Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum

Background: Using hematologic profiles including leukocyte count have been considered as prognostic factor for some cancers. We have been assessed the predictive value of leukocytosis before surgery in colorectal cancers.Methods: This cross-sectional study has been conducted on patients with colorectal cancer who underwent surgery from 2017 to 2019 in Sina hospital, Tehran. The patients were divided in two groups based on high and low leukocyte count before surgery. Results: A total of 84 patients were studied with colorectal cancers including 46 males (55.4%) and 37 females (44.6%) with the average age of 55.2 (± 13.63) years. 36.1% of patients had leukocytosis in laboratory data before surgery. There was a significant association between tumor’s grade and the incidence of leukocytosis before surgery (P <0.001). The existence of leukocytosis is highly associated with poorly differentiated tumor. Also, the relationship between the location of the tumor and leukocytosis was seen which the location was distal, the possibility of leukocytosis decreased significantly (P <0.005). Conclusion: Our findings suggest that the location of the tumor and its degree of tumor differentiation are related with leukocytosis. This current study by considering leukocytosis before surgery aimed to use this variable as a prognostic factor in patients with colorectal cancer alongside with other variables.

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ENDOSCOPIC ULTRASOUND IN THE DIAGNOSIS OF GASTROINTESTINAL SUBMUCOSAL TUMORS AT HUE UNIVERSIY OF MEDICINE AND PHARMACY HOSPITAL

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2019.2.3 ◽

2019 ◽

pp. 17-20

Author(s):

Van Huy Tran ◽

Thanh Long Nguyen

Keyword(s):

Endoscopic Ultrasound ◽

Submucosal Tumor ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Men And Women ◽

Submucosal Tumors ◽

Endoscopy Ultrasound ◽

Colon And Rectum ◽

The Mean

Background: Diagnosis of gastrointestinal submucosal tumors (SMT) is still a challenge in clinical practice and data about gastrointestinal submucosal tumors in our country was very limited. This study aimed to assess some characteristics of gastrointestinal submucosal tumors. Patients and Methods: cross–sectional study; 195 patients having gastrointestinal submucosal tumors diagnosed by endoscopic ultrasound at Hue University of Medicine and Pharmacy Hospital were enrolled from October 2013 to December 2018. Cutting biopsy or EUS- FNA in case necessary. Results: The mean age of patients was 48.92 ± 15.23. The prevalence was nearly equal in men and women with 48.2% and 51.8%, respectively. According to location, submucosal tumors were 45.6% in the stomach, 35.9% in the esophagus and 2.6% in the colon and rectum. According to etiology, the submucosal cyst was found in 23.6%, the leiomyoma was 22.1%, the Brunner’s gland was 1% and the unknown submucosal tumors was 19.5%. 58.1% of the leiomyoma and 67.4% of the submucosal cyst were found in the esophagus. 76% of the GIST, 83.3% of the ectopic pancreas and 64.7% of the lipoma were found in stomach. Conclusions: Based on endoscopy ultrasound, the most common locations of SMT were stomach and esophagus; the most common SMT were submucosal cyst and leiomyoma. Key words: Submucosal tumor (SMT), Endoscopic ultrasound (EUS)

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Promoter Hypermethylation and Underexpression of Patched Homolog 1 in Pancreatic and Colorectal Cancers: A Cross-Sectional Study

Turkish Journal of Oncology ◽

10.5505/tjo.2021.2890 ◽

2021 ◽

Author(s):

madiha niyaz

Keyword(s):

Promoter Hypermethylation ◽

Cross Sectional Study ◽

Colorectal Cancers ◽

Sectional Study ◽

Cross Sectional

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Priority stratification for colonoscopy based on two-sample faecal immunochemical test screening: results from a cross-sectional study at an endoscopy clinic in Japan

BMJ Open ◽

10.1136/bmjopen-2020-046055 ◽

2021 ◽

Vol 11 (5) ◽

pp. e046055

Author(s):

Osamu Toyoshima ◽

Yutaka Yamaji ◽

Toshihiro Nishizawa ◽

Shuntaro Yoshida ◽

Tomoharu Yamada ◽

...

