Novel Sterile Insect Technology (SIT) program results in suppression of a field mosquito population and subsequently to reduced incidence of dengue

2021 ◽  
Author(s):  
Lisiane Castro Poncio ◽  
Filipe Apolinário dos Anjos ◽  
Deborah A de Oliveira ◽  
Débora Rebechi ◽  
Rodrigo Neves de Oliveira ◽  
...  
Keyword(s):  
Successful Implementation ◽  
Mosquito Vector ◽  
Sterile Male ◽  
Double Stranded Rna ◽  
Treated Area ◽  
And Control ◽  
Alternative Solutions ◽  
Male Mosquitoes ◽  
Aegypti Population ◽  
No Releases

Abstract Background There is a steady rise in the global incidence of Aedes-borne arbovirus disease. It has become urgent to develop alternative solutions for mosquito vector control. We developed a new method of sterilization of male mosquitoes, with the goal to suppress a local Aedes aegypti population and to prevent the spread of dengue. Methods Sterile male mosquitoes were produced from a locally acquired Ae. aegypti colony by using a treatment that includes double-stranded RNA and thiotepa. A field study was conducted, with sterile mosquito releases being performed on a weekly basis in predefined areas. Two intervention periods (INT1 and INT2) were carried out, with treatment and control areas reversed between INT1 and INT2. Results During INT1, releases in the treated area resulted in up to 91.4% reduction of live progeny of field Ae. aegypti mosquitoes recorded over time, while the control neighborhoods (no releases of sterile male mosquitoes) remained highly infested. The successful implementation of the program during INT1 and INT2 were associated with a 15.9-fold and 13.7-fold lower incidences of dengue in the treated area compared to the control areas, respectively. Conclusions Our data show the success of this new SIT-based program in preventing the spread of dengue.

scholarly journals Successful suppression of a field population of Ae. aegypti mosquitoes using a novel biological vector control strategy is associated with significantly lower incidence of dengue

2019 ◽  
Author(s):  
Lisiane C Poncio ◽  
Filipe A dos Anjos ◽  
Deborah A de Oliveira ◽  
Débora Rebechi ◽  
Rodrigo N de Oliveira ◽  
...  
Keyword(s):  
Vector Control ◽  
Lower Incidence ◽  
Large Scale ◽  
Control Area ◽  
Environmentally Benign ◽  
Mosquito Population ◽  
Mosquito Vector ◽  
Sterile Male ◽  
Treated Area ◽  
Male Mosquitoes

AbstractBackgroundDespite extensive efforts to prevent recurrent Aedes-borne arbovirus epidemics, there is a steady rise in their global incidence. Vaccines/treatments show very limited efficacy and together with the emergence of mosquito resistance to insecticides, it has become urgent to develop alternative solutions for efficient, sustainable and environmentally benign mosquito vector control. Here we present a new Sterile Insect Technology (SIT)-based program that uses large-scale releases of sterile male mosquitoes produced by a highly effective, safe and environmentally benign method.Methods and findingsTo test the efficacy of this approach, a field trial was conducted in a Brazilian city (Jacarezinho), which presented a history of 3 epidemics of dengue in the past decade. Sterile male mosquitoes were produced from a locally acquired Aedes aegypti colony, and releases were carried out on a weekly basis for seven months in a predefined area. This treated area was matched to a control area, in terms of size, layout, historic mosquito infestation index, socioeconomic patterns and comparable prevalence of dengue cases in past outbreaks. Releases of sterile male mosquitoes resulted in up to 91.4% reduction of live progeny of field Ae. aegypti mosquitoes recorded over time. The reduction in the mosquito population was corroborated by the standard monitoring system (LIRAa index) as determined by the local municipality, which found that our treated neighborhoods were almost free of Ae. aegypti mosquitoes after 5 months of release, whereas neighborhoods adjacent to the treated area and the control neighborhoods were highly infested. Importantly, when a dengue outbreak started in Jacarezinho in March 2019, the effective mosquito population suppression was shown to be associated with a far lower incidence of dengue in the treated area (16 cases corresponding to 264 cases per 100,000 inhabitants) almost 16 times lower than the dengue incidence in the control area (198 cases corresponding to 4,360 dengue cases per 100,000 inhabitants).ConclusionsOur data present the first demonstration that a SIT-based intervention has the potential to prevent the spread of dengue, opening exciting new opportunities for preventing mosquito-borne disease.

