The effects of pharmacological levels of zinc, diet acidification and dietary crude protein on growth performance on nursery pigs

Author(s):  
Wade M Hutchens ◽  
Mike D Tokach ◽  
Steve S Dritz ◽  
Jordan Gebhardt ◽  
Jason C Woodworth ◽  
...  

Abstract This experiment was conducted to evaluate potential replacements for pharmacological levels of Zn (provided by Zn oxide), such as diet acidification (sodium diformate), and low dietary crude protein (CP: 21 vs 18%) on nursery pig performance and fecal dry matter (DM). A total of 360 weaned pigs (Line 200 × 400, DNA, Columbus, NE; initially 5.90 ± 0.014 kg) were used in a 42-d growth study. Pigs were weaned at approximately 21-d of age and randomly assigned to pens (5 pigs per pen). Pens were then allotted to 1 of 8 dietary treatments with 9 pens per treatment. Experimental diets were fed in two phases: Phase 1 from weaning to d 7 and phase 2 from d 7 to 21; with all pigs fed the same common diet from d 21 to 42. The eight treatment diets were arranged as a 2 × 2 × 2 factorial with main effects of Zn (110 mg/kg from d 0 to 21 or 3,000 mg/kg from d 0 to 7, and 2,000 mg/kg from d 7 to 21), diet acidification, (without or with 1.2% sodium diformate), and dietary CP (21 or 18%, 1.40 and 1.35% in Phase 1 and 2 vs 1.20% standardized ileal digestible Lys, respectively). Fecal samples were collected weekly from the same 3 pigs per pen to determine DM content. No 2- or 3-way interactions (P > 0.05) were observed throughout the 42-d study for growth performance; however, there was a Zn × acidifier × CP interaction (P < 0.05) for fecal DM on d 7 and for the overall average of the 6 collection periods. Reducing CP without acidification or pharmacological levels of Zn increased fecal DM, but CP had little effect when ZnO was present in the diet. From d 0 to 21, significant (P < 0.05) main effects were observed where average daily gain (ADG) and gain:feed (G:F) increased for pigs fed pharmacological levels of Zn, sodium diformate, or 21% CP (P < 0.065). In the subsequent period (d 21 to 42) after the experimental diets were fed, there was no evidence of difference in growth performance among treatments. Overall (d 0 to 42), main effect tendencies were observed (P < 0.066) for pigs fed added Zn or sodium diformate from d 0 to 21 whereas pigs fed 21% CP had greater G:F than those fed 18% CP. Pig weight on d 42 was increased by adding Zn (P < 0.05) or acidifier (P < 0.06) but not CP. In summary, none of the feed additives had a major influence on fecal DM, but dietary addition of pharmacological levels of Zn or sodium diformate independently improved nursery pig performance.

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 47-48
Author(s):  
Wade M Hutchens ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
Robert D Goodband ◽  
...  

Abstract Weanling pigs (n = 360, DNA 200 × 400, initially 5.90 kg) were used to evaluate pharmacological levels of Zn (ZnO), diet acidification (sodium diformate; Addcon, Bitterfeld-Wolfen, Germany), and crude protein (18 or 21% CP) on pig performance. At weaning, pigs were assigned to treatments with 5 pigs/pen and 9 pens/treatment. Treatments were arranged in a 2×2×2 factorial with main effects of Zn (110 mg/kg from d 0 to 21 or 3,000 mg/kg from d 0 to 7, and 2,000 mg/kg from d 7 to 21), diet acidification (without or with 1.2% sodium diformate), and dietary CP (21 or 18%). The 21% CP diets were formulated to 1.40 and 1.35% SID Lys in phase 1 and 2, respectively, and 18% CP diets were formulated to 1.20% SID Lys. Experimental diets were fed from d 0 to 21 with a common diet from d 21 to 42. Fecal samples were collected weekly to determine fecal dry matter (DM). Data were analyzed using R Studio as a RCBD. From d 0 to 21, ADG and G:F increased (P < 0.05) for pigs fed pharmacological Zn, and sodium diformate. Overall, ADG tended (P ≤ 0.069) to increase for pigs fed added Zn or sodium diformate. Pigs fed 21% CP had increased (P < 0.05) ADG and G:F from d 0 to 21 and overall G:F compared with those fed 18% CP. Feeding 18% CP diets increased fecal dry matter on d 7 when pharmacological Zn and sodium diformate were not in the diet (Zn×acidifier×CP interaction, P < 0.05). From d 21 to 42, there was no evidence of difference in growth performance. In conclusion, reducing CP without acidification increased fecal DM when pharmacological Zn were not in the diet, but had little effect when it was in the diet. Adding sodium diformate and pharmacological Zn independently improved nursery pig growth performance.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 94-95
Author(s):  
Kelsey Hammers ◽  
Hilda I Calderon ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Robert D Goodband ◽  
...  