Keyword(s):

Colorectal Neoplasia ◽

Cross Sectional Study ◽

Secondary Outcome ◽

Colorectal Cancers ◽

Sectional Study ◽

Cross Sectional ◽

Detection Rates ◽

Faecal Immunochemical Test ◽

Immunochemical Test ◽

Positive Results

ObjectivesLittle has been reported on the yield and characteristics of colorectal neoplasia detected by the two-sample faecal immunochemical test (FIT), particularly the difference between subjects with two-positive results on the two-sample FIT and those with one-positive results. We aimed to assess risk stratification among patients with positive two-sample FIT to prioritise colonoscopy.DesignA retrospective cross-sectional study.SettingA single-centre, representative endoscopy clinic in Japan.ParticipantsConsecutive patients who underwent colonoscopy were enrolled. Indications for colonoscopy included two-positive results on the two-sample FIT (FIT (+/+)), one-positive results on the two-sample FIT (FIT (+/−)), and other reasons (non-FIT group, including presence of symptoms, screening or surveillance).Primary and secondary outcome measuresPrimary outcomes were detection rates of colorectal cancers, including in situ (all cancers) and invasive cancers, based on the indications for colonoscopy. Secondary outcomes were cancer features, such as location, size, T stage and histological subtype.ResultsOf the 8724 patients, 264 underwent colonoscopy following FIT (+/+), 1018 following FIT (+/−) and 7442 for reasons other than positive FIT. Detection rates of all (and invasive) cancers in the FIT (+/+), FIT (+/−) and non-FIT groups were 12.1% (8.3%), 1.9% (0.3%) and 0.4% (0.2%), respectively. The cancer detection rates were much higher in the FIT (+/+) group than in the FIT (+/−) group, which in turn had higher rates than the non-FIT group. Moreover, the FIT (+/+) group showed more advanced T stages on tumour, node, metastasis (TNM) classification (Tis/T1/T2/T3/T4: 10/7/4/10/1) than the FIT (+/−) group (16/1/2/0/0, p<0.001).ConclusionsTwo-positive results for two-sample FIT showed a much higher yield for more advanced colorectal cancers than the one-positive result. High priority for diagnostic colonoscopy should be assigned to patients with two-positive-FIT results.

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Patients' understanding of words used to describe lumps: a cross-sectional study

The Journal of Laryngology & Otology ◽

10.1017/s0022215105006481 ◽

2005 ◽

pp. 1

Author(s):

Neil K Chadha ◽

Costa Repanos

Keyword(s):

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Does a Graduate Course in Fluency Disorders Make a Difference?

Perspectives on Fluency and Fluency Disorders ◽

10.1044/ffd20.1.10 ◽

2010 ◽

Vol 20 (1) ◽

pp. 10-14 ◽

Cited By ~ 2

Author(s):

Evelyn R. Klein ◽

Barbara J. Amster

Keyword(s):

Undergraduate Students ◽

Graduate Programs ◽

The United States ◽

Cross Sectional Study ◽

Sectional Study ◽

Graduate Course ◽

Cross Sectional ◽

Fluency Disorders ◽

Introductory Course ◽

Communicative Disorders

Abstract A study by Yaruss and Quesal (2002), based on responses from 134 of 239 ASHA accredited graduate programs, indicated that approximately 25% of graduate programs in the United States allow students to earn their degree without having coursework in fluency disorders and 66% of programs allow students to graduate without clinical experience treating people who stutter (PWS). It is not surprising that many clinicians report discomfort in treating PWS. This cross-sectional study compares differences in beliefs about the cause of stuttering between freshman undergraduate students enrolled in an introductory course in communicative disorders and graduate students enrolled and in the final weeks of a graduate course in fluency disorders.

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