasma concentrations of tHcy, folate, and vitamin B12 in 54 older patients aged ≥51 years (40 males; 14 females) of Nice hospital cardiology service. After excluding cases with a serum creatinine >120 mmol/L, we established the test properties of a plasma tHcy concentration <15 μmol/L (Group 1) or ≥15 μmol/L (Group 2). In the population aged ≥51 years, plasma tHcy was higher in women (18.0 μmol/L) than in men (15.5 μmol/L; not significant), conversely, serum vitamin B12 was higher in men (376.9 pg/ml) than in women (340.7 pg/ml; not significant). Average plasma tHcy was 11.5 μmol/L in Group 1 and 21.6 μmol/L in Group 2. Vice versa, serum vitamin B12 was higher in Group 1 (419.5 pg/ml) than in Group 2 (307.2 pg/ml) (p <0.05). Correlation analysis (Pearson's r) in the total study population (20-84 years) indicated an inverse correlation between serum folate and age (r = -0.231, p <0.05). In the subjects, aged ≥51 years, there was a significant negative correlation between age and tHcy levels (r = -0.283, p <0.05) and serum vitamin B12 concentrations (r = -0.326, p <0.01) but not with serum folate. However, in subjects with tHcy <15 μmol/L, a significant inverse correlation existed between plasma tHcy and serum folate (r = -0.455; p <0.05). In conclusion, these results highlight the relevance of the vitamin status and particularly of folate levels in the modulation of fasting tHcy levels in the patients with clinical hyperhomocysteinemia, defined as plasma tHcy >15 μmol/L.

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Intakes, Adequacy, and Biomarker Status of Iron, Folate, and Vitamin B12 in Māori and Non-Māori Octogenarians: Life and Living in Advanced Age: A Cohort Study in New Zealand (LiLACS NZ)

Nutrients ◽

10.3390/nu10081090 ◽

2018 ◽

Vol 10 (8) ◽

pp. 1090 ◽

Cited By ~ 4

Author(s):

Danika Pillay ◽

Carol Wham ◽

Simon Moyes ◽

Marama Muru-Lanning ◽

Ruth Teh ◽

...

Keyword(s):

Blood Cell ◽

Vitamin B12 ◽

Red Blood Cell ◽

Serum Iron ◽

Serum Vitamin ◽

Advanced Age ◽

Folate Intake ◽

Serum Folate ◽

Dietary Iron ◽

Folate And Vitamin B12

Advanced-age adults may be at risk of iron, folate, and vitamin B12 deficiency due to low food intake and poor absorption. This study aimed to investigate the intake and adequacy of iron, folate, and vitamin B12 and their relationship with respective biomarker status. Face-to-face interviews with 216 Māori and 362 non-Māori included a detailed dietary assessment using 2 × 24-h multiple pass recalls. Serum ferritin, serum iron, total iron binding capacity, transferrin saturation, red blood cell folate, serum folate, serum vitamin B12 and hemoglobin were available at baseline. Regression techniques were used to estimate the association between dietary intake and biomarkers. The Estimated Average Requirement (EAR) was met by most participants (>88%) for dietary iron and vitamin B12 (>74%) but less than half (>42%) for folate. Increased dietary folate intake was associated with increased red blood cell (RBC) folate for Māori (p = 0.001), non-Māori (p = 0.014) and serum folate for Māori (p < 0.001). Folate intake >215 µg/day was associated with reduced risk of deficiency in RBC folate for Māori (p = 0.001). Strategies are needed to optimize the intake and bioavailability of foods rich in folate. There were no significant associations between dietary iron and vitamin B12 intake and their respective biomarkers, serum iron and serum vitamin B12.

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Relationship of Maternal Folic Acid and Vitamin B12 with birth weight and body proportion of newborn

Journal of Dhaka National Medical College & Hospital ◽

10.3329/jdnmch.v18i1.12224 ◽

2012 ◽

Vol 18 (1) ◽

pp. 7-11 ◽

Cited By ~ 2

Author(s):

Afsana Ahmed ◽

Mahbooba Akhter ◽

Shafia Sharmin ◽

Shamim Ara ◽

Md Mozammel Hoque

Keyword(s):

