scholarly journals High Compared with Moderate Protein Intake Reduces Adaptive Thermogenesis and Induces a Negative Energy Balance during Long-term Weight-Loss Maintenance in Participants with Prediabetes in the Postobese State: A PREVIEW Study

2019 ◽  
Vol 150 (3) ◽  
pp. 458-463 ◽  
Author(s):  
Mathijs Drummen ◽  
Lea Tischmann ◽  
Blandine Gatta-Cherifi ◽  
Mikael Fogelholm ◽  
Anne Raben ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Weight Maintenance ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Positive Energy ◽  
Adaptive Thermogenesis ◽  
Resting Energy

ABSTRACT Background Weight loss has been associated with adaptations in energy expenditure. Identifying factors that counteract these adaptations are important for long-term weight loss and weight maintenance. Objective The aim of this study was to investigate whether increased protein/carbohydrate ratio would reduce adaptive thermogenesis (AT) and the expected positive energy balance (EB) during weight maintenance after weight loss in participants with prediabetes in the postobese state. Methods In 38 participants, the effects of 2 diets differing in protein/carbohydrate ratio on energy expenditure and respiratory quotient (RQ) were assessed during 48-h respiration chamber measurements ∼34 mo after weight loss. Participants consumed a high-protein (HP) diet (n = 20; 13 women/7 men; age: 64.0 ± 6.2 y; BMI: 28.9 ± 4.0 kg/m 2) with 25:45:30% or a moderate-protein (MP) diet (n = 18; 9 women/9 men; age: 65.1 ± 5.8 y; BMI: 29.0 ± 3.8 kg/m 2) with 15:55:30% of energy from protein:carbohydrate:fat. Predicted resting energy expenditure (REEp) was calculated based on fat-free mass and fat mass. AT was assessed by subtracting measured resting energy expenditure (REE) from REEp. The main outcomes included differences in components of energy expenditure, substrate oxidation, and AT between groups. Results EB (MP = 0.2 ± 0.9 MJ/d; HP = −0.5 ± 0.9 MJ/d) and RQ (MP = 0.84 ± 0.02; HP = 0.82 ± 0.02) were reduced and REE (MP: 7.3 ± 0.2 MJ/d compared with HP: 7.8 ± 0.2 MJ/d) was increased in the HP group compared with the MP group (P < 0.05). REE was not different from REEp in the HP group, whereas REE was lower than REEp in the MP group (P < 0.05). Furthermore, EB was positively related to AT (rs = 0.74; P < 0.001) and RQ (rs = 0.47; P < 0.01) in the whole group of participants. Conclusions In conclusion, an HP diet compared with an MP diet led to a negative EB and counteracted AT ∼34 mo after weight loss, in participants with prediabetes in the postobese state. These results indicate the relevance of compliance to an increased protein/carbohydrate ratio for long-term weight maintenance after weight loss. The trial was registered at clinicaltrials.gov as NCT01777893.

The contribution of fat-free mass to resting energy expenditure: implications for weight loss strategies in the treatment of adolescent obesity

2015 ◽  
Vol 27 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Matthew G. Browning ◽  
Ronald K. Evans
Keyword(s):  
Weight Loss ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Strong Relationship ◽  
Adolescent Obesity ◽  
Normal Weight ◽  
Fat Free Mass ◽  
Weight Loss Outcomes ◽  
Resting Energy

AbstractOwing to the strong relationship between fat-free mass (FFM) and resting energy expenditure (REE), the preservation of FFM is often emphasized in the treatment of adolescent obesity. Typical treatment regimens including an increased dietary consumption of protein and participation in resistance training are common components of adolescent weight management programs, despite limited evidence of a positive influence of FFM on weight loss outcomes in adolescents. Given the larger volume of FFM in obese relative to normal weight adolescents and the common treatment goals of both maximizing weight loss and attenuating the loss of FFM, a better understanding of the influence of FFM on energy balance is needed to determine whether strategies to preserve lean tissue or maximize absolute weight loss should be most emphasized. We review the associations among FFM, REE, and weight loss outcomes, focusing on how these relationships might influence energy balance in obese adolescents.

scholarly journals No consistent evidence of a disproportionately low resting energy expenditure in long-term successful weight-loss maintainers

2018 ◽  
Vol 108 (4) ◽  
pp. 658-666 ◽  
Author(s):  
Danielle M Ostendorf ◽  
Edward L Melanson ◽  
Ann E Caldwell ◽  
Seth A Creasy ◽  
Zhaoxing Pan ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Body Mass ◽  
Resting Energy Expenditure ◽  
Weight Loss Maintenance ◽  
Fat Free Mass ◽  
Predictive Equations ◽  
Successful Weight Loss ◽  
Resting Energy