scholarly journals A health worker knowledge, attitudes and practices survey of SARS-CoV-2 infection prevention and control in South Africa

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Saiendhra Vasudevan Moodley ◽  
Muzimkhulu Zungu ◽  
Molebogeng Malotle ◽  
Kuku Voyi ◽  
Nico Claassen ◽  
...  
Keyword(s):  
South Africa ◽  
Health Worker ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Health Workers ◽  
Health Facilities ◽  
World Health ◽  
Infection Prevention And Control ◽  
Successful Implementation ◽  
And Control

Abstract Background Health workers are crucial to the successful implementation of infection prevention and control strategies to limit the transmission of SARS-CoV-2 at healthcare facilities. The aim of our study was to determine SARS-CoV-2 infection prevention and control knowledge and attitudes of frontline health workers in four provinces of South Africa as well as explore some elements of health worker and health facility infection prevention and control practices. Methods A cross-sectional study design was utilised. The study population comprised both clinical and non-clinical staff working in casualty departments, outpatient departments, and entrance points of health facilities. A structured self-administered questionnaire was developed using the World Health Organization guidance as the basis for the knowledge questions. COVID-19 protocols were observed during data collection. Results A total of 286 health workers from 47 health facilities at different levels of care participated in the survey. The mean score on the 10 knowledge items was 6.3 (SD = 1.6). Approximately two-thirds of participants (67.4%) answered six or more questions correctly while less than a quarter of all participants (24.1%) managed to score eight or more. A knowledge score of 8 or more was significantly associated with occupational category (being either a medical doctor or nurse), age (< 40 years) and level of hospital (tertiary level). Only half of participants (50.7%) felt adequately prepared to deal with patients with COVD-19 at the time of the survey. The health workers displaying attitudes that would put themselves or others at risk were in the minority. Only 55.6% of participants had received infection prevention and control training. Some participants indicated they did not have access to medical masks (11.8%) and gloves (9.9%) in their departments. Conclusions The attitudes of participants reflected a willingness to engage in appropriate SARS-CoV-2 infection prevention and control practices as well as a commitment to be involved in COVID-19 patient care. Ensuring adequate infection prevention and control training for all staff and universal access to appropriate PPE were identified as key areas that needed to be addressed. Interim and final reports which identified key shortcomings that needed to be addressed were provided to the relevant provincial departments of health.

scholarly journals Feasibility Study of a Digital Screen-Based Calming Device for Managing BPSD During Care

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 755-755
Author(s):  
Gloria Gutman ◽  
Avantika Vashisht ◽  
Taranjot Kaur ◽  
Ryan Churchill ◽  
Amir Moztarzadeh ◽  
...  
Keyword(s):  
Usual Care ◽  
Psychological Symptoms ◽  
Care Home ◽  
Routine Care ◽  
Care Staff ◽  
Successful Implementation ◽  
Term Care ◽  
Item Checklist ◽  
And Control

Abstract MindfulGarden (MG) is a digital device resembling a flat screen TV, with touchless sensors that react to voice and motion. In this study 13 long-term care home residents aged 74-100 exhibiting Behavioural and Psychological Symptoms of Dementia (BPSD) were randomized to treatment and control groups. On days 1-3 the treatment group received usual care plus exposure to MG during morning and evening care - events well documented to be problematic for residents and care staff; controls received usual care only. On day 4 both groups were exposed to MG with verbal cueing. A 26-item checklist was used to record frequency and types of disruptive BPSD exhibited; care duration was recorded in minutes. There was a trend toward reduction of BPSD and duration of care during morning care. Findings suggest that verbal cueing may be important for successful implementation of MG in calming residents with dementia during routine care.

scholarly journals Interoperability in Smart Manufacturing: Research Challenges

Machines ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 21 ◽  
Author(s):  
Abe Zeid ◽  
Sarvesh Sundaram ◽  
Mohsen Moghaddam ◽  
Sagar Kamarthi ◽  
Tucker Marion
Keyword(s):  
Data Exchange ◽  
Research Area ◽  
Smart Manufacturing ◽  
Shop Floor ◽  
Successful Implementation ◽  
Integrated Networks ◽  
Software Packages ◽  
Industrial Internet ◽  
Logical Semantics ◽  
And Control

