269 Mycotoxin Mitigation Strategy to Improve Nursery Pig Performance During Natural Mycotoxin Challenge

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 99-100
Author(s):  
Shelby M Ramirez ◽  
Victoria C Wilson ◽  
Erika G Hendel ◽  
Ursula Hofstetter ◽  
G Raj Murugesan ◽  
...  

Abstract Mycotoxins (MTX) such as deoxynivalenol (DON), fumonisins (FUM), and zearalenone (ZEN) are a few of the most prevalent mycotoxins in livestock feed. Effects of MTX can vary based on contamination and type, but include losses in performance, immune function and reproduction impacting profitability. Effectiveness of mitigation strategies for MTX can greatly vary depending on type and contamination level. Therefore, the trial objective was to evaluate an in-feed mitigation strategy [Biofix® Plus (BPL), 1.5 kg/MT inclusion, BIOMIN America, Inc., Overland Park, KS] on nursery pig performance during a natural mixed MTX challenge. A total of 105 newly weaned pigs (BW = 5.5 ± 0.2 kg) were allotted to 1 of 4 treatments in a 2 × 2 factorial design with 2 MTX contamination levels [low (L-MTX) and high (H-MTX); Table 1] and 2 BPL levels [without (Control) and with (BPL)] with 3 pigs per pen and 8 to 9 pens per treatment for a 5-week trial. Data were analyzed using the GLIMMIX procedure of SAS with main effects of MTX and BPL and their interaction. There was no interaction of MTX and BPL on any of the cumulative 5-week performance metrics, therefore only main effects will be discussed. Average pig BW at 5-week was reduced (P < 0.05) in H-MTX compared with L-MTX diets (21.5 vs 18.5 kg, respectively). Similarly, ADG and ADFI were reduced (P < 0.05) in H-MTX pigs compared with L-MTX pigs. Feed efficiency was numerically reduced (P = 0.050) in H-MTX pigs compared with L-MTX pigs. However, BPL fed pigs had increased (P < 0.05) feed efficiency compared with pigs not fed BPL. Thus, MTX did effect BW, ADG, and ADFI and BPL was able to increase feed efficiency regardless of MTX level suggesting that BPL should be considered as a mitigation strategy to address mixed MTX challenges.

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 94-95
Author(s):  
Kelsey Hammers ◽  
Hilda I Calderon ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Robert D Goodband ◽  
...  

Abstract A total of 360 pigs (DNA 200′400, initially 5.0 kg) were used in a 45-d growth trial to determine the effects of fiber source and crude protein (CP) level in diets without pharmacological levels of ZnO on nursery pig growth performance and fecal dry matter (DM). Pigs were randomly assigned to 1 of 8 treatments with 5 pigs/pen and 9 pens/treatment. Treatments were arranged in a 2×4 factorial with main effects of CP (21 or 18%) and fiber source [none, coarse wheat bran (CWB), oat hulls, or cellulose (Arbocel, J. Rettenmaier USA, Schoolcraft, MI)]. Fiber source was added to equalize the level of insoluble fiber contributed from 4% CWB, resulting in the addition of 1.85% oat hulls or 1.55% cellulose. Diets were fed in two phases (d 0 to 10 and 10 to 24) followed by a common diet (d 24 to 45). The 21% CP diets contained 1.40% SID Lys in phase 1 and 1.35% SID Lys in phase 2. Treatment diets were formulated to a maximum SID Lys:digestible CP level of 6.35%, thus SID Lys decreased in the 18% CP (1.25% SID Lys) diets. Data were analyzed using the lmer function in R. No fiber source × CP level interactions (P >0.05) were observed. Decreasing dietary CP decreased (P = 0.05) ADG, G:F, and d 24 BW. Overall, ADG and d 45 BW decreased (P < 0.05) for pigs fed 18% CP diets. No main effects of fiber source were observed for growth performance throughout the study. Fecal DM increased (P < 0.05) for pigs fed added cellulose compared to pigs fed no fiber or CWB in the experimental period. In conclusion, reducing dietary CP decreased growth performance and the inclusion of cellulose improved fecal DM of nursery pigs.


2020 ◽  
Vol 98 (12) ◽  
Author(s):  
Jamil E G Faccin ◽  
Mike D Tokach ◽  
Matthew W Allerson ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
...  