Birth Weight ◽

Vitamin B12 ◽

Serum Vitamin ◽

Maternal Serum ◽

Serum Folate ◽

Lower Serum ◽

Lower Weight ◽

Group I ◽

Group Ii ◽

Folate And Vitamin B12

Vitamin B12 and folate are two important B vitamins that are related to normal fetal development and fetal growth because they act as co-enzyme for the synthesis of nucleic acid and take part in DNA replication and cell division. Reduced level of serum folate and vitamin B12 also results in hyperhomocysteinemia which causes IUGR. A cross sectional study was made in which 150 pregnant women were included according to set inclusion and exclusion criteria of the study. On the basis of anthropometric measurements (birth weight, birth length, OFC) of the newborn, study subjects were grouped into group-I those who delivered low birth weight babies and group-II those who delivered normal birth weight babies. Serum folate and vitamin B12 level were measured in all the study subjects after delivery. Maternal serum folate & vitamin B12 of group-I were significantly lower than that of group-II. Birth weight, length & OFC of newborns showed significant positive correlation with maternal serum folate & vitamin B12. The risk of lower serum folate was significant for lower weight (OR11.00, 95% CI 4.81-25.15), lower length (OR 3.67, 95% CI 1.42-9.47), lower OFC (OR 6.96, 95% CI 2.47-17.87). The risks of lower serum vitamin B12 were significant for lower weight (OR 4.09, 95% CI 1.67-10.00), lower length (OR 4.83, 95%CI 2.28-10.22), lower OFC (OR 4.11, 95%CI 1.97- 8.54). DOI: http://dx.doi.org/10.3329/jdnmch.v18i1.12224 J. Dhaka National Med. Coll. Hos. 2012; 18 (01): 7-11

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Relationships among Urinary Aminoimidazolecarboxamide in Urine and Folate, and Vitamin B12 Concentrations in Serum

Clinical Chemistry ◽

10.1093/clinchem/19.9.1049 ◽

1973 ◽

Vol 19 (9) ◽

pp. 1049-1052 ◽

Cited By ~ 2

Author(s):

J W Harrison ◽

B A Slade ◽

W Shaw

Keyword(s):

Vitamin B12 ◽

Serum Vitamin ◽

Vitamin B12 Deficiency ◽

Strong Relationship ◽

Automated System ◽

Serum Folate ◽

B12 Deficiency ◽

The Mean ◽

Folate And Vitamin B12

Abstract Urinary aminoimidazolecarboxamide (AIC), serum folate, and serum vitamin B12 values were determined in 84 apparently healthy individuals. An automated system for determination of AIC in urine is described. Despite claims to the contrary, we found no evidence of a strong relationship between elevated (e.g., >1.3 µg/mg of creatinine) AIC excretion as reflected in a casual sample of urine and folate or vitamin B12 deficiency. Urinary AIC values ranged from 0.10 to 5.20 µg/mg of creatinine. The mean for the population examined was 1.36 ± 1.02 µg/mg of creatinine.

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Association Between Total Dairy and Individual Dairy Foods and Markers for Folate and Vitamin B12 status in the U.S. Population

Current Developments in Nutrition ◽

10.1093/cdn/nzaa067_014 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1787-1787

Author(s):

Christopher Cifelli ◽

Sanjiv Agarwal ◽

Victor Fulgoni

Keyword(s):

Vitamin B12 ◽

Laboratory Data ◽

Serum Vitamin ◽

Nutrient Status ◽

Milk Intake ◽

Serum Folate ◽

Dietary Recall ◽

Dairy Foods ◽

Dairy Intake ◽

Folate And Vitamin B12

Abstract Objectives The objective of this study was to determine the association between the consumption of dairy foods with markers for folate and vitamin B12 status in a nationally representative sample. Methods Dietary recall data and laboratory data for RBC folate (ng/mL), serum folate (ng/mL) and serum vitamin B12 (pg/mL) from subjects 2 + years old participating in NHANES 2001–2016 were used (N = 61,234 after exclusions). Data were adjusted for age, gender and ethnicity and separate analyses were conducted for ages 2–8, 9–18 and 19 + years (y). Significant associations between quartiles of dairy intake and biomarkers of nutrient status were assessed at P < 0.05. Results Mean intakes of total dairy, milk, cheese and yogurt were 2.22, 1.56, 0.58 and 0.07 cup eq respectively for those 2–8 y; 2.14, 1.25, 0.84 and 0.03 cup eq respectively for those 9–18 y and 1.63, 0.83, 0.72, 0.06 cup eq respectively for 19 + years old. Quartiles of total dairy intake were inversely associated with serum folate (β = −0.61) and positively associated with vitamin B12 (β = 41.8) in 2–8 years old. Quartiles of total dairy intake were positively associated with RBC folate, serum folate and serum vitamin B12 in both those 9–18 y (β = 5.32, 0.55 and 34.4, respectively) and 19 + y (β = 14.6, 0.74 and 19.5, respectively). Similar to total dairy, quartiles of milk intake were inversely associated with RBC folate (β = −8.79) and serum folate (β = −0.57), and positively associated with serum vitamin B12 (β = 51.6) in those 2–8 y. Also, quartiles of milk intake were positively associated with RBC folate, serum folate and serum vitamin B12 in those 9–18 y (β = 3.92, 0.83 and 38.8 respectively) and in those 19 + y (β = 8.68, 1.00 and 17.4 respectively). In contrast to milk and total dairy, quartiles of cheese intake were positively associated with RBC folate only in those 2–8 y (β = 8.40) and in those 19 + y (β = 9.24). Quartiles of yogurt intake were positively associated with RBC folate (β = 5.57) in those 2–8 y; with RBC folate (β = 11.9) and serum folate (β = 0.50) in those 9–18 y; and with RBC folate (β = 16.3), serum folate (β = 0.70) and serum vitamin B12 (β = 16.3) in those 19 + y. Conclusions The results indicate that dairy foods are beneficially associated with RBC folate, serum folate and serum vitamin B12. Funding Sources National Dairy Council.

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