Abstract A total of 360 pigs (DNA 200′400, initially 5.0 kg) were used in a 45-d growth trial to determine the effects of fiber source and crude protein (CP) level in diets without pharmacological levels of ZnO on nursery pig growth performance and fecal dry matter (DM). Pigs were randomly assigned to 1 of 8 treatments with 5 pigs/pen and 9 pens/treatment. Treatments were arranged in a 2×4 factorial with main effects of CP (21 or 18%) and fiber source [none, coarse wheat bran (CWB), oat hulls, or cellulose (Arbocel, J. Rettenmaier USA, Schoolcraft, MI)]. Fiber source was added to equalize the level of insoluble fiber contributed from 4% CWB, resulting in the addition of 1.85% oat hulls or 1.55% cellulose. Diets were fed in two phases (d 0 to 10 and 10 to 24) followed by a common diet (d 24 to 45). The 21% CP diets contained 1.40% SID Lys in phase 1 and 1.35% SID Lys in phase 2. Treatment diets were formulated to a maximum SID Lys:digestible CP level of 6.35%, thus SID Lys decreased in the 18% CP (1.25% SID Lys) diets. Data were analyzed using the lmer function in R. No fiber source × CP level interactions (P >0.05) were observed. Decreasing dietary CP decreased (P = 0.05) ADG, G:F, and d 24 BW. Overall, ADG and d 45 BW decreased (P < 0.05) for pigs fed 18% CP diets. No main effects of fiber source were observed for growth performance throughout the study. Fecal DM increased (P < 0.05) for pigs fed added cellulose compared to pigs fed no fiber or CWB in the experimental period. In conclusion, reducing dietary CP decreased growth performance and the inclusion of cellulose improved fecal DM of nursery pigs.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 71-71
Author(s):  
Hadley Williams ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Robert D Goodband ◽  
Joel M DeRouchey ◽  
...  

Abstract Previous research has indicated that starch gelatinization during the pelleting process is greater for Enogen® Feed corn compared to conventional yellow dent corn. Increasing starch gelatinization in the pellet increases the starch digestibility in the pig, which potentially leads to increased growth rate. Therefore, the objective of this study was to determine the effects of feeding Enogen Feed corn in meal or pellet form on finishing pig growth performance and carcass characteristics. A total of 288 pigs (53.0 ± 0.5 kg) were used with 8 pigs/pen and 9 pens/treatment in a 72-d study. Treatments were arranged in a 2×2 factorial with main effects of corn source (Enogen Feed corn or conventional yellow dent corn) and diet form (meal or pellet). Main effects of corn source and diet form as well as their interactions were tested. Pelleting parameters were established with a target conditioner temperature of 82.2°C and corn moisture of 13 to 14%. When pelleting the diets, the conditioning temperature for conventional yellow dent corn averaged 68.4°C and Enogen Feed corn averaged 67.7°C. The hot pellet temperature for conventional yellow dent corn averaged 75.1°C and 75.8°C for Enogen feed corn. For overall performance (d 0 to 72), no interactions between corn source and diet form were observed (P > 0.05). There was a tendency (P < 0.10) for slightly improved average daily gain (ADG) and gain:feed ratio (G:F) for pigs fed conventional yellow dent corn compared to those fed Enogen Feed corn. Pigs fed pelleted diets had increased (P < 0.001) ADG, G:F, and hot carcass weight compared to pigs fed meal diets. In summary, feeding pelleted diets to finishing pigs increased ADG and G:F compared to those fed meal-based diets. There were no major differences observed between corn sources or interactions between corn source and diet form on growth performance.