Abstract A total of 2,184 pigs (DNA 600 × PIC L42) were used to evaluate the effects of weaning age and antibiotic (AB) use on pig performance from weaning to marketing in a commercial production system. Experimental treatments were arranged in a 3 × 2 factorial with main effects of weaning age (18.5, 21.5, or 24.5 d of age) and with the use of ABs or an antibiotic-free (NAE) program. At birth, pigs were ear tagged, and the date of birth and sex recorded. Pigs were weaned from a 4,000-sow farm over four consecutive weeks. Four weaning batches (one per week) of 546 pigs were used. Each weaning batch had one-third of pigs of each weaning age. Pigs were placed in pens by weaning age and then randomly assigned to an AB or NAE program. There were 14 replicate pens per treatment and 26 pigs per pen (13 barrows and 13 gilts). Pigs allocated to the AB program were fed a diet containing 441 mg/kg chlortetracycline (CTC) from day 8 to 21 postweaning. They were also administered 22 mg/kg of body weight (BW) of CTC via drinking water for five consecutive days after a porcine respiratory and reproductive syndrome outbreak during week 7 after weaning. In the first 42 d postweaning, increasing weaning age improved (linear, P < 0.001) BW at day 42, average daily gain (ADG), and average daily feed intake (ADFI). From weaning to 197 d of age, increasing weaning age increased (linear, P < 0.001) ADG and ADFI. Pigs on the AB program had greater (P = 0.031) ADG and ADFI compared with NAE pigs. An interaction (linear, P = 0.005) was observed for feed efficiency (G:F). When ABs were provided, increasing weaning age did not result in any change in G:F; however, in the NAE program, increasing weaning age increased G:F. Pigs on the AB program had lower (P < 0.001) total losses (mortality and removals) than those on the NAE program. Increasing weaning age marginally (linear, P = 0.097) decreased total losses. Increasing weaning age decreased (quadratic, P < 0.001) the number of pigs treated with an injectable AB but the AB program did not (P = 0.238). The weight sold (at 197 d of age) per pig weaned was increased (linear, P = 0.050) by increasing weaning age and by using AB in feed and water (P = 0.019). In summary, increasing weaning age linearly improved most of the pig performance criteria and relatively the short-term use of ABs reduced mortality and removals with both factors contributing to increased weight sold per pig weaned.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 73-74
Author(s):  
Lan Zheng ◽  
Chasity Pender ◽  
Paige N Gott ◽  
Erin F Schwandt ◽  
Shelby M Ramirez ◽  
...  

Abstract Mycotoxins are harmful secondary fungal metabolites central to food and feed safety management. These toxins are detrimental to animal health and even at low levels can compromise performance. Focus on clinical signs like decreased feed intake and vomiting overlook significant impacts of mycotoxicosis, including increased disease incidence and severity, immune dysfunction, inflammation, and modulation of the gastrointestinal environment. The objective of this study was to determine the effect of harvest year on five major mycotoxin groups: aflatoxins (Afla), type A trichothecenes (A-Trich), type B trichothecenes (B-Trich), fumonisins (FUM), and zearalenone (ZEN) in corn and corn DDGS samples. For each mycotoxin group within ingredient, 2019 harvest (329 corn and 20 corn DDGS) were compared with 2020 harvest (27 corn and 21 corn DDGS). Data were analyzed using GLIMMIX procedure of SAS with harvest year as fixed effect and sample as the experimental unit. Average B-Trich and FUM contamination levels in corn are significantly (P < 0.05) affected by harvest year. However, B-Trich levels remained consistent, whereas FUM decreased (P < 0.05) from 2019 to 2020. Contamination levels in corn for Afla, A-Trich, and ZEN have remained consistent (P > 0.05) from 2019 to 2020. In corn DDGS, B-Trich contamination level was decreased (P < 0.05) from 2019 to 2020, whereas FUM and ZEN contamination levels remained similar (P > 0.05). The 2020 crop risk profile is likely to change as the sample pool expands. A combination of hot weather, storm events, and drought during the 2020 growing season resulted in crop stress and damage, ultimately leading to grain quality and mycotoxin contamination concerns. Due to the continued risk of mycotoxin co-occurrence, expanding mitigation strategies beyond adsorption by mycotoxin deactivation with biotransformation and additional support of immune and liver function is essential.


