scholarly journals Changing Contact Patterns Over Disease Progression: Nipah Virus as a Case Study

2020 ◽  
Vol 222 (3) ◽  
pp. 438-442
Author(s):  
Kyu Han Lee ◽  
Birgit Nikolay ◽  
Hossain M S Sazzad ◽  
M Jahangir Hossain ◽  
A K M Dawlat Khan ◽  
...  
Keyword(s):  
Virus Infection ◽  
Disease Progression ◽  
Disease Transmission ◽  
Nipah Virus ◽  
Risk Of Infection ◽  
Course Of Illness ◽  
Bodily Fluids ◽  
Contact Patterns

Abstract Contact patterns play a key role in disease transmission, and variation in contacts during the course of illness can influence transmission, particularly when accompanied by changes in host infectiousness. We used surveys among 1642 contacts of 94 Nipah virus case patients in Bangladesh to determine how contact patterns (physical and with bodily fluids) changed as disease progressed in severity. The number of contacts increased with severity and, for case patients who died, peaked on the day of death. Given transmission has only been observed among fatal cases of Nipah virus infection, our findings suggest that changes in contact patterns during illness contribute to risk of infection.

scholarly journals Predictors of free-roaming domestic dogs' contact network centrality and their relevance for rabies control

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Charlotte Warembourg ◽  
Guillaume Fournié ◽  
Mahamat Fayiz Abakar ◽  
Danilo Alvarez ◽  
Monica Berger-González ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Small World ◽  
Domestic Dogs ◽  
Contact Network ◽  
Potential Contribution ◽  
Dog Ownership ◽  
Contact Patterns ◽  
Rabies Control ◽  
The Social ◽  
Study Sites

AbstractFree roaming domestic dogs (FRDD) are the main vectors for rabies transmission to humans worldwide. To eradicate rabies from a dog population, current recommendations focus on random vaccination with at least 70% coverage. Studies suggest that targeting high-risk subpopulations could reduce the required vaccination coverage, and increase the likelihood of success of elimination campaigns. The centrality of a dog in a contact network can be used as a measure of its potential contribution to disease transmission. Our objectives were to investigate social networks of FRDD in eleven study sites in Chad, Guatemala, Indonesia and Uganda, and to identify characteristics of dogs, and their owners, associated with their centrality in the networks. In all study sites, networks had small-world properties and right-skewed degree distributions, suggesting that vaccinating highly connected dogs would be more effective than random vaccination. Dogs were more connected in rural than urban settings, and the likelihood of contacts was negatively correlated with the distance between dogs’ households. While heterogeneity in dog's connectedness was observed in all networks, factors predicting centrality and likelihood of contacts varied across networks and countries. We therefore hypothesize that the investigated dog and owner characteristics resulted in different contact patterns depending on the social, cultural and economic context. We suggest to invest into understanding of the sociocultural structures impacting dog ownership and thus driving dog ecology, a requirement to assess the potential of targeted vaccination in dog populations.

Histopathologic and Immunohistochemical Characterization of Nipah Virus Infection in the Guinea Pig

2008 ◽  
Vol 45 (4) ◽  
pp. 576-585 ◽  
Author(s):  
F. J. Torres-Velez ◽  
W.-J. Shieh ◽  
P. E. Rollin ◽  
T. Morken ◽  
C. Brown ◽  
...  
Keyword(s):  
Virus Infection ◽  
Guinea Pig ◽  
Nipah Virus

scholarly journals Chloroquine Administration Does Not Prevent Nipah Virus Infection and Disease in Ferrets

2009 ◽  
Vol 83 (22) ◽  
pp. 11979-11982 ◽  
Author(s):  
Jackie Pallister ◽  
Deborah Middleton ◽  
Gary Crameri ◽  
Manabu Yamada ◽  
Reuben Klein ◽  
...  
Keyword(s):  
Virus Infection ◽  
Nipah Virus ◽  
Disease Outbreaks ◽  
Mortality Rates ◽  
Hendra Virus ◽  
Malaria Therapy ◽  
Sporadic Disease

ABSTRACT Hendra virus and Nipah virus, two zoonotic paramyxoviruses in the genus Henipavirus, have recently emerged and continue to cause sporadic disease outbreaks in humans and animals. Mortality rates of up to 75% have been reported in humans, but there are presently no clinically licensed therapeutics for treating henipavirus-induced disease. A recent report indicated that chloroquine, used in malaria therapy for over 70 years, prevented infection with Nipah virus in vitro. Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo.

scholarly journals Optimization of medical waste routing problem: The case of TRB1 region in Turkey

2019 ◽  
Vol 9 (2) ◽  
pp. 197-207
Author(s):  
Suleyman Mete ◽  
Faruk Serin
Keyword(s):  
Environmental Sustainability ◽  
Fundamental Problem ◽  
Medical Waste ◽  
Future Research ◽  
Risk Of Infection ◽  
Routing Problem ◽  
Solution Approach ◽  
Potential Risks ◽  
Health Institutions

A fundamental problem concerning medical waste disposal is the evaluation of the real and potential risks arising from waste with the focus on the risk of infection. Therefore, the optimization of medical waste routing from collection to disposal center can minimize the risk of infection. The routing of medical waste considers significant to determine potential routes and select the route with minimum distance. The management of the medical waste is important decision for environmental sustainability and includes the collection, transportation and disposal of these materials. In this paper, a geographic information system (GIS) solution approach is proposed to determine the best location of disposal center. Proposed approach is applied to medical waste transportation between 167 health institutions (collection centers) and predetermined 5 disposal centers through TRB1 region in Turkey, which consist of Malatya, Elaz??, Bingöl and Tunceli provinces. The results of case study are examined and suggestions for future research are provided.

scholarly journals Adaptive data-driven age and patch mixing in contact networks with recurrent mobility

2021 ◽  
Author(s):  
Jesse Knight ◽  
Huiting Ma ◽  
Amir Ghasemi ◽  
Mackenzie Hamilton ◽  
Kevin Brown ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Age Distribution ◽  
Age Groups ◽  
Data Driven ◽  
Infectious Disease Transmission ◽  
Mobility Data ◽  
Contact Patterns ◽  
Different Types ◽  
Mixing Patterns ◽  
Transmission Models

AbstractInfectious disease transmission models often stratify populations by age and geographic patches. Contact patterns between age groups and patches are key parameters in such models. Arenas et al. (2020) develop an approach to simulate contact patterns associated with recurrent mobility between patches, such as due to work, school, and other regular travel. Using their approach, mixing between patches is greater than mobility data alone would suggest, because individuals from patches A and B can form a contact if they meet in patch C. We build upon their approach to address three potential gaps that remain. First, our approach includes a distribution of contacts by age that is responsive to underlying age distribution of the mixing pool. Second, different age distributions by contact type are also maintained in our approach, such that changes to the numbers of different types of contacts are appropriately reflected in changes to the overall age mixing patterns. Finally, we introduce and distinguish between two mixing pools associated with each patch, with possible implications for the overall connectivity of the population: the home pool, in which contacts can only be formed with other individuals residing in the same patch; and the travel pool, in which contacts can be formed with some residents of, and any other visitors to the patch. We describe in detail the steps required to implement our approach, and present results of an example application.Graphical Abstract

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