2018 ◽  
Vol 3 (1) ◽  
pp. 369-376 ◽  
Author(s):  
Corey B Carpenter ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
Mike D Tokach ◽  
Robert D Goodband ◽  
...  

Abstract A total of 2,117 pigs were used in two 35-d growth experiments to determine the effects of increasing added Cu from tri-basic copper chloride (TBCC) or a Cu-methionine chelate (Cu-chelate) on nursery pig growth performance. In experiment 1, 1,452 pigs (350 barrows [DNA 200 × 400; initially 5.9 ± 0.17 kg] in group 1 and 1,102 pigs [PIC 1050 × 280; initially 6.0 ± 0.26 kg] in group 2) were weaned at approximately 21 d of age. In experiment 2, 665 pigs (350 barrows, DNA 200 × 400; initially 6.4 ± 0.19 kg, in group 3 and 315 pigs, DNA 241 × 600; initially 5.2 ± 0.49 kg, in group 4) were weaned at approximately 21 d of age. Pigs in groups 1, 2, and 3 were fed a common starter diet for 7 d and pigs in group 4 were fed a common diet for 5 d after weaning before starting experiments. On d 0 of each experiment, pens of pigs were blocked by body weight (BW) and assigned to 1 of 7 dietary treatments. Treatments were arranged as a 2 × 3 factorial plus one control diet, with main effects of Cu source (TBCC vs. Cu-chelate) and level. Copper levels were 50, 100, or 150 mg/kg in experiment 1 and 75, 150, or 225 mg/kg in experiment 2. Diets were corn-soybean meal-based and fed in meal form in two phases (d 0 to 14 and 14 to 35). In experiment 1 from d 0 to 35, there was a Cu source × level interaction (linear, P < 0.05) for average daily gain (ADG) and d 35 BW where the magnitude of improvement with increasing Cu was greater in pigs fed Cu-chelate compared to those fed TBCC. Increasing added Cu increased (linear, P < 0.01) average daily feed intake (ADFI) and gain:feed (G:F). Although Cu source did not influence G:F, pigs fed Cu from Cu-chelate had greater (P ≤ 0.01) ADG and ADFI than those fed Cu from TBCC. In experiment 2, from d 0 to 35, there were no evidence for Cu source × level interactions. Increasing Cu increased (linear, P < 0.05) ADG and final BW. The increase in ADG combined with unaffected ADFI resulted in marginally increased G:F (linear, P = 0.052). In summary, these results suggest that increasing dietary Cu from TBCC or a Cu-chelate improved overall ADG, and d 35 BW in nursery pigs and Cu source has potential to influence nursery pig performance.


Author(s):  
Kelsey L Batson ◽  
Hilda I Calderón ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Robert D Goodband ◽  
...  

Abstract Two experiments determined the effects of crude protein (CP) in diets containing coarse wheat bran (CWB) with or without pharmacological levels of Zn on weanling pig growth performance. In Exp. 1, treatments included a positive control (21% CP) with 3,000 mg/kg Zn in phase 1 and 2,000 mg/kg in phase 2; negative control (21% CP) with 110 mg/kg Zn, and four diets containing 4% CWB and 110 mg/kg Zn formulated to 21, 19.5, 18, or 16.5% CP. The three diets with 21% CP and CWB contained 1.40% standardized ileal digestible (SID) Lys in phase 1 and 1.35% SID Lys in phase 2, while the 19.5, 18, and 16.5% CP diets contained 1.35, 1.25 and 1.20% Lys, respectively. Pigs fed the diet containing pharmacological Zn had increased (P < 0.05) ADG and G:F compared to the negative control and the 21% CP CWB diet. Reducing CP decreased ADG and G:F (linear, P = 0.002). In Exp. 2, diets consisted of: 1) positive control with 2,000 mg/kg of Zn and 21% CP (1.35% SID Lys); 2) 110 mg/kg Zn and 21% CP; and 3 diets with 110 mg/kg Zn and 18% CP with 3) 1.2% SID Lys; 4) 1.35% SID Lys by the addition of crystalline AA, and 5) diet 4 with added non-essential AA. Pigs fed 21% CP with Zn had increased (P = 0.001) ADG compared to those fed 18% CP (1.35% SID Lys) or 1.2% SID Lys. In summary, added Zn improved growth performance, but reducing CP did not.