Abstract Background Evidence in humans is equivocal in regards to whether resting energy expenditure (REE) decreases to a greater extent than predicted for the loss of body mass with weight loss, and whether this disproportionate decrease in REE persists with weight-loss maintenance. Objectives We aimed to1) determine if a lower-than-predicted REE is present in a sample of successful weight-loss maintainers (WLMs) and 2) determine if amount of weight loss or duration of weight-loss maintenance are correlated with a lower-than-predicted REE in WLMs. Design Participants (18–65 y old) were recruited in 3 groups: WLMs (maintaining ≥13.6 kg weight loss for ≥1 y, n = 34), normal-weight controls [NCs, body mass index (BMI; in kg/m2) similar to current BMI of WLMs, n = 35], and controls with overweight/obesity (OCs, BMI similar to pre–weight-loss maximum BMI of WLMs, n = 33). REE was measured (REEm) with indirect calorimetry. Predicted REE (REEp) was determined via 1) a best-fit linear regression developed with the use of REEm, age, sex, fat-free mass, and fat mass from our control groups and 2) three standard predictive equations. Results REEm in WLMs was accurately predicted by equations developed from NCs and OCs (±1%) and by 3 standard predictive equations (±3%). In WLMs, individual differences between REEm and REEp ranged from −257 to +163 kcal/d. A lower REEm compared with REEp was correlated with amount of weight lost (r = 0.36, P < 0.05) but was not correlated with duration of weight-loss maintenance (r = 0.04, P = 0.81). Conclusions We found no consistent evidence of a significantly lower REE than predicted in a sample of long-term WLMs based on predictive equations developed from NCs and OCs as well as 3 standard predictive equations. Results suggest that sustained weight loss may not always result in a substantial, disproportionately low REE. This trial was registered at clinicaltrials.gov as NCT03422380.

scholarly journals Increasing Energy Flux to Maintain Diet-Induced Weight Loss

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2533 ◽  
Author(s):  
Christopher L. Melby ◽  
Hunter L. Paris ◽  
R. Drew Sayer ◽  
Christopher Bell ◽  
James O. Hill
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Body Weight ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Energy Flux ◽  
Weight Maintenance ◽  
High Energy ◽  
Daily Energy

Long-term maintenance of weight loss requires sustained energy balance at the reduced body weight. This could be attained by coupling low total daily energy intake (TDEI) with low total daily energy expenditure (TDEE; low energy flux), or by pairing high TDEI with high TDEE (high energy flux). Within an environment characterized by high energy dense food and a lack of need for movement, it may be particularly difficult for weight-reduced individuals to maintain energy balance in a low flux state. Most of these individuals will increase body mass due to an inability to sustain the necessary level of food restriction. This increase in TDEI may lead to the re-establishment of high energy flux at or near the original body weight. We propose that following weight loss, increasing physical activity can effectively re-establish a state of high energy flux without significant weight regain. Although the effect of extremely high levels of physical activity on TDEE may be constrained by compensatory reductions in non-activity energy expenditure, moderate increases following weight loss may elevate energy flux and encourage physiological adaptations favorable to weight loss maintenance, including better appetite regulation. It may be time to recognize that few individuals are able to re-establish energy balance at a lower body weight without permanent increases in physical activity. Accordingly, there is an urgent need for more research to better understand the role of energy flux in long-term weight maintenance.

scholarly journals Resistance Training Conserves Fat-free Mass and Resting Energy Expenditure Following Weight Loss

Obesity ◽  
2008 ◽  
Vol 16 (5) ◽  
pp. 1045-1051 ◽  
Author(s):  
Gary R. Hunter ◽  
Nuala M. Byrne ◽  
Bovorn Sirikul ◽  
José R. Fernández ◽  
Paul A. Zuckerman ◽  
...  
Keyword(s):  
Weight Loss ◽  
Resistance Training ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Resting Energy

scholarly journals Longitudinal changes in energy balance during pregnancy in South African women from the Tlokwe Municipal area

2019 ◽  
Author(s):  
Van Fourie Oort ◽  
Sarah J Moss ◽  
Y Schutz
Keyword(s):  
Energy Balance ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Resting Energy Expenditure ◽  
Positive Energy ◽  
Second Trimester ◽  
Third Trimester ◽  
The Third ◽  
Activity Energy ◽  
Resting Energy