2018 ◽  
Vol 2 (1) ◽  
pp. 62-73 ◽  
Author(s):  
J A Feldpausch ◽  
R G Amachawadi ◽  
M D Tokach ◽  
H M Scott ◽  
S S Dritz ◽  
...  

Abstract Two 47-d experiments were conducted with 21-d-old weaned pigs (PIC 1050, initially 6.1 kg) to determine the effects of feeding low or high doses of chlortetracycline (CTC) and antibiotic alternatives (Cu, Zn, and essential oil [EO]), alone or in combination, on growth performance. On d 5 postweaning, pens of 5 pigs were allotted to diet treatments with 8 (exp. 1) or 7 (exp. 2) replicate pens per treatment. In exp. 1, treatments were fed from d 5 to 26 postweaning and arranged in a 2 × 3 factorial with main effects of added ZnO (0 vs. 2,500 ppm of Zn) and CTC (0, 55, or 441 ppm). In exp. 2, treatments were fed from d 5 to 33 and structured in a (2 × 2 × 2) + 2 factorial with main effects of added CuSO4 (0 vs. 125 ppm Cu), added ZnO (0 vs. 3,000 ppm Zn from d 5 to 12 and 2,000 ppm Zn from d 12 to 33), and Regano EX (0 vs. 0.1% Regano EX containing 5% Origanum oil). The 2 additional treatments were subtherapeutic (55 ppm) and therapeutic (441 ppm) levels of CTC. Following the treatment period, a common diet without antimicrobial was fed until d 47. All diets contained 16.5 ppm Cu and 110 ppm Zn from the trace mineral premix. In exp. 1, no ZnO × CTC interactions were observed. Feeding ZnO increased (P < 0.05) ADG, ADFI, and BW during the treatment period and increased (P < 0.05) ADG and ADFI overall (d 5 to 47). Pigs fed CTC had increased (linear, P < 0.05) ADG, ADFI, and BW during the treatment period and had marginally significant increases (linear, P < 0.10) in overall ADG and ADFI, but overall G:F tended (quadratic, P = 0.070) to increase then decrease as CTC increased. During the treatment period in exp. 2, EO did not affect ADG or ADFI, whereas pharmacological levels of Cu, Zn, and CTC increased (P < 0.05) ADG with coinciding increases (P = 0.055, 0.006, and linear 0.079, respectively) in ADFI. Copper, Zn, and CTC did not affect G:F. EO decreased (P = 0.009) G:F. Diet treatments had minimal carryover effects on subsequent nursery pig growth performance. Overall from d 5 to 47, Cu increased (P = 0.018) ADG, Zn increased (P < 0.05) ADG and ADFI, and EO tended to decrease (P = 0.086) G:F. In conclusion, increased dietary Cu, Zn, or CTC improved weanling pig performance while EO elicited no growth benefits. The benefits of added Zn from ZnO and CTC were additive and could be included together in diets to maximize growth performance of weaned pigs.


2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 252-253
Author(s):  
Olivia Harrison ◽  
Ashton Yoder ◽  
Cassandra K Jones

Abstract A total of 350 nursery pigs (initially 7.6 kg BW) were used in a 28-d trial to evaluate the effects of conditioning temperature and pellet diameter on nursery pig performance. Pigs were randomly assigned to 1 of 7 treatments with 10 pens/treatment and 5 pigs/pen. The 7 treatments were arranged in a 2×3 factorial design plus a mash control, with the factors of pellet diameter (4.0 mm vs. 4.8 mm), and conditioning temperature (low, medium, vs. high). Phase 1 conditioning temperatures were 54°C, 66°C, and 77°C, while phase 2 conditioning temperatures were 54°C, 71°C, and 88°C for low, medium, and high, respectively. Pigs were fed phase 1 from d 0 to 14, which contained 10% spray dried whey, while phase 2 was fed from d 14 to 28, which did not contain milk products. Pig weights and feed disappearance were recorded weekly to determine ADG, ADFI, and G:F. Data were analyzed using the GLIMMIX procedure of SAS with pen as the experimental unit. Pellet diameter did not impact (P > 0.05) nursery pig growth performance. Pigs fed pelleted diets had greater (P < 0.05) G:F than those fed mash diets. During phase 1 and overall, there were no significant (P > 0.05) interactive or main effects. However, conditioning phase 2 diets at lower temperatures improved (P < 0.05) ADG and G:F than medium and high conditioning temperatures. In conclusion, pelleting improves nursery pig feed efficiency. To maximize nursery pig feed efficiency, phase 2 diets should be conditioned at relatively low temperatures.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 47-48
Author(s):  
Wade M Hutchens ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
Robert D Goodband ◽  
...  

