scholarly journals A246 THE GLOBAL INCIDENCE OF ACUTE PANCREATITIS IS INCREASING OVER TIME: A SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 304-306
Author(s):  
J Iannuzzi ◽  
J H Leong ◽  
J Quan ◽  
J A King ◽  
J W Windsor ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Data Extraction ◽  
Meta Analysis ◽  
Temporal Trends ◽  
Western World ◽  
Common Disease ◽  
Biliary Disease ◽  
Comprehensive Overview ◽  
Annual Percent Change ◽  
Over Time

Abstract Background Acute pancreatitis is a common disease with significant associated morbidity and mortality. Historically, acute pancreatitis has been considered a disease with multiple etiologies and risk factors but is driven by alcohol and biliary disease. Multiple studies have shown that the incidence of acute pancreatitis is increasing globally among both adults and children. Aims The purpose of this study was to assess temporal trends in incidence of acute pancreatitis globally. Methods We performed a systematic literature search to identify population-based studies reporting the annual incidence of acute pancreatitis. Abstracts were independently assessed in duplicate to identify applicable papers for full-text review and data extraction. Joinpoint temporal trend analyses were performed to calculate the average annual percent change (AAPC) with 95% confidence intervals (CI). The AAPCs were pooled in a meta-analysis to capture the overall and regional trends in acute pancreatitis incidence over time. Temporal data were summarized in a static map and an interactive, web-based map to illustrate global differences. Results Forty-five studies reported the temporal incidence of acute pancreatitis (static map provided, online interactive map: https://kaplan-acute-pancreatitis-ucalgary.hub.arcgis.com/). The incidence of acute pancreatitis has increased from 1961 to 2016 (AAPC = 2.89%; 95% CI: 2.26, 3.52; n=41). Increasing incidence was observed in North America (AAPC = 2.71%; 95% CI: 1.93, 3.50; n=10) and Europe (AAPC = 2.79%; 95% CI: 1.95, 3.63; n=24). The incidence of acute pancreatitis was stable in Asia (AAPC = −0.28%; 95% CI: −5.03, 4.47; n=2). Conclusions This meta-analysis provides a comprehensive overview of the global incidence of acute pancreatitis over the last five decades and demonstrates a steadily rising incidence over time in most countries of the Western world. More studies are needed to better define the changing incidence of acute pancreatitis in Asia, Africa and Latin America. Funding Agencies None

scholarly journals The prevalence, temporal trends, and geographical distribution of HIV-1 subtypes among men who have sex with men in China: A systematic review and meta-analysis

2019 ◽  
Vol 147 ◽  
Author(s):  
Yueqi Yin ◽  
Yuxiang Liu ◽  
Jing Zhu ◽  
Xiang Hong ◽  
Rui Yuan ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Temporal Trends ◽  
Molecular Monitoring ◽  
Comprehensive Overview ◽  
Time Period ◽  
Control And Prevention ◽  
Sex With Men ◽  
English Articles ◽  
Hiv 1 ◽  
Over Time

AbstractThe aim of this meta-analysis was to provide a comprehensive overview of human immunodeficiency virus (HIV)-1 subtypes and to investigate temporal and geographical trends of the HIV-1 epidemic among men who have sex with men (MSM) in China. Chinese and English articles published between January 2007 and December 2017 were systematically searched. Pooled HIV-1 prevalence was calculated, and its stability was analysed using sensitivity analysis. Subgroups were based on study time period, sampling area and prevalence. Publication bias was measured using Funnel plot and Egger's test. A total of 68 independent studies that included HIV-1 molecular investigations were eligible for meta-analysis. Circulating recombinant form (CRF) 01_AE (57.36%, 95% confidence interval (CI) 53.76–60.92) was confirmed as the most prevalent HIV-1 subtype among MSM in China. Subgroup analysis for time period found that CRF01_AE steadily increased prior to 2012 but decreased during 2012–2016. Further whereas CRF07_BC increased over time, B/B′ decreased over time. CRF55_01B has increased in recent years, with higher pooled estimated rate in Guangdong (12.22%, 95% CI 10.34–13.17) and Fujian (8.65%, 95% CI 4.98–13.17) provinces. The distribution of HIV-1 subtypes among MSM in China has changed across different regions and periods. HIV-1 strains in MSM are becoming more complex. Long-term molecular monitoring in this population remains necessary for HIV-1 epidemic control and prevention.