2018 ◽  
Vol 2 (1) ◽  
pp. 62-73 ◽  
Author(s):  
J A Feldpausch ◽  
R G Amachawadi ◽  
M D Tokach ◽  
H M Scott ◽  
S S Dritz ◽  
...  

Abstract Two 47-d experiments were conducted with 21-d-old weaned pigs (PIC 1050, initially 6.1 kg) to determine the effects of feeding low or high doses of chlortetracycline (CTC) and antibiotic alternatives (Cu, Zn, and essential oil [EO]), alone or in combination, on growth performance. On d 5 postweaning, pens of 5 pigs were allotted to diet treatments with 8 (exp. 1) or 7 (exp. 2) replicate pens per treatment. In exp. 1, treatments were fed from d 5 to 26 postweaning and arranged in a 2 × 3 factorial with main effects of added ZnO (0 vs. 2,500 ppm of Zn) and CTC (0, 55, or 441 ppm). In exp. 2, treatments were fed from d 5 to 33 and structured in a (2 × 2 × 2) + 2 factorial with main effects of added CuSO4 (0 vs. 125 ppm Cu), added ZnO (0 vs. 3,000 ppm Zn from d 5 to 12 and 2,000 ppm Zn from d 12 to 33), and Regano EX (0 vs. 0.1% Regano EX containing 5% Origanum oil). The 2 additional treatments were subtherapeutic (55 ppm) and therapeutic (441 ppm) levels of CTC. Following the treatment period, a common diet without antimicrobial was fed until d 47. All diets contained 16.5 ppm Cu and 110 ppm Zn from the trace mineral premix. In exp. 1, no ZnO × CTC interactions were observed. Feeding ZnO increased (P < 0.05) ADG, ADFI, and BW during the treatment period and increased (P < 0.05) ADG and ADFI overall (d 5 to 47). Pigs fed CTC had increased (linear, P < 0.05) ADG, ADFI, and BW during the treatment period and had marginally significant increases (linear, P < 0.10) in overall ADG and ADFI, but overall G:F tended (quadratic, P = 0.070) to increase then decrease as CTC increased. During the treatment period in exp. 2, EO did not affect ADG or ADFI, whereas pharmacological levels of Cu, Zn, and CTC increased (P < 0.05) ADG with coinciding increases (P = 0.055, 0.006, and linear 0.079, respectively) in ADFI. Copper, Zn, and CTC did not affect G:F. EO decreased (P = 0.009) G:F. Diet treatments had minimal carryover effects on subsequent nursery pig growth performance. Overall from d 5 to 47, Cu increased (P = 0.018) ADG, Zn increased (P < 0.05) ADG and ADFI, and EO tended to decrease (P = 0.086) G:F. In conclusion, increased dietary Cu, Zn, or CTC improved weanling pig performance while EO elicited no growth benefits. The benefits of added Zn from ZnO and CTC were additive and could be included together in diets to maximize growth performance of weaned pigs.


