Helicobacter pylori infection, peptic ulceration, and Meckel's diverticulum

2011 ◽  
Author(s):  
R. Mark Beattie ◽  
Anil Dhawan ◽  
John W.L. Puntis
Keyword(s):  
Developing Countries ◽  
Helicobacter Pylori ◽  
Meckel’S Diverticulum ◽  
Meckel's Diverticulum ◽  
Peptic Ulceration ◽  
Helicobacter Pylori Infection ◽  
Prevalence Rates ◽  
Gram Negative ◽  
H Pylori ◽  
Common Infection

Helicobacter pylori194Other causes of antral gastritis and peptic (gastric and duodenal) ulceration 196Meckel's diverticulum 197•H. pylori is a Gram-negative organism. It is a very common infection worldwide. Infection is usually acquired in childhood, but prevalence rates are variable, being highest in developing countries. Most individuals infected with ...

scholarly journals Helicobacter Pylori Infection: Causes, Diagnosis and Treatment

2020 ◽  
Vol 03 (12) ◽  
Author(s):  
Rahul Rao ◽  
Keyword(s):  
Developing Countries ◽  
Helicobacter Pylori ◽  
Preventive Measure ◽  
Helicobacter Pylori Infection ◽  
Diagnosis And Treatment ◽  
Adults And Children ◽  
The Common ◽  
H Pylori ◽  
Common Infections

Helicobacter Pylori infection is one of the common infections worldwide. The rates of infection are reducing in both developed and developing countries, but it is still a widespread infection. In this paper we will discuss about H. pylori causes and the disease that could arise due to infection, preventive measure, precautions, treatment, and several important information regarding the infection. We also reviewed several papers and studies conducted on patients both adults and children who are affected with H. pylori.

scholarly journals An Update of Helicobacter pylori Prevalence and Associated Risk Factors in Southern Iran: A Population-Based Study

2020 ◽  
Vol 23 (10) ◽  
pp. 665-671
Author(s):  
Fateme Ziyaee ◽  
Abdolvahab Alborzi ◽  
Gholamreza Pouladfar ◽  
Bahman Pourabbas ◽  
Sadaf Asaee ◽  
...  
Keyword(s):  
Developing Countries ◽  
Helicobacter Pylori ◽  
Parental Education ◽  
Population Based ◽  
Current Status ◽  
Preventive Strategies ◽  
Prevalence Rates ◽  
Population Based Study ◽  
Southern Iran ◽  
H Pylori

Background: The childhood period is considered to be the primary period for acquisition of the Helicobacter pylori. The high prevalence rates from developing countries are associated with gastric cancer. A decreasing trend of its prevalence has been reported from different parts of the world. Determining the prevalence rate could be important in choosing preventive strategies. This study aimed to determine the prevalence of H. pylori among a group of children from southern Iran to provide an update on the current status of the disease. Methods: This is a cross-sectional population-based study conducted in Shiraz, southern Iran, from January 2014 to December 2015. Four groups including neonates, children aged 6 months to 3 years, 10- and 15-year-old children were included. Multi-monoclonal stool antibody test was used for diagnosis. Results: Among 436 participants, 24.8% (95% CI: 20.8–29.1) had a positive test for H. pylori: 25% in neonates (95% CI: 16.2–36.1), 22% in children aged 6 months to 3 years (95% CI: 15.2–30.2), 19.5% in the 10-year-old (95% CI: 12.3–29.4), and 29.2% in 15-year-old children (95% CI: 21–39). Sex, age, number of siblings, owning a pet, parents’ smoking status, parental education, residential area, birth weight, and feeding status were not found to be statistically significant predictors of H. pylori antigen positivity (P > 0.05). Conclusion: The prevalence of H. pylori was estimated to be low in southern Iran in comparison with previous reports or other developing countries. Preventive strategies with respect to low prevalence rates may be considered in the childhood period.

scholarly journals Symptoms Investigate the Frequency of Various Presentations of the Meckel’s Diverticulum and Help Identify Sign Promptly

2020 ◽  
pp. 1-8
Author(s):  
Ashjaei Bahar ◽  
Ashjaei Bahar ◽  
Amiri Shakiba ◽  
Najdi Fatemeh ◽  
Movahedi Jadid Merisa
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Meckel’S Diverticulum ◽  
Case Series ◽  
Meckel's Diverticulum ◽  
Helicobacter Pylori Infection ◽  
Female Ratio ◽  
Gastric Type