scholarly journals New Syphilis Cases in Older Adults, 2004–2019: An Analysis of Surveillance Data From South China

2021 ◽  
Vol 8 ◽  
Author(s):  
Cheng Wang ◽  
Peizhen Zhao ◽  
Mingzhou Xiong ◽  
Joseph D. Tucker ◽  
Jason J. Ong ◽  
...  
Keyword(s):  
Older Adults ◽  
Health Care ◽  
Health Care Providers ◽  
Temporal Trends ◽  
Health Concern ◽  
Targeted Prevention ◽  
Care Providers ◽  
Annual Percent Change ◽  
Syphilis Infection ◽  
Over Time

Background: Sexual health among older adults is a major public health concern globally. The syphilis burden is increasing in older adults in China. This study aimed to describe factors associated with syphilis infection and diagnosis among older adults in China during a 16 year period.Methods: Using 16 years of data (2004–2019) from the syphilis case report system of Guangdong, China, we compared data from older adults (aged ≥50 years) with those from younger people (aged 15–49 years). We compared the two age group with the Chi-square test for difference, and Joinpoint regression models to assess the temporal trends.Results: During the study period, 242,115 new syphilis diagnoses were reported in older adults. The mean notification rate of new diagnoses was 64.1 per 100,000 population across the entire 16-year period, which significantly increased over time (average annual percent change [AAPC] 16.2%, 95% CI 13.7–18.7). Syphilis diagnoses increased significantly over time among less developed cities and older women. In 2019, compared with younger adults, newly diagnosed older adults were more likely to be male, native to reporting city, had unknown transmission routes, and were diagnosed late.Conclusion: Our findings call for an urgent need to deliver more targeted prevention interventions for older adults, such as strengthen awareness among health care providers, and integration of syphilis services and primary health care for older adults.

scholarly journals Psychological factors for the onset of depression: a meta-analysis of prospective studies

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e050129
Author(s):  
Zhongfang Fu ◽  
Marlies Brouwer ◽  
Mitzy Kennis ◽  
Alishia Williams ◽  
Pim Cuijpers ◽  
...  
Keyword(s):  
Psychological Factors ◽  
Data Extraction ◽  
Meta Analysis ◽  
Evaluation Criteria ◽  
Dysfunctional Attitudes ◽  
Secondary Outcome ◽  
Comprehensive Overview ◽  
Psychological Theories ◽  
First Onset ◽  
Prospective Longitudinal

ObjectivesA comprehensive overview of the evidence for factors derived from leading psychological theories of the onset of major depressive disorder (MDD) that underpin psychological interventions is scarce . We aimed to systematically investigate the prospective evidence for factors derived from the behavioural, cognitive, diathesis–stress, psychodynamic and personality-based theories for the first onset of MDD.DesignSystematic review and meta-analysis.MethodsDatabases PubMed, PsycINFO, Cochrane and Embase and published articles were systematically searched from inception up to August 2019. Prospective, longitudinal studies that investigated theory-derived factors before the first onset of MDD, established by a clinical interview, were included. Screening, selection and data extraction of articles were conducted by two screeners. The Grading of Recommendations Assessment, Development and Evaluation criteria were used to estimate level of confidence and risk of bias. Meta-analysis was conducted using random-effects models and mixed-method subgroup analyses.Primary and secondary outcome measuresEffect size of a factor predicting the onset of MDD (OR, risk ratio or HR).ResultsFrom 42 133 original records published to August 2019, 26 studies met the inclusion criteria. Data were only available for the cognitive (n=6585) and personality-based (n=14 394) theories. Factors derived from cognitive theories and personality-based theories were related to increased odds of MDD onset (pooled OR=2.12, 95% CI: 1.12 to 4.00; pooled OR=2.43, 95% CI: 1.41 to 4.19). Publication bias and considerable heterogeneity were observed.ConclusionThere is some evidence that factors derived from cognitive and personality-based theories indeed predict the onset of MDD (ie, dysfunctional attitudes and negative emotionality). There were no studies that prospectively studied factors derived from psychodynamic theories and not enough studies to examine the robust evidence for behavioural and diathesis–stress theories. Overall, the prospective evidence for psychological factors of MDD is limited, and more research on the leading psychological theories is needed.PROSPERO registration numberCRD42017073975.