2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 252-253
Author(s):  
Olivia Harrison ◽  
Ashton Yoder ◽  
Cassandra K Jones

Abstract A total of 350 nursery pigs (initially 7.6 kg BW) were used in a 28-d trial to evaluate the effects of conditioning temperature and pellet diameter on nursery pig performance. Pigs were randomly assigned to 1 of 7 treatments with 10 pens/treatment and 5 pigs/pen. The 7 treatments were arranged in a 2×3 factorial design plus a mash control, with the factors of pellet diameter (4.0 mm vs. 4.8 mm), and conditioning temperature (low, medium, vs. high). Phase 1 conditioning temperatures were 54°C, 66°C, and 77°C, while phase 2 conditioning temperatures were 54°C, 71°C, and 88°C for low, medium, and high, respectively. Pigs were fed phase 1 from d 0 to 14, which contained 10% spray dried whey, while phase 2 was fed from d 14 to 28, which did not contain milk products. Pig weights and feed disappearance were recorded weekly to determine ADG, ADFI, and G:F. Data were analyzed using the GLIMMIX procedure of SAS with pen as the experimental unit. Pellet diameter did not impact (P > 0.05) nursery pig growth performance. Pigs fed pelleted diets had greater (P < 0.05) G:F than those fed mash diets. During phase 1 and overall, there were no significant (P > 0.05) interactive or main effects. However, conditioning phase 2 diets at lower temperatures improved (P < 0.05) ADG and G:F than medium and high conditioning temperatures. In conclusion, pelleting improves nursery pig feed efficiency. To maximize nursery pig feed efficiency, phase 2 diets should be conditioned at relatively low temperatures.


2018 ◽  
Vol 3 (1) ◽  
pp. 378-383 ◽  
Author(s):  
Aaron M Jones ◽  
Fangzhou Wu ◽  
Jason C Woodworth ◽  
Steve S Dritz ◽  
Mike D Tokach ◽  
...  

Abstract Increasing dietary electrolyte balance (dEB) has been reported to linearly improve pig growth performance up to approximately 200 to 250 mEq/kg. However, recent data indicate that increasing dietary dEB reduced growth performance of nursery pigs. To attempt to solve this discrepancy, a total of 2,880 weanling pigs (327 × 1,050; PIC, Hendersonville, TN; 5.2 kg initial BW) were used to determine the effects of increasing dEB on nursery pig performance. Pens of pigs were blocked by BW and gender on arrival. Within block, pens were randomly assigned to one of four dietary treatments. There were 30 pigs per pen (60 pigs per double-sided feeder) and 12 replications (feeder) per treatment. Dietary treatments were fed in two phases. The phase 1 diet was based on corn–soybean meal, contained dried distillers grains with soblubles (DDGS), spray-dried whey, and specialty protein sources, and was fed from days 0 to 8. The phase 2 (days 8 to 21) diets contained corn, soybean meal, and DDGS with reduced amounts of specialty protein sources. Dietary electrolyte balance was determined using the following equation: dEB = [(Na × 434.98) + (K × 255.74) − (Cl × 282.06)] mEq/kg. The dEB of the four phase 1 diets were 84, 137, 190, and 243 mEq/kg, and dEB of the four phase 2 diets were 29, 86, 143, and 199 mEq/kg. After feeding experimental diets for 21 day, a common, commercial corn–soybean meal diet was fed to all pigs from days 21 to 35 and contained a dEB of 257 mEq/kg. During days 0 to 8, increasing dEB increased (quadratic, P < 0.05) ADG, ADFI, and G:F. From days 8 to 21, increasing dEB improved ADG (quadratic, P = 0.022) and ADFI (linear, P = 0.001), resulting in an improvement (quadratic, P = 0.001) in G:F. Overall (days 0 to 21), increasing dEB increased (linear, P < 0.05) ADG, ADFI, and improved (quadratic, P < 0.001) G:F. When a common diet was fed to all pigs from days 21 to 35, there was a linear reduction in ADG and G:F with increasing dietary dEB, but no effect of ADFI. For the overall nursery period (days 0 to 35), increasing dEB from days 0 to 21 increased (linear, P < 0.001) ADG and final BW, which was the result of increased (quadratic, P < 0.05) G:F and marginally greater (linear, P = 0.077) ADFI. In conclusion, increasing dietary dEB up to 243 and 199 mEq/kg (in phases 1 and 2, respectively) in nursery diets improved growth performance of weanling pigs.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 96-97
Author(s):  
Kelsey Hammers ◽  
Hilda I Calderon ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Robert D Goodband ◽  
...  

