scholarly journals Intakes, Adequacy, and Biomarker Status of Iron, Folate, and Vitamin B12 in Māori and Non-Māori Octogenarians: Life and Living in Advanced Age: A Cohort Study in New Zealand (LiLACS NZ)

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1090 ◽  
Author(s):  
Danika Pillay ◽  
Carol Wham ◽  
Simon Moyes ◽  
Marama Muru-Lanning ◽  
Ruth Teh ◽  
...  
Keyword(s):  
Blood Cell ◽  
Vitamin B12 ◽  
Red Blood Cell ◽  
Serum Iron ◽  
Serum Vitamin ◽  
Advanced Age ◽  
Folate Intake ◽  
Serum Folate ◽  
Dietary Iron ◽  
Folate And Vitamin B12

Advanced-age adults may be at risk of iron, folate, and vitamin B12 deficiency due to low food intake and poor absorption. This study aimed to investigate the intake and adequacy of iron, folate, and vitamin B12 and their relationship with respective biomarker status. Face-to-face interviews with 216 Māori and 362 non-Māori included a detailed dietary assessment using 2 × 24-h multiple pass recalls. Serum ferritin, serum iron, total iron binding capacity, transferrin saturation, red blood cell folate, serum folate, serum vitamin B12 and hemoglobin were available at baseline. Regression techniques were used to estimate the association between dietary intake and biomarkers. The Estimated Average Requirement (EAR) was met by most participants (>88%) for dietary iron and vitamin B12 (>74%) but less than half (>42%) for folate. Increased dietary folate intake was associated with increased red blood cell (RBC) folate for Māori (p = 0.001), non-Māori (p = 0.014) and serum folate for Māori (p < 0.001). Folate intake >215 µg/day was associated with reduced risk of deficiency in RBC folate for Māori (p = 0.001). Strategies are needed to optimize the intake and bioavailability of foods rich in folate. There were no significant associations between dietary iron and vitamin B12 intake and their respective biomarkers, serum iron and serum vitamin B12.

scholarly journals Validation of a Semi-Quantitative Food-Frequency Questionnaire for Dutch Pregnant Women from the General Population Using the Method or Triads

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1341 ◽  
Author(s):  
Trudy Voortman ◽  
Régine P.M. Steegers-Theunissen ◽  
Nienke E. Bergen ◽  
Vincent W. V. Jaddoe ◽  
Caspar W. N. Looman ◽  
...  
Keyword(s):  
Fatty Acids ◽  
General Population ◽  
Blood Cell ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Red Blood Cell ◽  
Food Frequency Questionnaire ◽  
Serum Folate ◽  
Food Frequency ◽  
Folate And Vitamin B12

Objective: We aimed to validate a food-frequency questionnaire (FFQ) for Dutch pregnant women, against three 24 h-recalls and blood concentrations of B-vitamins and fatty acids, using the method of triads. Methods: We included 83 pregnant women from the general population of Rotterdam, the Netherlands, at a median gestational age of 15.6 weeks. Participants completed three non-consecutive 24 h-recalls, and subsequently filled out the 293-item FFQ. Participants provided blood samples from which we analyzed serum folate and vitamin B12, as well as red blood cell folate, linoleic acid, and total saturated, monounsaturated, and polyunsaturated fatty acids. Results: Estimated energy intake did not differ between the FFQ and 24 h-recalls. Deattenuated Pearson’s correlation coefficients, between energy-adjusted nutrient intake estimates from the FFQ and the 24 h-recalls, ranged from 0.41 (fat) to 0.88 (fiber) for macronutrients, and were around 0.6 for most micronutrients, except for vitamin E (0.27). Using the triad method, we obtained validity coefficients of 0.86 (95% Confidence Interval (CI) 0.36, 1.00) for serum folate, 0.86 (95% CI 0.18, 1.00) for red blood cell folate, and 1.00 (95% CI 0.42, 1.00) for vitamin B12. Validity coefficients for serum fatty acids ranged from 0.22 to 0.67. Conclusion: This FFQ is a reliable tool for estimating intake of energy, macronutrients, folate and vitamin B12 among women in mid-pregnancy.