Recent advances in manufacturing technology, such as cyber–physical systems, industrial Internet, AI (Artificial Intelligence), and machine learning have driven the evolution of manufacturing architectures into integrated networks of automation devices, services, and enterprises. One of the resulting challenges of this evolution is the increased need for interoperability at different levels of the manufacturing ecosystem. The scope ranges from shop–floor software, devices, and control systems to Internet-based cloud-platforms, providing various services on-demand. Successful implementation of interoperability in smart manufacturing would, thus, result in effective communication and error-prone data-exchange between machines, sensors, actuators, users, systems, and platforms. A significant challenge to this is the architecture and the platforms that are used by machines and software packages. A better understanding of the subject can be achieved by studying industry-specific communication protocols and their respective logical semantics. A review of research conducted in this area is provided in this article to gain perspective on the various dimensions and types of interoperability. This article provides a multi-faceted approach to the research area of interoperability by reviewing key concepts and existing research efforts in the domain, as well as by discussing challenges and solutions.

scholarly journals Impact of dams and irrigation schemes in Anopheline (Diptera: Culicidae) bionomics and malaria epidemiology

2012 ◽  
Vol 54 (4) ◽  
pp. 179-191 ◽  
Author(s):  
Jordi Sanchez-Ribas ◽  
Gabriel Parra-Henao ◽  
Anthony Érico Guimarães
Keyword(s):  
Control Measures ◽  
Successful Implementation ◽  
Negative Effects ◽  
Irrigation Scheme ◽  
Tropical Regions ◽  
Malaria Epidemiology ◽  
The Pacific ◽  
The Tropics ◽  
And Control ◽  
Anopheline Mosquitoes

Irrigation schemes and dams have posed a great concern on public health systems of several countries, mainly in the tropics. The focus of the present review is to elucidate the different ways how these human interventions may have an effect on population dynamics of anopheline mosquitoes and hence, how local malaria transmission patterns may be changed. We discuss different studies within the three main tropical and sub-tropical regions (namely Africa, Asia and the Pacific and the Americas). Factors such as pre-human impact malaria epidemiological patterns, control measures, demographic movements, human behaviour and local Anopheles bionomics would determine if the implementation of an irrigation scheme or a dam will have negative effects on human health. Some examples of successful implementation of control measures in such settings are presented. The use of Geographic Information System as a powerful tool to assist on the study and control of malaria in these scenarios is also highlighted.

Collaborative Governance and the Implementation of Fiscal Responsibility Frameworks

2017 ◽  
pp. 463-482
Author(s):  
Sonia D. Gatchair
Keyword(s):  
Local Governments ◽  
Central Government ◽  
Collaborative Governance ◽  
Small Island ◽  
Successful Implementation ◽  
Policy Reforms ◽  
Local Authorities ◽  
Fiscal Responsibility ◽  
Fiscal Management ◽  
And Control

Local governments, like their central government counterparts, must demonstrate increased fiscal responsibility. Although the Jamaican finance ministry has overall responsibility for direction and control of fiscal management at all levels of government, successful implementation cannot be achieved solely by the finance ministry's efforts, but requires the inputs of other actors, including central government, local authorities, the private sector, and civil society groups. This chapter examines the strategic use of collaborations among local authorities and other stakeholders in the implementation of fiscal management policies, in particular revenue-raising efforts in Jamaica, a small island state. The study examines relationships/partnerships (collaborative governance) focusing on the actors, structure, and processes in the implementation of fiscal policy reforms in local authorities. It finds that deliberate efforts must be made to manage complexity arising from overlapping networks with unclear boundaries and fluidity in participation and leadership.

Operators' Monitoring Patterns and Fault Recovery in the Supervisory Control of a Semi-Automatic Process

1992 ◽  
Vol 36 (15) ◽  
pp. 1143-1147
Author(s):  
John D. Lee ◽  
Neville Moray
Keyword(s):  
Individual Differences ◽  
Supervisory Control ◽  
Critical Role ◽  
Normal Operation ◽  
Large Individual ◽  
Automatic Process ◽  
Successful Implementation ◽  
Control Actions ◽  
Integrate Control ◽  
And Control