Abstract Background Energy balance in the era of obesity, contributes to challenges in healthy weight maintenance. The study aims to determine the changes in energy intake and expenditure from the first to the third trimester of pregnancy in women from the Tlokwe Municipal area.Methods We followed a longitudinal observational design to measure healthy pregnant women in the first (9–12 weeks), second (20–22 weeks) and third trimester (28–32 weeks). A valitdated, semi-quantitative food frequency questionnaire determined energy and macronutrient intakes. Energy expenditure (EE) was calculated from resting energy expenditure, as measured by indirect calorimetry (FitMate®), whereas activity energy expenditure was measured by combining heart rate and accelerometry (ActiHeart®). Energy balance was calculated as the difference between energy expenditure and energy intake. A mixed-model analysis was performed to determine significant differences between energy expenditure and intake during pregnancy.Results Energy intake increased from the first (8841 ± 3456 kJ/day) to the second trimester (9134 ± 3046 kJ/day) and declined in the third trimester of pregnancy (8171 ± 3017 kJ/day). A negative energy balance was found during the first (-1374 ± 4548 kJ/day) and third trimesters (-1331 ± 3734 kJ/day), whereas a minor positive energy balance was observed in the second trimester (380 ± 14212 kJ/day). Resting energy expenditure showed significant differences between the second and third, as well as the first and third trimesters. Changes in activity energy expenditure throughout pregnancy showed practical significance between the first and third trimesters.Conclusions Energy intake and expenditure during pregnancy did not differ. The additional energy expenditure in the third trimester could be attributed to resting energy expenditure and a decrease in activity energy expenditure.

scholarly journals Timeline of changes in adaptive physiological responses, at the level of energy expenditure, with progressive weight loss

2018 ◽  
Vol 120 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Siren Nymo ◽  
Silvia R. Coutinho ◽  
Linn-Christin H. Torgersen ◽  
Ola J. Bomo ◽  
Ingrid Haugvaldstad ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Energy Expenditure ◽  
Weight Maintenance ◽  
Resting Energy Expenditure ◽  
Very Low Energy Diet ◽  
Adaptive Thermogenesis ◽  
Progressive Weight Loss ◽  
Exercise Induced ◽  
First Time

AbstractDiet-induced weight loss (WL) is associated with reduced resting and non-resting energy expenditure (EE), driven not only by changes in body composition but also potentially by adaptive thermogenesis (AT). When exactly this happens, during progressive WL, remains unknown. The aim of this study was to determine the timeline of changes in RMR and exercise-induced EE (EIEE), stemming from changes in body compositionv. the presence of AT, during WL with a very-low-energy diet (VLED). In all, thirty-one adults (eighteen men) with obesity (BMI: 37 (sem4·5) kg/m2; age: 43 (sem10) years) underwent 8 weeks of a VLED, followed by 4 weeks of weight maintenance. Body weight and composition, RMR, net EIEE (10, 25 and 50 W) and AT (for RMR (ATRMR) and EIEE (ATEIEE)) were measured at baseline, day 3 (2 (sem1) % WL), after 5 and 10 % WL and at weeks 9 (16 (sem2) %) and 13 (16 (sem1) %). RMR and fat mass were significantly reduced for the first time at 5 % WL (12 (sem8) d) (P<0·01 andP<0·001, respectively) and EIEE at 10 % WL (32 (sem8) d), for all levels of power (P<0·05), and sustained up to week 13. ATRMRwas transiently present at 10 % WL (−460 (sem690) kJ/d,P<0·01). A fall in RMR should be anticipated at ≥5 % WL and a reduction in EIEE at ≥10 % WL. Transient ATRMRcan be expected at 10 % WL. These physiological adaptations may make progressive WL difficult and will probably contribute to relapse.

scholarly journals Impact of Protein Intake during Weight Loss on Preservation of Fat-Free Mass, Resting Energy Expenditure, and Physical Function in Overweight Postmenopausal Women: A Randomized Controlled Trial

Obesity Facts ◽  
2021 ◽  
pp. 1-12
Author(s):  
Isabell Englert ◽  
Anja Bosy-Westphal ◽  
Stephan C. Bischoff ◽  
Kathrin Kohlenberg-Müller
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Physical Function ◽  
Postmenopausal Women ◽  
Protein Intake ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
The Impact ◽  
Resting Energy