Red Blood Cell Folate and Serum Vitamin B12 Status in Children With Sickle Cell Disease

2001 ◽  
Vol 23 (3) ◽  
pp. 165-169 ◽  
Author(s):  
Tay S. Kennedy ◽  
Ellen B. Fung ◽  
Deborah A. Kawchak ◽  
Babette S. Zemel ◽  
Kwaku Ohene-Frempong ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Blood Cell ◽  
Vitamin B12 ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Serum Vitamin ◽  
Cell Disease

VITAMIN B12 AND FOLIC ACID VALUES IN PREMATURE INFANTS

PEDIATRICS ◽  
1972 ◽  
Vol 50 (4) ◽  
pp. 584-589
Author(s):  
Ambadas Pathak ◽  
Herman A. Godwin ◽  
Luis M. Prudent
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Premature Infants ◽  
Serum Vitamin ◽  
Serum Folate ◽  
Born Infant ◽  
Low Concentrations ◽  
Folate And Vitamin B12 ◽  
Relationship Of ◽  
The Relationship

The relationship of serum vitamin B12 and folic acid was studied in 24 premature infants. In 14 of the 24, low serum vitamin B12 values were found around 40 days of age. Serum folic acid concentrations were less frequently depressed and were usually associated with normal red cell folate values. No correlation between hematocrits and vitamin B12 or folate levels was found. It is suggested that low concentrations of serum folate and vitamin B12 result from low dietary intake coupled with increased demand by the prematurely born infant.

scholarly journals Estimating the Serum Folate Concentration Associated With the Red Blood Cell Folate Threshold for Optimal Neural Tube Defects Prevention: A Population Based Biomarker Survey

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 644-644
Author(s):  
Amy Fothergill ◽  
Charles Rose ◽  
Krista Crider ◽  
Beena Bose ◽  
Heather Guetterman ◽  
...  
Keyword(s):  
Blood Cell ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Red Blood Cell ◽  
Vitamin B12 Deficiency ◽  
Population Based ◽  
World Health ◽  
Serum Folate ◽  
Total Vitamin ◽  
B12 Deficiency

Abstract Objectives To estimate the serum folate insufficiency threshold (sf-IT) corresponding to the red blood cell (RBC) folate insufficiency threshold for optimal neural tube defect (NTD) prevention. Methods Participants were 977 women of reproductive age (WRA; 15–40y; not pregnant or lactating) from a population-based biomarker survey in Southern India. Venous blood samples were collected at enrollment. Plasma, serum, and red blood cells were centrifuged, processed, and stored &lt; -80°C until batch analysis. Total vitamin B12 concentrations were measured via chemiluminescence; RBC and serum folate concentrations were measured using the World Health Organization-recommended microbiological assay. Vitamin B12 deficiency was defined as total vitamin B12 &lt; 148 pmol/L. Folate insufficiency was defined as RBC folate &lt; 748 nmol/L, the recommended calibrator-adjusted equivalent of the threshold for population optimal NTD prevention. A previously developed Bayesian model and the RBC and serum folate distributions in this population were used to estimate the sf-IT corresponding to the RBC folate insufficiency threshold for optimal NTD prevention, overall and by age, body mass index (BMI) category, HbA1c, anemia, and vitamin B12 status. Results The overall estimated median sf-IT was 37.8 nmol/L (95% credible interval [33.8–43.3]). This threshold was lower in overweight WRA (BMI: ≥25.0 kg/m2: 32.0 nmol/L [27.3–40.2] vs. BMI &lt; 25.0 kg/m2: 36.2 nmol/L [32.2–43.3]), and varied by age (&lt; 25y: 61.3 nmol/L [44.3–111.8]; 25 to 35y: 35.7 nmol/L [30.8–43.5]; ≥35y: 30.8 nmol/L [26.9–37.2]). The sf-IT was lower in anemic WRA (32.9 nmol/L [28.5–40.1]) compared to non-anemic WRA (42.0 nmol/L [36.1–51.3]), and lower in WRA with elevated HbA1c (≥5.7% to &lt; 6.5: 32.4 nmol/L [27.3–41.6]; ≥6.5%: 20.9 nmol/L [17.8–25.6]) vs. WRA with HbA1c &lt; 5.7% (43.8 nmol/L, [37.5–53.7]). The median sf-IT was higher in WRA with vitamin B12 deficiency (72.1 nmol/L [52.0–126.0]), compared to women who were not vitamin B12 deficient (28.1 nmol/L [25.6–31.5]). Conclusions The estimated sf-IT is dependent on anemia, elevated HbA1c, BMI, age, and vitamin B12 status. Funding Sources Centers for Disease Control and Prevention; AF was supported by the National Institutes of Health #5 T32 HD087137.

