Field Stimulation | ScienceGate

AbstractLate Onset Alzheimer’s Disease is the most common cause of dementia, characterized by extracellular deposition of plaques primarily of amyloid-β (Aβ) peptide and tangles primarily of hyperphosphorylated tau protein. We present data to suggest a noninvasive strategy to decrease potentially toxic Aβ levels, using repeated electromagnetic field stimulation (REMFS) in primary human brain (PHB) cultures. We examined effects of REMFS on Aβ levels (Aβ40 and Aβ42, that are 40 or 42 amino acid residues in length, respectively) in PHB cultures at different frequencies, powers, and specific absorption rates (SAR). PHB cultures at day in vitro 7 (DIV7) treated with 64 MHz, and 1 hour daily for 14 days (DIV 21) had significantly reduced levels of secreted Aβ40 (p = 001) and Aβ42 (p = 0.029) peptides, compared to untreated cultures. PHB cultures (DIV7) treated at 64 MHz, for 1 or 2 hour during 14 days also produced significantly lower Aβ levels. PHB cultures (DIV28) treated with 64 MHz 1 hour/day during 4 or 8 days produced a similar significant reduction in Aβ40 levels. 0.4 W/kg was the minimum SAR required to produce a biological effect. Exposure did not result in cellular toxicity nor significant changes in secreted Aβ precursor protein-α (sAPPα) levels, suggesting the decrease in Aβ did not likely result from redirection toward the α-secretase pathway. EMF frequency and power used in our work is utilized in human magnetic resonance imaging (MRI, thus suggesting REMFS can be further developed in clinical settings to modulate Aβ deposition.

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Effects of the combination therapy of electric field stimulation and polyethylene glycol in the ex vivo spinal cord of female rats after compression

Journal of Neuroscience Research ◽

10.1002/jnr.24839 ◽

2021 ◽

Author(s):

Cheng Zhang ◽

Aihua Wang ◽

Guanghao Zhang ◽

Wei Rong ◽

Changzhe Wu ◽

...

Keyword(s):

Spinal Cord ◽

Polyethylene Glycol ◽

Combination Therapy ◽

Electric Field ◽

Ex Vivo ◽

Female Rats ◽

Field Stimulation ◽

Electric Field Stimulation

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Preoperative Elevated Levels for Depression, Anxiety, and Subjective Mental Stress Have No Influence on Outcome Measures of Peripheral Nerve Field Stimulation for Chronic Low Back Pain—A Prospective Study

Neuromodulation Technology at the Neural Interface ◽

10.1111/ner.13368 ◽

2021 ◽

Author(s):

Frank P. Schwarm ◽

Marc Ott ◽

Jasmin Nagl ◽

Frank Leweke ◽

Marco Stein ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Peripheral Nerve ◽

Prospective Study ◽

Chronic Low Back Pain ◽

Mental Stress ◽

Field Stimulation ◽

Low Back ◽

A Prospective Study ◽

Peripheral Nerve Field Stimulation

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Pulsed electromagnetic field stimulation may improve fusion rates in cervical arthrodesis in high-risk populations

Bone and Joint Research ◽

10.1302/2046-3758.72.bjr-2017-0221.r1 ◽

2018 ◽

Vol 7 (2) ◽

pp. 124-130 ◽

Cited By ~ 3

Author(s):

D. Coric ◽

D. E. Bullard ◽

V. V. Patel ◽

J. T. Ryaby ◽

B. L. Atkinson ◽

...

Keyword(s):

Electromagnetic Field ◽

Risk Factor ◽

High Risk ◽

Clinical Risk Factor ◽

Field Stimulation ◽

Pulsed Electromagnetic Field ◽

Exact Test ◽

High Risk Populations ◽

Pulsed Electromagnetic ◽

Pemf Treatment

Objectives Pulsed electromagnetic field (PEMF) stimulation was evaluated after anterior cervical discectomy and fusion (ACDF) procedures in a randomized, controlled clinical study performed for United States Food and Drug Administration (FDA) approval. PEMF significantly increased fusion rates at six months, but 12-month fusion outcomes for subjects at elevated risk for pseudoarthrosis were not thoroughly reported. The objective of the current study was to evaluate the effect of PEMF treatment on subjects at increased risk for pseudoarthrosis after ACDF procedures. Methods Two evaluations were performed that compared fusion rates between PEMF stimulation and a historical control (160 subjects) from the FDA investigational device exemption (IDE) study: a post hoc (PH) analysis of high-risk subjects from the FDA study (PH PEMF); and a multicentre, open-label (OL) study consisting of 274 subjects treated with PEMF (OL PEMF). Fisher’s exact test and multivariate logistic regression was used to compare fusion rates between PEMF-treated subjects and historical controls. Results In separate comparisons of PH PEMF and OL PEMF groups to the historical control group, PEMF treatment significantly (p < 0.05, Fisher’s exact test) increased the fusion rate at six and 12 months for certain high-risk subjects who had at least one clinical risk factor of being elderly, a nicotine user, osteoporotic, or diabetic; and for those with at least one clinical risk factor and who received at least a two- or three-level arthrodesis. Conclusion Adjunctive PEMF treatment can be recommended for patients who are at high risk for pseudoarthrosis. Cite this article: D. Coric, D. E. Bullard, V. V. Patel, J. T. Ryaby, B. L. Atkinson, D. He, R. D. Guyer. Pulsed electromagnetic field stimulation may improve fusion rates in cervical arthrodesis in high-risk populations. Bone Joint Res 2018;7:124–130. DOI: 10.1302/2046-3758.72.BJR-2017-0221.R1.

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Null Effect of Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex on Behavioral Performance in a Go/NoGo Task

Brain Sciences ◽

10.3390/brainsci11040483 ◽

2021 ◽

Vol 11 (4) ◽

pp. 483

Author(s):

Tatsunori Watanabe ◽

Nami Kubo ◽

Xiaoxiao Chen ◽

Keisuke Yunoki ◽

Takuya Matsumoto ◽

...

Keyword(s):

Magnetic Field ◽

Prefrontal Cortex ◽

Inhibitory Control ◽

Static Magnetic Field ◽

Dorsolateral Prefrontal Cortex ◽

Cortical Excitability ◽

Control Function ◽

Field Stimulation ◽

Dorsolateral Prefrontal ◽

The Right

The purpose of this pilot study was to investigate whether transcranial static magnetic field stimulation (tSMS), which can modulate cortical excitability, would influence inhibitory control function when applied over the dorsolateral prefrontal cortex (DLPFC). Young healthy adults (n = 8, mean age ± SD = 24.4 ± 4.1, six females) received the following stimulations for 30 min on different days: (1) tSMS over the left DLPFC, (2) tSMS over the right DLPFC, and (3) sham stimulation over either the left or right DLPFC. The participants performed a Go/NoGo task before, immediately after, and 10 min after the stimulation. They were instructed to extend the right wrist in response to target stimuli. We recorded the electromyogram from the right wrist extensor muscles and analyzed erroneous responses (false alarm and missed target detection) and reaction times. As a result, 50% of the participants made erroneous responses, and there were five erroneous responses in total (0.003%). A series of statistical analyses revealed that tSMS did not affect the reaction time. These preliminary findings suggest the possibility that tSMS over the DLPFC is incapable of modulating inhibitory control and/or that the cognitive load imposed in this study was insufficient to detect the effect.

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