<b><i>Introduction:</i></b> Weight loss in old age increases the risk of sarcopenia caused by the age-related reduction of fat-free mass (FFM). Due to the strong correlation between FFM and resting energy expenditure (REE), the maintenance of this must also be considered. Besides, the physical function (PF) must be maintained. <b><i>Objective:</i></b> The impact of protein intake on changes in FFM, REE, and PF during weight loss in overweight postmenopausal women was investigated. <b><i>Methods:</i></b> Fifty-four postmenopausal women (BMI 30.9 ± 3.4; age 59 ± 7 years) were randomized into 2 groups receiving energy-restricted diets with either 0.8 g (normal protein; NP) or 1.5 g protein/kg body weight (high protein; HP) for 12 weeks, followed by a 6-month follow-up phase with an ad libitum food intake. FFM, REE, and PF (strength, endurance, and balance) were measured at baseline, after weight loss, and after follow-up. <b><i>Results:</i></b> Forty-six women completed the weight loss intervention and 29 were followed up. The weight loss was –4.6 ± 3.6 kg (HP) and –5.2 ± 3.4 kg (NP; both <i>p</i> &#x3c; 0.001) and the weight regain during follow-up was 1.3 ± 2.8 kg (HP; <i>p</i> = 0.03) and 0.4 ± 2.5 kg (NP; <i>p</i> = 0.39), with no differences between groups. Similar decreases in FFM (–0.9 ± 1.1 [HP] vs. –1.0 ± 1.3 kg [NP]) and REE (–862 ± 569 [HP] vs. –1,000 ± 561 kJ [NP]; both <i>p</i> &#x3c; 0.001) were observed in both groups. During follow-up, no changes in FFM were detected in either group, whereas in the NP group the REE increased again (+138 ± 296; <i>p</i> = 0.02). The main determinants of FFM loss were the energy deficit and the speed of weight loss. In the NP group, the Short Physical Performance Battery score improved with weight loss (+0.6 ± 0.8; <i>p</i> &#x3c; 0.001) and handgrip strength decreased (–1.7 ± 3.4 kg; <i>p</i> &#x3c; 0.001), whereas no changes were observed in the HP group. <b><i>Conclusions:</i></b> An HP weight-loss diet without exercise had no impact on preservation of FFM and REE but may help to maintain muscle strength in postmenopausal women.

Resting Energy Expenditure in Obese Women with Primary Hypothyroidism and Appropriate Levothyroxine Replacement Therapy

2020 ◽  
Vol 105 (4) ◽  
pp. e1741-e1748 ◽  
Author(s):  
Emanuele Muraca ◽  
Stefano Ciardullo ◽  
Alice Oltolini ◽  
Francesca Zerbini ◽  
Eleonora Bianconi ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Replacement Therapy ◽  
Resting Energy Expenditure ◽  
Primary Hypothyroidism ◽  
Normal Serum ◽  
Fat Free Mass ◽  
Model Assessment ◽  
Obese Women ◽  
Resting Energy

Abstract Context Growing evidence suggests that appropriate levothyroxine (LT4) replacement therapy may not correct the full set of metabolic defects afflicting individuals with hypothyroidism. Objective To assess whether obese subjects with primary hypothyroidism are characterized by alterations of the resting energy expenditure (REE). Design Retrospective analysis of a set of data about obese women attending the outpatients service of a single obesity center from January 2013 to July 2019. Patients A total of 649 nondiabetic women with body mass index (BMI) &gt; 30 kg/m2 and thyrotropin (TSH) level 0.4–4.0 mU/L were segregated into 2 groups: patients with primary hypothyroidism taking LT4 therapy (n = 85) and patients with normal thyroid function (n = 564). Main outcomes REE and body composition assessed using indirect calorimetry and bioimpedance. Results REE was reduced in women with hypothyroidism in LT4 therapy when compared with controls (28.59 ± 3.26 vs 29.91 ± 3.59 kcal/kg fat-free mass (FFM)/day), including when adjusted for age, BMI, body composition, and level of physical activity (P = 0.008). This metabolic difference was attenuated only when adjustment for homeostatic model assessment of insulin resistance (HOMA-IR) was performed. Conclusions This study demonstrated that obese hypothyroid women in LT4 therapy, with normal serum TSH level compared with euthyroid controls, are characterized by reduced REE, in line with the hypothesis that standard LT4 replacement therapy may not fully correct metabolic alterations related to hypothyroidism. We are not able to exclude that this feature may be influenced by the modulation of insulin sensitivity at the liver site, induced by LT4 oral administration.

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