Women’s Issues

Author(s):  
Sara Gorman ◽  
Judith Currier ◽  
Elise Hall ◽  
Julia del Amo

This chapter explores some of the unique challenges that often put women at higher risk of HIV infection and that create a course of illness that may differ from that found in men living with HIV. The first portion of the chapter discusses manifestations of HIV infection and the course of infection in women. It also addresses the particular issues associated with antiretroviral treatment (ART) and women, and the interactions between ART and depression in women. The chapter then goes on to broach an important topic that puts many women at high risk for HIV infection: gender-based violence, as well as some of the key, albeit limited, research on effective interventions for gender-based violence and HIV prevention. The third part of the chapter addresses issues related specifically to HIV and pregnancy, including vertical transmission. Finally, the chapter concludes with a discussion of a relatively neglected topic, HIV and menopause.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Manuela Colombini ◽  
◽  
Fiona Scorgie ◽  
Anne Stangl ◽  
Sheila Harvey ◽  
...  

Abstract Background Gender-based violence (GBV) undermines HIV prevention and treatment cascades, particularly among women who report partner violence. Screening for violence during HIV testing, and prior to offering pre-exposure prophylaxis (PrEP) to HIV uninfected women, provides an opportunity to identify those at heightened HIV risk and greater potential for non-adherence or early discontinuation of PrEP. The paper describes our experience with offering integrated GBV screening and referral as part of HIV counselling and testing. This component was implemented within EMPOWER, a demonstration project offering combination HIV prevention, including daily oral PrEP, to young women in South Africa and Tanzania. Methods Between February 2017 and March 2018, a process evaluation was conducted to explore views, experiences and practices of stakeholders (study participants and study clinical staff) during implementation of the GBV screening component. This article assesses the feasibility and acceptability of the approach from multiple stakeholder perspectives, drawing on counselling session observations (n = 10), in-depth interviews with participants aged 16–24 (n = 39) and clinical staff (n = 13), and notes from debriefings with counsellors. Study process data were also collected (e.g. number of women screened and referred). Following a thematic inductive approach, qualitative data were analysed using qualitative software (NVivo 11). Results Findings show that 31% of young women screened positive for GBV and only 10% requested referrals. Overall, study participants accessing PrEP were amenable to being asked about violence during HIV risk assessment, as this offered the opportunity to find emotional relief and seek help, although a few found this traumatic. In both sites, the sensitive and empathetic approach of the staff helped mitigate distress of GBV disclosure. In general, the delivery of GBV screening in HCT proved to be feasible, provided that the basic principles of confidentiality, staff empathy, and absence of judgment were observed. However, uptake of linkage to further care remained low in both sites. Conclusion Most stakeholders found GBV screening acceptable and feasible. Key principles that should be in place for young women to be asked safely about GBV during HIV counselling and testing included respect for confidentiality, a youth-friendly and non-judgmental environment, and a functioning referral network.


Author(s):  
Dean Follmann

Abstract Effective HIV prevention has the potential to change the landscape of HIV prevention trials. Low infection rates will make superiority studies necessarily large while non-inferiority trials will need some evidence that a counterfactual placebo group had a meaningful HIV infection rate in order to provide evidence of effective interventions. This paper explores these challenges in the context of immune related interventions of mAbs and vaccines. We discuss the issue of effect modification in the presence of PrEP, where subjects on PrEP may have less of a benefit of a mAb or (vaccine) than subjects off PrEP. We also discuss different methods of placebo infection rate imputation. We estimate infection risk as a function of mAb level (or vaccine induced immune response) in the mAb (or vaccine) arm and then extrapolate this infection risk to zero mAbs as a proxy for the placebo infection rate. Important aspects are the use of triangulation or multiple methods to impute the placebo infection rate, concern about extrapolation if few mAbs are close to zero, and the use of currently available data with placebo groups to rigorously evaluate the accuracy of imputation methods. We also discuss use of historical controls and some generalizations of the idea of (DMurray, J. 2019. “Regulatory Perspectives for Streamlining HIV Prevention Trials.” Statistical Communications in Infectious Diseases.) to use rectal gonorrhea rates to impute HIV infection rate. Generalizations include regression adjustment to calibrate for potential differences in baseline covariates for ongoing vs historical studies and the use of the gonorrhea, HIV relationship in a contemporaneous observational study. Examples of recent and ongoing trials of malaria chemoprophylaxis and HPV vaccines, where extremely effect prevention methods are available, are provided.


