scholarly journals Non-linear association between long-term outcome and preoperative neutrophil-to-lymphocyte ratio in patients undergoing curative resection for gastric cancer: a retrospective analysis of 1335 cases in a tetrachotomous manner

2018 ◽  
Vol 48 (4) ◽  
pp. 343-349 ◽  
Author(s):  
Masayuki Urabe ◽  
Hiroharu Yamashita ◽  
Yukari Uemura ◽  
Asami Tanabe ◽  
Koichi Yagi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Retrospective Analysis ◽  
Curative Resection ◽  
Neutrophil To Lymphocyte Ratio ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Lymphocyte Ratio ◽  
Linear Association ◽  
Non Linear

Neutrophil to Lymphocyte Ratio as a Predictor of Long-Term Outcome in Peritoneal Dialysis Patients: A 5-Year Cohort Study

2021 ◽  
pp. 1-7
Author(s):  
Lin Zhang ◽  
Yuxin Nie ◽  
Man Guo ◽  
Li Wang ◽  
Yiqin Shi ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Cardiovascular Mortality ◽  
Cox Proportional Hazards Model ◽  
Older Age ◽  
Neutrophil To Lymphocyte Ratio ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Lymphocyte Ratio ◽  
All Cause Mortality

<b><i>Introduction:</i></b> The mortality of peritoneal dialysis (PD) patients remains high. The neutrophil to lymphocyte ratio (NLR), as an indicator of systemic inflammation, has been considered to be a predictor of cardiovascular and all-cause mortality in hemodialysis patients. The present study aims to investigate the relationship between NLR and long-term outcome in PD patients. <b><i>Materials and Methods:</i></b> The study included patients who initiated PD for at least 3 months between January 1, 2013, and December 31, 2015. All the patients were followed up until death, cessation of PD, or to the end of the study (June 31, 2018). NLR was calculated as the ratio of neutrophils to lymphocytes. <b><i>Results:</i></b> A total of 140 patients were included in this study. The median NLR reported was 2.87. Patients with lower NLR showed a higher survival rate than patients with higher NLR (log rank 6.886, <i>p</i> = 0.009). Furthermore, patients with higher NLR had a significantly higher cardiovascular mortality (log rank 5.221, <i>p</i> = 0.022). Multivariate Cox proportional hazards model showed that older age (HR 1.054, 95% CI 1.017–1.092, <i>p</i> = 0.004), higher Ca × P (HR 1.689, 95% CI 1.131–2.523, <i>p</i> = 0.010), and higher NLR (HR 2.603, 95% CI 1.037–6.535, <i>p</i> = 0.042) were independent predictors of increased all-cause mortality. NLR was also independently associated with cardiovascular mortality (HR 2.886, 95% CI 1.005–8.283, <i>p</i> = 0.039). Higher NLR (HR 2.667, 95% CI 1.333–5.337, <i>p</i> = 0.006), older age (HR 1.028, 95% CI 1.005–1.052, <i>p</i> = 0.016), and history of cardiovascular disease (HR 1.426, 95% CI 1.195–3.927, <i>p</i> = 0.031) were significantly independently associated with poor peritonitis-free survival in this study. <b><i>Conclusions:</i></b> NLR could be a strong predictor of long-term outcome in PD patients.

scholarly journals Short-term and long-term outcomes of robotic, laparoscopic and open radical gastrectomy in gastric cancer: A single-center retrospective study

2019 ◽  
Author(s):  
Weifan Zhang ◽  
Xinhui Zhao ◽  
Zhao Liu ◽  
Hui Dang ◽  
Lei Meng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Nodes ◽  
Learning Curve ◽  
Operation Time ◽  
Open Gastrectomy ◽  
Short Term ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Estimated Blood Loss

Abstract Background: Few studies on the comparison among robotic, laparoscopic, and open gastrectomy had been reported in gastric cancer . The goal of this study was to evaluate the advantages of robotic-assisted gastrectomy (RAG) by comparing with laparoscopic-assisted gastrectomy(LAG) and open gastrectomy (OG). Methods: 147 gastric cancer patients who underwent gastrectomy were enrolled and retrospectively analyzed between January 2017 and July 2019. Short-term outcomes such as operation time, intraoperative estimated blood loss(EBL),number of retrieved lymph nodes, postoperative recovery, learning curve, and long-term outcome such as overall survival(OS) was compared among RAG, LAG and OG groups. Results: RAG group included 47 patients, 44 in the LAG, and 61 in the OG. Basic information such as gender, age, BMI, ASA degree were similar among three groups, and there were no statistically significances in pathological TNM staging, tumor resection extent, resection margin, methods of reconstruction( P ＞0.05). The cumulative sum(CUSUM) method showed that learning curve of RAG reached stability after 17 cases . For short-term outcomes, the RAG group had the shortest EBL( P =0.033), the shortest time to first flatus( P ＜0.001), shortest time to first intake liquid diet ( P =0.004),shortest postoperative hospital stay ( P =0.023)and the largest number of retrieved lymph nodes( P =0.044),the longest operation time( P ＜0.001), the most expensive treatment cost( P ＜0.001),however, there were no significant differences in postoperative drainage, postoperative white blood cell(WBC)count and early complications among three group( P ＞0.05). In addition to long-term outcome, similar OS was observed in three groups. Conclusion: Compared with LAG and OG, RAG has certain advantages in short-term outcomes and is a safe and reliable surgical method. But still need further prospective, multi-center research to confirm this.

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