Sa280 THE GLOBAL INCIDENCE OF ACUTE PANCREATITIS IS INCREASING OVER TIME: A SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 160 (6) ◽  
pp. S-466-S-467
Author(s):  
Jordan P. Iannuzzi ◽  
Jessica Leong ◽  
Joshua Quan ◽  
James A. King ◽  
Joseph W. Windsor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Pancreatitis ◽  
Meta Analysis ◽  
Over Time

scholarly journals Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Emese Réka Bálint ◽  
Gabriella Fűr ◽  
Lóránd Kiss ◽  
Dávid István Németh ◽  
Alexandra Soós ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Recurrence Rate ◽  
Pancreatic Necrosis ◽  
Meta Analysis ◽  
Fluid Collection ◽  
Length Of Hospital Stay ◽  
Biliary Disease ◽  
Severe Condition ◽  
Potential Association ◽  
Organ Failures

Abstract The main causes of acute pancreatitis (AP) are biliary disease, alcohol consumption, hypertriglyceridaemia (HTG) and endoscopic retrograde cholangiopancreatography (ERCP). The aim of this meta-analysis was to evaluate the effects of these aetiological factors on the severity and outcome of AP. Pubmed and Embase were searched between 01/01/2012 and 31/05/2020. Included articles involved adult alcoholic, biliary, HTG- or post-ERCP AP (PAP) patients. Primary outcome was severity, secondary outcomes were organ failures, intensive care unit admission, recurrence rate, pancreatic necrosis, mortality, length of hospital stay, pseudocyst, fluid collection and systematic inflammatory response syndrome. Data were analysed from 127 eligible studies. The risk for non-mild (moderately severe and severe) condition was the highest in HTG-induced AP (HTG-AP) followed by alcoholic AP (AAP), biliary AP (BAP) and PAP. Recurrence rate was significantly lower among BAP vs. HTG-AP or AAP patients (OR = 2.69 and 2.98, 95% CI 1.55–4.65 and 2.22–4.01, respectively). Mortality rate was significantly greater in HTG-AP vs. AAP or BAP (OR = 1.72 and 1.50, 95% CI 1.04–2.84 and 0.96–2.35, respectively), pancreatic necrosis occurred more frequently in AAP than BAP patients (OR = 1.58, 95% CI 1.08–2.30). Overall, there is a potential association between aetiology and the development and course of AP. HTG-AP is associated with the highest number of complications. Furthermore, AAP is likely to be more severe than BAP or PAP. Greater emphasis should be placed on determining aetiology on admission.

scholarly journals Temporal Trends in Effect Sizes: Causes, Detection, and Implications

2013 ◽  
Author(s):  
Julia Koricheva ◽  
Michael D. Jennions ◽  
Joseph Lau
Keyword(s):  
Evolutionary Biology ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Temporal Trends ◽  
Temporal Changes ◽  
Effect Sizes ◽  
The Social ◽  
The Stability ◽  
Meta Analyses ◽  
Over Time

The general aim of meta-analysis is to combine scientific evidence scattered through a number of individual studies addressing the same topic. Evidence, however, is not static and tends to evolve over time due to changes in research methods, changes in the characteristics of the subjects being studied, for example. A number of recent studies in ecology and evolution have shown that temporal trends in effect sizes are common and often quite dramatic in these fields. Temporal changes in effect sizes could jeopardize the stability of conclusions (i.e., the conclusions of meta-analyses on the same topic conducted in different years might differ). For these reasons, this chapter is devoted to temporal changes in effect sizes. It first summarizes the findings of studies that examined temporal changes in the magnitude and direction of effect sizes in ecology, evolutionary biology, medicine, and the social sciences. It then discusses their possible causes, methods of detection, and implications for the interpretation of the results of the meta-analysis.