Abstract Weanling pigs (n = 360, DNA 200 × 400, initially 5.90 kg) were used to evaluate pharmacological levels of Zn (ZnO), diet acidification (sodium diformate; Addcon, Bitterfeld-Wolfen, Germany), and crude protein (18 or 21% CP) on pig performance. At weaning, pigs were assigned to treatments with 5 pigs/pen and 9 pens/treatment. Treatments were arranged in a 2×2×2 factorial with main effects of Zn (110 mg/kg from d 0 to 21 or 3,000 mg/kg from d 0 to 7, and 2,000 mg/kg from d 7 to 21), diet acidification (without or with 1.2% sodium diformate), and dietary CP (21 or 18%). The 21% CP diets were formulated to 1.40 and 1.35% SID Lys in phase 1 and 2, respectively, and 18% CP diets were formulated to 1.20% SID Lys. Experimental diets were fed from d 0 to 21 with a common diet from d 21 to 42. Fecal samples were collected weekly to determine fecal dry matter (DM). Data were analyzed using R Studio as a RCBD. From d 0 to 21, ADG and G:F increased (P < 0.05) for pigs fed pharmacological Zn, and sodium diformate. Overall, ADG tended (P ≤ 0.069) to increase for pigs fed added Zn or sodium diformate. Pigs fed 21% CP had increased (P < 0.05) ADG and G:F from d 0 to 21 and overall G:F compared with those fed 18% CP. Feeding 18% CP diets increased fecal dry matter on d 7 when pharmacological Zn and sodium diformate were not in the diet (Zn×acidifier×CP interaction, P < 0.05). From d 21 to 42, there was no evidence of difference in growth performance. In conclusion, reducing CP without acidification increased fecal DM when pharmacological Zn were not in the diet, but had little effect when it was in the diet. Adding sodium diformate and pharmacological Zn independently improved nursery pig growth performance.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 92-93
Author(s):  
Jenna A Chance ◽  
Mike D Tokach ◽  
Hilda I Calderon ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
...  

Abstract A total of 1,296 pigs (PIC L337×1050; initially 4.8 kg) were used in a 42-d study to evaluate cellulose in diets with and without pharmacological levels of Zn on nursery pig performance. Our hypothesis was that added fiber (cellulose) may provide more benefit in diets without ZnO. Pens were assigned to 1 of 4 dietary treatments in a RCBD by BW with 27 pigs/pen and 12 pens/treatment. Dietary treatments were arranged in a 2×2 factorial with main effects of cellulose (0 vs 1%; J. Rettenmaier USA, Schoolcraft, MI) and Zn (200 vs. 3,000 mg/kg in phase 1 and 110 vs. 2,000 mg/kg in phase 2). Treatment diets were formulated in two phases fed from d 0 to 7 and 7 to 21 with a common diet fed from d 21 to 42 post-weaning. Pig weights and feed disappearance were collected weekly to determine ADG, ADFI, and G:F. On d 16 or 17, fecal samples were collected from 3 pigs/pen to determine fecal DM, and all pens were visually evaluated for fecal consistency. There were no Zn×cellulose interactions. For the experimental and overall period, pigs fed diets containing added Zn had increased (P < 0.001) ADG, ADFI, G:F and BW while those that were fed cellulose had decreased (P < 0.05) ADG. For fecal dry matter, there was no evidence for difference (P >0.10) between any of the treatments but those fed added ZnO had visually firmer feces as evidenced by lower (P < 0.001) fecal scores. When fed a common diet from d 21 to 42, pigs previously fed added ZnO had increased (P < 0.001) ADG (502 vs. 523 g/d) and ADFI (697 vs. 734 g/d). In conclusion, there were no interactive effects between added cellulose and Zn; however, cellulose reduced ADG while the inclusion of pharmacological levels of Zn improved all growth criteria.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 159-160
Author(s):  
Josh K Knapp ◽  
Alison Bartenslager ◽  
Shana M Winkel ◽  
Melanie D Trenhaile-Grannemann ◽  
Joice V San Andres ◽  
...  