The Lancet ◽  
2004 ◽  
Vol 363 (9419) ◽  
pp. 1415-1421 ◽  
Author(s):  
Kristin L Dunkle ◽  
Rachel K Jewkes ◽  
Heather C Brown ◽  
Glenda E Gray ◽  
James A McIntryre ◽  
...  

2021 ◽  
pp. 1-2
Author(s):  
Savadogo M ◽  
Diallo I ◽  
Sondo K A

Introduction: Sub-Saharan Africa remains one of the regions most affected by HIV infection with severe lethality.Most deaths of patients living with HIV are caused by opportunistic infections. Objective: to determine the prevalence of opportunistic infections among patients living with HIV in hospital serving infectious diseases of UHC YO of Ouagadougou. Patients and Methods:This is a cross-sectional descriptive study covering a 14-month period from 1 January 2017 to 28 February 2018. Included were all HIV-positive patients, hospitalized at the service of Infectious Diseases, in which an opportunistic infection was diagnosed on the basis of clinical and/or para-clinical arguments. Results: During the study period a total of 55 patients living with HIV were hospitalized in the infectious disease unit,35 of whom had at least one opportunistic infection or 63.6% of the patients.The average age of patients was 37 years with extremes of 18 and 66 years.Twenty-two patients were female versus 13 male, a sex ratio = 0.59. HIV1 was involved in 97% of patients.The mean TCD4 lymphocyte rate was 156 cell/mm3 with extremes of 7 and 718 cell/mm3.Tuberculosis and digestive mycosis were the most frequently diagnosed opportunistic infections. Opportunistic infection was the circumstance for HIV testing in two patients.She revealed immune restoration syndrome in two other patients.Nineteen patients were already on antiretroviral treatment upon admission to the service.Half of the patients on treatment were in therapeutic failure.The evolution was marked by 26.5% lethality. Conclusion:The frequency of opportunistic infections is high in patients living with HIV.Their prevention requires early detection of HIV infection and antiretroviral treatment.


Author(s):  
Anthony Wainaina Ndungu

Gender Based Violence is a universal catastrophe affecting global health, and thus development and is a major human rights concern. This study’s major objective was to establish what extent gender-based violence prevention influence performance of HIV prevention projects for young women and teenagers in Kisumu County. The study population constituted of teenage girls, and young women enrolled in HIV prevention projects implemented in Kisumu County for at least two years. Interviews were also conducted with key project implementers including project managers and monitoring and evaluation managers. Data collection for the study was done by utilizing data collection tools which included focused group discussion, structured questionnaires and an interview guide. 364 respondents were taken from 89,611 adolescents enrolled in HIV prevention projects using stratified random sampling technique. For descriptive data the study employed percentages, frequencies Arithmetic Mean as analytical tools of analysis. The Pearson’s value and Linear Regression were manipulated as statistical tools for inferential statistics. To test the hypotheses, the Fisher (F) test utilized. Descriptive statistics showed that gender-based violence prevention has a noteworthy effect on the production of HIV prevention projects for young women and adolescent girls in Kisumu County. The value of r2 was 0.452, indicating that gender-based violence prevention explained 45.2% of the change in the effectiveness of HIV prevention projects in Kisumu. The beta coefficient was 0.623, implying that gender-based violence had a noteworthy statistical impact on the performance of HIV prevention projects (β=0.623, t=10.928, p=0.000<0.05).


2021 ◽  
Vol 40 (12) ◽  
pp. 1096-1100
Author(s):  
Marta Illán Ramos ◽  
Beatriz Soto Sánchez ◽  
Diana Mazariegos Orellana ◽  
Luis Manuel Prieto Tato ◽  
Sara Guillén Martín ◽  
...  

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Michelle R. Kaufman ◽  
Ashlie M. Williams ◽  
Graziele Grilo ◽  
Christina X. Marea ◽  
Fasil Walelign Fentaye ◽  
...  