Abstract An experiment was conducted to determine the effect of reduced crude protein (CP) in diets containing coarse wheat bran (CWB) without pharmacological levels of Zn (ZnO) on growth performance and fecal dry matter (DM) of nursery pigs. A total of 650 pigs (DNA 241′600; initially 6.6 kg), were used with 5 pigs/pen and 26 replicate pens/treatment. Pens were assigned to 1 of 5 treatments in a RCB design based on BW. Treatments were fed for 13-d, contained 4% CWB, and consisted of: 1) diet with pharmacological ZnO (2,000 mg/kg Zn) and 21% CP formulated to 1.35% standardized ileal digestible (SID) Lys; 2) a diet with 110 ppm added Zn and 21% CP (1.35% SID Lys); 3) a diet with 110 ppm added Zn formulated to 18% CP (1.20% SID Lys); 4) an 18% CP diet with 110 ppm added Zn formulated to 1.35% SID Lys by the addition of increased levels of feed grade amino acids; and 5) diet 4 with addition of non-essential amino acids (NEAA; glycine and glutamic acid). Data were analyzed using the lmer function in R. Overall, pigs fed 21% CP with ZnO had increased (P < 0.05) ADG compared to those fed 18% CP (1.35% SID Lys) with high levels of feed grade amino acids or those fed the reduced SID Lys (1.2%) diet. Gain-to-feed ratio was increased (P < 0.05) for pigs fed 21% CP diets and those fed the 18% CP diet with NEAA compared to pigs fed 1.2% SID Lys and pigs fed high levels of feed grade amino acids. Fecal DM was increased (P < 0.05) for pigs fed reduced SID Lys diet. In conclusion, reducing CP (subsequently SID Lys) in diets without ZnO decreased growth performance but increased fecal DM.


2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 92-93
Author(s):  
Jenna A Chance ◽  
Mike D Tokach ◽  
Hilda I Calderon ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
...  

Abstract A total of 1,296 pigs (PIC L337×1050; initially 4.8 kg) were used in a 42-d study to evaluate cellulose in diets with and without pharmacological levels of Zn on nursery pig performance. Our hypothesis was that added fiber (cellulose) may provide more benefit in diets without ZnO. Pens were assigned to 1 of 4 dietary treatments in a RCBD by BW with 27 pigs/pen and 12 pens/treatment. Dietary treatments were arranged in a 2×2 factorial with main effects of cellulose (0 vs 1%; J. Rettenmaier USA, Schoolcraft, MI) and Zn (200 vs. 3,000 mg/kg in phase 1 and 110 vs. 2,000 mg/kg in phase 2). Treatment diets were formulated in two phases fed from d 0 to 7 and 7 to 21 with a common diet fed from d 21 to 42 post-weaning. Pig weights and feed disappearance were collected weekly to determine ADG, ADFI, and G:F. On d 16 or 17, fecal samples were collected from 3 pigs/pen to determine fecal DM, and all pens were visually evaluated for fecal consistency. There were no Zn×cellulose interactions. For the experimental and overall period, pigs fed diets containing added Zn had increased (P < 0.001) ADG, ADFI, G:F and BW while those that were fed cellulose had decreased (P < 0.05) ADG. For fecal dry matter, there was no evidence for difference (P >0.10) between any of the treatments but those fed added ZnO had visually firmer feces as evidenced by lower (P < 0.001) fecal scores. When fed a common diet from d 21 to 42, pigs previously fed added ZnO had increased (P < 0.001) ADG (502 vs. 523 g/d) and ADFI (697 vs. 734 g/d). In conclusion, there were no interactive effects between added cellulose and Zn; however, cellulose reduced ADG while the inclusion of pharmacological levels of Zn improved all growth criteria.


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