Although technological innovations have changed the role of operators from active participants to supervisors of semiautomatic processes, an understanding of the cognitive demands of supervisory control has not kept pace. In particular, little is known about when, and how well, operators might intervene and switch control from automatic to manual. This research addresses this issue by monitoring the information use and control actions of operators of a simulated semiautomatic pasteurization plant. The results of this experiment shows that individual differences in operators” monitoring patterns during the normal operation of the plant correspond to differences in their ability to mitigate the effects of faults. Specifically, an operator who controls the plant well during both normal and fault conditions tends to observe the plant frequently, integrating control actions with other control actions, and does not fixate on narrow sub-systems of the plant. On the other hand, an operator who performs poorly when exposed to faults tends to observe the plant less often, fails to integrate control actions, and fixates attention on a narrow subset of plant variables. Although all operators interacted with the plant using the same interface and automation, large individual differences in the operators” monitoring patterns, and the associated differences in performance suggest that individuals” attitudes, motivation, and training may play a critical role in the successful implementation of automation.

scholarly journals Immunity-related genes and signaling pathways under hypoxic stresses in Haliotis diversicolor: a transcriptome analysis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yulong Sun ◽  
Xin Zhang ◽  
Yilei Wang ◽  
Robert Day ◽  
Huiping Yang ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Vibrio Parahaemolyticus ◽  
Control Group ◽  
Signal Pathways ◽  
Quantitative Real Time Pcr ◽  
Haliotis Diversicolor ◽  
Double Stranded Rna ◽  
Immunologic Function ◽  
Negative Impacts ◽  
And Control

AbstractDue to increased temperatures and aquaculture density, thermal and hypoxia stresses have become serious problems for the aquaculture of abalone Haliotis diversicolor. Stresses lead to immunosuppression, which can cause severe negative impacts on aquaculture farms. To study the mechanism of immunosuppression after hypoxia stress and bacterial challenge, transcriptomes of H. diversicolor hemocytes involved in immunity were profiled. A total of 307,395,572 clean reads were generated and assembled into 99,774 unigenes. KEGG analysis indicated that 225 unigenes with immunologic function were mapped into immune-related pathways. Expression of 41 unigenes measured by quantitative real-time PCR (qRT-PCR) showed consistent results with that of transcriptome analysis. When exposure challenge of Vibrio parahaemolyticus, it is indicated that the PI3K-AKT, MAPK, NF-κB and P53 signal pathways were involved in the hypoxia-induced immunosuppression of H. diversicolor. Furthermore, when the AKT gene (HdAKT) was inhibited by double-stranded RNA (dsRNA), expression levels of HdAKT was lower than the blank and control group in hemocytes at 4 h, 12 h and 24 h (p < 0.05).

scholarly journals Yes, Irradiated Sterile Male Mosquitoes Can Be Sexually Competitive!

2020 ◽  
Vol 36 (11) ◽  
pp. 877-880 ◽  
Author(s):  
Jérémy Bouyer ◽  
Marc J.B. Vreysen
Keyword(s):  
Sterile Male ◽  
Male Mosquitoes

scholarly journals Working towards a Co-Ordinated Approach to Invasive Mosquito Detection, Response and Control in the UK

2020 ◽  
Vol 17 (14) ◽  
pp. 5166 ◽  
Author(s):  
Alexander G. C. Vaux ◽  
Colin Johnston ◽  
Thom Dallimore ◽  
Liz McGinley ◽  
Clare Strode ◽  
...  
Keyword(s):  
Local Health ◽  
Mosquito Vector ◽  
Source Reduction ◽  
Medical Entomology ◽  
Authority Control ◽  
The United Kingdom ◽  
Positive Site ◽  
Invasive Mosquito ◽  
The Uk ◽  
And Control

The United Kingdom (UK) has reported a single detection of the eggs of the invasive mosquito vector Aedes albopictus in each of the three years from 2016 to 2018, all in southeast England. Here, we report the detection of mosquito eggs on three occasions at two sites in London and southeast England in September 2019. Mosquito traps were deployed at 56 sites, in England, Scotland, Wales, and Northern Ireland, as part of a coordinated surveillance programme with local authorities, Edge Hill University, and government departments. Response to each detection was coordinated by Public Health England’s (PHE) local health protection teams, with technical support from PHE’s Medical Entomology group, and control conducted by the respective local authority. Control, including source reduction and larviciding, was conducted within a 300 metre radius of the positive site. The response followed a National Contingency Plan for Invasive Mosquitoes: Detection of Incursions. Although the response to these incidents was rapid and well co-ordinated, recommendations are made to further develop mosquito surveillance and control capability for the UK.

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