The Impact of Theory in HPV Vaccination Promotion Research: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 089011712110125
Author(s):  
Xizhu Xiao ◽  
Danielle Ka Lai Lee ◽  
Rachel Min Wong ◽  
Porismita Borah
Keyword(s):  
Systematic Review ◽  
Data Extraction ◽  
Meta Analysis ◽  
Hpv Vaccination ◽  
Future Research ◽  
Comprehensive Overview ◽  
Promotional Strategies ◽  
K 12 ◽  
Theory Use ◽  
The Impact

Objective: Numerous studies examined HPV vaccination promotional strategies. However, an overview of theory use, a synthesis of strategies’ effectiveness and an examination of the moderating influence of theory are absent. Data Source: We retrieved studies from Academic Search Complete, Business Source Complete, PubMed, PsycINFO, Web of Science, CMMC, CINAHL, and MEDLINE. Study Inclusion and Exclusion Criteria: 1) peer-reviewed articles written in English, 2) experimental or quasi-experimental, 3) measure HPV vaccination-related outcomes, 4) had to contain a control condition and report statistics necessary for conversion (for meta-analysis only). Data Extraction: 70 and 30 studies were included for the systematic review and meta-analysis respectively. Data Synthesis: Four major categories were coded: study information, theory use, type of theory, and outcomes. Two independent coders coded the sample (Cohen’s Kappa ranged from .8 to 1). Results: Most of the studies were based in the U.S. (77%, k = 54) with convenient samples (80%, k = 56), targeted toward females (46%, k = 32), and around a quarter did not employ any theories (47%, k = 33). Among theory-driven studies, the most commonly used were Framing (22%, k = 19), Health Belief Model (HBM; 13%, k = 12), and Narrative (7%, k = 6). Among controlled studies, promotional strategies were significantly more effective compared to the control (r+ = .25, p < .001). Strategies guided by the information, motivation, behavioral skills model (IMB) were more effective (r+ = .75, p < .001) than studies guided by framing theory (r+ = −.23, p < .001), HBM (r+ = .01, p < .001), and other theories (r+ = .11, p < .001). Conclusion: This review contributes to HPV vaccination promotion literature by offering a comprehensive overview of promotional strategies and practical suggestions for future research and practices.

scholarly journals The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials

2022 ◽  
Vol 22 (3) ◽  
pp. 196-202
Author(s):  
Dwita Nitoya Esterini ◽  
Kirsten Putriani Hartman ◽  
Joue Abraham Trixie ◽  
Yessi Setianegari ◽  
Kurniyanto Kurniyanto
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Data Extraction ◽  
Meta Analysis ◽  
Infected Pancreatic Necrosis ◽  
Definitive Treatment ◽  
Medical Database ◽  
Infected Necrosis ◽  
Risk Of Mortality ◽  
Significant Difference

Background: Acute pancreatitis (AP) is an inflammation of the pancreas, a serious emergency with no definitive treatment. It may progress to infected necrosis, non-pancreatitis infection, also death that may occur within the first 1 to 2 weeks. The use of prophylactic antibiotics in AP to prevent complications remains a controversy. The objective of this meta-analysis is to assess the benefit of prophylaxis antibiotics administration to prevent the complication.Method: Trials were identified by searching the medical database. Literature range is within the year 1975 to 2021.  Review Manager 5.4.1 was used to analyse data extraction and risk of bias of included studies were elaborated. Risk ratio (RR) was calculated with 95% confidence interval (CI). P 0.05 was considered significant.Results: Twenty trials with a total of 1.287 patients of AP were analysed; 646 patients treated with antibiotic prophylaxis and 641 patients treated with placebo. Prophylaxis antibiotics were found to have significant difference between the two groups. The administration of prophylaxis antibiotics lower the risk of non-pancreatic infections (RR = 0.77; 95% CI: 0.62–0.95; p 0.05) and infected pancreatic necrosis (RR = 0.74; 95% CI: 0.58-0.94; p 0.05). Meanwhile, prophylaxis antibiotics were found to be insignificant to lower the risk of mortality (RR = 0.75; 95% CI: 0.54-1.03; p 0.05). Conclusion: Prophylaxis antibiotics lower the risk of non-pancreatic infections and infected pancreatic necrosis, but did not lower the risk of mortality.

scholarly journals Global Incidence of Acute Pancreatitis is Increasing Over Time: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Jordan P. Iannuzzi ◽  
James A. King ◽  
Jessica Hope Leong ◽  
Joshua Quan ◽  
Joseph W. Windsor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Pancreatitis ◽  
Meta Analysis ◽  
Over Time
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