Abstract Background There is a high prevalence of gender-based violence (GBV) victimization among young Ethiopian women, including in universities, where female enrollment is low but growing. Understanding factors contributing to GBV in this context and students’ perspectives on gender, relationships, and interpersonal violence is essential to creating effective interventions to prevent GBV and support female students’ rights and wellbeing. Methods In-depth interviews (IDIs) and focus group discussions (FGDs) were held with male and female students (male IDI n = 36, female IDI n = 34, male FGD n = 18, female FGD n = 19) and faculty and staff (FGD n = 19) at two Ethiopian universities. Audio recordings were transcribed and translated into English. Transcripts were coded thematically to identify key factors contributing to GBV and provide narratives of students’ experiences. Results GBV against female students was a salient issue, including narrative accounts of harassment, intimidation, and physical and sexual violence on the university campuses and the towns in which they are located. Reported risks for GBV included receiving academic support from male peers, exercising agency in relationship decision-making, having a negative self-concept, belief in stereotypical gender expectations, and engaging in transactional sex and/or substance use. While students recognized these risk factors, they also suggested GBV may be the result of females’ “improper” behavior, attire, use of males for personal gain, or personal failure to prevent violence. Conclusions GBV is a serious issue in these two Ethiopian universities, creating a tenuous learning environment for female students. Programs are needed to address areas of vulnerability and negative attitudes toward female students in order to decrease female victimization.


2019 ◽  
Vol 5 (Supplement_1) ◽  
Author(s):  
Francois Cholette ◽  
Christina Daniuk ◽  
Emma Lee ◽  
Rupert Capina ◽  
Eve Cheuk ◽  
...  

Abstract The transitions study examines HIV risk among adolescent girls and young women through their sexual life course from first sex, to past and current engagement in casual sex, transactional sex, and, for some, formal sex work (FSW). Understanding the timing of HIV infection and the circumstances around early infection in young females is critical to HIV prevention interventions. We inferred time since HIV infection using next-generation sequencing (NGS) of the HIV pol gene isolated from cross-sectional samples among high-risk young women in Dnipro, Ukraine. Dried blood spots were collected on Whatman 903 cards from young women aged 14–24 engaged in casual sex (n = 894), transactional sex (n = 464), and FSW (n = 452). The HIV pol gene was sequenced using an in-house NGS HIV drug resistance mutation genotyping assay. Time since HIV infection was inferred using an online tool as described by Puller et al. (2017) freely available at https://hiv.biozentrum.unibas.ch/ETI/. The mean estimated time since HIV infection (ETI) for participants engaged in casual sex, transactional sex, and FSW is 1.98, 1.84, and 3.01 years, respectively. ETI was used to determine the duration of HIV infection for each participant and compared to the number of sexually active years prior to FSW. Among FSW, 61 per cent of participants were infected with HIV prior to entry into sex work. In general, ETI from NGS data suggests that FSWs were infected with HIV before entry into FSW. Expansion of targeted prevention programs beyond FSW could play an important role in mitigating HIV transmission at the population level.


1994 ◽  
Vol 15 (2) ◽  
pp. 145-163 ◽  
Author(s):  
Kathleen M. Lux ◽  
Rick Petosa

The purpose of this study was to use an enhanced version of the Health Belief Model as a conceptual framework to describe health beliefs and safer sex intentions for HIV prevention educational needs of juvenile delinquents between the ages of thirteen to eighteen years incarcerated in state supported training schools in Ohio. An accessible sample ( n = 452) of juvenile delinquents from four of nine institutions was the study population. Juvenile delinquents in this study were at high risk for HIV infection. They reported low rates of safer sex intentions. Rates of perceived barriers to condom use and perceived social barriers to safer sex were high and consistent with low rates of safer sex intention. Rates of self-efficacy for condom use were high but inconsistent with intentions. While a majority of subjects reported self-efficacy for discussion of sexual histories, a larger majority reported low efficacy for disclosing previous high-risk behavior. This suggests that discussion of sexual history with a partner may not be effective in reducing risk among this population. The primary source of information about HIV was the mass media. HIV prevention programs for juvenile delinquents should consider the current health beliefs of this high-risk, hard-to-reach population.


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