scholarly journals Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women

2021 ◽  
Vol 8 ◽  
Author(s):  
Shelby C. Osburn ◽  
Paul A. Roberson ◽  
Jessica A. Medler ◽  
Jacob Shake ◽  
Robert D. Arnold ◽  
...  
Keyword(s):  
Vitamin D ◽  
Placebo Group ◽  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Serum Vitamin ◽  
Serum Folate ◽  
Omega 3 ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The purpose of this study was to validate the efficacy of a customized vitamin-mineral supplement on blood biomarkers in pre-menopausal females. Women (21–40 years old) who were apparently healthy were recruited from the local community (ClinicalTrials.gov trial registration NCT03828097). Pretesting (PRE) occurred in the morning 5 ± 2 days following each participant's menses and involved a fasted blood draw, body mass assessment, and blood pressure assessment. Participants were then randomly assigned in a double-blinded fashion to either the multivitamins (MV) (n = 43) or placebo group (n = 51). Participants consumed two capsules per day with breakfast for 12 weeks. Following the trial, participants reported to the laboratory for POST assessments, which replicated PRE procedures. Red blood cell fatty acid and serum micronutrient analyses were performed in a blinded fashion at hematology laboratories. A group × time interaction was observed for serum vitamin D levels (p &lt; 0.001). MV increased levels from PRE to POST (+43.7%, p &lt; 0.001), whereas no change occurred in the placebo group. Additionally, 78% of MV participants at PRE exhibited inadequate vitamin D levels (&lt;40 ng/dl), whereas only 30% exhibited levels below this threshold at POST. An interaction was also observed for serum folate levels (p &lt; 0.001). MV increased serum folate from PRE to POST (p &lt; 0.001), whereas no change occurred in the placebo group. Red blood cell omega-3 fatty acid content increased from PRE to POST in the MV group (p &lt; 0.001) and placebo group (p &lt; 0.05), although POST values were greater in the MV group (p &lt; 0.001). An interaction was observed for serum HDL cholesterol levels (p = 0.047), and a non-significant increase in this variable from PRE to POST occurred in the MV group (p = 0.060). Four-day food recalls indicated MV increased intake of omega-3 fatty acids, vitamin D, folate, and other micronutrients. In summary, MV supplementation increased serum vitamin D, serum folate, and red blood cell omega-3 fatty acid levels. However, these data are limited to healthy females, and more research is needed to examine if MV can affect metabolic disturbances in individuals with micronutrient deficiencies.

scholarly journals Plasma Total Homocysteine, Folate, and Vitamin B12 Status and Hospitalizations for Cardiovascular Disease

Pteridines ◽  
2007 ◽  
Vol 18 (1) ◽  
pp. 122-127
Author(s):  
Bakhouche Houcher ◽  
Mirande Candito ◽  
Pierre Gibelin
Keyword(s):  
Vitamin B12 ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Serum Folate ◽  
Plasma Thcy ◽  
Total Homocysteine ◽  
Group 2 ◽  
Folate And Vitamin B12 ◽  
Plasma Total Homocysteine ◽  
Group 1