Background: Meckel's diverticulum is the most common anomaly of the intestine. It is usually asymptomatic but could also be symptomatic with complications such as bleeding, intestinal obstruction, and inflammation. This study was performed to assess the frequency of various presentations of the patients who underwent surgery with the diagnosis of Meckel's diverticulum in Children's Medical Center, Tehran, Iran from March 2005 to March 2011. Material and Methods: Since this study is a case series report (retrospective descriptive study) and the purpose is assessing the various presentation of Meckel’s` diverticulum, we express the frequency and percent frequency of each presentation. The data collection tool was a five-part survey form. The first part was related to demographic data, the second part was related to clinical data, the third part was related to diagnostic data, the fourth part was related to treatment data and the fifth part was related to histological data. Data were analysed using SPSS statistical program. Result: We found 49 patients in this period (71% male 29% female). The mean age was 3.5 years (1 month to 9 years). The male to female ratio was 2.5. The most common clinical symptoms were abdominal pain (63%). forty-three percent of patients had single symptoms and the others had combined symptoms such as abdominal pain and hematochezia. Only 8 patients with lower gastrointestinal bleeding had a Technetium scan and all of them were positive. Associated findings during surgery included appendicitis and invagination. Our sonographic imaging findings were nonspecific. In the pathologic report, 6 patients had gangrene in specimens and 2 perforations. The lining was of gastric type in 24 specimens pancreatic in 3 and mixed in 2 specimens. None of those with the gastric type of mucosa showed Helicobacter pylori infection. Conclusion: Regarding our findings, clinical findings of Meckel's diverticulum in our study were rather the same as in the literature. Pathologic examination of specimens revealed that most diverticula were lined by gastric type of mucosa. None of those with the gastric type of mucosa showed Helicobacter pylori infection.

scholarly journals Studying Association between Thyroid Disorders and Helicobacter pylori infection in Iraqi Patients

2014 ◽  
Vol 11 (4) ◽  
pp. 1528-1541
Author(s):  
Baghdad Science Journal
Keyword(s):  
Helicobacter Pylori ◽  
Thyroid Stimulating Hormone ◽  
Helicobacter Pylori Infection ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Prevalence Rates ◽  
Igg Antibodies ◽  
Healthy Individuals ◽  
Blood Samples ◽  
H Pylori

This study was aimed to investigate the association between thyroid disorder and Helicobacter pylori infection in 122 patients (100 females and 22 males )and for comparison, 60 healthy individuals (31females and 29 males),who had no thyroid disorder, were also included in the study. Blood samples were collected from both patients and the healthier individuals. Enzyme Linked Fluorescent Assay (ELFA) technique through using Vitek Immuno Diagnostic Assay System (VIDAS) was applied to measure levels of the thyroid hormones (tri-iodothyronine T3, tetra-iodothyroxine T4) and thyroid stimulating hormone (TSH). From the results obtained, patients were classified into three groups: 40 were considered as belonging to the controlled group (26 females and 14 males), 57 to the hypothyroidism group (52 females and 5 males) and25 belonged to hyperthyroidism group (22 females and 3 males). On the other hand, highest incidence rate of thyroidism was recorded in the age group of (30-39)yrs. 19.67% , followed by (40-49)yrs. with 24.59% and(50-59)yrs. with 18.03%. When concentration and presence of anti -Helicobacter pylori IgG antibodies in the human blood samples were detected and measured by Enzyme Linked Immuno Sorrbent Assay (ELISA) technique , the results were showed high prevalence rates of H. pylori infection were detected in the hypothyroidism patients (94.07%), while the lowest prevalence rates were recorded in the healthy individuals ( 66.7%).Statistical analysis of anti –Helicobacter pylori IgG antibodies distribution among both healthy and thyroidism patients showed that highly significant differences at p < 0.01 were found between thyroid disorders patients groups.

Helicobacter pylori infection – when and how to treat

1993 ◽  
Vol 31 (4) ◽  
pp. 13-15
Keyword(s):  
Helicobacter Pylori ◽  
Relapse Rate ◽  
Clinical Relevance ◽  
Peptic Ulceration ◽  
Helicobacter Pylori Infection ◽  
Duodenal Ulceration ◽  
Short Course ◽  
H Pylori ◽  
Ulcer Treatment

Infection with Helicobacter pylori is common in patients with peptic ulceration. A short course of standard ulcer treatment usually heals ulceration but about 85 % of patients relapse within a year. In patients with duodenal ulceration, if H. pylori is eradicated the relapse rate falls to 0–20%. In this article we review the clinical relevance of H. pylori infection and the drugs used for its eradication.

scholarly journals A High-Throughput Metabolic Microarray Assay Reveals Antibacterial Effects of Black and Red Raspberries and Blackberries against Helicobacter pylori Infection

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 845
Author(s):  
Candace Goodman ◽  
Katrina N. Lyon ◽  
Aitana Scotto ◽  
Cyra Smith ◽  
Thomas A. Sebrell ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
High Throughput ◽  
Antibacterial Properties ◽  
Treatment Strategies ◽  
Helicobacter Pylori Infection ◽  
Antibacterial Effects ◽  
Biolog System ◽  
Freeze Dried ◽  
H Pylori