Abstract The use of probiotics may be an effective strategy in sustainable pig production. The objective of this experiment was to examine the effects of Lactobacillus fermentum (LF) on nursery pig performance. Weaned pigs (n = 70; average initial BW 6.464 kg) were randomly allotted to 1 of 3 treatments, forming 6 replicates per treatment. Treatments included: 1) pigs fed a standard nursery diet (NRC 2012); CTL; 2) pigs fed CTL with the addition of 10^10 CFU LF per day for phase 1 (wk 2 and 3; LF1); and 3) pigs fed CTL with the addition of 10^10 CFU LF per day for phase 1 and phase 2 (wk 2 thru 5). A common diet was fed during adaptation (wk 1) and during a wash out phase (wk 6). Individual piglet BW were recorded weekly along with pen feed disappearance. No differences were observed in BW by the end of phase 1; at the end of phase 2 the pigs fed LF had a lower BW than the others (19.38, 19.22, 17.3 kg; P = 0.031). This was associated with a reduced feed efficiency seen in week 5 (0.679, 0.656, 0.445; P = 0.0404). However, no differences (P > 0.10) were observed in BW of the pigs throughout the trial and final BW were 24.15, 24.45, 24.3 kg. No differences were observed in ADFI between treatments (ADFI Phase 1: 0.359, 0.366, 0.353 kg/d;P = 0.965; Phase 2: 0.906, 0.896, 0.843 kg/d; P = 0.578; Phase 3: 1.183, 1.227, 1.196 kg; P = 0.920). Results suggest that pigs fed diets supplemented with Lactobacillus fermentum performed similar to pigs fed a conventional diet.


Author(s):  
Wade M Hutchens ◽  
Mike D Tokach ◽  
Steve S Dritz ◽  
Jordan Gebhardt ◽  
Jason C Woodworth ◽  
...  

Abstract This experiment was conducted to evaluate potential replacements for pharmacological levels of Zn (provided by Zn oxide), such as diet acidification (sodium diformate), and low dietary crude protein (CP: 21 vs 18%) on nursery pig performance and fecal dry matter (DM). A total of 360 weaned pigs (Line 200 × 400, DNA, Columbus, NE; initially 5.90 ± 0.014 kg) were used in a 42-d growth study. Pigs were weaned at approximately 21-d of age and randomly assigned to pens (5 pigs per pen). Pens were then allotted to 1 of 8 dietary treatments with 9 pens per treatment. Experimental diets were fed in two phases: Phase 1 from weaning to d 7 and phase 2 from d 7 to 21; with all pigs fed the same common diet from d 21 to 42. The eight treatment diets were arranged as a 2 × 2 × 2 factorial with main effects of Zn (110 mg/kg from d 0 to 21 or 3,000 mg/kg from d 0 to 7, and 2,000 mg/kg from d 7 to 21), diet acidification, (without or with 1.2% sodium diformate), and dietary CP (21 or 18%, 1.40 and 1.35% in Phase 1 and 2 vs 1.20% standardized ileal digestible Lys, respectively). Fecal samples were collected weekly from the same 3 pigs per pen to determine DM content. No 2- or 3-way interactions (P > 0.05) were observed throughout the 42-d study for growth performance; however, there was a Zn × acidifier × CP interaction (P < 0.05) for fecal DM on d 7 and for the overall average of the 6 collection periods. Reducing CP without acidification or pharmacological levels of Zn increased fecal DM, but CP had little effect when ZnO was present in the diet. From d 0 to 21, significant (P < 0.05) main effects were observed where average daily gain (ADG) and gain:feed (G:F) increased for pigs fed pharmacological levels of Zn, sodium diformate, or 21% CP (P < 0.065). In the subsequent period (d 21 to 42) after the experimental diets were fed, there was no evidence of difference in growth performance among treatments. Overall (d 0 to 42), main effect tendencies were observed (P < 0.066) for pigs fed added Zn or sodium diformate from d 0 to 21 whereas pigs fed 21% CP had greater G:F than those fed 18% CP. Pig weight on d 42 was increased by adding Zn (P < 0.05) or acidifier (P < 0.06) but not CP. In summary, none of the feed additives had a major influence on fecal DM, but dietary addition of pharmacological levels of Zn or sodium diformate independently improved nursery pig performance.


2005 ◽  
Author(s):  
David R. Stender ◽  
Jerry Weiss ◽  
Dennis DeWitt ◽  
Colin D. Johnson ◽  
Kenneth J Stalder ◽  
...  

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