Abstract Elevated plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease (CVD). Also known is that plasma folate and vitamin B12 influence homocysteine metabolism as cosubstrate and cofactor, respectively. This population-based study was conducted to evaluate the plasma concentrations of tHcy, folate, and vitamin B12 in 54 older patients aged ≥51 years (40 males; 14 females) of Nice hospital cardiology service. After excluding cases with a serum creatinine >120 mmol/L, we established the test properties of a plasma tHcy concentration <15 μmol/L (Group 1) or ≥15 μmol/L (Group 2). In the population aged ≥51 years, plasma tHcy was higher in women (18.0 μmol/L) than in men (15.5 μmol/L; not significant), conversely, serum vitamin B12 was higher in men (376.9 pg/ml) than in women (340.7 pg/ml; not significant). Average plasma tHcy was 11.5 μmol/L in Group 1 and 21.6 μmol/L in Group 2. Vice versa, serum vitamin B12 was higher in Group 1 (419.5 pg/ml) than in Group 2 (307.2 pg/ml) (p <0.05). Correlation analysis (Pearson's r) in the total study population (20-84 years) indicated an inverse correlation between serum folate and age (r = -0.231, p <0.05). In the subjects, aged ≥51 years, there was a significant negative correlation between age and tHcy levels (r = -0.283, p <0.05) and serum vitamin B12 concentrations (r = -0.326, p <0.01) but not with serum folate. However, in subjects with tHcy <15 μmol/L, a significant inverse correlation existed between plasma tHcy and serum folate (r = -0.455; p <0.05). In conclusion, these results highlight the relevance of the vitamin status and particularly of folate levels in the modulation of fasting tHcy levels in the patients with clinical hyperhomocysteinemia, defined as plasma tHcy >15 μmol/L.

scholarly journals Relationship of Maternal Folic Acid and Vitamin B12 with birth weight and body proportion of newborn

2012 ◽  
Vol 18 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Afsana Ahmed ◽  
Mahbooba Akhter ◽  
Shafia Sharmin ◽  
Shamim Ara ◽  
Md Mozammel Hoque
Keyword(s):  
Birth Weight ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Serum Folate ◽  
Lower Serum ◽  
Lower Weight ◽  
Group I ◽  
Group Ii ◽  
Folate And Vitamin B12

Vitamin B12 and folate are two important B vitamins that are related to normal fetal development and fetal growth because they act as co-enzyme for the synthesis of nucleic acid and take part in DNA replication and cell division. Reduced level of serum folate and vitamin B12 also results in hyperhomocysteinemia which causes IUGR. A cross sectional study was made in which 150 pregnant women were included according to set inclusion and exclusion criteria of the study. On the basis of anthropometric measurements (birth weight, birth length, OFC) of the newborn, study subjects were grouped into group-I those who delivered low birth weight babies and group-II those who delivered normal birth weight babies. Serum folate and vitamin B12 level were measured in all the study subjects after delivery. Maternal serum folate & vitamin B12 of group-I were significantly lower than that of group-II. Birth weight, length & OFC of newborns showed significant positive correlation with maternal serum folate & vitamin B12. The risk of lower serum folate was significant for lower weight (OR11.00, 95% CI 4.81-25.15), lower length (OR 3.67, 95% CI 1.42-9.47), lower OFC (OR 6.96, 95% CI 2.47-17.87). The risks of lower serum vitamin B12 were significant for lower weight (OR 4.09, 95% CI 1.67-10.00), lower length (OR 4.83, 95%CI 2.28-10.22), lower OFC (OR 4.11, 95%CI 1.97- 8.54). DOI: http://dx.doi.org/10.3329/jdnmch.v18i1.12224 J. Dhaka National Med. Coll. Hos. 2012; 18 (01): 7-11

Relationships among Urinary Aminoimidazolecarboxamide in Urine and Folate, and Vitamin B12 Concentrations in Serum

1973 ◽  
Vol 19 (9) ◽  
pp. 1049-1052 ◽  
Author(s):  
J W Harrison ◽  
B A Slade ◽  
W Shaw
Keyword(s):  
Vitamin B12 ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Strong Relationship ◽  
Automated System ◽  
Serum Folate ◽  
B12 Deficiency ◽  
The Mean ◽  
Folate And Vitamin B12

Abstract Urinary aminoimidazolecarboxamide (AIC), serum folate, and serum vitamin B12 values were determined in 84 apparently healthy individuals. An automated system for determination of AIC in urine is described. Despite claims to the contrary, we found no evidence of a strong relationship between elevated (e.g., &gt;1.3 µg/mg of creatinine) AIC excretion as reflected in a casual sample of urine and folate or vitamin B12 deficiency. Urinary AIC values ranged from 0.10 to 5.20 µg/mg of creatinine. The mean for the population examined was 1.36 ± 1.02 µg/mg of creatinine.

scholarly journals Is  food frequency questionnaire a valid tools to assess intake of folate and vitamin B12 in Azar cohort population?