Helicobacter pylori infection is commonly treated with a combination of antibiotics and proton pump inhibitors. However, since H. pylori is becoming increasingly resistant to standard antibiotic regimens, novel treatment strategies are needed. Previous studies have demonstrated that black and red berries may have antibacterial properties. Therefore, we analyzed the antibacterial effects of black and red raspberries and blackberries on H. pylori. Freeze-dried powders and organic extracts from black and red raspberries and blackberries were prepared, and high-performance liquid chromatography was used to measure the concentrations of anthocyanins, which are considered the major active ingredients. To monitor antibiotic effects of the berry preparations on H. pylori, a high-throughput metabolic growth assay based on the Biolog system was developed and validated with the antibiotic metronidazole. Biocompatibility was analyzed using human gastric organoids. All berry preparations tested had significant bactericidal effects in vitro, with MIC90 values ranging from 0.49 to 4.17%. Antimicrobial activity was higher for extracts than powders and appeared to be independent of the anthocyanin concentration. Importantly, human gastric epithelial cell viability was not negatively impacted by black raspberry extract applied at the concentration required for complete bacterial growth inhibition. Our data suggest that black and red raspberry and blackberry extracts may have potential applications in the treatment and prevention of H. pylori infection but differ widely in their MICs. Moreover, we demonstrate that the Biolog metabolic assay is suitable for high-throughput antimicrobial susceptibility screening of H. pylori.

Prospective Assessment of Helicobacter Pylori Infection and Gastric Pathologies in Sidi Bel Abbes region, Western Algeria

2018 ◽  
Vol 7 (5) ◽  
pp. 217-224
Author(s):  
Zouaouia Chama ◽  
Khedoudj Kanoun ◽  
Fatima Zohra Elkadi ◽  
Kara Turqui Douidi ◽  
Noria Harir ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Histological Study ◽  
Helicobacter Pylori Infection ◽  
University Hospital ◽  
Infection Prevalence ◽  
Gastric Diseases ◽  
Number Of Patients ◽  
H Pylori ◽  
The Impact

Helicobacter pylori infection concerns half of the world’s population, mainly in developing countries. It causes several gastrodudenal pathologies such as gastritis, ulcer and gastric adenocarcinoma. The aim of our study was to determine the prevalence of H.pylori infection and to assess the impact of different epidemiological factors as well as principal gastric diseases associ-ated to this infection. We underwent a prospective study during 18 months (month 2016-month 2017) which implicated 201 symptomatic patients for gastric fiboptic endoscopy at the level of Sidi Bel Abbes University hospital. We collected patients’ biopsies to perform a histological study and H. pylori culture. H. pylori identification was carried out based on bacteriological and biochemical analysis. The middle age of our population was (47.29 ±15.97ans) and the sex-ratio =0,8. The global prevalence of Helicobacter pylori infection is of 61.2% (123/201). This rate, after a statistic analysis, seems to be significantly related to age. It is particularly high especially for patients belonging to age range (20-30)-(51-60) years. The gender did not affect the infection prevalence that is more frequent in the gastritis case. We noticed also that HP infection prevalence was important in SBA the hospital. The range age (20-30)-(51-60) years had the highest prevalence of H. pylori and of gastritis which might be a risky ground of gastric cancer appearance. The ulcer pathology maximal rate concerned the group of 51 to 60 years. Above this age, this rate dropped whereas the number of patients suffering from gastric cancer, which presents an important rate in our study, increase for the group of 61-70 years.

scholarly journals Epidemiology of upper gastrointestinal bleeding and Helicobacter pylori infection: review of 3,488 Thai patients

2017 ◽  
Vol 9 (1) ◽  
pp. 87-93
Author(s):  
Sakolwan Suchartlikitwong ◽  
Kamolyut Lapumnuaypol ◽  
Rungsun Rerknimitr ◽  
Duangporn Werawatganon
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Helicobacter Pylori Infection ◽  
Exclusion Criteria ◽  
Common Causes ◽  
Mucosal Lesions ◽  
H Pylori ◽  
Upper Gastrointestinal

Abstract Background The current epidemiology of upper gastrointestinal bleeding (UGIB) in Thailand is poorly understood and the reported prevalence of Helicobacter pylori infection is outdated. Objectives To investigate the etiologies of UGIB and prevalence of H. pylori infection in Thailand, including its association with UGIB. Methods We retrieved information regarding patients attending the endoscopic unit of King Chulalongkorn Memorial Hospital from June 2007 to January 2013. A database search using keywords “upper gastrointestinal bleeding” and “iron deficiency” was used. From 4,454 diagnoses, after exclusion criteria, 3,488 patients (2,042 male (58.5%) and 1,446 female (41.5%); mean age 63.3 ± 15.94 years, range 13–103 years) were included. Results The three most common causes of UGIB were peptic ulcer (38.2%), nonulcer-mucosal lesions (23.4%), and esophageal-related causes (20.4%). The 5 year-incidence of H. pylori was 25%–30%. The overall prevalence was 27%. The prevalence of H. pylori infection was found to decrease with age from 43.8% at <40 years to 21.7% at >79 years old. H. pylori infection was significantly associated with duodenal and gastroduodenal ulcers. Cirrhosis and nonulcer-mucosal lesions were significantly unrelated to H. pylori infection. Patients with concurrent cirrhosis with peptic ulcer were found to be negative for H. pylori infection. Conclusion Peptic ulcer is the leading cause of UGIB in Thailand. However, its incidence is declining. Patients who presented to hospital with UGIB were older, compared with those a decade ago. H. pylori infection plays an important role in UGIB and its incidence was stable during the past 5 years.

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