2021 ◽  
Author(s):  
Sona Azimi ◽  
Elnaz Faramarzi ◽  
Parvin Sarbakhsh ◽  
Alireza Ostadrahimi
Keyword(s):  
Blood Cell ◽  
Vitamin B12 ◽  
Food Frequency Questionnaire ◽  
Serum Folate ◽  
Dietary Vitamin ◽  
P Value ◽  
Food Frequency ◽  
Dietary Folate ◽  
Folate And Vitamin B12 ◽  
Adjusted Model

Abstract Background: Repeated 24-hour recalls and diet diaries are the most dietary methods, which have been used as gold standards in food frequency questionnaire (FFQ ) validation studies. But associated random errors between the FFQ and these two dietary assessment methods can result in flawed estimates of validity. Therefore, evaluation biochemical indices have been considered as a reference method in validation studies.Objective: The aim of this study was to evaluate the validity of the FFQ by comparing the estimated intakes of folate and vitamin B12 with corresponding biochemical markers. Methods: Participants were 95 healthy adults from Azar Cohort Study. We compared folate and vitamin B12 intakes of food frequency questionnaire with their concentrations in blood specimens. Serum folate and vitamin B12, and of red blood cell folate concentrations, were determined using electrochemiluminescence immunoassay method respectively. Results: Spearman correlation coefficients between dietary folate and corresponding biomarkers (serum and RBC folate) concentrations were 0.04 (P-value = 0.65), 0.06 ( P-value = 0.52) respectively. There was no correlation between dietary vitamin B12 and serum concentrations of this vitamin, whether in crude or energy-adjusted model in the total population studied(r = - 0.134 , p = 0.19 in crude model and r = -0.137, p = 0.18 in energy-adjusted model ). According to the findings of this study, 64.51, 60.21 and 54.83 percent of studied population were in the same/adjacent quartiles of dietary folate-serum folate, dietary folate-red blood cell folate and dietary vitamin B12-serum vitamin B12 respectively.Conclusion: According to our results, it seems that this FFQ may not be a reliable tool to assess intakes of folate and vitamin B12. Therefore, further studies with large sample size are needed to achieve more clear results.

scholarly journals 385Prospective associations between serum homocysteine, folate, vitamin B12 and risk of metabolic syndrome

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Hye Won Woo ◽  
Min-Ho Shin ◽  
Yumi Kim ◽  
Bo-Youl Choi ◽  
M-iKyung Kim
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Serum Folate ◽  
Community Based ◽  
Serum Homocysteine ◽  
Adjusted Incidence Rate ◽  
Folate And Vitamin B12 ◽  
Adjusted Incidence

Abstract Background Both elevated homocysteine (Hcy) and metabolic syndrome (MetS) are associated with cardio-metabolic disease. However, the potential causality in the association between Hcy and MetS is unclear, and there is uncertainty about the importance of serum level of folate and vitamin B12 for MetS. The aim of this study was to determine the prospective associations between serum homocysteine, folate and vitamin B12, and incidence of MetS in a community-based cohort of Korean adults aged ≥ 40 years. Methods We measured serum Hcy, folate and vitamin B12 in 2,895 participants (1,187 men and 1,708 women) who did not have MetS. During follow-up (10,043 person-years), 471 MetS cases were newly diagnosed. Results Higher Hcy levels were positively associated with risk of MetS (adjusted incidence rate ratio, IRR 1.87; 95% CI, 1.07–3.25 for ≥15 compared with &lt;10 μmol/L of Hcy in men; IRR 1.81; 95% CI, 1.06–3.08 for ≥10 compared with &lt;5 μmol/L of Hcy in women). However, serum folate was not associated with MetS, and higher serum vitamin B12 levels were associated with a statistically significant protection of MetS in men only (IRR 0.61; 95% CI, 0.42–0.90; P for trend=0.0082 in the highest tertile). Conclusions Hcy levels were positively associated in men and women, and serum vitamin B12 was inversely associated with risk of MetS in men but not in women. Serum folate do not seem to be a protective marker for MetS. Key messages Our results extend previously reported associations of Hcy with MetS, and the absence of associations of folate with MetS.

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